{"data":{"id":"10.5061/dryad.x3ffbg7zw","type":"dois","attributes":{"doi":"10.5061/dryad.x3ffbg7zw","prefix":"10.5061","suffix":"dryad.x3ffbg7zw","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Chaudhari, Abhijit","nameType":"Personal","givenName":"Abhijit","familyName":"Chaudhari","affiliation":["University of California, Davis"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-4211-1900","nameIdentifierScheme":"ORCID"}]},{"name":"Abdelhafez, Yasser","nameType":"Personal","givenName":"Yasser","familyName":"Abdelhafez","affiliation":["University of California, Davis"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-1989-3094","nameIdentifierScheme":"ORCID"}]},{"name":"Nardo, Lorenzo","nameType":"Personal","givenName":"Lorenzo","familyName":"Nardo","affiliation":["University of California, Davis"],"nameIdentifiers":[]}],"titles":[{"title":"Total-body PET for assessing myofascial pain"}],"publisher":"Dryad","container":{},"publicationYear":2025,"subjects":[{"subject":"In vivo imaging","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Lower back pain","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Positron emission tomography","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Engineering and technology","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Engineering and technology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Medical engineering","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Medical engineering","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Medical and health sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Medical and health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"computed tomography"},{"subject":"Imaging biomarkers"},{"subject":"total-body PET"}],"contributors":[{"name":"University of California, Davis","nameType":"Personal","givenName":"Davis","familyName":"University of California","affiliation":[],"contributorType":"Sponsor","nameIdentifiers":[]}],"dates":[{"date":"2025-09-15T18:50:39Z","dateType":"Created"},{"date":"2025-09-15T18:50:52Z","dateType":"Submitted"},{"date":"2025-10-08T00:00:00Z","dateType":"Issued"},{"date":"2025-10-08T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":["8842659389 bytes"],"formats":[],"version":"4","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Chronic low back pain due to myofascial pain syndrome is a widespread and\n debilitating condition, with substantial clinical and socioeconomic\n impact. Despite its prevalence, there remains a critical lack of objective\n and reproducible biomarkers for diagnosis and therapeutic assessment.\n Conventional methods for evaluating myofascial pain rely primarily on\n subjective clinician assessment and patient report, which are subject to\n high inter-observer variability and may provide only limited insight into\n tissue-level pathology. This project leveraged total-body positron\n emission tomography/computed tomography (TB-PET/CT) using a dual-tracer\n approach: [11C]Butanol for tissue perfusion quantification and [18F]FDG\n for assessment of glucose metabolism and, exploratorily, tissue perfusion.\n By integrating information from these tracers, the study aimed to dissect\n the biological underpinnings of painful versus non-painful myofascial\n tissues, with participant-reported outcomes collected simultaneously. This\n study was funded by the National Institutes of Health, National Center for\n Complementary and Integrative Health, via grant R61 AT012187, titled:\n Total-body PET for assessing myofascial pain (PIs: Abhijit J\n Chaudhari; Lorenzo Nardo). More information is also available at\n ClinicalTrials.gov (NCT05876858).","descriptionType":"Abstract"},{"description":"# **Total-Body PET for Assessing Myofascial Pain** ## **Background**\n Chronic low back pain due to myofascial pain syndrome is a widespread and\n debilitating condition, with substantial clinical and socioeconomic\n impact. Despite its prevalence, there remains a critical lack of objective\n and reproducible biomarkers for diagnosis and therapeutic assessment.\n Conventional methods for evaluating myofascial pain rely primarily on\n subjective clinician assessment and patient report, which are subject to\n high inter-observer variability and may provide only limited insight into\n tissue-level pathology. This project leveraged total-body positron\n emission tomography/computed tomography (TB-PET/CT) using a dual-tracer\n approach: [11C]Butanol for tissue perfusion quantification and [18F]FDG\n for assessment of glucose metabolism and exploratorily, tissue perfusion.\n By integrating information from these tracers, the study aimed to dissect\n the biological underpinnings of painful versus non-painful myofascial\n tissues, with participant-reported outcomes collected simultaneously. This\n study was funded by the National Institutes of Health, National Center for\n Complementary and Integrative Health, via grant R61 AT012187, titled:\n Total-body PET for assessing myofascial pain (PIs: Abhijit J\n Chaudhari; Lorenzo Nardo). More information is also available at\n ClinicalTrials.gov (NCT05876858). ## **Data Organization and Naming\n Convention** The study received explicit consent from study participants\n to publish de-identified data. Code numbers were assigned to the human\n subjects and data are completely de-identified. No identifiers are present\n in any form. Only code numbers are used in the uploaded data. Imaging data\n within the Total-body_PET_Myofascial_Pain.zip file are organized in\n subject-specific folders using the structure: \\[SubjectID]_[Radiotracer].\n \\[SubjectID]: three-digit participant identifier (e.g., 079)\n \\[Radiotracer]: either FDG for [18F]FDG, or BTL for [11C]Butanol Within\n each folder, the following NRRD files are provided: CT image:\n Sub[SubjectID]_[Radiotracer]CT_cropped.nrrd PET image:\n Sub[SubjectID][Radiotracer]PT_cropped.nrrd Segmentation (L4–S1 region):\n Sub[SubjectID][Radiotracer]_L4_S1.seg.nrrd Example: For subject 079 and\n butanol scan, filenames are: Sub079_BTL_CT_cropped.nrrd\n Sub079_BTL_PT_cropped.nrrd Sub079_BTL_L4_S1.seg.nrrd Clinical Measures The\n repository includes a CSV file (PEG_Scores.csv) containing PEG (Pain,\n Enjoyment, General activity) scores for each participant. The CSV provides\n breakdowns for all three PEG questions. The scores are matched to imaging\n folders via Subject ID. File Specifications Format: All image files are in\n .nrrd format. PET images: Expressed in Bq/ml units, cropped to the\n lumbosacral region. CT images: Attenuation-correction CT in Hounsfield\n Units, cropped to lumbosacral region. Segmentations: Binary mask (1 =\n L4–S1, 0 = background). SUV_Conversion_Factor.csv: CSV, subject-matched,\n to convert Bq/ml into PET SUV PEG scores: CSV, subject-matched. ##\n Technical Details Scanner Model: All scans were performed on the EXPLORER\n total-body PET/CT scanner (United Imaging Healthcare), located at UC\n Davis. Acquisition Protocol: Tracers: [11C]Butanol and [18F]FDG\n \\[11C]Butanol: Used to assess regional perfusion; dynamic TB-PET\n acquisition initiated at tracer injection. \\[18F]FDG: Used to evaluate\n glucose metabolism and, via early framing, perfusion. CT: Low-dose CT was\n acquired for attenuation correction prior to PET. Imaging region:\n Acquisition covered the entire body; files provided are cropped to the\n lumbosacral region (L4–S1). Duration: [11C]Butanol dynamic acquisition\n typically covered 10 minutes, [18F]FDG dynamic images were collected for\n up to 70 min. Image Reconstruction: Images provided are over 50-65min for\n [18F]FDG and 1-5 min for [11C]Butanol, in Bq/ml PET: Images reconstructed\n using OSEM (ordered subset expectation maximization), with time-of-flight\n and no point-spread function modeling. Standardized corrections applied\n for attenuation, scatter, and decay. CT: Reconstructions generated in\n Hounsfield Units. All images exported in NRRD format for interoperability\n with open-source analysis tools. Segmentations: L4–S1 paraspinal muscles\n were automatically segmented using MOOSE (PMID: 35772962) then manually\n curated by an experienced nuclear medicine physician on co-registered\n PET/CT using 3D Slicer, and exported as binary masks. ## Citation If you\n use this dataset, we encourage citing as: \"Chaudhari AJ, et al.\n Total-body PET for Assessing Myofascial Pain: multi-tracer dataset with\n lumbosacral segmentations and pain scores. Dryad Digital Repository\n (2025).\n [https://doi.org/10.5061/dryad.x3ffbg7zw]()\" ## Human subjects data The study has received explicit consent from study participants to publish de-identified data. Code numbers were assigned to the human subjects and data are completely de-identified. No identifiers are present in any form. Only code numbers are used in the uploaded data.","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","awardTitle":"Total-body PET for assessing myofascial pain","funderName":"National Center for Complementary and Integrative Health","awardNumber":"R61AT012187","funderIdentifier":"https://ror.org/00190t495","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.X3FFBG7ZW</identifier>
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    <creator>
      <creatorName nameType="Personal">Chaudhari, Abhijit</creatorName>
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    <creator>
      <creatorName nameType="Personal">Abdelhafez, Yasser</creatorName>
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      <affiliation affiliationIdentifier="https://ror.org/05rrcem69" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Davis</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Nardo, Lorenzo</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05rrcem69" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Davis</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Total-body PET for assessing myofascial pain</title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
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    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">In vivo imaging</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Lower back pain</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Positron emission tomography</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Engineering and technology</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Medical engineering</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Medical and health sciences</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Health sciences</subject>
    <subject>computed tomography</subject>
    <subject>Imaging biomarkers</subject>
    <subject>total-body PET</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>National Center for Complementary and Integrative Health</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/00190t495</funderIdentifier>
      <awardNumber>R61AT012187</awardNumber>
      <awardTitle>Total-body PET for assessing myofascial pain</awardTitle>
    </fundingReference>
  </fundingReferences>
  <contributors>
    <contributor contributorType="Sponsor">
      <contributorName>University of California, Davis</contributorName>
    </contributor>
  </contributors>
  <dates>
    <date dateType="Created">2025-09-15T18:50:39Z</date>
    <date dateType="Submitted">2025-09-15T18:50:52Z</date>
    <date dateType="Issued">2025-10-08T00:00:00Z</date>
    <date dateType="Available">2025-10-08T00:00:00Z</date>
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  <descriptions>
    <description descriptionType="Abstract">
      Chronic low back pain due to myofascial pain syndrome is a widespread and
      debilitating condition, with substantial clinical and socioeconomic
      impact. Despite its prevalence, there remains a critical lack of objective
      and reproducible biomarkers for diagnosis and therapeutic assessment.
      Conventional methods for evaluating myofascial pain rely primarily on
      subjective clinician assessment and patient report, which are subject to
      high inter-observer variability and may provide only limited insight into
      tissue-level pathology. This project leveraged total-body positron
      emission tomography/computed tomography (TB-PET/CT) using a dual-tracer
      approach: [11C]Butanol for tissue perfusion quantification and [18F]FDG
      for assessment of glucose metabolism and, exploratorily, tissue perfusion.
      By integrating information from these tracers, the study aimed to dissect
      the biological underpinnings of painful versus non-painful myofascial
      tissues, with participant-reported outcomes collected simultaneously. This
      study was funded by the National Institutes of Health, National Center for
      Complementary and Integrative Health, via grant R61 AT012187, titled:
      Total-body PET for assessing myofascial pain (PIs: Abhijit J
      Chaudhari;&amp;nbsp;Lorenzo Nardo). More information is also available at
      ClinicalTrials.gov (NCT05876858).
    </description>
    <description descriptionType="TechnicalInfo">
      # **Total-Body PET for Assessing Myofascial Pain** ## **Background**
      Chronic low back pain due to myofascial pain syndrome is a widespread and
      debilitating condition, with substantial clinical and socioeconomic
      impact. Despite its prevalence, there remains a critical lack of objective
      and reproducible biomarkers for diagnosis and therapeutic assessment.
      Conventional methods for evaluating myofascial pain rely primarily on
      subjective clinician assessment and patient report, which are subject to
      high inter-observer variability and may provide only limited insight into
      tissue-level pathology. This project leveraged total-body positron
      emission tomography/computed tomography (TB-PET/CT) using a dual-tracer
      approach: [11C]Butanol for tissue perfusion quantification and [18F]FDG
      for assessment of glucose metabolism and exploratorily, tissue perfusion.
      By integrating information from these tracers, the study aimed to dissect
      the biological underpinnings of painful versus non-painful myofascial
      tissues, with participant-reported outcomes collected simultaneously. This
      study was funded by the National Institutes of Health, National Center for
      Complementary and Integrative Health, via grant R61 AT012187, titled:
      Total-body PET for assessing myofascial pain (PIs: Abhijit J
      Chaudhari; Lorenzo Nardo). More information is also available at
      ClinicalTrials.gov (NCT05876858). ## **Data Organization and Naming
      Convention** The study received explicit consent from study participants
      to publish de-identified data. Code numbers were assigned to the human
      subjects and data are completely de-identified. No identifiers are present
      in any form. Only code numbers are used in the uploaded data. Imaging data
      within the Total-body_PET_Myofascial_Pain.zip file are organized in
      subject-specific folders using the structure: \[SubjectID]_[Radiotracer].
      \[SubjectID]: three-digit participant identifier (e.g., 079)
      \[Radiotracer]: either FDG for [18F]FDG, or BTL for [11C]Butanol Within
      each folder, the following NRRD files are provided: CT image:
      Sub[SubjectID]_[Radiotracer]CT_cropped.nrrd PET image:
      Sub[SubjectID][Radiotracer]PT_cropped.nrrd Segmentation (L4–S1 region):
      Sub[SubjectID][Radiotracer]_L4_S1.seg.nrrd Example: For subject 079 and
      butanol scan, filenames are: Sub079_BTL_CT_cropped.nrrd
      Sub079_BTL_PT_cropped.nrrd Sub079_BTL_L4_S1.seg.nrrd Clinical Measures The
      repository includes a CSV file (PEG_Scores.csv) containing PEG (Pain,
      Enjoyment, General activity) scores for each participant. The CSV provides
      breakdowns for all three PEG questions. The scores are matched to imaging
      folders via Subject ID. File Specifications Format: All image files are in
      .nrrd format. PET images: Expressed in Bq/ml units, cropped to the
      lumbosacral region. CT images: Attenuation-correction CT in Hounsfield
      Units, cropped to lumbosacral region. Segmentations: Binary mask (1 =
      L4–S1, 0 = background). SUV_Conversion_Factor.csv: CSV, subject-matched,
      to convert Bq/ml into PET SUV PEG scores: CSV, subject-matched. ##
      Technical Details Scanner Model: All scans were performed on the EXPLORER
      total-body PET/CT scanner (United Imaging Healthcare), located at UC
      Davis. Acquisition Protocol: Tracers: [11C]Butanol and [18F]FDG
      \[11C]Butanol: Used to assess regional perfusion; dynamic TB-PET
      acquisition initiated at tracer injection. \[18F]FDG: Used to evaluate
      glucose metabolism and, via early framing, perfusion. CT: Low-dose CT was
      acquired for attenuation correction prior to PET. Imaging region:
      Acquisition covered the entire body; files provided are cropped to the
      lumbosacral region (L4–S1). Duration: [11C]Butanol dynamic acquisition
      typically covered 10 minutes, [18F]FDG dynamic images were collected for
      up to 70 min. Image Reconstruction: Images provided are over 50-65min for
      [18F]FDG and 1-5 min for [11C]Butanol, in Bq/ml PET: Images reconstructed
      using OSEM (ordered subset expectation maximization), with time-of-flight
      and no point-spread function modeling. Standardized corrections applied
      for attenuation, scatter, and decay. CT: Reconstructions generated in
      Hounsfield Units. All images exported in NRRD format for interoperability
      with open-source analysis tools. Segmentations: L4–S1 paraspinal muscles
      were automatically segmented using MOOSE (PMID: 35772962) then manually
      curated by an experienced nuclear medicine physician on co-registered
      PET/CT using 3D Slicer, and exported as binary masks. ## Citation If you
      use this dataset, we encourage citing as: "Chaudhari AJ, et al.
      Total-body PET for Assessing Myofascial Pain: multi-tracer dataset with
      lumbosacral segmentations and pain scores. Dryad Digital Repository
      (2025).
      [https://doi.org/10.5061/dryad.x3ffbg7zw](&lt;https://doi.org/10.5061/dryad.x3ffbg7zw &gt;)" ## Human subjects data The study has received explicit consent from study participants to publish de-identified data. Code numbers were assigned to the human subjects and data are completely de-identified. No identifiers are present in any form. Only code numbers are used in the uploaded data.
    </description>
  </descriptions>
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