{"data":{"id":"10.6084/m9.figshare.1293479.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1293479.v1","prefix":"10.6084","suffix":"m9.figshare.1293479.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Kurara Takagane","affiliation":[],"nameIdentifiers":[]},{"name":"Nojima, Jun","nameType":"Personal","givenName":"Jun","familyName":"Nojima","affiliation":[],"nameIdentifiers":[]},{"name":"Mitsuhashi, Hiroaki","nameType":"Personal","givenName":"Hiroaki","familyName":"Mitsuhashi","affiliation":[],"nameIdentifiers":[]},{"name":"Suo, Satoshi","nameType":"Personal","givenName":"Satoshi","familyName":"Suo","affiliation":[],"nameIdentifiers":[]},{"name":"Yanagihara, Dai","nameType":"Personal","givenName":"Dai","familyName":"Yanagihara","affiliation":[],"nameIdentifiers":[]},{"name":"Takaiwa, Fumio","nameType":"Personal","givenName":"Fumio","familyName":"Takaiwa","affiliation":[],"nameIdentifiers":[]},{"name":"Yasuomi Urano","affiliation":[],"nameIdentifiers":[]},{"name":"Noguchi, Noriko","nameType":"Personal","givenName":"Noriko","familyName":"Noguchi","affiliation":[],"nameIdentifiers":[]},{"name":"Ishiura, Shoichi","nameType":"Personal","givenName":"Shoichi","familyName":"Ishiura","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Aβ induces oxidative stress in senescence-accelerated (SAMP8) mice"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Science Policy"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Neuroscience"},{"subject":"Molecular Biology"},{"subject":"Cell Biology"}],"contributors":[],"dates":[{"date":"2015-06-03","dateType":"Created"},{"date":"2016-01-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/09168451.2014.1002449","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1293479","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["3790682 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"According to the amyloid hypothesis, amyloid β accumulates in brains with Alzheimer’s disease (AD) and triggers cell death and memory deficit. Previously, we developed a rice Aβ vaccine expressing Aβ, which reduced brain Aβ levels in the Tg2576 mouse model of familial AD. We used senescence-accelerated SAMP8 mice as a model of sporadic AD and investigated the relationship between Aβ and oxidative stress. Insoluble Aβ and 4-hydroxynonenal (4-HNE) levels tended to be reduced in SAMP8 mice-fed the rice Aβ vaccine. We attempted to clarify the relationship between oxidative stress and Aβ \u003ci\u003ein vitro\u003c/i\u003e. Addition of Aβ peptide to the culture medium resulted in an increase in 4-HNE levels in SH-SY5Y cells. Tg2576 mice, which express large amounts of Aβ in their brain, also exhibited increased 4-HNE levels; this increase was inhibited by the Aβ vaccine. These results indicate that Aβ induces oxidative stress in cultured cells and in the mouse brain.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/A_946_induces_oxidative_stress_in_senescence_accelerated_SAMP8_mice/1293479/1","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-01-19T13:55:14.000Z","registered":"2016-01-19T13:55:15.000Z","published":"2015","updated":"2020-09-04T19:21:35.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.1293479.v1","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}