{"data":{"id":"10.5061/dryad.x3ffbg7rc","type":"dois","attributes":{"doi":"10.5061/dryad.x3ffbg7rc","prefix":"10.5061","suffix":"dryad.x3ffbg7rc","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Valenzuela-Ponce, Humberto","nameType":"Personal","givenName":"Humberto","familyName":"Valenzuela-Ponce","affiliation":["National Institute of Respiratory Diseases"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0350-2391","nameIdentifierScheme":"ORCID"}]},{"name":"Ávila-Ríos, Santiago","nameType":"Personal","givenName":"Santiago","familyName":"Ávila-Ríos","affiliation":["National Institute of Respiratory Diseases"],"nameIdentifiers":[]}],"titles":[{"title":"HLA class I Sanger sequences data of Honduras HIV cohort"}],"publisher":"Dryad","container":{},"publicationYear":2023,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"HLA raw Sanger sequences"},{"subject":"HLA class I genes"},{"subject":"Honduras HIV cohort"}],"contributors":[{"name":"CIENI Center for Research in Infectious Diseases*","affiliation":[],"contributorType":"Sponsor","nameIdentifiers":[]}],"dates":[{"date":"2023-09-16T21:36:20Z","dateType":"Created"},{"date":"2023-09-16T21:37:54Z","dateType":"Submitted"},{"date":"2023-09-28T00:00:00Z","dateType":"Issued"},{"date":"2023-09-28T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1128/spectrum.01613-23","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["392441795 bytes"],"formats":[],"version":"3","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"HLA polymorphisms represent the strongest genetic modifier of HIV disease\n progression. Diverse HLA distribution can lead to distinct HIV control\n landscapes at the population level. We aimed to describe HLA allele and\n haplotype frequencies (linkage disequilibrium, LD), CCR5-Δ32 frequency and\n the impact of these variants on HIV disease outcome. HLA class I (cI) loci\n were typed at 4-digit resolution, and CCR5 variants were determined in 402\n HIV clade B-infected, ART-naïve individuals from Honduras. HLA LD were\n assessed using Fisher’s exact test. Using univariable and multivariable\n analyses we evaluated HLA associations with HIV pVL and CD4 counts. We did\n not find any effect on HIV control between CCR5 genotypes. Previously\n defined HLA associations were found: B*57:01/03, B*42:01, A*25:01 and\n C*12:03 (protective), and B*53:01 and A*68:01 (risk). Being consistent\n with our previous research in a Mesoamerican HIV cohort, Amerindian\n B*35:12 was associated to poor HIV control. Other HLA-HIV associations not\n previously described were C*03:04 and B*08:01 that were associated with\n higher pVL. Overall, this first report highlights the immunogenetic\n uniqueness admixture of the Honduras population that express Amerindian,\n Caucasian and African HLA subtypes. These findings not only support this\n cohort as ideal for identifying HLA correlates of HIV control but also may\n improve future research regarding allotransplantation and disease\n association.","descriptionType":"Abstract"},{"description":"HLA class I loci\n \u003cem\u003e(HLA-A\u003c/em\u003e, \u003cem\u003eHLA-C\u003c/em\u003e and\n \u003cem\u003eHLA-B)\u003c/em\u003e were resolved at second field resolution\n (i.e., subtype or protein level) using a previously described protocol.\n Briefly, a nested PCR with locus-specific primers were used to amplify a\n ~1000 bp region spanning exons 2 and 3. These PCR products were directly\n sequenced using a set of sequencing primers as previously described\n (Cotton LA, et al. 2012. HLA class I sequence-based typing using DNA\n recovered from frozen plasma. J Immunol Methods 382:40–47) on a 3730xl\n Genetic Analyzer (Applied Biosystems, Foster City). HLA subtypes were\n assigned using UType v7.1 RUO (Applied Biosystems) using the IPD-IMGT/HLA\n Database (release 3.31.0, 2018-01). Primer (allelic) and phase resolution\n ambiguities were resolved as previously explained (Valenzuela-Ponce H, et\n al. 2018. Novel HLA class I associations with HIV-1 control in a unique\n genetically admixed population. Sci Rep 8:17.).","descriptionType":"Methods"},{"description":"# HLA class I Sanger sequences data of Honduras HIV cohort\n [https://doi.org/10.5061/dryad.x3ffbg7rc](https://doi.org/10.5061/dryad.x3ffbg7rc) HLA Sanger sequences encompassing exons 2 and 3 of HLA-A, HLA-B and HLA-C loci of Honduras HIV cohort ## Description of the data and file structure HLA class I loci *(HLA-A*, *HLA-C* and *HLA-B)* were resolved at second field resolution (i.e., subtype or protein level) using a previously described protocol (Valenzuela-Ponce H., et al. 2018. Novel HLA class I associations with HIV-1 control in a unique genetically admixed population. Sci Rep 8:17.). Briefly, a nested PCR with locus-specific primers were used to amplify a \\~1000 bp region spanning exons 2 and 3. These PCR products were directly sequenced using a set of sequencing primers as previously described (Cotton LA, et al. 2012. HLA class I sequence-based typing using DNA recovered from frozen plasma. J Immunol Methods 382:40–47.) on a 3730xl Genetic Analyzer (Applied Biosystems, Foster City). HLA subtypes were assigned using UType v7.1 RUO (Applied Biosystems) using the IPD-IMGT/HLA Database (release 3.31.0, 2018-01). Primer (allelic) and phase resolution ambiguities were resolved as previously explained (Valenzuela-Ponce H., et al. 2018. Novel HLA class I associations with HIV-1 control in a unique genetically admixed population. Sci Rep 8:17.). Each folder contains the Sanger sequences (ab1 files and related files) of the 3 amplified genes (exons 2 and 3 of HLA-A, B and C loci) where the files were properly anonymized and randomized. Folders and files were renamed as donor-1, donor-2, and so on. Files were compressed into a zip file. ## Sharing/Access information Data was derived from the following sources: * Article named \"Honduras HIV cohort: HLA class I and CCR5-Δ32 profile and their associations with HIV disease outcome\" to be publish in Microbiology Spectrum (American Society of Microbiology)","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Consejo Nacional de Humanidades, Ciencias y Tecnologías","awardNumber":"CONACyT - PRONAII Virología 303079","funderIdentifier":"https://ror.org/059ex5q34","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Consejo Nacional de Humanidades, Ciencias y Tecnologías","awardNumber":"CONACyT-CF-2019-2558583","funderIdentifier":"https://ror.org/059ex5q34","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4/metadata.xsd">
  <identifier identifierType="DOI">10.5061/DRYAD.X3FFBG7RC</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Valenzuela-Ponce, Humberto</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0350-2391</nameIdentifier>
      <affiliation>National Institute of Respiratory Diseases</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ávila-Ríos, Santiago</creatorName>
      <affiliation>National Institute of Respiratory Diseases</affiliation>
    </creator>
  </creators>
  <titles>
    <title>HLA class I Sanger sequences data of Honduras HIV cohort</title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2023</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject>HLA raw Sanger sequences</subject>
    <subject>HLA class I genes</subject>
    <subject>Honduras HIV cohort</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>Consejo Nacional de Humanidades, Ciencias y Tecnologías</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/059ex5q34</funderIdentifier>
      <awardNumber>CONACyT - PRONAII Virología 303079</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Consejo Nacional de Humanidades, Ciencias y Tecnologías</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/059ex5q34</funderIdentifier>
      <awardNumber>CONACyT-CF-2019-2558583</awardNumber>
    </fundingReference>
  </fundingReferences>
  <contributors>
    <contributor contributorType="Sponsor">
      <contributorName>CIENI Center for Research in Infectious Diseases*</contributorName>
    </contributor>
  </contributors>
  <dates>
    <date dateType="Created">2023-09-16T21:36:20Z</date>
    <date dateType="Submitted">2023-09-16T21:37:54Z</date>
    <date dateType="Issued">2023-09-28T00:00:00Z</date>
    <date dateType="Available">2023-09-28T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1128/spectrum.01613-23</relatedIdentifier>
  </relatedIdentifiers>
  <sizes>
    <size>392441795 bytes</size>
  </sizes>
  <version>3</version>
  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      HLA polymorphisms represent the strongest genetic modifier of HIV disease
      progression. Diverse HLA distribution can lead to distinct HIV control
      landscapes at the population level. We aimed to describe HLA allele and
      haplotype frequencies (linkage disequilibrium, LD), CCR5-Δ32 frequency and
      the impact of these variants on HIV disease outcome. HLA class I (cI) loci
      were typed at 4-digit resolution, and CCR5 variants were determined in 402
      HIV clade B-infected, ART-naïve individuals from Honduras. HLA LD were
      assessed using Fisher’s exact test. Using univariable and multivariable
      analyses we evaluated HLA associations with HIV pVL and CD4 counts. We did
      not find any effect on HIV control between CCR5 genotypes. Previously
      defined HLA associations were found: B*57:01/03, B*42:01, A*25:01 and
      C*12:03 (protective), and B*53:01 and A*68:01 (risk). Being consistent
      with our previous research in a Mesoamerican HIV cohort, Amerindian
      B*35:12 was associated to poor HIV control. Other HLA-HIV associations not
      previously described were C*03:04 and B*08:01 that were associated with
      higher pVL. Overall, this first report highlights the immunogenetic
      uniqueness admixture of the Honduras population that express Amerindian,
      Caucasian and African HLA subtypes. These findings not only support this
      cohort as ideal for identifying HLA correlates of HIV control but also may
      improve future research regarding allotransplantation and disease
      association.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;&lt;span lang="EN-US"&gt;HLA class I loci
      &lt;em&gt;(HLA-A&lt;/em&gt;, &lt;em&gt;HLA-C&lt;/em&gt; and
      &lt;em&gt;HLA-B)&lt;/em&gt; were resolved at second field resolution
      (i.e., subtype or protein level) using a previously described protocol.
      Briefly, a nested PCR with locus-specific primers were used to amplify a
      ~1000 bp region spanning exons 2 and 3. These PCR products were directly
      sequenced using a set of sequencing primers as previously described
      (Cotton LA, et al. 2012. HLA class I sequence-based typing using DNA
      recovered from frozen plasma. J Immunol Methods 382:40–47) on a 3730xl
      Genetic Analyzer (Applied Biosystems, Foster City). HLA subtypes were
      assigned using UType v7.1 RUO (Applied Biosystems) using the IPD-IMGT/HLA
      Database (release 3.31.0, 2018-01). Primer (allelic) and phase resolution
      ambiguities were resolved as previously explained (Valenzuela-Ponce H, et
      al. 2018. Novel HLA class I associations with HIV-1 control in a unique
      genetically admixed population. Sci Rep 8:17.).&lt;/span&gt;&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      # HLA class I Sanger sequences data of Honduras HIV cohort
      [https://doi.org/10.5061/dryad.x3ffbg7rc](https://doi.org/10.5061/dryad.x3ffbg7rc) HLA Sanger sequences encompassing exons 2 and 3 of HLA-A, HLA-B and HLA-C loci of Honduras HIV cohort ## Description of the data and file structure HLA class I loci *(HLA-A*, *HLA-C* and *HLA-B)* were resolved at second field resolution (i.e., subtype or protein level) using a previously described protocol (Valenzuela-Ponce H., et al. 2018. Novel HLA class I associations with HIV-1 control in a unique genetically admixed population. Sci Rep 8:17.). Briefly, a nested PCR with locus-specific primers were used to amplify a \~1000 bp region spanning exons 2 and 3. These PCR products were directly sequenced using a set of sequencing primers as previously described (Cotton LA, et al. 2012. HLA class I sequence-based typing using DNA recovered from frozen plasma. J Immunol Methods 382:40–47.) on a 3730xl Genetic Analyzer (Applied Biosystems, Foster City). HLA subtypes were assigned using UType v7.1 RUO (Applied Biosystems) using the IPD-IMGT/HLA Database (release 3.31.0, 2018-01). Primer (allelic) and phase resolution ambiguities were resolved as previously explained (Valenzuela-Ponce H., et al. 2018. Novel HLA class I associations with HIV-1 control in a unique genetically admixed population. Sci Rep 8:17.). Each folder contains the Sanger sequences (ab1 files and related files) of the 3 amplified genes (exons 2 and 3 of HLA-A, B and C loci) where the files were properly anonymized and randomized. Folders and files were renamed as donor-1, donor-2, and so on. Files were compressed into a zip file. ## Sharing/Access information Data was derived from the following sources: * Article named "Honduras HIV cohort: HLA class I and CCR5-Δ32 profile and their associations with HIV disease outcome" to be publish in Microbiology Spectrum (American Society of Microbiology)
    </description>
  </descriptions>
</resource>","url":"https://datadryad.org/dataset/doi:10.5061/dryad.x3ffbg7rc","contentUrl":null,"metadataVersion":7,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":81,"viewsOverTime":[{"yearMonth":"2023-09","total":8},{"yearMonth":"2023-10","total":15},{"yearMonth":"2023-11","total":8},{"yearMonth":"2023-12","total":13},{"yearMonth":"2024-02","total":1},{"yearMonth":"2024-03","total":1},{"yearMonth":"2024-04","total":3},{"yearMonth":"2024-06","total":2},{"yearMonth":"2024-08","total":1},{"yearMonth":"2024-09","total":1},{"yearMonth":"2024-10","total":2},{"yearMonth":"2024-11","total":1},{"yearMonth":"2025-01","total":2},{"yearMonth":"2025-02","total":4},{"yearMonth":"2025-07","total":2},{"yearMonth":"2025-08","total":3},{"yearMonth":"2025-11","total":1},{"yearMonth":"2025-12","total":3},{"yearMonth":"2026-01","total":3},{"yearMonth":"2026-02","total":3},{"yearMonth":"2026-03","total":1},{"yearMonth":"2026-05","total":3}],"downloadCount":13,"downloadsOverTime":[{"yearMonth":"2023-10","total":2},{"yearMonth":"2023-12","total":2},{"yearMonth":"2024-02","total":1},{"yearMonth":"2024-03","total":1},{"yearMonth":"2024-04","total":1},{"yearMonth":"2024-06","total":0},{"yearMonth":"2024-08","total":0},{"yearMonth":"2024-09","total":0},{"yearMonth":"2024-10","total":0},{"yearMonth":"2024-11","total":1},{"yearMonth":"2025-01","total":0},{"yearMonth":"2025-02","total":0},{"yearMonth":"2025-07","total":1},{"yearMonth":"2025-08","total":1},{"yearMonth":"2025-11","total":1},{"yearMonth":"2025-12","total":1},{"yearMonth":"2026-01","total":0},{"yearMonth":"2026-02","total":0},{"yearMonth":"2026-03","total":1},{"yearMonth":"2026-05","total":0}],"referenceCount":0,"citationCount":1,"citationsOverTime":[{"year":"2026","total":1}],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2023-09-28T16:54:11.000Z","registered":"2023-09-28T16:54:12.000Z","published":"2023","updated":"2026-03-24T19:04:03.000Z"},"relationships":{"client":{"data":{"id":"dryad.dryad","type":"clients"}},"provider":{"data":{"id":"dryad","type":"providers"}},"media":{"data":{"id":"10.5061/dryad.x3ffbg7rc","type":"media"}},"references":{"data":[]},"citations":{"data":[{"id":"10.1128/spectrum.01613-23","type":"dois"}]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}