{"data":{"id":"10.5281/zenodo.20321203","type":"dois","attributes":{"doi":"10.5281/zenodo.20321203","prefix":"10.5281","suffix":"zenodo.20321203","identifiers":[{"identifier":"oai:zenodo.org:20321203","identifierType":"oai"}],"alternateIdentifiers":[{"alternateIdentifierType":"oai","alternateIdentifier":"oai:zenodo.org:20321203"}],"creators":[{"name":"Maeson Zietowski, BA","nameType":"Personal","givenName":"BA","familyName":"Maeson Zietowski","affiliation":["The University of Chicago, Chicago, IL, USA"],"nameIdentifiers":[]},{"name":"Elam Coalson, MD","nameType":"Personal","givenName":"MD","familyName":"Elam Coalson","affiliation":["The University of Chicago, Chicago, IL, USA"],"nameIdentifiers":[]},{"name":"Summer E. Hanson, MD, PhD","nameType":"Personal","familyName":"Summer E. Hanson, MD, PhD","affiliation":["The University of Chicago, Chicago, IL, USA"],"nameIdentifiers":[]}],"titles":[{"title":"A Pilot Study Evaluating Autologous Fat Transfer To Address Radiation Fibrosis"}],"publisher":"Zenodo","container":{},"publicationYear":2026,"subjects":[],"contributors":[],"dates":[{"date":"2026-05-21","dateType":"Issued"}],"language":null,"types":{"ris":"CPAPER","bibtex":"article","citeproc":"","schemaOrg":"Article","resourceType":"","resourceTypeGeneral":"ConferencePaper"},"relatedIdentifiers":[{"relationType":"IsVersionOf","relatedIdentifier":"10.5281/zenodo.20290151","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"PURPOSE: Breast cancer treatment often includes radiation therapy as part of the multi-modal approach; however, this is not without adverse effects. Radiation induced fibrosis (RIF) can lead to significant tightness, discomfort, and distortion of radiated soft tissue. The purpose of this pilot study was to investigate the effect of autologous fat transfer on radiation fibrosis after oncologic breast reconstruction. METHODS: A prospective, longitudinal observational study of patients undergoing autologous fat grafting following post-mastectomy radiation was performed from 2023-2024. Outcomes include patient satisfaction and well-being, severity of radiation-induced changes by LENT-SOMA score, tissue elasticity or fibrosis measured by an indentation-based device, and skin thickness measured by ultrasound. Outcomes before and after autologous fat grafting were compared at 1, 6, and 12 months from the procedure. RESULTS: 10 patients were enrolled in this pilot study with one year follow up. All patients were female. Average age was 58.5 (39-76) years with BMI 27.9 (21.7-36.7). Most patients had mastectomy (70%) while 3 had partial mastectomy. 5/10 patients had implant-based reconstruction. All patients underwent post-surgical radiation. There were no incidents of recurrence, metastasis, or new cancer in the study period. There was a significant difference in skin thickness on US between the preoperative values and 12 months post-fat transfer (0.192 +/- 0.002 vs 0.255 +/- 0.042 cm; p=0.002). All patients had Grade 3 or 4 atrophy and fibrosis by LENT-SOMA at baseline while 12-month scores ranged from Grade 1 to 3. Overall fibrosis as measured with an indentation-based device did not significantly change over time. CONCLUSION: The authors demonstrate safety and feasibility of a prospective, longitudinal pilot study in the setting of autologous fat transfer for radiation fibrosis. While the overall soft tissue elasticity remained similar, epidermal-dermal thickness increased over one year from grafting despite no direct intradermal injections. Clinical effects were also observed with significant improvement in LENT-SOMA scores over time.","descriptionType":"Abstract"},{"description":"Abstract ID: EP36","descriptionType":"Other"}],"geoLocations":[],"fundingReferences":[],"xml":"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