{"data":{"id":"10.6084/m9.figshare.1284400","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1284400","prefix":"10.6084","suffix":"m9.figshare.1284400","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Purcell, Maggie","nameType":"Personal","givenName":"Maggie","familyName":"Purcell","affiliation":[],"nameIdentifiers":[]},{"name":"Kruger, Adele","nameType":"Personal","givenName":"Adele","familyName":"Kruger","affiliation":[],"nameIdentifiers":[]},{"name":"Tainsky, Michael A","nameType":"Personal","givenName":"Michael A","familyName":"Tainsky","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Gene expression profiling of replicative and induced senescence"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2014,"subjects":[{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"Evolutionary Biology"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"},{"subject":"Cancer"}],"contributors":[],"dates":[{"date":"2015-01-04","dateType":"Created"},{"date":"2020-05-18","dateType":"Updated"},{"date":"2014","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.4161/15384101.2014.973327","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1238762 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Cellular senescence is a cell cycle arrest accompanied by high expression of cyclin dependent kinase inhibitors which counteract overactive growth signals, which serves as a tumor suppressive mechanism. Senescence can be a result of telomere shortening (natural or replicative senescence) or DNA damage resulting from exogenous stressors (induced senescence). Here, we performed gene expression profiling through RNA-seq of replicative senescence, adriamycin-induced senescence, H\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e-induced senescence, and 5-aza-2-deoxycytidine-induced senescence in order to profile the pathways controlling various types of senescence. Overall, the pathways common to all 4 types of senescence were related to inflammation and the innate immune system. It was also evident that 5-aza-induced senescence mirrors natural replicative senescence due to telomere shortening. We also examined the prevalence of senescence-associated secretory phenotype (SASP) factors in the RNA-seq data, showing that it is a common characteristic of all 4 types of senescence. In addition, we could discriminate changes in gene expression due to quiescence during cellular senescence from those that were specific to senescence.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Gene_expression_profiling_of_replicative_and_induced_senescence/1284400","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":1,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-01-04T01:16:36.000Z","registered":"2015-01-04T01:16:38.000Z","published":"2014","updated":"2020-09-04T19:41:43.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.1284400","type":"media"}},"references":{"data":[{"id":"10.4161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