{"data":{"id":"10.5281/zenodo.3242594","type":"dois","attributes":{"doi":"10.5281/zenodo.3242594","prefix":"10.5281","suffix":"zenodo.3242594","identifiers":[{"identifier":"https://zenodo.org/record/3242595","identifierType":"URL"}],"alternateIdentifiers":[{"alternateIdentifierType":"URL","alternateIdentifier":"https://zenodo.org/record/3242595"}],"creators":[{"name":"Kanaporis, Giedrius","nameType":"Personal","givenName":"Giedrius","familyName":"Kanaporis","affiliation":[],"nameIdentifiers":[]},{"name":"Blatter, Lothar A.","nameType":"Personal","givenName":"Lothar A.","familyName":"Blatter","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Membrane potential determines calcium alternans through modulation of SR Ca2 + load and L-type Ca2 + current"}],"publisher":"Zenodo","container":{},"publicationYear":2017,"subjects":[{"subject":"Action potential"},{"subject":"Alternans"},{"subject":"Ca signaling"},{"subject":"Excitation-contraction coupling"}],"contributors":[],"dates":[{"date":"2017-04-10","dateType":"Issued"}],"language":null,"types":{"ris":"JOUR","bibtex":"article","citeproc":"article-journal","schemaOrg":"ScholarlyArticle","resourceType":"Journal article","resourceTypeGeneral":"Text"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.1016/j.yjmcc.2017.02.004","relatedIdentifierType":"DOI"},{"relationType":"HasVersion","relatedIdentifier":"10.5281/zenodo.3242595","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"},{"rights":"Open Access","rightsUri":"info:eu-repo/semantics/openAccess"}],"descriptions":[{"description":"Alternans is a risk factor for cardiac arrhythmia, including atrial fibrillation. At the cellular level alternans is observed as beat-to-beat alternations in contraction, action potential (AP) morphology and magnitude of the Ca2 + transient (CaT). It is widely accepted that the bi-directional interplay between membrane voltage and Ca2 + is crucial for the development of alternans, however recently the attention has shifted to instabilities in cellular Ca2 + handling, while the role of AP alternation remains poorly understood. This study provides new insights how beat- to-beat alternation in AP morphology affects occurrence of CaT alternans in atrial myocytes.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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