{"data":{"id":"10.6084/m9.figshare.1284396.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1284396.v1","prefix":"10.6084","suffix":"m9.figshare.1284396.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Lu, Han","nameType":"Personal","givenName":"Han","familyName":"Lu","affiliation":[],"nameIdentifiers":[]},{"name":"Liu, Bin","nameType":"Personal","givenName":"Bin","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Fu-Jun","nameType":"Personal","givenName":"Fu-Jun","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Jin","nameType":"Personal","givenName":"Jin","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Dong, Rong","nameType":"Personal","givenName":"Rong","familyName":"Dong","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Lei","nameType":"Personal","givenName":"Lei","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Qu, Dong-Mei","nameType":"Personal","givenName":"Dong-Mei","familyName":"Qu","affiliation":[],"nameIdentifiers":[]},{"name":"Lu, Yan","nameType":"Personal","givenName":"Yan","familyName":"Lu","affiliation":[],"nameIdentifiers":[]},{"name":"Bu-Wei Yu","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2014,"subjects":[{"subject":"Computational Biology"},{"subject":"Plant Biology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"Cancer"},{"subject":"Developmental Biology"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Meta Science"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"Cell Biology"},{"subject":"Microbiology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2014-12-15","dateType":"Created"},{"date":"2020-05-18","dateType":"Updated"},{"date":"2014","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.4161/15384101.2014.973302","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1284396","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1766470 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Activity-dependent stimuli induced a calcineurin-mediated dephosphorylation of the transcriptional factor MEF2A at serine408 and promoted a switch from SUMOylation to acetylation at lysine403 which led to MEF2A transcriptional activation. We previously identified SENP2 is the de-SUMOylation enzyme for MEF2A and promotes MEF2A-dependent transcription. We report here a requirement for APC\u003csup\u003eCdh1\u003c/sup\u003e-SENP2-MEF2A axis in the regulation of MEF2A transcriptional activation. APC\u003csup\u003eCdh1\u003c/sup\u003e interacts with and targets SENP2 for ubiquitination and destruction in the cytoplasm by recognizing a conserved canonical D-box motif in SENP2. Moreover, Cdh1 regulates the transcriptional activity of MEF2A in a SENP2 dependent manner. Activity-dependent stimuli prevented APC\u003csup\u003eCdh1\u003c/sup\u003e-induced SENP2 ubiquitination, promoted SENP2 nuclear accumulations, and caused MEF2A de-SUMOylation and MEF2A acetylation, leading to MEF2A transcriptional activation. Thus, our findings defined a post-transcriptional mechanism underlying activity-dependent stimuli-induced MEF2A transcriptional activation.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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