{"data":{"id":"10.6084/m9.figshare.1289845","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1289845","prefix":"10.6084","suffix":"m9.figshare.1289845","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Wang, Na","givenName":"Na","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"She, Junjun","givenName":"Junjun","familyName":"She","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Wei","givenName":"Wei","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Shi, Jing","givenName":"Jing","familyName":"Shi","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, Qi","givenName":"Qi","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Shi, Bingyin","givenName":"Bingyin","familyName":"Shi","affiliation":[],"nameIdentifiers":[]},{"name":"Hou, Peng","givenName":"Peng","familyName":"Hou","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Frequent amplification of \u003ci\u003ePTP1B\u003c/i\u003e is associated with poor survival of gastric cancer patients"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"Physical Sciences not elsewhere classified"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Chemical Sciences not elsewhere classified"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences not elsewhere classified"},{"subject":"Cancer"},{"subject":"Science Policy"},{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2015-10-09","dateType":"Created"},{"date":"2023-05-30","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15384101.2014.998047","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["996440 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The protein tyrosine phosphatase 1B (\u003ci\u003ePTP1B\u003c/i\u003e), a non-transmembrane protein tyrosine phosphatase, has been implicated in gastric pathogenesis. Several lines of recent evidences have shown that \u003ci\u003ePTP1B\u003c/i\u003e is highly amplified in breast and prostate cancers. The aim of this study was to investigate \u003ci\u003ePTP1B\u003c/i\u003e amplification in gastric cancer and its association with poor prognosis of gastric cancer patients, and further determine the role of \u003ci\u003ePTP1B\u003c/i\u003e in gastric tumorigenesis. Our data demonstrated that \u003ci\u003ePTP1B\u003c/i\u003e was significantly up-regulated in gastric cancer tissues as compared with matched normal gastric tissues by using quantitative RT-PCR (qRT-PCR) assay. In addition, copy number analysis showed that \u003ci\u003ePTP1B\u003c/i\u003e was amplified in 68/131 (51.9%) gastric cancer cases, whereas no amplification was found in the control subjects. Notably, \u003ci\u003ePTP1B\u003c/i\u003e amplification was positively associated with its protein expression, and was significantly related to poor survival of gastric cancer patients. Knocking down \u003ci\u003ePTP1B\u003c/i\u003e expression in gastric cancer cells significantly inhibited cell proliferation, colony formation, migration and invasion, and induced cell cycle arrested and apoptosis. Mechanically, \u003ci\u003ePTP1B\u003c/i\u003e promotes gastric cancer cell proliferation, survival and invasiveness through modulating Src-related signaling pathways, such as Src/Ras/MAPK and Src/phosphatidylinositol-3-kinase (PI3K)/Akt pathways. Collectively, our data demonstrated frequent overexpression and amplification \u003ci\u003ePTP1B\u003c/i\u003e in gastric cancer, and further determined the oncogenic role of \u003ci\u003ePTP1B\u003c/i\u003e in gastric carcinogenesis. Importantly, \u003ci\u003ePTP1B\u003c/i\u003e amplification predicts poor survival of gastric cancer patients.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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