{"data":{"id":"10.5522/04/14555715","type":"dois","attributes":{"doi":"10.5522/04/14555715","prefix":"10.5522","suffix":"04/14555715","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Gordillo-Maranon, Maria","givenName":"Maria","familyName":"Gordillo-Maranon","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics"}],"publisher":"University College London","container":{},"publicationYear":2021,"subjects":[{"subject":"110201 Cardiology (incl. Cardiovascular Diseases)","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110311 Medical Genetics (excl. Cancer Genetics)","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2021-07-30","dateType":"Created"},{"date":"2021-08-06","dateType":"Updated"},{"date":"2021","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":["13323614830 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution Non Commercial Share Alike 4.0 International","rightsUri":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-nc-sa-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"# README file\u003cbr\u003eThis file describes the code and data in the repository \"Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics\" DOI: 10.5522/04/14555715.\u003cbr\u003eOverview of the directories:\u003cbr\u003e- **data**: includes data used to generate the figures of the manuscript. The data is divided in subcategories: bnf_data, clinical_trials, coloc, drug_target_mr, drug_target_mvmr, phewas and tissue_expression, based on the different sections of the main results.\u003cbr\u003e- **scripts**: includes the python code (`.ipynb`) used to generate the figures in the main body and supplementary materials. `Fig2_Fig3B_SuppFig1-3-4-34-5-33B.ipynb` has the code to generate Figure 2, Figure 3B, Supplementary Figure 1, Supplementary Figure 3, Supplementary Figure 4, Supplementary Figure 34, Supplementary Figure 5B - Supplementary Figure33 B. `Fig3A_SuppFig5-33A.ipynb` includes the code for Figure 3A, Supplementary Figure 5A to Supplementary Figure 33A. `Fig3C_SuppFig5-33C.ipynb` includes the code for Figure 3A, Supplementary Figure 5A to Supplementary Figure 33A. `SuppFig2.ipynb` includes the code for the Supplementary Figure 2.\u003cbr\u003ePlease contact Maria Gordillo-Maranon for any queries: maria.maranon.16@ucl.ac.uk\u003cbr\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://rdr.ucl.ac.uk/articles/dataset/Validation_of_lipid-related_therapeutic_targets_for_coronary_heart_disease_prevention_using_human_genetics/14555715","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2021-05-07T14:40:39.000Z","registered":"2021-05-07T14:40:40.000Z","published":"2021","updat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