{"data":{"id":"10.6084/m9.figshare.1289845.v3","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1289845.v3","prefix":"10.6084","suffix":"m9.figshare.1289845.v3","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Wang, Na","givenName":"Na","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"She, Junjun","givenName":"Junjun","familyName":"She","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Wei","givenName":"Wei","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Shi, Jing","givenName":"Jing","familyName":"Shi","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, Qi","givenName":"Qi","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Shi, Bingyin","givenName":"Bingyin","familyName":"Shi","affiliation":[],"nameIdentifiers":[]},{"name":"Hou, Peng","givenName":"Peng","familyName":"Hou","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Frequent amplification of \u003ci\u003ePTP1B\u003c/i\u003e is associated with poor survival of gastric cancer patients"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Science Policy"},{"subject":"Cancer"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Medicine"},{"subject":"Physics"},{"subject":"Biochemistry"},{"subject":"Biophysics"}],"contributors":[],"dates":[{"date":"2015-10-08","dateType":"Created"},{"date":"2023-06-29","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1289845","relatedIdentifierType":"DOI"},{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15384101.2014.998047","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["996440 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The protein tyrosine phosphatase 1B (\u003ci\u003ePTP1B\u003c/i\u003e), a non-transmembrane protein tyrosine phosphatase, has been implicated in gastric pathogenesis. Several lines of recent evidences have shown that \u003ci\u003ePTP1B\u003c/i\u003e is highly amplified in breast and prostate cancers. The aim of this study was to investigate \u003ci\u003ePTP1B\u003c/i\u003e amplification in gastric cancer and its association with poor prognosis of gastric cancer patients, and further determine the role of \u003ci\u003ePTP1B\u003c/i\u003e in gastric tumorigenesis. Our data demonstrated that \u003ci\u003ePTP1B\u003c/i\u003e was significantly up-regulated in gastric cancer tissues as compared with matched normal gastric tissues by using quantitative RT-PCR (qRT-PCR) assay. In addition, copy number analysis showed that \u003ci\u003ePTP1B\u003c/i\u003e was amplified in 68/131 (51.9%) gastric cancer cases, whereas no amplification was found in the control subjects. Notably, \u003ci\u003ePTP1B\u003c/i\u003e amplification was positively associated with its protein expression, and was significantly related to poor survival of gastric cancer patients. Knocking down \u003ci\u003ePTP1B\u003c/i\u003e expression in gastric cancer cells significantly inhibited cell proliferation, colony formation, migration and invasion, and induced cell cycle arrested and apoptosis. Mechanically, \u003ci\u003ePTP1B\u003c/i\u003e promotes gastric cancer cell proliferation, survival and invasiveness through modulating Src-related signaling pathways, such as Src/Ras/MAPK and Src/phosphatidylinositol-3-kinase (PI3K)/Akt pathways. Collectively, our data demonstrated frequent overexpression and amplification \u003ci\u003ePTP1B\u003c/i\u003e in gastric cancer, and further determined the oncogenic role of \u003ci\u003ePTP1B\u003c/i\u003e in gastric carcinogenesis. Importantly, \u003ci\u003ePTP1B\u003c/i\u003e amplification predicts poor survival of gastric cancer patients.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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