{"data":{"id":"10.6084/m9.figshare.1284396.v3","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1284396.v3","prefix":"10.6084","suffix":"m9.figshare.1284396.v3","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Lu, Han","nameType":"Personal","givenName":"Han","familyName":"Lu","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Bin","nameType":"Personal","givenName":"Bin","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Fu-Jun","nameType":"Personal","givenName":"Fu-Jun","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Jin","nameType":"Personal","givenName":"Jin","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Dong, Rong","nameType":"Personal","givenName":"Rong","familyName":"Dong","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Lei","nameType":"Personal","givenName":"Lei","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Qu, Dong-Mei","nameType":"Personal","givenName":"Dong-Mei","familyName":"Qu","affiliation":[],"nameIdentifiers":[]},{"name":"Lu, Yan","nameType":"Personal","givenName":"Yan","familyName":"Lu","affiliation":[],"nameIdentifiers":[]},{"name":"Bu-Wei Yu","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"Molecular Biology"},{"subject":"Science Policy"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"},{"subject":"Cancer"},{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"Plant Biology"},{"subject":"Computational Biology"}],"contributors":[],"dates":[{"date":"2015-10-09","dateType":"Created"},{"date":"2020-05-18","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.4161/15384101.2014.973302","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.1284396","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1766470 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Activity-dependent stimuli induced a calcineurin-mediated dephosphorylation of the transcriptional factor MEF2A at serine408 and promoted a switch from SUMOylation to acetylation at lysine403 which led to MEF2A transcriptional activation. We previously identified SENP2 is the de-SUMOylation enzyme for MEF2A and promotes MEF2A-dependent transcription. We report here a requirement for APC\u003csup\u003eCdh1\u003c/sup\u003e-SENP2-MEF2A axis in the regulation of MEF2A transcriptional activation. APC\u003csup\u003eCdh1\u003c/sup\u003e interacts with and targets SENP2 for ubiquitination and destruction in the cytoplasm by recognizing a conserved canonical D-box motif in SENP2. Moreover, Cdh1 regulates the transcriptional activity of MEF2A in a SENP2 dependent manner. Activity-dependent stimuli prevented APC\u003csup\u003eCdh1\u003c/sup\u003e-induced SENP2 ubiquitination, promoted SENP2 nuclear accumulations, and caused MEF2A de-SUMOylation and MEF2A acetylation, leading to MEF2A transcriptional activation. Thus, our findings defined a post-transcriptional mechanism underlying activity-dependent stimuli-induced MEF2A transcriptional activation.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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