{"data":{"id":"10.6084/m9.figshare.1218425.v2","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1218425.v2","prefix":"10.6084","suffix":"m9.figshare.1218425.v2","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Sampath Chinnam","affiliation":[],"nameIdentifiers":[]},{"name":"Chamarthi Naga Raju","affiliation":[],"nameIdentifiers":[]},{"name":"Chunduri Venkata Rao","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Synthesis, Spectroscopic Characterization, Antimicrobial and Antioxidant Activities of Novel Phosphorylated Derivatives of Amlodipine"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"60506 Virology","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Ecology"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-02-11","dateType":"Created"},{"date":"2016-01-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/10426507.2014.909429","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1218425","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["47366 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"A series of novel phosphorylated derivatives of Amlodipine were synthesized by the reaction of amlodipine with 2-chlorophenyl phosphorodichloridate in the presence of tetramethylguanidine in dry THF to form an intermediate product. The intermediate on further reaction with various aminoacid esters in the presence of tetramethylguanidine in dry THF afforded the title compounds. Their structures were characterized by IR, \u003csup\u003e1\u003c/sup\u003eH, \u003csup\u003e13\u003c/sup\u003eC, \u003csup\u003e31\u003c/sup\u003eP NMR, mass, and elemental analyses. All the title compounds exhibited promising antimicrobial and antioxidant activities. Their bioactivity was greatly influenced by different groups present at the phosphorus.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Synthesis_Spectroscopic_Characterization_Antimicrobial_and_Antioxidant_Activities_of_Novel_Phosphorylated_Derivatives_of_Amlodipine/1218425/2","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-01-19T09:51:05.000Z","registered":"2016-01-19T09:51:06.000Z","published":"2015","updated":"2020-09-04T20:49:55.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.1218425.v2","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"vers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