{"data":{"id":"10.5061/dryad.sf7m0cgms","type":"dois","attributes":{"doi":"10.5061/dryad.sf7m0cgms","prefix":"10.5061","suffix":"dryad.sf7m0cgms","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"He, Cheng","nameType":"Personal","givenName":"Cheng","familyName":"He","affiliation":["Nantong University"],"nameIdentifiers":[]},{"name":"Ma, Ling-Jie","nameType":"Personal","givenName":"Ling-Jie","familyName":"Ma","affiliation":["Nantong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0664-6163","nameIdentifierScheme":"ORCID"}]},{"name":"Fu, Yuan-Yuan","nameType":"Personal","givenName":"Yuan-Yuan","familyName":"Fu","affiliation":["Nantong University"],"nameIdentifiers":[]},{"name":"Zhang, Ke-Chen","nameType":"Personal","givenName":"Ke-Chen","familyName":"Zhang","affiliation":["Nantong University"],"nameIdentifiers":[]},{"name":"Tao, Ye","nameType":"Personal","givenName":"Ye","familyName":"Tao","affiliation":["Nantong University"],"nameIdentifiers":[]},{"name":"Wei, Xiao","nameType":"Personal","givenName":"Xiao","familyName":"Wei","affiliation":["Nantong University"],"nameIdentifiers":[]},{"name":"Shen, Yong-Liang","nameType":"Personal","givenName":"Yong-Liang","familyName":"Shen","affiliation":["Yancheng Third People's Hospital"],"nameIdentifiers":[]},{"name":"Wang, Juan","nameType":"Personal","givenName":"Juan","familyName":"Wang","affiliation":["Nantong University"],"nameIdentifiers":[]},{"name":"Gao, Yong-Jing","nameType":"Personal","givenName":"Yong-Jing","familyName":"Gao","affiliation":["Affiliated Hospital of Nantong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7432-7458","nameIdentifierScheme":"ORCID"}]},{"name":"Zhang, Zhi-Jun","nameType":"Personal","givenName":"Zhi-Jun","familyName":"Zhang","affiliation":["Nantong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6996-8683","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Peripheral CRH orchestrates neuropathic pain through transcriptional control by SMAD1 and spinal CRHR2 activation"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"Neuro"},{"subject":"Neuropathic pain","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Natural sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Natural sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Itch"}],"contributors":[],"dates":[{"date":"2025-12-10T05:33:54Z","dateType":"Created"},{"date":"2026-04-09T14:43:24Z","dateType":"Submitted"},{"date":"2026-04-27T00:00:00Z","dateType":"Issued"},{"date":"2026-04-27T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1126/scisignal.aeb3953","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["141911233 bytes"],"formats":[],"version":"8","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Neuropathic pain is a debilitating condition that lacks effective\n treatments. Corticotropin-releasing hormone (CRH) is associated with the\n central neural circuits involved in stress and pain. Here, we identified a\n peripheral CRH–mediated signaling axis in dorsal root ganglion (DRG) and\n spinal neurons underlying neuropathic pain. Spared nerve injury (SNI) in\n male mice increased the abundance of CRH in small- and medium-diameter DRG\n neurons, specifically within their central terminals in the spinal dorsal\n horn. DRG-specific knockdown of CRH alleviated neuropathic pain. SNI\n increased Crh expression by inducing the binding of the transcription\n factor SMAD1 to the Crh promoter. Silencing SMAD1 in the DRG reduced\n neuropathic pain symptoms, which was accompanied by a decrease in the\n amount of CRH in the DRG tissue. Pharmacological antagonism of CRH\n receptor 2 (CRHR2), but not of CRHR1, attenuated neuropathic pain and\n suppressed the activation of spinal neurons and glia. Spinal CRHR2 is\n predominantly localized to excitatory neurons and somatostatin-positive\n interneurons in the superficial dorsal horn. These findings reveal a\n SMAD1-CRH-CRHR2 axis in DRG-to-spine signaling that promotes neuropathic\n pain and suggest that CRHR2 antagonists be explored for its management.","descriptionType":"Abstract"},{"description":"Animal models: spared nerve injury (SNI) in rodents.\n Behavioral tests: Mechanical allodynia: von\n Frey filaments (paw withdrawal threshold, grams). Motor\n coordination: Rotarod test (latency, seconds).\n Molecular assays: qPCR (fold change relative to\n naïve/sham/treatment group). Immunohistochemistry: CRH,\n SMAD1, c-Fos, GFAP, IBA1; colocalization with IB4, CGRP, NF200.\n Pharmacology: CRHR1 antagonist NBI 27914 (1\n μg/10 μL, i.t.).\u003cbr\u003e CRHR2 antagonist Astressin 2B (0.01–1 μg/10 μL,\n i.t.). Gene manipulation: siRNA (DRG injection),\n AAV-shRNA (spinal cord), luciferase promoter assay.","descriptionType":"Methods"},{"description":"# Peripheral CRH orchestrates neuropathic pain through transcriptional\n control by SMAD1 and spinal CRHR2 activation Dataset DOI:\n [10.5061/dryad.sf7m0cgms](https://doi.org/10.5061/dryad.sf7m0cgms)\n **Descriptions** We have submitted our main quantitative data\n (aeb3953_data_file.csv), raw microarray data folder (E‑MTAB‑3326/), raw\n gene expression data folder (GSE75072_RAW/), and dataset description file\n (README.txt). Key Information Sources Raw microarray data: ArrayExpress\n (E-MTAB-3326) Raw gene expression data: NCBI GEO (GSE75072) **Usage\n notes** Microsoft Excel or similar spreadsheet software can be used to\n view aeb3953_data_file.csv. Microarray data files can be processed using\n standard bioinformatics tools in R or Python. **Reproducibility\n Statement** All data required to reproduce the analyses, statistics, and\n conclusions of the study are fully included. Raw fluorescence microscopy\n images are not required for quantitative or statistical reproducibility\n and are not included in this archive. No additional underlying data are\n needed. ### Files and variables #### File: GSE75072_RAW.tar\n **Description:** Raw gene expression data downloaded from NCBI GEO\n (GSE75072).GSM1942148_Sham_1.txt.gz: Raw expression data, Sham control\n replicate 1 GSM1942149_Sham_2.txt.gz: Raw expression data, Sham control\n replicate 2 GSM1942150_SNL_1.txt.gz: Raw expression data, SNL model\n replicate 1 GSM1942151_SNL_2.txt.gz: Raw expression data, SNL model\n replicate 2 Raw gene expression data downloaded from NCBI GEO (GSE75072).\n All files are provided in standard compressed GEO raw text format\n containing probe-level intensity values. #### File: E-MTAB-3326.zip\n **Description:**  Raw microarray data downloaded from ArrayExpress\n (E-MTAB-3326). Files included: E-MTAB-3326.idf: Investigation Description\n Format file containing experiment metadata, study design, protocols, and\n platform information. E-MTAB-3326.sdrf: Sample and Data Relationship\n Format file linking each sample to its raw data file. AK1.CEL to AK9.CEL:\n Raw Affymetrix microarray probe intensity files for each biological\n sample. Variables in E-MTAB-3326.sdrf: Source Name: Unique sample\n identifier Characteristics[organism]: Species Characteristics[disease\n state]: Experimental condition (Sham / SNL) Protocol REF: Experiment\n protocol reference Array Design REF: Microarray platform information\n Derived Array Data File: Corresponding CEL file for each sample #### File:\n aeb3953_data_file.csv **Description:**  This file contains all\n quantitative data supporting all main figures (Fig. 1–8) and supplementary\n figures (Fig. S1–S4). Rows represent individual biological replicates.\n **Variables** * Naïve: Naïve control group * Sham: Sham-operated control\n group * SNL/SNI: Spinal nerve ligation/Spinal nerve injury model group *\n 1d, 3d, 10d, 21d: Time points after surgery * NC siRNA: Negative control\n siRNA * Crh siRNA: CRH-targeting siRNA * Smad1 siRNA: SMAD1-targeting\n siRNA * AAV-mCherry / AAV-shCrh / AAV-shCrhr2: Viral vector treatment\n groups * Vehicle: Vehicle control treatment * NBI 27914: CRHR1 antagonist\n * Astressin 2B: CRHR2 antagonist Values include raw measurements, group\n mean (mean), standard error of the mean (SEM), sample size (n), mean\n difference, 95% confidence interval, adjusted P-value, and significance\n summary. Statistical tests include two-way ANOVA, one-way ANOVA, unpaired\n t-test, and the Bonferroni multiple comparisons test. #### File:\n README.txt **Description:** dataset description file (**README.txt**).","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"82371229","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"82200817","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"31970938","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <creators>
    <creator>
      <creatorName nameType="Personal">He, Cheng</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02afcvw97" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Nantong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ma, Ling-Jie</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0664-6163</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/02afcvw97" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Nantong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Fu, Yuan-Yuan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02afcvw97" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Nantong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhang, Ke-Chen</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02afcvw97" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Nantong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Tao, Ye</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02afcvw97" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Nantong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Wei, Xiao</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02afcvw97" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Nantong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Shen, Yong-Liang</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/030cwsf88" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Yancheng Third People's Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Wang, Juan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02afcvw97" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Nantong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Gao, Yong-Jing</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-7432-7458</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/001rahr89" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Affiliated Hospital of Nantong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhang, Zhi-Jun</creatorName>
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      <affiliation affiliationIdentifier="https://ror.org/02afcvw97" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Nantong University</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Peripheral CRH orchestrates neuropathic pain through transcriptional
      control by SMAD1 and spinal CRHR2 activation
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2026</publicationYear>
  <subjects>
    <subject>Neuro</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Neuropathic pain</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Biological sciences</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Natural sciences</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Clinical medicine</subject>
    <subject>Itch</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>82371229</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>82200817</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>31970938</awardNumber>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Created">2025-12-10T05:33:54Z</date>
    <date dateType="Submitted">2026-04-09T14:43:24Z</date>
    <date dateType="Issued">2026-04-27T00:00:00Z</date>
    <date dateType="Available">2026-04-27T00:00:00Z</date>
  </dates>
  <language>en</language>
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  <descriptions>
    <description descriptionType="Abstract">
      Neuropathic pain is a debilitating condition that lacks effective
      treatments. Corticotropin-releasing hormone (CRH) is associated with the
      central neural circuits involved in stress and pain. Here, we identified a
      peripheral CRH–mediated signaling axis in dorsal root ganglion (DRG) and
      spinal neurons underlying neuropathic pain. Spared nerve injury (SNI) in
      male mice increased the abundance of CRH in small- and medium-diameter DRG
      neurons, specifically within their central terminals in the spinal dorsal
      horn. DRG-specific knockdown of CRH alleviated neuropathic pain. SNI
      increased Crh expression by inducing the binding of the transcription
      factor SMAD1 to the Crh promoter. Silencing SMAD1 in the DRG reduced
      neuropathic pain symptoms, which was accompanied by a decrease in the
      amount of CRH in the DRG tissue. Pharmacological antagonism of CRH
      receptor 2 (CRHR2), but not of CRHR1, attenuated neuropathic pain and
      suppressed the activation of spinal neurons and glia. Spinal CRHR2 is
      predominantly localized to excitatory neurons and somatostatin-positive
      interneurons in the superficial dorsal horn. These findings reveal a
      SMAD1-CRH-CRHR2 axis in DRG-to-spine signaling that promotes neuropathic
      pain and suggest that CRHR2 antagonists be explored for its management.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;Animal models: spared nerve injury (SNI) in rodents.&lt;/p&gt;
      &lt;p&gt;Behavioral tests:&lt;/p&gt; &lt;p&gt;Mechanical allodynia: von
      Frey filaments (paw withdrawal threshold, grams).&lt;/p&gt; &lt;p&gt;Motor
      coordination: Rotarod test (latency, seconds).&lt;/p&gt;
      &lt;p&gt;Molecular assays: qPCR (fold change relative to
      naïve/sham/treatment group).&lt;/p&gt; &lt;p&gt;Immunohistochemistry: CRH,
      SMAD1, c-Fos, GFAP, IBA1; colocalization with IB4, CGRP, NF200.&lt;/p&gt;
      &lt;p&gt;Pharmacology:&lt;/p&gt; &lt;p&gt;CRHR1 antagonist NBI 27914 (1
      μg/10 μL, i.t.).&lt;br&gt; CRHR2 antagonist Astressin 2B (0.01–1 μg/10 μL,
      i.t.).&lt;/p&gt; &lt;p&gt;Gene manipulation: siRNA (DRG injection),
      AAV-shRNA (spinal cord), luciferase promoter assay.&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      # Peripheral CRH orchestrates neuropathic pain through transcriptional
      control by SMAD1 and spinal CRHR2 activation Dataset DOI:
      [10.5061/dryad.sf7m0cgms](https://doi.org/10.5061/dryad.sf7m0cgms)
      **Descriptions** We have submitted our main quantitative data
      (aeb3953_data_file.csv), raw microarray data folder (E‑MTAB‑3326/), raw
      gene expression data folder (GSE75072_RAW/), and dataset description file
      (README.txt). Key Information Sources Raw microarray data: ArrayExpress
      (E-MTAB-3326) Raw gene expression data: NCBI GEO (GSE75072) **Usage
      notes** Microsoft Excel or similar spreadsheet software can be used to
      view aeb3953_data_file.csv. Microarray data files can be processed using
      standard bioinformatics tools in R or Python. **Reproducibility
      Statement** All data required to reproduce the analyses, statistics, and
      conclusions of the study are fully included. Raw fluorescence microscopy
      images are not required for quantitative or statistical reproducibility
      and are not included in this archive. No additional underlying data are
      needed. ### Files and variables #### File: GSE75072_RAW.tar
      **Description:** Raw gene expression data downloaded from NCBI GEO
      (GSE75072).GSM1942148_Sham_1.txt.gz: Raw expression data, Sham control
      replicate 1 GSM1942149_Sham_2.txt.gz: Raw expression data, Sham control
      replicate 2 GSM1942150_SNL_1.txt.gz: Raw expression data, SNL model
      replicate 1 GSM1942151_SNL_2.txt.gz: Raw expression data, SNL model
      replicate 2 Raw gene expression data downloaded from NCBI GEO (GSE75072).
      All files are provided in standard compressed GEO raw text format
      containing probe-level intensity values. #### File: E-MTAB-3326.zip
      **Description:**  Raw microarray data downloaded from ArrayExpress
      (E-MTAB-3326). Files included: E-MTAB-3326.idf: Investigation Description
      Format file containing experiment metadata, study design, protocols, and
      platform information. E-MTAB-3326.sdrf: Sample and Data Relationship
      Format file linking each sample to its raw data file. AK1.CEL to AK9.CEL:
      Raw Affymetrix microarray probe intensity files for each biological
      sample. Variables in E-MTAB-3326.sdrf: Source Name: Unique sample
      identifier Characteristics[organism]: Species Characteristics[disease
      state]: Experimental condition (Sham / SNL) Protocol REF: Experiment
      protocol reference Array Design REF: Microarray platform information
      Derived Array Data File: Corresponding CEL file for each sample #### File:
      aeb3953_data_file.csv **Description:**  This file contains all
      quantitative data supporting all main figures (Fig. 1–8) and supplementary
      figures (Fig. S1–S4). Rows represent individual biological replicates.
      **Variables** * Naïve: Naïve control group * Sham: Sham-operated control
      group * SNL/SNI: Spinal nerve ligation/Spinal nerve injury model group *
      1d, 3d, 10d, 21d: Time points after surgery * NC siRNA: Negative control
      siRNA * Crh siRNA: CRH-targeting siRNA * Smad1 siRNA: SMAD1-targeting
      siRNA * AAV-mCherry / AAV-shCrh / AAV-shCrhr2: Viral vector treatment
      groups * Vehicle: Vehicle control treatment * NBI 27914: CRHR1 antagonist
      * Astressin 2B: CRHR2 antagonist Values include raw measurements, group
      mean (mean), standard error of the mean (SEM), sample size (n), mean
      difference, 95% confidence interval, adjusted P-value, and significance
      summary. Statistical tests include two-way ANOVA, one-way ANOVA, unpaired
      t-test, and the Bonferroni multiple comparisons test. #### File:
      README.txt **Description:** dataset description file (**README.txt**).
    </description>
  </descriptions>
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