{"data":{"id":"10.6084/m9.figshare.1134664.v4","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1134664.v4","prefix":"10.6084","suffix":"m9.figshare.1134664.v4","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Ramirez, Jorge H","nameType":"Personal","givenName":"Jorge H","familyName":"Ramirez","affiliation":[],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6176-2816","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Unpublished and published liraglutide studies in humans"}],"publisher":"figshare","container":{},"publicationYear":2014,"subjects":[{"subject":"Statistics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Mathematics","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Diseases"}],"contributors":[],"dates":[{"date":"2014-08-25","dateType":"Created"},{"date":"2016-01-19","dateType":"Updated"},{"date":"2014","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1134664","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1504125 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003cstrong\u003eUnpublished and published liraglutide studies in humans - Completed before Jan 2011\u003c/strong\u003e Unpublished (n=37): 68.5%\u003cbr\u003ePublished (n=17): 31.5% ----\u0026gt; 3.1 papers per registry ___________________________________________ Google Drive spreadsheet ---\u0026gt; Open Settings --\u0026gt; Anybody can post comments 5th URL __________________________________________ \u003cem\u003e\"In the Novo Nordisk study, the rats treated with liraglutide showed increased ductal proliferation and acinar to ductal metaplasia. One rat treated with exenatide had a “hemorrhagic pancreas” at necropsy with 'moderate apoptosis-like necrosis, minimal inflammatory infiltration and slight hemorrhage/edema.”13Although the pancreases did not increase in weight, the incretin treated rats had “significantly higher” levels of pancreatic amylase. Three of the liraglutide treated animals died from a 'single erroneous dosing.'\u003c/em\u003e \u003cem\u003eA spokeswoman from Novo Nordisk told the BMJ, 'Importantly, the study did not find any abnormalities in the pancreas associated with liraglutide treatment.'\"\u003c/em\u003e \u003cstrong\u003eCohen D. Has pancreatic damage from glucagon suppressing diabetes drugs been underplayed? BMJ 2013; 346.\u003c/strong\u003e - 6th URL - Liraglutide findings in monkeys added to the fileset - Full paper available in this fileset 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