{"data":{"id":"10.6084/m9.figshare.1300170.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1300170.v1","prefix":"10.6084","suffix":"m9.figshare.1300170.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Karami, Sara","nameType":"Personal","givenName":"Sara","familyName":"Karami","affiliation":[],"nameIdentifiers":[]},{"name":"Andreotti, Gabriella","nameType":"Personal","givenName":"Gabriella","familyName":"Andreotti","affiliation":[],"nameIdentifiers":[]},{"name":"Liao, Linda M","nameType":"Personal","givenName":"Linda M","familyName":"Liao","affiliation":[],"nameIdentifiers":[]},{"name":"Pfeiffer, Ruth M","nameType":"Personal","givenName":"Ruth M","familyName":"Pfeiffer","affiliation":[],"nameIdentifiers":[]},{"name":"Weinstein, Stephanie J","nameType":"Personal","givenName":"Stephanie J","familyName":"Weinstein","affiliation":[],"nameIdentifiers":[]},{"name":"Purdue, Mark P","nameType":"Personal","givenName":"Mark P","familyName":"Purdue","affiliation":[],"nameIdentifiers":[]},{"name":"Hofmann, Jonathan N","nameType":"Personal","givenName":"Jonathan N","familyName":"Hofmann","affiliation":[],"nameIdentifiers":[]},{"name":"Albanes, Demetrius","nameType":"Personal","givenName":"Demetrius","familyName":"Albanes","affiliation":[],"nameIdentifiers":[]},{"name":"Mannisto, Satu","nameType":"Personal","givenName":"Satu","familyName":"Mannisto","affiliation":[],"nameIdentifiers":[]},{"name":"Moore, Lee E","nameType":"Personal","givenName":"Lee E","familyName":"Moore","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"LINE-1 methylation levels in pre-diagnostic leukocyte DNA and future renal cell carcinoma risk"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Science Policy"},{"subject":"Cancer"},{"subject":"Biotechnology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"}],"contributors":[],"dates":[{"date":"2015-04-03","dateType":"Created"},{"date":"2016-01-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15592294.2015.1006505","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1300170","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["91136 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":": (N=281)Higher levels of LINE1 methylation in blood DNA have been associated with increased kidney cancer risk using post-diagnostically collected samples; however, this association has never been examined using pre-diagnostic samples. We examined the association between LINE1 %5mC and renal cell carcinoma (RCC) risk using pre-diagnostic blood DNA from the United States-based, prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) (215 cases/436 controls), and the α-tocopherol, β-carotene cancer prevention study (ATBC) of Finnish male smokers (191 cases/575 controls). Logistic regression adjusted for age at blood draw, study center, pack-years of smoking, body mass index, hypertension, dietary alcohol intake, family history of cancer, and sex was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) using cohort and sex-specific methylation categories. In PLCO, higher, although non-significant, RCC risk was observed for participants at or above median methylation level (M2) compared to those below the median (M1) (OR: 1.37, 95% CI: 0.96-1.95). The association was stronger in males (M2 vs. M1, OR: 1.54, 95% CI: 1.00-2.39) and statistically significant among male smokers (M2 vs. M1, OR: 2.60, 95% CI: 1.46-4.63). A significant interaction for smoking was also detected (\u003ci\u003eP\u003c/i\u003e-interaction: 0.01). No association was found among females or female smokers. Findings for male smokers were replicated in ATBC (M2 vs. M1, OR: 1.31, 95% CI: 1.07-1.60). In a pooled analysis of PLCO and ATBC male smokers (281cases/755controls), the OR among subjects at or above median methylation level (M2) compared to those below the median (M1) was 1.89 (95% CI: 1.34-2.67, \u003ci\u003eP\u003c/i\u003e-value: 3 x 10\u003csup\u003e−4\u003c/sup\u003e); a trend was also observed by methylation quartile (\u003ci\u003eP\u003c/i\u003e-trend: 0.002). These findings suggest that higher LINE1 methylation levels measured prior to cancer diagnosis may be a biomarker of future RCC risk among male smokers.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjEvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLjEzMDAxNzAuVjE8L2lkZW50aWZpZXI+CiAgPGNyZWF0b3JzPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5TYXJhIEthcmFtaTwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPkdhYnJpZWxsYSBBbmRyZW90dGk8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5MaW5kYSBNIExpYW88L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5SdXRoIE0gUGZlaWZmZXI8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5TdGVwaGFuaWUgSiBXZWluc3RlaW48L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5NYXJrIFAgUHVyZHVlPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+Sm9uYXRoYW4gTiBIb2ZtYW5uPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+RGVtZXRyaXVzIEFsYmFuZXM8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5TYXR1IE1hbm5pc3RvPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+TGVlIEUgTW9vcmU8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogIDwvY3JlYXRvcnM+CiAgPHRpdGxlcz4KICAgIDx0aXRsZT5MSU5FLTEgbWV0aHlsYXRpb24gbGV2ZWxzIGluIHByZS1kaWFnbm9zdGljIGxldWtvY3l0ZSBETkEgYW5kIGZ1dHVyZSByZW5hbCBjZWxsIGNhcmNpbm9tYSByaXNrPC90aXRsZT4KICA8L3RpdGxlcz4KICA8ZGVzY3JpcHRpb25zPgogICAgPGRlc2NyaXB0aW9uIGRlc2NyaXB0aW9uVHlwZT0iQWJzdHJhY3QiPiZsdDtkaXYmZ3Q7Jmx0O3AmZ3Q7OiAoTj0yODEpJmx0Oy9wJmd0OyZsdDtwJmd0O0hpZ2hlciBsZXZlbHMgb2YgTElORTEgbWV0aHlsYXRpb24gaW4gYmxvb2QgRE5BIGhhdmUgYmVlbiBhc3NvY2lhdGVkIHdpdGggaW5jcmVhc2VkIGtpZG5leSBjYW5jZXIgcmlzayB1c2luZyBwb3N0LWRpYWdub3N0aWNhbGx5IGNvbGxlY3RlZCBzYW1wbGVzOyBob3dldmVyLCB0aGlzIGFzc29jaWF0aW9uIGhhcyBuZXZlciBiZWVuIGV4YW1pbmVkIHVzaW5nIHByZS1kaWFnbm9zdGljIHNhbXBsZXMuIFdlIGV4YW1pbmVkIHRoZSBhc3NvY2lhdGlvbiBiZXR3ZWVuIExJTkUxICU1bUMgYW5kIHJlbmFsIGNlbGwgY2FyY2lub21hIChSQ0MpIHJpc2sgdXNpbmcgcHJlLWRpYWdub3N0aWMgYmxvb2QgRE5BIGZyb20gdGhlIFVuaXRlZCBTdGF0ZXMtYmFzZWQsIHByb3N0YXRlLCBsdW5nLCBjb2xvcmVjdGFsLCBhbmQgb3ZhcmlhbiBjYW5jZXIgc2NyZWVuaW5nIHRyaWFsIChQTENPKSAoMjE1IGNhc2VzLzQzNiBjb250cm9scyksIGFuZCB0aGUgzrEtdG9jb3BoZXJvbCwgzrItY2Fyb3RlbmUgY2FuY2VyIHByZXZlbnRpb24gc3R1ZHkgKEFUQkMpIG9mIEZpbm5pc2ggbWFsZSBzbW9rZXJzICgxOTEgY2FzZXMvNTc1IGNvbnRyb2xzKS4gTG9naXN0aWMgcmVncmVzc2lvbiBhZGp1c3RlZCBmb3IgYWdlIGF0IGJsb29kIGRyYXcsIHN0dWR5IGNlbnRlciwgcGFjay15ZWFycyBvZiBzbW9raW5nLCBib2R5IG1hc3MgaW5kZXgsIGh5cGVydGVuc2lvbiwgZGlldGFyeSBhbGNvaG9sIGludGFrZSwgZmFtaWx5IGhpc3Rvcnkgb2YgY2FuY2VyLCBhbmQgc2V4IHdhcyB1c2VkIHRvIGNhbGN1bGF0ZSBvZGRzIHJhdGlvcyAoT1JzKSBhbmQgOTUlIGNvbmZpZGVuY2UgaW50ZXJ2YWxzIChDSXMpIHVzaW5nIGNvaG9ydCBhbmQgc2V4LXNwZWNpZmljIG1ldGh5bGF0aW9uIGNhdGVnb3JpZXMuIEluIFBMQ08sIGhpZ2hlciwgYWx0aG91Z2ggbm9uLXNpZ25pZmljYW50LCBSQ0MgcmlzayB3YXMgb2JzZXJ2ZWQgZm9yIHBhcnRpY2lwYW50cyBhdCBvciBhYm92ZSBtZWRpYW4gbWV0aHlsYXRpb24gbGV2ZWwgKE0yKSBjb21wYXJlZCB0byB0aG9zZSBiZWxvdyB0aGUgbWVkaWFuIChNMSkgKE9SOiAxLjM3LCA5NSUgQ0k6IDAuOTYtMS45NSkuIFRoZSBhc3NvY2lhdGlvbiB3YXMgc3Ryb25nZXIgaW4gbWFsZXMgKE0ywqB2cy4gTTEsIE9SOiAxLjU0LCA5NSUgQ0k6IDEuMDAtMi4zOSkgYW5kIHN0YXRpc3RpY2FsbHkgc2lnbmlmaWNhbnQgYW1vbmcgbWFsZSBzbW9rZXJzIChNMsKgdnMuIE0xLCBPUjogMi42MCwgOTUlIENJOiAxLjQ2LTQuNjMpLiBBIHNpZ25pZmljYW50IGludGVyYWN0aW9uIGZvciBzbW9raW5nIHdhcyBhbHNvIGRldGVjdGVkICgmbHQ7aSZndDtQJmx0Oy9pJmd0Oy1pbnRlcmFjdGlvbjogMC4wMSkuIE5vIGFzc29jaWF0aW9uIHdhcyBmb3VuZCBhbW9uZyBmZW1hbGVzIG9yIGZlbWFsZSBzbW9rZXJzLiBGaW5kaW5ncyBmb3IgbWFsZSBzbW9rZXJzIHdlcmUgcmVwbGljYXRlZCBpbiBBVEJDIChNMsKgdnMuIE0xLCBPUjogMS4zMSwgOTUlIENJOiAxLjA3LTEuNjApLiBJbiBhIHBvb2xlZCBhbmFseXNpcyBvZiBQTENPIGFuZCBBVEJDIG1hbGUgc21va2VycyAoMjgxY2FzZXMvNzU1Y29udHJvbHMpLCB0aGUgT1IgYW1vbmcgc3ViamVjdHMgYXQgb3IgYWJvdmUgbWVkaWFuIG1ldGh5bGF0aW9uIGxldmVsIChNMikgY29tcGFyZWQgdG8gdGhvc2UgYmVsb3cgdGhlIG1lZGlhbiAoTTEpIHdhcyAxLjg5ICg5NSUgQ0k6IDEuMzQtMi42NywgJmx0O2kmZ3Q7UCZsdDsvaSZndDstdmFsdWU6IDMgeCAxMCZsdDtzdXAmZ3Q74oiSNCZsdDsvc3VwJmd0Oyk7IGEgdHJlbmQgd2FzIGFsc28gb2JzZXJ2ZWQgYnkgbWV0aHlsYXRpb24gcXVhcnRpbGUgKCZsdDtpJmd0O1AmbHQ7L2kmZ3Q7LXRyZW5kOiAwLjAwMikuIFRoZXNlIGZpbmRpbmdzIHN1Z2dlc3QgdGhhdCBoaWdoZXIgTElORTEgbWV0aHlsYXRpb24gbGV2ZWxzIG1lYXN1cmVkIHByaW9yIHRvIGNhbmNlciBkaWFnbm9zaXMgbWF5IGJlIGEgYmlvbWFya2VyIG9mIGZ1dHVyZSBSQ0MgcmlzayBhbW9uZyBtYWxlIHNtb2tlcnMuJmx0Oy9wJmd0OyZsdDsvZGl2Jmd0OzwvZGVzY3JpcHRpb24+CiAgPC9kZXNjcmlwdGlvbnM+CiAgPHN1YmplY3RzPgogICAgPHN1YmplY3Qgc2NoZW1lVVJJPSJodHRwOi8vd3d3LmFicy5nb3YuYXUvYXVzc3RhdHMvYWJzQC5uc2YvMC82QkI0MjdBQjk2OTZDMjI1Q0EyNTc0MTgwMDA0NDYzRSIgc3ViamVjdFNjaGVtZT0iRk9SIj4xMTE3MTQgTWVudGFsIEhlYWx0aDwvc3ViamVjdD4KICAgIDxzdWJqZWN0PlNjaWVuY2UgUG9saWN5PC9zdWJqZWN0PgogICAgPHN1YmplY3Q+Q2FuY2VyPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+QmlvdGVjaG5vbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkdlbmV0aWNzPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+Q2VsbCBCaW9sb2d5PC9zdWJqZWN0PgogIDwvc3ViamVjdHM+CiAgPHB1Ymxpc2hlcj5UYXlsb3IgJmFtcDsgRnJhbmNpczwvcHVibGlzaGVyPgogIDxwdWJsaWNhdGlvblllYXI+MjAxNTwvcHVibGljYXRpb25ZZWFyPgogIDxkYXRlcz4KICAgIDxkYXRlIGRhdGVUeXBlPSJDcmVhdGVkIj4yMDE1LTA0LTAzPC9kYXRlPgogICAgPGRhdGUgZGF0ZVR5cGU9IlVwZGF0ZWQiPjIwMTYtMDEtMTk8L2RhdGU+CiAgPC9kYXRlcz4KICA8cmVzb3VyY2VUeXBlIHJlc291cmNlVHlwZUdlbmVyYWw9IkRhdGFzZXQiPkRhdGFzZXQ8L3Jlc291cmNlVHlwZT4KICA8c2l6ZXM+CiAgICA8c2l6ZT45MTEzNiBCeXRlczwvc2l6ZT4KICA8L3NpemVzPgogIDxyZWxhdGVkSWRlbnRpZmllcnM+CiAgICA8cmVsYXRlZElkZW50aWZpZXIgcmVsYXRlZElkZW50aWZpZXJUeXBlPSJET0kiIHJlbGF0aW9uVHlwZT0iSXNTdXBwbGVtZW50VG8iPjEwLjEwODAvMTU1OTIyOTQuMjAxNS4xMDA2NTA1PC9yZWxhdGVkSWRlbnRpZmllcj4KICAgIDxyZWxhdGVkSWRlbnRpZmllciByZWxhdGVkSWRlbnRpZmllclR5cGU9IkRPSSIgcmVsYXRpb25UeXBlPSJJc1ByZXZpb3VzVmVyc2lvbk9mIj4xMC42MDg0L205LmZpZ3NoYXJlLjEzMDAxNzA8L3JlbGF0ZWRJZGVudGlmaWVyPgogIDwvcmVsYXRlZElkZW50aWZpZXJzPgogIDxyaWdodHNMaXN0PgogICAgPHJpZ2h0cyByaWdodHNVUkk9Imh0dHBzOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS80LjAvIj5DQyBCWSA0LjA8L3JpZ2h0cz4KICA8L3JpZ2h0c0xpc3Q+CjwvcmVzb3VyY2U+","url":"https://tandf.figshare.com/articles/dataset/LINE_1_methylation_levels_in_pre_diagnostic_leukocyte_DNA_and_future_renal_cell_carcinoma_risk/1300170/1","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-01-19T14:30:30.000Z","registered":"2016-01-19T14:30:31.000Z","published":"2015","updated":"2020-09-04T19:13:03.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.1300170.v1","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}