{"data":{"id":"10.5061/dryad.z612jm69r","type":"dois","attributes":{"doi":"10.5061/dryad.z612jm69r","prefix":"10.5061","suffix":"dryad.z612jm69r","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Stankoff, Bruno","nameType":"Personal","givenName":"Bruno","familyName":"Stankoff","affiliation":["Sorbonne Université"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9631-4674","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Supplemental tables for: A periventricular gradient of innate immune cell activation in Multiple Sclerosis"}],"publisher":"Dryad","container":{},"publicationYear":2021,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2021-06-24T07:36:02Z","dateType":"Submitted"},{"date":"2021-06-29T00:00:00Z","dateType":"Issued"},{"date":"2021-06-29T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1212/wnl.0000000000011700","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["84282 bytes"],"formats":[],"version":"3","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Objectives: To explore in-vivo innate immune\n cell activation as a function of the distance from ventricular CSF in\n patients with Multiple Sclerosis (MS) using [18F]-DPA714 PET, and to\n investigate its relationship with periventricular microstructural damage,\n evaluated by magnetization transfer ratio (MTR), and with trajectories of\n disability worsening. Methods: Thirty-seven MS patients and\n nineteen healthy controls underwent MRI and [18F]-DPA714 TSPO\n dynamic PET, from which individual maps of voxels characterized by innate\n immune cell activation (DPA+) were generated. White matter (WM) was\n divided in 3mm-thick concentric rings radiating from the ventricular\n surface toward the cortex, and the percentage of DPA+ voxels and mean MTR\n were extracted from each ring. Two-year trajectories of disability\n worsening were collected to identify patients with and without recent\n disability worsening. Results: The percentage of DPA+ voxels was\n higher in patients compared to controls in the periventricular WM\n (p=6.10e-6), and declined with increasing distance from ventricular\n surface, with a steeper gradient in patients compared to controls\n (p=0.001). This gradient was found both in periventricular lesions and\n normal-appearing WM. In the total WM, it correlated with a gradient of\n microstructural tissue damage measured by MTR (rs=-0.65,\n p=1.0e-3). When compared to clinically stable\n patients, patients with disability worsening were\n characterized by a higher percentage of DPA+ voxels in\n the periventricular normal-appearing WM (p=0.025).\n Conclusions: Our results demonstrate that in MS the innate immune\n cell activation predominates in periventricular regions and associates\n with microstructural damage and disability worsening. This could result\n from the diffusion of pro-inflammatory CSF-derived factors into\n surrounding tissues.","descriptionType":"Abstract"},{"description":"Thirty-seven MS patients and nineteen healthy controls underwent MRI and [18F]-DPA714 TSPO dynamic PET, from which individual maps of voxels characterized by innate immune cell activation (DPA+) were generated. White matter (WM) was divided in 3mm-thick concentric rings radiating from the ventricular surface toward the cortex, and the percentage of DPA+ voxels and mean MTR were extracted from each ring. Two-year trajectories of disability worsening were collected to identify patients with and without recent disability worsening.","descriptionType":"Methods"},{"description":"Supplemental table 1 and 2","descriptionType":"Other"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Agence Nationale de la Recherche","awardNumber":"MNP2008-007125","funderIdentifier":"https://ror.org/00rbzpz17","funderIdentifierType":"ROR"}],"xml":"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