{"data":{"id":"10.6084/m9.figshare.c.5413930.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.5413930.v1","prefix":"10.6084","suffix":"m9.figshare.c.5413930.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Aravindan Kolandaivelu","affiliation":[],"nameIdentifiers":[]},{"name":"Bruce, Chris G.","nameType":"Personal","givenName":"Chris G.","familyName":"Bruce","affiliation":[],"nameIdentifiers":[]},{"name":"Ramasawmy, Rajiv","nameType":"Personal","givenName":"Rajiv","familyName":"Ramasawmy","affiliation":[],"nameIdentifiers":[]},{"name":"Yildirim, Dursun Korel","nameType":"Personal","givenName":"Dursun Korel","familyName":"Yildirim","affiliation":[],"nameIdentifiers":[]},{"name":"O’Brien, Kendall J.","nameType":"Personal","givenName":"Kendall J.","familyName":"O’Brien","affiliation":[],"nameIdentifiers":[]},{"name":"Schenke, William H.","nameType":"Personal","givenName":"William H.","familyName":"Schenke","affiliation":[],"nameIdentifiers":[]},{"name":"Rogers, Toby","nameType":"Personal","givenName":"Toby","familyName":"Rogers","affiliation":[],"nameIdentifiers":[]},{"name":"Campbell-Washburn, Adrienne E.","nameType":"Personal","givenName":"Adrienne E.","familyName":"Campbell-Washburn","affiliation":[],"nameIdentifiers":[]},{"name":"Lederman, Robert J.","nameType":"Personal","givenName":"Robert J.","familyName":"Lederman","affiliation":[],"nameIdentifiers":[]},{"name":"Herzka, Daniel A.","nameType":"Personal","givenName":"Daniel A.","familyName":"Herzka","affiliation":[],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9400-7814","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Native contrast visualization and tissue characterization of myocardial radiofrequency ablation and acetic acid chemoablation lesions at 0.55 T"}],"publisher":"figshare","container":{},"publicationYear":2021,"subjects":[{"subject":"Biochemistry"},{"subject":"Space Science"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Neuroscience"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Hematology"},{"subject":"Computational Biology"}],"contributors":[],"dates":[{"date":"2021-05-06","dateType":"Created"},{"date":"2021-05-06","dateType":"Updated"},{"date":"2021","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1186/s12968-020-00693-1","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.5413930","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Abstract Purpose Low-field (0.55 T) high-performance cardiovascular magnetic resonance (CMR) is an attractive platform for CMR-guided intervention as device heating is reduced around 7.5-fold compared to 1.5 T. This work determines the feasibility of visualizing cardiac radiofrequency (RF) ablation lesions at low field CMR and explores a novel alternative method for targeted tissue destruction: acetic acid chemoablation. Methods N = 10 swine underwent X-ray fluoroscopy-guided RF ablation (6–7 lesions) and acetic acid chemoablation (2–3 lesions) of the left ventricle. Animals were imaged at 0.55 T with native contrast 3D-navigator gated T1-weighted T1w) CMR for lesion visualization, gated single-shot imaging to determine potential for real-time visualization of lesion formation, and T1 mapping to measure change in T1 in response to ablation. Seven animals were euthanized on ablation day and hearts imaged ex vivo. The remaining animals were imaged again in vivo at 21 days post ablation to observe lesion evolution. Results Chemoablation lesions could be visualized and displayed much higher contrast than necrotic RF ablation lesions with T1w imaging. On the day of ablation, in vivo myocardial T1 dropped by 19 ± 7% in RF ablation lesion cores, and by 40 ± 7% in chemoablation lesion cores 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