{"data":{"id":"10.5061/dryad.vt4b8gv7r","type":"dois","attributes":{"doi":"10.5061/dryad.vt4b8gv7r","prefix":"10.5061","suffix":"dryad.vt4b8gv7r","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Wang, Xiaoyin","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6667-5209","nameIdentifierScheme":"ORCID"}]},{"name":"Han, Daniel","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Qiu, Huiliang","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Punnati, Chaitanya","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Goyal, Natasha","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Parangan, Alyssa","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Mukunda, Jayita","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Tabibiazar, Parmis","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Tran, Lam","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Tan, Kelly","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Kamzabek, Arailym","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Derakhshandeh, Ronak","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Springer, Matthew","nameType":"Personal","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]}],"titles":[{"title":"Supplemental data from: Tobacco and marijuana induce adverse effects on cardiac function and Platelet activity and reduce tissue preservation following myocardial infarction"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Medical and health sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"smoke"},{"subject":"cardiac function"},{"subject":"Myocardial infarction","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Platelet aggregation","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Tobacco","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Marijuana","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[],"dates":[{"date":"2026-07-16T22:41:03Z","dateType":"Created"},{"date":"2026-08-11T03:43:00Z","dateType":"Submitted"},{"date":"2026-08-26T00:00:00Z","dateType":"Issued"},{"date":"2026-08-26T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1152/ajpheart.00407.2026","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["32943423 bytes"],"formats":[],"version":"10","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Smoking disrupts cardiac autonomic regulation, vascular biology, and\n platelet function; however, the acute and longer-term cardiovascular\n effects of resurging and emerging tobacco and marijuana products remain\n incompletely characterized. We investigated the impact of exposure to\n smoke and aerosol from several tobacco and marijuana products on cardiac\n function, platelet activity, and myocardial susceptibility to\n ischemia/reperfusion myocardial infarction (MI). Male/female\n Sprague-Dawley rats underwent single or daily 5-min pulsatile exposure\n sessions to emissions from tobacco cigarettes, e-cigarettes (JUUL), heated\n tobacco products (IQOS), marijuana cigarettes, or cannabinoid-depleted\n (“placebo”) marijuana cigarettes; with an air negative control. Cardiac\n function was assessed immediately after single exposure using\n echocardiography and intraventricular hemodynamics. Platelet aggregation\n was measured immediately after single exposure and one day after repeated\n (2-week) exposure. Myocardial infarct size, normalized to area-at-risk,\n was assessed following MI after repeated (4-week) exposure. Single\n exposure to tobacco smoke or JUUL aerosol reduced left ventricular\n ejection fraction relative to pre-exposure. Acute marijuana smoke exposure\n similarly impaired left ventricular function assessed by hemodynamics.\n Single exposure to tobacco, marijuana, and placebo marijuana smoke\n increased collagen-induced platelet aggregation, with more pronounced\n responses in females, whereas repeated (2-week) exposure to smoke/aerosol\n from tobacco cigarettes, JUUL, IQOS, and placebo marijuana increased\n platelet aggregation across groups. Notably, repeated (4-week) exposure to\n tobacco smoke/aerosol or marijuana smoke prior to MI reduced myocardial\n tissue preservation, resulting in greater infarct size post-MI. These\n findings indicate that individual tobacco and marijuana smoking and vaping\n similarly impair cardiac function, enhance platelet reactivity, and reduce\n myocardial tolerance to ischemia/reperfusion injury.","descriptionType":"Abstract"},{"description":"# Supplemental data from: Tobacco and marijuana induce adverse effects on\n cardiac function and Platelet activity and reduce tissue preservation\n following myocardial infarction Dataset DOI:\n [10.5061/dryad.vt4b8gv7r](https://doi.org/10.5061/dryad.vt4b8gv7r) ##\n Description of the data and file structure Description of methods used for\n collection/generation of data: (1) Raw echocardiographic data and\n hemodynamic data are not included but are available from the corresponding\n author upon reasonable request. (2) For platelet data, we obtained\n platelet aggregation data for platelet aggregation analysis. We have\n included the data in folders (see section for Figure 4 data). Area under\n the curve (AUC) of the aggregation tracing was calculated by AGGRO/LINK^®^\n (Chrono-Log Corporation) for Windows software. For viewing the data, open\n each PDF file to see the aggregation tracing and AUC data. Supplemental\n Material file is included, which includes Tables S1, S2, and Figures\n S1-S6. A more detailed README is also included: README_file.docx ### Files\n and variables File/Folder List: 1. Supplemental_Material.pdf: including\n Tables S1, S2, and Figures S1-S6. 2. Platelet aggregation data for Figure\n 4: Primary zip folders named Figure4-A-platelet-aggregation-raw-data.zip\n and Figure4-B-platelet-aggregation-raw-data.zip. The zip folder\n Figure4-A-platelet-aggregation-raw-data includes a subfolder named\n Xiaoyin_Acute_Exposure_1D, which includes files named from Acute\n Exposure_1D_Xiaoyin_Rat_33 to Acute Exposure_1D_Xiaoyin_Rat_91 in order.\n Note: we removed the file Acute Exposure_1D_Xiaoyin_Rat_37_duplicate\n because it was zero bytes. Duplicate versions are the same as the\n originals and should be used accordingly.  The zip folder\n Figure4-B-platelet-aggregation-raw-data includes a subfolder named\n Xiaoyin_Chronic Exposure_14D, which includes files named from Chronic\n Exposure_14D_Xiaoyin_Rat_1 to Chronic Exposure_14D_Xiaoyin_Rat_115 in\n order. All primary folders contain raw platelet aggregation data for area\n under the curve (AUC) of the aggregation tracing. AUC was calculated by\n AGGRO/LINK^®^  (Chrono-Log Corporation) for Windows software. Each\n subfolder contains files corresponding to each animal at each\n smoking/vaping condition. Smoke conditions are Marlboro Red cigarettes,\n JUUL, IQOS-Rus, IQOS-USA, Marijuana cigarettes, and placebo marijuana\n cigarettes. For viewing the raw data, open each PDF file to see the\n aggregation tracing and data. ## Code/software 1. For viewing the platelet\n aggregation data, open each PDF file to see the aggregation tracing and\n data. ## Access information Other publicly accessible locations of the\n data: * No Data was derived from the following sources: * No","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"awardUri":"https://reporter.nih.gov/project-details/10468880","awardTitle":"\n        Integrated Health, Behavioral and Economic Research on Current and\n        Emerging Tobacco Products\n      ","funderName":"National Heart Lung and Blood Institute","awardNumber":"5U54HL147127-10","funderIdentifier":"https://ror.org/012pb6c26","funderIdentifierType":"ROR"},{"funderName":"United States Food and Drug Administration","awardNumber":"T29IP0490","funderIdentifier":"https://ror.org/034xvzb47","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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      <creatorName nameType="Personal">Han, Daniel</creatorName>
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      <creatorName nameType="Personal">Qiu, Huiliang</creatorName>
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    <creator>
      <creatorName nameType="Personal">Punnati, Chaitanya</creatorName>
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    </creator>
    <creator>
      <creatorName nameType="Personal">Goyal, Natasha</creatorName>
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      <creatorName nameType="Personal">Parangan, Alyssa</creatorName>
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    <creator>
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      <creatorName nameType="Personal">Tran, Lam</creatorName>
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    <creator>
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    </creator>
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    </creator>
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  <titles>
    <title>
      Supplemental data from: Tobacco and marijuana induce adverse effects on
      cardiac function and Platelet activity and reduce tissue preservation
      following myocardial infarction
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
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    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject>smoke</subject>
    <subject>cardiac function</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Myocardial infarction</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Platelet aggregation</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Tobacco</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Marijuana</subject>
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      <awardNumber awardURI="https://reporter.nih.gov/project-details/10468880">5U54HL147127-10</awardNumber>
      <awardTitle>
        Integrated Health, Behavioral and Economic Research on Current and
        Emerging Tobacco Products
      </awardTitle>
    </fundingReference>
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      <funderName>United States Food and Drug Administration</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/034xvzb47</funderIdentifier>
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      <awardTitle/>
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    <date dateType="Created">2026-07-16T22:41:03Z</date>
    <date dateType="Submitted">2026-08-11T03:43:00Z</date>
    <date dateType="Issued">2026-08-26T00:00:00Z</date>
    <date dateType="Available">2026-08-26T00:00:00Z</date>
  </dates>
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  <descriptions>
    <description descriptionType="Abstract">
      Smoking disrupts cardiac autonomic regulation, vascular biology, and
      platelet function; however, the acute and longer-term cardiovascular
      effects of resurging and emerging tobacco and marijuana products remain
      incompletely characterized. We investigated the impact of exposure to
      smoke and aerosol from several tobacco and marijuana products on cardiac
      function, platelet activity, and myocardial susceptibility to
      ischemia/reperfusion myocardial infarction (MI). Male/female
      Sprague-Dawley rats underwent single or daily 5-min pulsatile exposure
      sessions to emissions from tobacco cigarettes, e-cigarettes (JUUL), heated
      tobacco products (IQOS), marijuana cigarettes, or cannabinoid-depleted
      (“placebo”) marijuana cigarettes; with an air negative control. Cardiac
      function was assessed immediately after single exposure using
      echocardiography and intraventricular hemodynamics. Platelet aggregation
      was measured immediately after single exposure and one day after repeated
      (2-week) exposure. Myocardial infarct size, normalized to area-at-risk,
      was assessed following MI after repeated (4-week) exposure. Single
      exposure to tobacco smoke or JUUL aerosol reduced left ventricular
      ejection fraction relative to pre-exposure. Acute marijuana smoke exposure
      similarly impaired left ventricular function assessed by hemodynamics.
      Single exposure to tobacco, marijuana, and placebo marijuana smoke
      increased collagen-induced platelet aggregation, with more pronounced
      responses in females, whereas repeated (2-week) exposure to smoke/aerosol
      from tobacco cigarettes, JUUL, IQOS, and placebo marijuana increased
      platelet aggregation across groups. Notably, repeated (4-week) exposure to
      tobacco smoke/aerosol or marijuana smoke prior to MI reduced myocardial
      tissue preservation, resulting in greater infarct size post-MI. These
      findings indicate that individual tobacco and marijuana smoking and vaping
      similarly impair cardiac function, enhance platelet reactivity, and reduce
      myocardial tolerance to ischemia/reperfusion injury.
    </description>
    <description descriptionType="TechnicalInfo">
      # Supplemental data from: Tobacco and marijuana induce adverse effects on
      cardiac function and Platelet activity and reduce tissue preservation
      following myocardial infarction Dataset DOI:
      [10.5061/dryad.vt4b8gv7r](https://doi.org/10.5061/dryad.vt4b8gv7r) ##
      Description of the data and file structure Description of methods used for
      collection/generation of data: (1) Raw echocardiographic data and
      hemodynamic data are not included but are available from the corresponding
      author upon reasonable request. (2) For platelet data, we obtained
      platelet aggregation data for platelet aggregation analysis. We have
      included the data in folders (see section for Figure 4 data). Area under
      the curve (AUC) of the aggregation tracing was calculated by AGGRO/LINK^®^
      (Chrono-Log Corporation) for Windows software. For viewing the data, open
      each PDF file to see the aggregation tracing and AUC data. Supplemental
      Material file is included, which includes Tables S1, S2, and Figures
      S1-S6. A more detailed README is also included: README_file.docx ### Files
      and variables File/Folder List: 1. Supplemental_Material.pdf: including
      Tables S1, S2, and Figures S1-S6. 2. Platelet aggregation data for Figure
      4: Primary zip folders named Figure4-A-platelet-aggregation-raw-data.zip
      and Figure4-B-platelet-aggregation-raw-data.zip. The zip folder
      Figure4-A-platelet-aggregation-raw-data includes a subfolder named
      Xiaoyin_Acute_Exposure_1D, which includes files named from Acute
      Exposure_1D_Xiaoyin_Rat_33 to Acute Exposure_1D_Xiaoyin_Rat_91 in order.
      Note: we removed the file Acute Exposure_1D_Xiaoyin_Rat_37_duplicate
      because it was zero bytes. Duplicate versions are the same as the
      originals and should be used accordingly.  The zip folder
      Figure4-B-platelet-aggregation-raw-data includes a subfolder named
      Xiaoyin_Chronic Exposure_14D, which includes files named from Chronic
      Exposure_14D_Xiaoyin_Rat_1 to Chronic Exposure_14D_Xiaoyin_Rat_115 in
      order. All primary folders contain raw platelet aggregation data for area
      under the curve (AUC) of the aggregation tracing. AUC was calculated by
      AGGRO/LINK^®^  (Chrono-Log Corporation) for Windows software. Each
      subfolder contains files corresponding to each animal at each
      smoking/vaping condition. Smoke conditions are Marlboro Red cigarettes,
      JUUL, IQOS-Rus, IQOS-USA, Marijuana cigarettes, and placebo marijuana
      cigarettes. For viewing the raw data, open each PDF file to see the
      aggregation tracing and data. ## Code/software 1. For viewing the platelet
      aggregation data, open each PDF file to see the aggregation tracing and
      data. ## Access information Other publicly accessible locations of the
      data: * No Data was derived from the following sources: * No
    </description>
  </descriptions>
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