{"data":{"id":"10.6084/m9.figshare.12018429.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.12018429.v1","prefix":"10.6084","suffix":"m9.figshare.12018429.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Hart, Steven N.","nameType":"Personal","givenName":"Steven N.","familyName":"Hart","affiliation":[],"nameIdentifiers":[]},{"name":"Polley, Eric C.","nameType":"Personal","givenName":"Eric C.","familyName":"Polley","affiliation":[],"nameIdentifiers":[]},{"name":"Hermella Shimelis","affiliation":[],"nameIdentifiers":[]},{"name":"Siddhartha Yadav","affiliation":[],"nameIdentifiers":[]},{"name":"Couch, Fergus J.","nameType":"Personal","givenName":"Fergus J.","familyName":"Couch","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Metadata associated with the published article: Prediction of the functional impact of missense variants in BRCA1 and BRCA2 with BRCA-ML"}],"publisher":"figshare","container":{},"publicationYear":2020,"subjects":[{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"111203 Cancer Genetics","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Genetics"},{"subject":"110311 Medical Genetics (excl. Cancer Genetics)","subjectScheme":"FOR"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Basic medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"}],"contributors":[],"dates":[{"date":"2020-04-21","dateType":"Created"},{"date":"2020-07-02","dateType":"Updated"},{"date":"2020","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1038/s41523-020-0159-x","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.12018429","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["51184876 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"MIT License","rightsUri":"https://opensource.org/licenses/MIT","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"mit","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003cb\u003eSummary\u003c/b\u003eThe data described in this metadata record underlie the figures and supplementary tables in the related manuscript. The data are in silico predictions of missense variants of uncertain significance (VUS) in the BRCA1 and BRCA2 genes (BReast CAncer genes), generated by training and evaluating hundreds of machine learning algorithms based on results from validated functional assays to better predict missense variants in these genes as damaging or neutral.\u003cb\u003e\u003cbr\u003e\u003c/b\u003e\u003cb\u003eData description\u003c/b\u003eThe primary data output of the related publication is Supplemental Data Set 1 (as it appears in the article), which contains all possible SNVs (single nucleotide variants) in both BRCA1 and BRCA2 genes. In the GitHub repository and the zip file that appears as part of this metadata record, this data output is named as TableS2.tsv, in the following location: BRCA-ML\\results\\TableS2.tsv.\u003cb\u003e\u003cbr\u003e\u003c/b\u003eThe AutoML approach was employed, with the R (version 3.4.2) CRAN - Package h2o.ai (version: 3.16.0.2). This is available at https://CRAN.R-project.org/package=h2o (Accessed: 29th January 2018).\u003cb\u003e\u003cbr\u003e\u003c/b\u003e\u003cb\u003eData access\u003c/b\u003eThe data and code are available at GitHub here: https://github.com/Steven-N-Hart/BRCA-MLAdditionally, a static version of the data and code as it was at the time the related publication was published is available in the zipped folder attached to this metadata record.\u003cbr\u003eThe data is shared under an MIT 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