{"data":{"id":"10.5061/dryad.vt4b8gv5w","type":"dois","attributes":{"doi":"10.5061/dryad.vt4b8gv5w","prefix":"10.5061","suffix":"dryad.vt4b8gv5w","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Hinterwirth, Armin","nameType":"Personal","givenName":"Armin","familyName":"Hinterwirth","affiliation":["University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6450-488X","nameIdentifierScheme":"ORCID"}]},{"name":"Chen, Cindy","nameType":"Personal","givenName":"Cindy","familyName":"Chen","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Zhong, Lina","nameType":"Personal","givenName":"Lina","familyName":"Zhong","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Zhou, Zhaoxia","nameType":"Personal","givenName":"Zhaoxia","familyName":"Zhou","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Liu, YuHeng","nameType":"Personal","givenName":"YuHeng","familyName":"Liu","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Keenan, Jeremy","nameType":"Personal","givenName":"Jeremy","familyName":"Keenan","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"O’Brien, Kieran S.","nameType":"Personal","givenName":"Kieran S.","familyName":"O’Brien","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Lebas, Elodie","nameType":"Personal","givenName":"Elodie","familyName":"Lebas","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Porco, Travis C.","nameType":"Personal","givenName":"Travis C.","familyName":"Porco","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Lietman, Thomas M.","nameType":"Personal","givenName":"Thomas M.","familyName":"Lietman","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Doan, Thuy","nameType":"Personal","givenName":"Thuy","familyName":"Doan","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]}],"titles":[{"title":"Data from: Co-selection of genetic antibiotic resistance in \u003cem\u003eStreptococcus pneumoniae\u003c/em\u003e after repeated Azithromycin mass drug administrations in Niger"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Medical and health sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Medical and health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Streptococcus pneumoniae"},{"subject":"Antibiotic resistance","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Antibiotics","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[],"dates":[{"date":"2025-11-11T19:37:10Z","dateType":"Created"},{"date":"2025-12-23T19:28:19Z","dateType":"Submitted"},{"date":"2026-01-21T00:00:00Z","dateType":"Issued"},{"date":"2026-01-21T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1128/aac.01562-25","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["186259924 bytes"],"formats":[],"version":"5","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"We performed long-read whole-genome sequencing and phenotypic resistance\n analysis on Streptococcus pneumoniae isolated from the nasopharynx of\n Nigerien children from communities treated with either 6 twice-yearly\n azithromycin distributions or placebo. This dataset contains the annotated\n genome files for the 122 samples used in the study, as well as the\n associated metadata.","descriptionType":"Abstract"},{"description":"Isolated pneumococcal colonies were subjected to long-read WGS\n using the SMRTbell Prep Kit 3.0 and sequenced on the PacBio Revio platform\n (Pacific Biosciences of California). PacBio HiFi reads were \u003cem\u003ede\n novo\u003c/em\u003e assembled using Canu (version 2.2) with the ‘-pacbio-hifi’\n option and evaluated for quality using BUSCO (version 5.7.1). Assemblies\n achieving a completeness score \u0026gt;90% underwent a ‘Comprehensive\n Genome Analysis’ using BV-BRC online tools (accessed April 2025).\n BV-BRC-annotated genomes were subsequently screened for mobile elements\n utilizing ICEscreen (version 1.3.3). Annotated genomes were saved in\n genbank format.","descriptionType":"Methods"},{"description":"# Data from: Co-selection of genetic antibiotic resistance in\n *Streptococcus pneumoniae* after repeated Azithromycin mass drug\n administrations in Niger Dataset DOI:\n [10.5061/dryad.vt4b8gv5w](https://doi.org/10.5061/dryad.vt4b8gv5w) ##\n Description of the data and file structure This repository contains the\n annotated genomes of *Streptococcus pneumoniae*, as well as associated\n metadata. Isolated pneumococcal colonies were subjected to long-read\n whole-genome-sequencing using the SMRTbell Prep Kit 3.0 and sequenced on\n the PacBio Revio platform (Pacific Biosciences of California). PacBio HiFi\n reads were *de novo* assembled using Canu (version 2.2) with the\n ‘-pacbio-hifi’ option and evaluated for quality using BUSCO (version\n 5.7.1). Assemblies achieving a completeness score \u0026gt;90% underwent a\n ‘Comprehensive Genome Analysis’ using BV-BRC online tools (accessed April\n 2025). BV-BRC-annotated genomes were subsequently screened for mobile\n elements utilizing ICEscreen (version 1.3.3). Annotated genomes were saved\n in *genbank* format. ### Files and variables #### File:\n annotated_genomes.tgz **Description:** Compressed archive of the annotated\n genomes (in genbank format) used for this study. Sample names follow the\n convention\n `Streptococcus_pneumoniae_sample__canu_BV-BRC-annotated.gb`,\n where `lab_ID` is a unique identifier for each sample. Use command `tar\n cvfz annotated_genomes.tgz` to un-compress. #### File:\n genomes_metadata_v1.3.csv A comma-delimited text file containing metadata\n associated with the genomes. **Variables:** * `Lab_ID`: a unique\n identifier for each sample * `whg_code`: a unique, de-identified code for\n the village the sample originated from. (Dosso region of Niger) * `group`:\n treatment group. `A`: azithromycin, `P`: placebo * `beta_lactam`: boolean\n indicator of genetic beta-lactam resistance status (0: not resistant, 1:\n resistant) * `erythromycin`: boolean indicator of genetic erythromycin\n resistance status (0: not resistant, 1: resistant) *\n `trimethoprim_sulfamethoxazole`: boolean indicator of genetic\n trimethoprim-sulfamethoxazole resistance status (0: not resistant, 1:\n resistant) * `tetracycline`: boolean indicator of genetic tetracylcine\n resistance status (0: not resistant, 1: resistant) * `erythromycin_arup`:\n boolean indicator of phenotypic erythromycin resistance status (0: not\n resistant, 1: resistant) * `betalactams_arup`: boolean indicator of\n phenotypic beta-lactam resistance status (0: not resistant, 1: resistant)\n * `trimethoprim_sulfamethoxazole_arup`: boolean indicator of phenotypic\n trimethoprim-sulfamethoxazole resistance status (0: not resistant, 1:\n resistant) * `tetracycline_arup`: boolean indicator of phenotypic\n tetracylcine resistance status (0: not resistant, 1: resistant) *\n `genbank_filename`: The filename of the associated *Streptococcus\n pneumoniae* genome found in the `annotated_genomes.tgz` tar archive file.","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Gates Foundation","funderIdentifier":"https://ror.org/0456r8d26","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Research to Prevent Blindness","funderIdentifier":"https://ror.org/04drjs621","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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      <creatorName nameType="Personal">Hinterwirth, Armin</creatorName>
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      <creatorName nameType="Personal">Chen, Cindy</creatorName>
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      <creatorName nameType="Personal">Zhong, Lina</creatorName>
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      <creatorName nameType="Personal">Zhou, Zhaoxia</creatorName>
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      <creatorName nameType="Personal">Liu, YuHeng</creatorName>
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      <creatorName nameType="Personal">Keenan, Jeremy</creatorName>
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      <creatorName nameType="Personal">Lebas, Elodie</creatorName>
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    </creator>
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  <titles>
    <title>
      Data from: Co-selection of genetic antibiotic resistance in
      &lt;em&gt;Streptococcus pneumoniae&lt;/em&gt; after repeated Azithromycin
      mass drug administrations in Niger
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
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    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Health sciences</subject>
    <subject>Streptococcus pneumoniae</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Antibiotic resistance</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Antibiotics</subject>
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    <date dateType="Created">2025-11-11T19:37:10Z</date>
    <date dateType="Submitted">2025-12-23T19:28:19Z</date>
    <date dateType="Issued">2026-01-21T00:00:00Z</date>
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    <description descriptionType="Abstract">
      We performed long-read whole-genome sequencing and phenotypic resistance
      analysis on Streptococcus pneumoniae isolated from the nasopharynx of
      Nigerien children from communities treated with either 6 twice-yearly
      azithromycin distributions or placebo. This dataset contains the annotated
      genome files for the 122 samples used in the study, as well as the
      associated metadata.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;Isolated pneumococcal colonies were subjected to long-read WGS
      using the SMRTbell Prep Kit 3.0 and sequenced on the PacBio Revio platform
      (Pacific Biosciences of California). PacBio HiFi reads were &lt;em&gt;de
      novo&lt;/em&gt; assembled using Canu (version 2.2) with the ‘-pacbio-hifi’
      option and evaluated for quality using BUSCO (version 5.7.1). Assemblies
      achieving a completeness score &amp;gt;90% underwent a ‘Comprehensive
      Genome Analysis’ using BV-BRC online tools (accessed April 2025).
      BV-BRC-annotated genomes were subsequently screened for mobile elements
      utilizing ICEscreen (version 1.3.3). Annotated genomes were saved in
      genbank format.&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      # Data from: Co-selection of genetic antibiotic resistance in
      *Streptococcus pneumoniae* after repeated Azithromycin mass drug
      administrations in Niger Dataset DOI:
      [10.5061/dryad.vt4b8gv5w](https://doi.org/10.5061/dryad.vt4b8gv5w) ##
      Description of the data and file structure This repository contains the
      annotated genomes of *Streptococcus pneumoniae*, as well as associated
      metadata. Isolated pneumococcal colonies were subjected to long-read
      whole-genome-sequencing using the SMRTbell Prep Kit 3.0 and sequenced on
      the PacBio Revio platform (Pacific Biosciences of California). PacBio HiFi
      reads were *de novo* assembled using Canu (version 2.2) with the
      ‘-pacbio-hifi’ option and evaluated for quality using BUSCO (version
      5.7.1). Assemblies achieving a completeness score &gt;90% underwent a
      ‘Comprehensive Genome Analysis’ using BV-BRC online tools (accessed April
      2025). BV-BRC-annotated genomes were subsequently screened for mobile
      elements utilizing ICEscreen (version 1.3.3). Annotated genomes were saved
      in *genbank* format. ### Files and variables #### File:
      annotated_genomes.tgz **Description:** Compressed archive of the annotated
      genomes (in genbank format) used for this study. Sample names follow the
      convention
      `Streptococcus_pneumoniae_sample_&lt;lab_ID&gt;_canu_BV-BRC-annotated.gb`,
      where `lab_ID` is a unique identifier for each sample. Use command `tar
      cvfz annotated_genomes.tgz` to un-compress. #### File:
      genomes_metadata_v1.3.csv A comma-delimited text file containing metadata
      associated with the genomes. **Variables:** * `Lab_ID`: a unique
      identifier for each sample * `whg_code`: a unique, de-identified code for
      the village the sample originated from. (Dosso region of Niger) * `group`:
      treatment group. `A`: azithromycin, `P`: placebo * `beta_lactam`: boolean
      indicator of genetic beta-lactam resistance status (0: not resistant, 1:
      resistant) * `erythromycin`: boolean indicator of genetic erythromycin
      resistance status (0: not resistant, 1: resistant) *
      `trimethoprim_sulfamethoxazole`: boolean indicator of genetic
      trimethoprim-sulfamethoxazole resistance status (0: not resistant, 1:
      resistant) * `tetracycline`: boolean indicator of genetic tetracylcine
      resistance status (0: not resistant, 1: resistant) * `erythromycin_arup`:
      boolean indicator of phenotypic erythromycin resistance status (0: not
      resistant, 1: resistant) * `betalactams_arup`: boolean indicator of
      phenotypic beta-lactam resistance status (0: not resistant, 1: resistant)
      * `trimethoprim_sulfamethoxazole_arup`: boolean indicator of phenotypic
      trimethoprim-sulfamethoxazole resistance status (0: not resistant, 1:
      resistant) * `tetracycline_arup`: boolean indicator of phenotypic
      tetracylcine resistance status (0: not resistant, 1: resistant) *
      `genbank_filename`: The filename of the associated *Streptococcus
      pneumoniae* genome found in the `annotated_genomes.tgz` tar archive file.
    </description>
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