{"data":{"id":"10.5061/dryad.zkh1893qx","type":"dois","attributes":{"doi":"10.5061/dryad.zkh1893qx","prefix":"10.5061","suffix":"dryad.zkh1893qx","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Ona, Nathan","nameType":"Personal","givenName":"Nathan","familyName":"Ona","affiliation":["University of Pennsylvania"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-8729-2223","nameIdentifierScheme":"ORCID"}]},{"name":"Zhang, Dapeng","nameType":"Personal","givenName":"Dapeng","familyName":"Zhang","affiliation":["East China University of Science and Technology"],"nameIdentifiers":[]},{"name":"Lindesmith, Lisa","nameType":"Personal","givenName":"Lisa","familyName":"Lindesmith","affiliation":["University of North Carolina at Chapel Hill"],"nameIdentifiers":[]},{"name":"Park, Wook-Jin","nameType":"Personal","givenName":"Wook-Jin","familyName":"Park","affiliation":["University of 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RNA-based\n vaccines, particularly during the SARS-CoV2 pandemic, demonstrating a\n rapid and cost-effective approach for addressing infectious diseases. A\n major challenge remains in developing a delivery system that protects mRNA\n from degradation and facilitates its passage through tissue and cellular\n barriers. Current four-component lipid nanoparticles enable efficient\n endosomal escape and are a pivotal technology for the delivery of mRNA\n vaccines. However, challenges such as stability, availability, durability,\n and adverse effects persist. We have developed a self-assembling\n one-component ionizable amphiphilic Janus dendrimers (IAJD) delivery\n system with naturally occurring amino heads, capable of efficiently\n delivering mRNA to the spleen and lymph nodes.  This\n single-component system simplifies synthesis, reduces development\n complexity, and enable rapid global distribution of mRNA vaccines during\n pandemics. As a proof of concept, one-component IAJD97, formulated with\n mRNA encoding norovirus mRNA capsid protein, demonstrates the potential of\n IAJDs as efficient delivery platform for mRNA vaccines, advancing their\n effectiveness and expanding applications to improve public health\n outcomes.","descriptionType":"Abstract"},{"description":"# One-component ionizable amphiphilic Janus dendrimers as a delivery\n platform for efficient mRNA vaccine development Dataset DOI:\n [10.5061/dryad.zkh1893qx](https://doi.org/10.5061/dryad.zkh1893qx) ##\n Description of the data and file structure **Description of the data and\n file structure** The scope of this evaluation is to assess potential acute\n toxic effects associated with the experimental treatment under study. The\n samples evaluated include mouse heart, lung, kidney, liver, and spleen\n tissues fixed in 10% formalin. Samples were collected 24 hours post\n treatment with a single-component IAJD97 formulated with mRNA. There were\n five naive animals and six treated animals, comprising two dose groups (10\n µg and 30 µg mRNA per mouse). ### Files and variables #### File:\n Histology_score__table.csv **Description:** H\u0026amp;E staining of the main\n mouse organs was examined by a board-certified veterinary pathologist.\n Findings were reported as semi-quantitative pathology scores for each\n organ. ##### Variables * Description: * Naive 1: untreated mouse 1 * Naive\n 2: untreated mouse 2 * Naive 3: untreated mouse 3 * Naive 4: untreated\n mouse 4 * Naive 5: untreated mouse 5 * 10 ug per mouse 9: mouse treated\n with 10 ug of mRNA * 10 ug per mouse 10: mouse treated with 10 ug of mRNA\n * 10 ug per mouse 11: mouse treated with 10 ug of mRNA * 30 ug per mouse\n 6: mouse treated with 30 ug of mRNA * 30 ug per mouse 7: mouse treated\n with 30 ug of mRNA * 30 ug per mouse 8: mouse treated with 30 ug of mRNA\n #### File: Histology_score_table_legend.csv **Description:** Scoring\n system ##### Variables * 0 = unremarkable; 1 = minimal changes; 2 = mild\n changes; 3 = moderate changes; 4 = severe changes. ## Code/software n/a ##\n Access information Other publicly accessible locations of the data: * n/a\n Data was derived from the following sources: * n/a","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"awardUri":"https://reporter.nih.gov/project-details/10806942","schemeUri":"https://ror.org","awardTitle":"Antibody Landscape following Human Norovirus Infection and Vaccination","funderName":"National Institute of Allergy and Infectious Diseases","awardNumber":"5R01AI148260-05","funderIdentifier":"https://ror.org/043z4tv69","funderIdentifierType":"ROR"},{"awardUri":"https://reporter.nih.gov/project-details/10842500","schemeUri":"https://ror.org","awardTitle":"Core 2: Biocontainment and Immune Monitoring Core","funderName":"National Institute of Allergy and Infectious Diseases","awardNumber":"3P01AI158571-01A1S1","funderIdentifier":"https://ror.org/043z4tv69","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","awardTitle":"\n        Perfecting Complex Assemblies of Covalent and Supramolecular Polymers\n        via Biological Principles\n      ","funderName":"U.S. National Science Foundation","awardNumber":"2104554","funderIdentifier":"https://ror.org/021nxhr62","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","awardTitle":"Materials Research Science and Engineering Center","funderName":"Division of Materials Research","awardNumber":"1720530","funderIdentifier":"https://ror.org/01pc7k308","funderIdentifierType":"ROR"},{"funderName":"Wellcome Leap R3"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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      <creatorName nameType="Personal">Park, Wook-Jin</creatorName>
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      <creatorName nameType="Personal">Baboo, Ishana</creatorName>
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      <creatorName nameType="Personal">Pan, Liuyan</creatorName>
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      <creatorName nameType="Personal">May, Samantha</creatorName>
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      <creatorName nameType="Personal">Baric, Ralph</creatorName>
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      <creatorName nameType="Personal">Li, Yongsheng</creatorName>
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  <titles>
    <title>
      One-component ionizable amphiphilic Janus dendrimers as a delivery
      platform for efficient mRNA vaccine development
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
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  <subjects>
    <subject>One-component ionizable amphiphilic Janus dendrimers</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Norovirus</subject>
    <subject>mRNA vaccine</subject>
    <subject>Neutralizing antibody</subject>
    <subject>cellular responses</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Biological sciences</subject>
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      <awardNumber awardURI="https://reporter.nih.gov/project-details/10806942">5R01AI148260-05</awardNumber>
      <awardTitle>Antibody Landscape following Human Norovirus Infection and Vaccination</awardTitle>
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      <awardTitle>Core 2: Biocontainment and Immune Monitoring Core</awardTitle>
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      <awardNumber>2104554</awardNumber>
      <awardTitle>
        Perfecting Complex Assemblies of Covalent and Supramolecular Polymers
        via Biological Principles
      </awardTitle>
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    <fundingReference>
      <funderName>Division of Materials Research</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01pc7k308</funderIdentifier>
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      <awardTitle>Materials Research Science and Engineering Center</awardTitle>
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      <funderName>Wellcome Leap R3</funderName>
      <awardTitle/>
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    <contributor contributorType="Sponsor">
      <contributorName>University of Pennsylvania</contributorName>
    </contributor>
  </contributors>
  <dates>
    <date dateType="Created">2026-02-04T00:33:39Z</date>
    <date dateType="Submitted">2026-02-06T21:38:48Z</date>
    <date dateType="Issued">2026-02-24T00:00:00Z</date>
    <date dateType="Available">2026-02-24T00:00:00Z</date>
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  <descriptions>
    <description descriptionType="Abstract">
      There have been rapid advances in nucleoside-modified messenger RNA-based
      vaccines, particularly during the SARS-CoV2 pandemic, demonstrating a
      rapid and cost-effective approach for addressing infectious diseases. A
      major challenge remains in developing a delivery system that protects mRNA
      from degradation and facilitates its passage through tissue and cellular
      barriers. Current four-component lipid nanoparticles enable efficient
      endosomal escape and are a pivotal technology for the delivery of mRNA
      vaccines. However, challenges such as stability, availability, durability,
      and adverse effects persist. We have developed a self-assembling
      one-component ionizable amphiphilic Janus dendrimers (IAJD) delivery
      system with naturally occurring amino heads, capable of efficiently
      delivering mRNA to the spleen and lymph nodes.&amp;nbsp; This
      single-component system simplifies synthesis, reduces development
      complexity, and enable rapid global distribution of mRNA vaccines during
      pandemics. As a proof of concept, one-component IAJD97, formulated with
      mRNA encoding norovirus mRNA capsid protein, demonstrates the potential of
      IAJDs as efficient delivery platform for mRNA vaccines, advancing their
      effectiveness and expanding applications to improve public health
      outcomes.
    </description>
    <description descriptionType="TechnicalInfo">
      # One-component ionizable amphiphilic Janus dendrimers as a delivery
      platform for efficient mRNA vaccine development Dataset DOI:
      [10.5061/dryad.zkh1893qx](https://doi.org/10.5061/dryad.zkh1893qx) ##
      Description of the data and file structure **Description of the data and
      file structure** The scope of this evaluation is to assess potential acute
      toxic effects associated with the experimental treatment under study. The
      samples evaluated include mouse heart, lung, kidney, liver, and spleen
      tissues fixed in 10% formalin. Samples were collected 24 hours post
      treatment with a single-component IAJD97 formulated with mRNA. There were
      five naive animals and six treated animals, comprising two dose groups (10
      µg and 30 µg mRNA per mouse). ### Files and variables #### File:
      Histology_score__table.csv **Description:** H&amp;E staining of the main
      mouse organs was examined by a board-certified veterinary pathologist.
      Findings were reported as semi-quantitative pathology scores for each
      organ. ##### Variables * Description: * Naive 1: untreated mouse 1 * Naive
      2: untreated mouse 2 * Naive 3: untreated mouse 3 * Naive 4: untreated
      mouse 4 * Naive 5: untreated mouse 5 * 10 ug per mouse 9: mouse treated
      with 10 ug of mRNA * 10 ug per mouse 10: mouse treated with 10 ug of mRNA
      * 10 ug per mouse 11: mouse treated with 10 ug of mRNA * 30 ug per mouse
      6: mouse treated with 30 ug of mRNA * 30 ug per mouse 7: mouse treated
      with 30 ug of mRNA * 30 ug per mouse 8: mouse treated with 30 ug of mRNA
      #### File: Histology_score_table_legend.csv **Description:** Scoring
      system ##### Variables * 0 = unremarkable; 1 = minimal changes; 2 = mild
      changes; 3 = moderate changes; 4 = severe changes. ## Code/software n/a ##
      Access information Other publicly accessible locations of the data: * n/a
      Data was derived from the following sources: * n/a
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