{"data":{"id":"10.6084/m9.figshare.1288861.v2","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1288861.v2","prefix":"10.6084","suffix":"m9.figshare.1288861.v2","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Malhotra, Ritu","nameType":"Personal","givenName":"Ritu","familyName":"Malhotra","affiliation":[],"nameIdentifiers":[]},{"name":"Warne, James P","nameType":"Personal","givenName":"James P","familyName":"Warne","affiliation":[],"nameIdentifiers":[]},{"name":"Salas, Eduardo","nameType":"Personal","givenName":"Eduardo","familyName":"Salas","affiliation":[],"nameIdentifiers":[]},{"name":"Xu, Allison W","nameType":"Personal","givenName":"Allison W","familyName":"Xu","affiliation":[],"nameIdentifiers":[]},{"name":"Jayanta Debnath","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Loss of \u003ci\u003eAtg12\u003c/i\u003e, but not \u003ci\u003eAtg5\u003c/i\u003e, in pro-opiomelanocortin neurons exacerbates diet-induced obesity"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Neuroscience"},{"subject":"Cell Biology"}],"contributors":[],"dates":[{"date":"2015-02-21","dateType":"Created"},{"date":"2016-01-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15548627.2014.998917","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.1288861","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["6512140 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The autophagy-related proteins ATG12 and ATG5 form a covalent complex essential for autophagy. Here, we demonstrate that ATG12 has distinct functions from ATG5 in pro-opiomelanocortin (POMC)-expressing neurons. Upon high-fat diet (HFD) consumption, mice lacking \u003ci\u003eAtg12\u003c/i\u003e in POMC-positive neurons exhibit accelerated weight gain, adiposity, and glucose intolerance, which is associated with increased food intake, reduced ambulation, and decreased LEP/leptin sensitivity. Importantly, although genetic deletion of either \u003ci\u003eAtg12\u003c/i\u003e or \u003ci\u003eAtg5\u003c/i\u003e renders POMC neurons autophagy-deficient, mice lacking \u003ci\u003eAtg5\u003c/i\u003e in POMC neurons do not exhibit these phenotypes. Hence, we propose nonautophagic functions for ATG12 in POMC neurons that counteract excessive weight gain in response to HFD consumption.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Loss_of_i_Atg12_i_but_not_i_Atg5_i_in_pro_opiomelanocortin_neurons_exacerbates_diet_induced_obesity/1288861/2","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":1,"viewsOverTime":[{"yearMonth":"2025-10","total":1}],"downloadCount":0,"downloadsOverTime":[{"yearMonth":"2025-10","total":0}],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-01-19T13:22:47.000Z","registered":"2016-01-19T13:22:48.000Z","published":"2015","updated":"2020-09-04T19:33:10.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.1288861.v2","type":"media"}},"references":{"data":[]},"citations":{"data":[]}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