{"data":{"id":"10.6084/m9.figshare.1031662.v4","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1031662.v4","prefix":"10.6084","suffix":"m9.figshare.1031662.v4","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Pelsue, Stephen","nameType":"Personal","givenName":"Stephen","familyName":"Pelsue","affiliation":[],"nameIdentifiers":[]},{"name":"Hannum, Lynn G.","nameType":"Personal","givenName":"Lynn G.","familyName":"Hannum","affiliation":[],"nameIdentifiers":[]},{"name":"Hill, Beth L.","nameType":"Personal","givenName":"Beth L.","familyName":"Hill","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"IL-4 in Autoimmune Flaky Skin Mice"}],"publisher":"figshare","container":{},"publicationYear":2014,"subjects":[{"subject":"Molecular Biology"},{"subject":"Cell Biology"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2014-05-20","dateType":"Created"},{"date":"2016-01-19","dateType":"Updated"},{"date":"2014","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.1031662","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["169764582 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Flaky skin mutant (Ttc7fsn) mice display systemic immune dysfunction including splenomegaly, glomerulonephritis, elevated levels of serum IgE, a substantial increase in the number of splenic B cells and a dramatic increase in IL-4 production. Previous work indicated constitutively activated Stat6 in splenic B cells; herein we have demonstrated this to be the result of continuous IL-4 signaling as nuclear localization studies suggested B cells have the ability to turn over activated Stat6 ex vivo when the IL-4 signal is removed. In addition, actinomycin D studies provide evidence for an increase in IL-4 mRNA stability which leads to dramatically increased IL-4 protein production resulting in a driving force toward systemic autoimmunity. Although the function of the Ttc7fsn gene is as yet unknown, we suggest that it may lead to a greater understanding of the mechanisms involved in IL-4 regulation.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://figshare.com/articles/dataset/IL_4_in_Autoimmune_Flaky_Skin_Mice/1031662/4","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-01-19T01:27:51.000Z","registered":"2016-01-19T01:27:52.000Z","published":"2014","updated":"2020-09-04T23:05:43.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.1031662.v4","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}