{"data":{"id":"10.6084/m9.figshare.103144","type":"dois","attributes":{"doi":"10.6084/m9.figshare.103144","prefix":"10.6084","suffix":"m9.figshare.103144","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Daza, Daniel Ocampo","nameType":"Personal","givenName":"Daniel Ocampo","familyName":"Daza","affiliation":[],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6521-8807","nameIdentifierScheme":"ORCID"}]},{"name":"Bergqvist, Christina A","nameType":"Personal","givenName":"Christina A","familyName":"Bergqvist","affiliation":[],"nameIdentifiers":[]},{"name":"Larhammar, Dan","nameType":"Personal","givenName":"Dan","familyName":"Larhammar","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Phylogenetic analyses of the insulin-like growth factor binding protein (IGFBP) family"}],"publisher":"figshare","container":{},"publicationYear":2012,"subjects":[{"subject":"Molecular Biology"},{"subject":"60102 Bioinformatics","subjectScheme":"FOR"},{"subject":"FOS: Computer and information sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Computer and information sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Evolutionary Biology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2012-12-06","dateType":"Created"},{"date":"2017-01-09","dateType":"Updated"},{"date":"2012","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":["4972942 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Phylogenetic re-analyses of Insulin-like Growth Factor Binding Proteins (IGFBPs) based on amino acid sequences. The sequences and alignment described in \u003cem\u003eOcampo Daza et al. (2011) Endocrinology 152(6):2278-89 \u003c/em\u003e(link below) were used to analyze additional IGFBP sequences identified in the genome databases of \u003cem\u003eAnolis carolinensis\u003c/em\u003e (anole lizard),\u003cem\u003e Latimeria chalumnae\u003c/em\u003e (coelacanth)\u003cem\u003e \u003c/em\u003eand \u003cem\u003eLepisosteus oculatus \u003c/em\u003e(spotted gar). Phylogenetic trees were made using neighbor joining (NJ) and phylogenetic maximum likelihood (PhyML) methods, both supported by bootstrap analyses (details below). Figures (PDF-files) of the finished trees are included in the files \u003cem\u003eIGFBP_NJ_figure.pdf \u003c/em\u003eand \u003cem\u003eIGFBP_PhyML_figure.pdf\u003c/em\u003e. Branch colors are based on chromosomal locations and follow the trees published in \u003cem\u003eOcampo Daza et al. (2011) \u003c/em\u003e(link below). \u003cstrong\u003eSpecies abbreviations\u003c/strong\u003e \u003cem\u003eHomo sapiens\u003c/em\u003e (Hsa, human), \u003cem\u003eMus musculus\u003c/em\u003e (Mmu, mouse), \u003cem\u003eCanis familiaris\u003c/em\u003e (Cfa, dog), \u003cem\u003eMonodelphis domestica\u003c/em\u003e (Mdo, opossum), \u003cem\u003eGallus gallus\u003c/em\u003e (Gga, chicken), \u003cem\u003eTaeniopygia guttata\u003c/em\u003e (Tgu, zebra finch), \u003cem\u003eAnolis carolinensis \u003c/em\u003e(Aca, anole lizard), \u003cem\u003eLatimeria chalumnae \u003c/em\u003e(Lch, coelacanth), \u003cem\u003eLepisosteus oculatus \u003c/em\u003e(Loc, spotted gar), \u003cem\u003eDanio rerio\u003c/em\u003e (Dre, zebrafish), \u003cem\u003eOryzias latipes\u003c/em\u003e (Ola, medaka),\u003cem\u003eGasterosteus aculeatus\u003c/em\u003e (Gac, stickleback), \u003cem\u003eTetraodon nigroviridis\u003c/em\u003e (Tni, green-spotted pufferfish),\u003cem\u003eTakifugu rubripes\u003c/em\u003e (Tru, fugu), \u003cem\u003eCiona intestinalis\u003c/em\u003e (Cin, vase tunicate), \u003cem\u003eCiona savignyi \u003c/em\u003e(Csa, Pacific transparent tunicate) and \u003cem\u003eBranchiostoma floridae \u003c/em\u003e(Bfl, Florida lancelet). \u003cstrong\u003eSequences used\u003c/strong\u003e Detailed information about all sequences that were used is included in the file \u003cem\u003eSequence_info_Tab1.xlsx \u003c/em\u003e(MS Excel spreadsheet). This includes database identifiers and chromosome/linkage group locations as well as notes on the manual curation/annotation of the sequences. \u003cstrong\u003eAlignment\u003c/strong\u003e The full amino acid sequence alignment used for the phylogenetic analyses is included in an interleaved format (.aln) and a sequential format (.fasta) in the files \u003cem\u003eIGFBP_alignment_interleaved.aln\u003c/em\u003e and \u003cem\u003eIGFBP_alignment_sequential.fasta\u003c/em\u003e. The alignment was made using the ClustalW algorithm and edited manually as described in \u003cem\u003eOcampo Daza et al. (2011) Endocrinology 152(6):2278-89 \u003c/em\u003e(link below). Anole lizard, coelacanth and spotted gar sequences marked with asterisks are fragments and do not span the full length of the alignment (details in the file \u003cem\u003eSequence_info_Tab1.xlsx\u003c/em\u003e). \u003cstrong\u003ePhylogenetic analysis, NJ method\u003c/strong\u003e The Neighbor Joining tree was made in ClustalX 2.0, with settings as described in \u003cem\u003eOcampo Daza et al. (2011)\u003c/em\u003e (link below). The tree is supported by a bootstrap analysis with 1000 bootstrap replicates. The raw output is included in the file \u003cem\u003eIGFBP_NJ.txt \u003c/em\u003eand the final tree, rooted with the lancelet IGFBP sequence, is included in the file \u003cem\u003eIGFBP_NJ_rooted.phb\u003c/em\u003e. Both files are in the Newick/Phylip data format. \u003cstrong\u003ePhylogenetic trees, PhyML method\u003c/strong\u003e The Phylogenetic Maximum Likelihood tree was made using the PhyML3.0 algorithm implemented through the web-based interface available at \u003cem\u003ehttp://www.atgc-montpellier.fr/phyml/\u003c/em\u003e. The following settings were used: . Amino acid subst. model : LG\u003cbr\u003e. Proportion of invariable sites : estimated\u003cbr\u003e. Number of subst. rate categs : 8\u003cbr\u003e. Gamma distribution parameter : estimated\u003cbr\u003e. 'Middle' of each rate class : mean\u003cbr\u003e. Amino acid equilibrium frequencies : empirical\u003cbr\u003e. Optimise tree topology : yes\u003cbr\u003e. Tree topology search : NNIs\u003cbr\u003e. Starting tree : BioNJ\u003cbr\u003e. Add random input tree : no\u003cbr\u003e. Optimise branch lengths : yes\u003cbr\u003e. Optimise substitution model parameters : yes The tree is supported by a bootstrap analysis with 100 bootstrap replicates. The final tree, rooted with the lancelet IGFBP sequence, is included in the file \u003cem\u003eIGFBP_PhyML.phb \u003c/em\u003e(Newick/Phylip format). The raw output files of the PhyML analysis are included in the following files: . \u003cem\u003eigfbp_ml_121119_phy_stdout.txt\u003c/em\u003e . \u003cem\u003eigfbp_ml_121119_phy_phyml_tree.txt\u003c/em\u003e . \u003cem\u003eigfbp_ml_121119_phy_phyml_stats.txt\u003c/em\u003e . \u003cem\u003eigfbp_ml_121119_phy_phyml_boot_trees.txt\u003c/em\u003e . \u003cem\u003eigfbp_ml_121119_phy_phyml_boot_stats\u003c/em\u003e \u003cstrong\u003eFile formats\u003c/strong\u003e All phylogenetic data is included in the Newick/Phylip format. For more information on the PhyML output files and data formats, see \u003cem\u003ehttp://www.atgc-montpellier.fr/download/papers/phyml_manual_2009.pdf\u003c/em\u003e.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.6084/M9.FIGSHARE.103144</identifier>
  <creators>
    <creator>
      <creatorName>Daniel Ocampo Daza</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org">0000-0002-6521-8807</nameIdentifier>
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    <creator>
      <creatorName>Christina A Bergqvist</creatorName>
    </creator>
    <creator>
      <creatorName>Dan Larhammar</creatorName>
    </creator>
  </creators>
  <titles>
    <title>Phylogenetic analyses of the insulin-like growth factor binding protein (IGFBP) family</title>
  </titles>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Phylogenetic re-analyses of Insulin-like Growth Factor Binding Proteins (IGFBPs) based on amino acid sequences. The sequences and alignment described in &lt;em&gt;Ocampo Daza et al. (2011) Endocrinology 152(6):2278-89 &lt;/em&gt;(link below) were used to analyze additional IGFBP sequences identified in the genome databases of &lt;em&gt;Anolis carolinensis&lt;/em&gt; (anole lizard),&lt;em&gt; Latimeria chalumnae&lt;/em&gt; (coelacanth)&lt;em&gt; &lt;/em&gt;and &lt;em&gt;Lepisosteus oculatus &lt;/em&gt;(spotted gar). Phylogenetic trees were made using neighbor joining (NJ) and phylogenetic maximum likelihood (PhyML) methods, both supported by bootstrap analyses (details below). Figures (PDF-files) of the finished trees are included in the files &lt;em&gt;IGFBP_NJ_figure.pdf &lt;/em&gt;and &lt;em&gt;IGFBP_PhyML_figure.pdf&lt;/em&gt;. Branch colors are based on chromosomal locations and follow the trees published in &lt;em&gt;Ocampo Daza et al. (2011) &lt;/em&gt;(link below).&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Species abbreviations&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;em&gt;Homo sapiens&lt;/em&gt; (Hsa, human), &lt;em&gt;Mus musculus&lt;/em&gt; (Mmu, mouse), &lt;em&gt;Canis familiaris&lt;/em&gt; (Cfa, dog), &lt;em&gt;Monodelphis domestica&lt;/em&gt; (Mdo, opossum), &lt;em&gt;Gallus gallus&lt;/em&gt; (Gga, chicken), &lt;em&gt;Taeniopygia guttata&lt;/em&gt; (Tgu, zebra finch), &lt;em&gt;Anolis carolinensis &lt;/em&gt;(Aca, anole lizard), &lt;em&gt;Latimeria chalumnae &lt;/em&gt;(Lch, coelacanth), &lt;em&gt;Lepisosteus oculatus &lt;/em&gt;(Loc, spotted gar), &lt;em&gt;Danio rerio&lt;/em&gt; (Dre, zebrafish), &lt;em&gt;Oryzias latipes&lt;/em&gt; (Ola, medaka),&lt;em&gt;Gasterosteus aculeatus&lt;/em&gt; (Gac, stickleback), &lt;em&gt;Tetraodon nigroviridis&lt;/em&gt; (Tni, green-spotted pufferfish),&lt;em&gt;Takifugu rubripes&lt;/em&gt; (Tru, fugu), &lt;em&gt;Ciona intestinalis&lt;/em&gt; (Cin, vase tunicate), &lt;em&gt;Ciona savignyi &lt;/em&gt;(Csa, Pacific transparent tunicate) and &lt;em&gt;Branchiostoma floridae &lt;/em&gt;(Bfl, Florida lancelet). &lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Sequences used&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Detailed information about all sequences that were used is included in the file &lt;em&gt;Sequence_info_Tab1.xlsx &lt;/em&gt;(MS Excel spreadsheet). This includes database identifiers and chromosome/linkage group locations as well as notes on the manual curation/annotation of the sequences.&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Alignment&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The full amino acid sequence alignment used for the phylogenetic analyses is included in an interleaved format (.aln) and a sequential format (.fasta) in the files &lt;em&gt;IGFBP_alignment_interleaved.aln&lt;/em&gt; and &lt;em&gt;IGFBP_alignment_sequential.fasta&lt;/em&gt;. The alignment was made using the ClustalW algorithm and edited manually as described in &lt;em&gt;Ocampo Daza et al. (2011) Endocrinology 152(6):2278-89 &lt;/em&gt;(link below). Anole lizard, coelacanth and spotted gar sequences marked with asterisks are fragments and do not span the full length of the alignment (details in the file &lt;em&gt;Sequence_info_Tab1.xlsx&lt;/em&gt;). &lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Phylogenetic analysis, NJ method&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Neighbor Joining tree was made in ClustalX 2.0, with settings as described in &lt;em&gt;Ocampo Daza et al. (2011)&lt;/em&gt; (link below). The tree is supported by a bootstrap analysis with 1000 bootstrap replicates. The raw output is included in the file &lt;em&gt;IGFBP_NJ.txt &lt;/em&gt;and the final tree, rooted with the lancelet IGFBP sequence, is included in the file &lt;em&gt;IGFBP_NJ_rooted.phb&lt;/em&gt;. Both files are in the Newick/Phylip data format. &lt;/p&gt;
&lt;p&gt;&lt;strong&gt;Phylogenetic trees, PhyML method&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;The Phylogenetic Maximum Likelihood tree was made using the PhyML3.0 algorithm implemented through the web-based interface available at &lt;em&gt;http://www.atgc-montpellier.fr/phyml/&lt;/em&gt;. The following settings were used: &lt;/p&gt;
&lt;p&gt;. Amino acid subst. model : LG&lt;br&gt;. Proportion of invariable sites : estimated&lt;br&gt;. Number of subst. rate categs : 8&lt;br&gt;. Gamma distribution parameter : estimated&lt;br&gt;. 'Middle' of each rate class : mean&lt;br&gt;. Amino acid equilibrium frequencies : empirical&lt;br&gt;. Optimise tree topology : yes&lt;br&gt;. Tree topology search : NNIs&lt;br&gt;. Starting tree : BioNJ&lt;br&gt;. Add random input tree : no&lt;br&gt;. Optimise branch lengths : yes&lt;br&gt;. Optimise substitution model parameters : yes&lt;/p&gt;
&lt;p&gt;The tree is supported by a bootstrap analysis with 100 bootstrap replicates. The final tree, rooted with the lancelet IGFBP sequence, is included in the file &lt;em&gt;IGFBP_PhyML.phb &lt;/em&gt;(Newick/Phylip format). The raw output files of the PhyML analysis are included in the following files:&lt;/p&gt;
&lt;p&gt;. &lt;em&gt;igfbp_ml_121119_phy_stdout.txt&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;. &lt;em&gt;igfbp_ml_121119_phy_phyml_tree.txt&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;. &lt;em&gt;igfbp_ml_121119_phy_phyml_stats.txt&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;. &lt;em&gt;igfbp_ml_121119_phy_phyml_boot_trees.txt&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;. &lt;em&gt;igfbp_ml_121119_phy_phyml_boot_stats&lt;/em&gt;&lt;/p&gt;
&lt;p&gt;&lt;strong&gt;File formats&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;All phylogenetic data is included in the Newick/Phylip format. For more information on the PhyML output files and data formats, see &lt;em&gt;http://www.atgc-montpellier.fr/download/papers/phyml_manual_2009.pdf&lt;/em&gt;.&lt;/p&gt;</description>
  </descriptions>
  <subjects>
    <subject>Molecular Biology</subject>
    <subject schemeURI="http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E" subjectScheme="FOR">60102 Bioinformatics</subject>
    <subject>Evolutionary Biology</subject>
  </subjects>
  <publisher>figshare</publisher>
  <publicationYear>2012</publicationYear>
  <dates>
    <date dateType="Created">2012-12-06</date>
    <date dateType="Updated">2017-01-09</date>
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