{"data":{"id":"10.6084/m9.figshare.1284400.v3","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1284400.v3","prefix":"10.6084","suffix":"m9.figshare.1284400.v3","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Purcell, Maggie","nameType":"Personal","givenName":"Maggie","familyName":"Purcell","affiliation":[],"nameIdentifiers":[]},{"name":"Kruger, Adele","nameType":"Personal","givenName":"Adele","familyName":"Kruger","affiliation":[],"nameIdentifiers":[]},{"name":"Tainsky, Michael A","nameType":"Personal","givenName":"Michael A","familyName":"Tainsky","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Gene expression profiling of replicative and induced senescence"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Hematology"},{"subject":"Cancer"},{"subject":"Developmental Biology"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Evolutionary Biology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Physiology"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"Cell Biology"},{"subject":"Microbiology"}],"contributors":[],"dates":[{"date":"2015-10-09","dateType":"Created"},{"date":"2020-05-18","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.4161/15384101.2014.973327","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1284400","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1238762 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Cellular senescence is a cell cycle arrest accompanied by high expression of cyclin dependent kinase inhibitors which counteract overactive growth signals, which serves as a tumor suppressive mechanism. Senescence can be a result of telomere shortening (natural or replicative senescence) or DNA damage resulting from exogenous stressors (induced senescence). Here, we performed gene expression profiling through RNA-seq of replicative senescence, adriamycin-induced senescence, H\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e-induced senescence, and 5-aza-2-deoxycytidine-induced senescence in order to profile the pathways controlling various types of senescence. Overall, the pathways common to all 4 types of senescence were related to inflammation and the innate immune system. It was also evident that 5-aza-induced senescence mirrors natural replicative senescence due to telomere shortening. We also examined the prevalence of senescence-associated secretory phenotype (SASP) factors in the RNA-seq data, showing that it is a common characteristic of all 4 types of senescence. In addition, we could discriminate changes in gene expression due to quiescence during cellular senescence from those that were specific to senescence.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Gene_expression_profiling_of_replicative_and_induced_senescence/1284400/3","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":1,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"cre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