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One factor in its development is c-Jun N-terminal kinases (JNKs), a type of protein related to brain function. JNK3, found mainly in the brain, contributes to AD by promoting brain abnormalities. Current research aims to create new JNK3 inhibitors for AD treatment using a virtual screening method. A database of compounds was filtered, and five potential compounds were identified with better scores than a reference. These compounds underwent simulations and energy calculations, showing stability and potential as JNK3 inhibitors.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://zenodo.org/record/8278364","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reaso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