{"data":{"id":"10.6084/m9.figshare.1170000.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1170000.v1","prefix":"10.6084","suffix":"m9.figshare.1170000.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Shu-Ching Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Yu-Chia Su","affiliation":[],"nameIdentifiers":[]},{"name":"Lu, Ya-Ting","nameType":"Personal","givenName":"Ya-Ting","familyName":"Lu","affiliation":[],"nameIdentifiers":[]},{"name":"Ko, Patrick Chow-In","nameType":"Personal","givenName":"Patrick Chow-In","familyName":"Ko","affiliation":[],"nameIdentifiers":[]},{"name":"Chang, Pei-Yu","nameType":"Personal","givenName":"Pei-Yu","familyName":"Chang","affiliation":[],"nameIdentifiers":[]},{"name":"Hung-Ju Lin","affiliation":[],"nameIdentifiers":[]},{"name":"Hong-Nerng Ho","affiliation":[],"nameIdentifiers":[]},{"name":"Yo-Ping Lai","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Defects in the Acquisition of Tumor-Killing Capability of CD8+ Cytotoxic T Cells in Streptozotocin-induced Diabetic Mice"}],"publisher":"figshare","container":{},"publicationYear":2014,"subjects":[{"subject":"Medicine"},{"subject":"Cancer"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2014-11-10","dateType":"Created"},{"date":"2016-01-19","dateType":"Updated"},{"date":"2014","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.1170000","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["12088274 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Diabetes mellitus has been known not only to associate with an increased risk of cancers but also heighten the mortality rate. However, whether the antitumor CD8+ T cell immunity is down-modulated in diabetic hosts remains not clear. Our data depicts that, even harboring intact proliferative capacity, streptozotocin-induced diabetic (STZ-diabetic) CD8+ T cells produce less perforin and TNFa and express less CD103 protein after stimulation. In advance, adoptive transfer of STZ-diabetic P14 CD8+ T effector cells show insufficient infiltration to B16.gp33 melanoma in vivo and inadequate production of perforin, granzyme B and TNFa in the tumor. STZ-diabetic CD8+ CTLs are neither able to eliminate tumor nor improve survival of tumor-bearing mice. In conclusion, diabetic CD8+ CTLs are crippled to infiltrate into tumors and fail to acquire tumor-killing capability. These new findings will have major impact on elucidating how diabetic CD8+ T cells are dysregulated and impeded by the acquisition of full effector functions and tumor-killing capability. With such exciting findings, we believe that our study will advance strategies of inducing protective antitumor immunity in diabetic hosts.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://figshare.com/articles/dataset/Defects_in_the_Acquisition_of_Tumor_Killing_Capability_of_CD8_Cytotoxic_T_Cells_in_Streptozotocin_induced_Diabetic_Mice/1170000/1","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-01-19T07:52:03.000Z","registered":"2016-01-19T07:52:04.000Z","published":"2014","updated":"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