{"data":{"id":"10.6084/m9.figshare.1100173.v4","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1100173.v4","prefix":"10.6084","suffix":"m9.figshare.1100173.v4","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Ramirez, Jorge H","nameType":"Personal","givenName":"Jorge H","familyName":"Ramirez","affiliation":[],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6176-2816","nameIdentifierScheme":"ORCID"}]},{"name":"Atanasov, Atanas G.","nameType":"Personal","givenName":"Atanas G.","familyName":"Atanasov","affiliation":[],"nameIdentifiers":[]},{"name":"Bravo, Paco","nameType":"Personal","givenName":"Paco","familyName":"Bravo","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Reanalysis of JUPITER clinical trial (NCT00239681)- Crestor 20mg Versus Placebo in Prevention of Cardiovascular (CV) Events"}],"publisher":"figshare","container":{},"publicationYear":2014,"subjects":[{"subject":"Statistics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Mathematics","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Diseases"},{"subject":"Pharmacology"}],"contributors":[],"dates":[{"date":"2014-09-01","dateType":"Created"},{"date":"2016-01-19","dateType":"Updated"},{"date":"2014","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1100173","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["346445 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Table: Reanalysis of adverse events\u003cbr\u003eNCT00239681: JUPITER - Crestor 20mg Versus Placebo in Prevention of Cardiovascular (CV) Events Chi-square statistics ______ 1. Not all adverse drug reactions are included in this Table. 2. Adverse events appear to be much higher than 18%. (1) 3. Results available at ClinicalTrials.gov for the JUPITER study are not consistent with publications reporting the results of this trial. http://www.ncbi.nlm.nih.gov/pubmed/?term=NCT00239681 For example: - Discordance between results reported in the number of patients diagnosed with diabetes mellitus. 1. ClinicalTrials.gov: Placebo=13; Rosuvastatin=14 | 2. Article (PMID: 22883507): Placebo=216; Rosuvastatin=270) 4. Primary outcome was modified in the registry history available at ClinicalTrials.gov http://clinicaltrials.gov/archive/NCT00239681/2014_03_21/changes 5. It is not clear why the study was terminated. \u003cstrong\u003eMarch 13, 2008.\u003c/strong\u003e \u003cbr\u003e\u003cem\u003e\"Independent Data Monitoring Committee for JUPITER met and agreed that the studyshould continue as planned.\"\u003c/em\u003e \u003cstrong\u003eApril 2, 2008.\u003c/strong\u003e\u003cem\u003e \u003cbr\u003e\"AstraZeneca announced it has decided to stop the CRESTOR JUPITER clinicalstudy early based on a recommendation from an Independent Data Monitoring Boardand the JUPITER Steering Committee, which met on March 29, 2008. The study willbe stopped early because there is unequivocal evidence of a reduction incardiovascular morbidity and mortality amongst patients who received CRESTOR when compared to placebo.\"\u003c/em\u003e http://clinicaltrials.gov/archive/NCT00239681/2008_04_02/changes \u003cstrong\u003eReferences\u003c/strong\u003e 1. Should people at low risk of cardiovascular disease take a statin? BMJ 2014; 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