{"data":{"id":"10.5061/dryad.rxwdbrvfh","type":"dois","attributes":{"doi":"10.5061/dryad.rxwdbrvfh","prefix":"10.5061","suffix":"dryad.rxwdbrvfh","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Ohue-Kitano, Ryuji","nameType":"Personal","givenName":"Ryuji","familyName":"Ohue-Kitano","affiliation":["Kyoto University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-4609-0980","nameIdentifierScheme":"ORCID"}]},{"name":"Banno, Yukika","nameType":"Personal","givenName":"Yukika","familyName":"Banno","affiliation":["Kyoto University"],"nameIdentifiers":[]},{"name":"Masujima, Yuki","nameType":"Personal","givenName":"Yuki","familyName":"Masujima","affiliation":["Kyoto University"],"nameIdentifiers":[]},{"name":"Kimura, Ikuo","nameType":"Personal","givenName":"Ikuo","familyName":"Kimura","affiliation":["Kyoto University"],"nameIdentifiers":[]}],"titles":[{"title":"Gut microbial metabolites reveal diet-dependent metabolic changes induced by nicotine administration"}],"publisher":"Dryad","container":{},"publicationYear":2024,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"16S rRNA gene sequence data"},{"subject":"Gut bacteria","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Nicotine","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[],"dates":[{"date":"2023-07-24T05:38:05Z","dateType":"Created"},{"date":"2024-01-09T15:50:54Z","dateType":"Submitted"},{"date":"2024-01-12T00:00:00Z","dateType":"Issued"},{"date":"2024-01-12T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1038/s41598-024-51528-3","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["2417806886 bytes"],"formats":[],"version":"5","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The gut microbiota has emerged as an important factor that potentially\n influences various physiological functions and pathophysiological\n processes such as obesity and type 2 diabetes mellitus. Accumulating\n evidence from human and animal studies suggests that gut microbial\n metabolites play a critical role as integral molecules in host–microbe\n interactions. Notably, several dietary environment-dependent fatty acid\n metabolites have been recognized as potent modulators of host metabolic\n homeostasis. More recently, nicotine, the primary active molecule in\n tobacco, has been shown to potentially affect host metabolism through\n alterations in the gut microbiota and its metabolites. However, the\n mechanisms underlying the interplay between host nutritional status,\n diet-derived microbial metabolites, and metabolic homeostasis during\n nicotine exposure remain unclear. Our findings revealed that nicotine\n administration had potential effects on weight regulation and metabolic\n phenotype, independent of reduced caloric intake. Moreover,\n nicotine-induced body weight suppression is associated with specific\n changes in gut microbial composition, including Lactobacillus spp., and\n KetoB, a nicotine-sensitive gut microbiota metabolite, which could be\n linked to changes in host body weight, suggesting its potential role in\n modulating host metabolism. Our findings highlight the remarkable impact\n of the interplay between nutritional control and the gut environment on\n host metabolism during smoking and smoking cessation.","descriptionType":"Abstract"},{"description":"Fecal samples were collected from\n mice treated with nicotine under normal diet or high-fat diet feeding\n condition. Fecal DNA was extracted using the FastDNA® SPIN Kit for Feces.\n Sequencing of the amplicons was carried out on an Illumina MiSeq\n instrument with a MiSeq Reagent Kit V3, following established protocols.\n Read processing and quality filtering were performed using Quantitative\n Insights into Microbial Ecology (QIIME) version 1.9.1. and aligned with\n the SILVA database (http://www.arb-silva.de) at the Unclassified level. ","descriptionType":"Methods"},{"description":"# Gut microbial metabolites reveal diet-dependent metabolic changes\n induced by nicotine administration\n 1. Analysis of gut\n microbiota by 16S rRNA gene sequencing following with nicotine\n administration by intraperitoneal injection. At 7 weeks of age, the male\n mice with comparable average body weight were divided into two groups: the\n normal diet (ND) group and the high-fat diet (HFD) group (D12492, 60% kcal\n fat; Research Diets, Inc., NJ, USA) and received twice daily injections of\n nicotine (0.75 mg/kg body weight, intraperitoneal administration) or\n saline for 4 weeks. 2. Analysis of gut microbiota by 16S rRNA gene\n sequencing following with nicotine administration by drinking water. At 7\n weeks of age, the male mice received a nicotine solution (200 mg/mL in 2%\n saccharin vehicle) in drinking water during the 4-week period of HFD\n exposure. The V4 region of the 16S rRNA gene was amplified using\n dual-indexed primers. Sequencing of the amplicons was carried out on an\n Illumina MiSeq instrument with a MiSeq Reagent Kit V3 (Illumina, San\n Diego, CA, USA). Description of the data and file structure 1\\) Analysis\n of gut microbiota by 16S rRNA gene sequencing followed with nicotine\n administration by intraperitoneal injection 1\\) Fecal DNA from mice fed\n normal diet (ND) Vehicle control group (n = 8) DRR493554 *\n DRR493554_1.fastq.bz2 * DRR493554_2.fastq.bz2 DRR493555 *\n DRR493555_1.fastq.bz2 * DRR493555_2.fastq.bz2 DRR493556 *\n DRR493556_1.fastq.bz2 * DRR493556_2.fastq.bz2 DRR493557 *\n DRR493557_1.fastq.bz2 * DRR493557_2.fastq.bz2 DRR493558 *\n DRR493558_1.fastq.bz2 * DRR493558_2.fastq.bz2 DRR493559 *\n DRR493559_1.fastq.bz2 * DRR493559_2.fastq.bz2 DRR493560 *\n DRR493560_1.fastq.bz2 * DRR493560_2.fastq.bz2 DRR493561 *\n DRR493561_1.fastq.bz2 * DRR493561_2.fastq.bz2 Nicotine administered group\n (n = 8) DRR493562 * DRR493562_1.fastq.bz2 * DRR493562_2.fastq.bz2\n DRR493563 * DRR493563_1.fastq.bz2 * DRR493563_2.fastq.bz2 DRR493564 *\n DRR493564_1.fastq.bz2 * DRR493564_2.fastq.bz2 DRR493565 *\n DRR493565_1.fastq.bz2 * DRR493565_2.fastq.bz2 DRR493566 *\n DRR493566_1.fastq.bz2 * DRR493566_2.fastq.bz2 DRR493567 *\n DRR493567_1.fastq.bz2 * DRR493567_2.fastq.bz2 DRR493568 *\n DRR493568_1.fastq.bz2 * DRR493568_2.fastq.bz2 DRR493569 *\n DRR493569_1.fastq.bz2 * DRR493569_2.fastq.bz2 2\\)  Fecal DNA from mice fed\n high-fat diet (HFD) Vehicle control group (n = 8) DRR493570 *\n DRR493570_1.fastq.bz2 * DRR493570_2.fastq.bz2 DRR493571 *\n DRR493571_1.fastq.bz2 * DRR493571_2.fastq.bz2 DRR493572 *\n DRR493572_1.fastq.bz2 * DRR493572_2.fastq.bz2 DRR493573 *\n DRR493573_1.fastq.bz2 * DRR493573_2.fastq.bz2 DRR493574 *\n DRR493574_1.fastq.bz2 * DRR493574_2.fastq.bz2 DRR493575 *\n DRR493575_1.fastq.bz2 * DRR493575_2.fastq.bz2 DRR493576 *\n DRR493576_1.fastq.bz2 * DRR493576_2.fastq.bz2 DRR493577 *\n DRR493577_1.fastq.bz2 * DRR493577_2.fastq.bz2 Nicotine administered group\n (n = 8) DRR493578 * DRR493578_1.fastq.bz2 * DRR493578_2.fastq.bz2\n DRR493579 * DRR493579_1.fastq.bz2 * DRR493579_2.fastq.bz2 DRR493580 *\n DRR493580_1.fastq.bz2 * DRR493580_2.fastq.bz2 DRR493581 *\n DRR493581_1.fastq.bz2 * DRR493581_2.fastq.bz2 DRR493582 *\n DRR493582_1.fastq.bz2 * DRR493582_2.fastq.bz2 DRR493583 *\n DRR493583_1.fastq.bz2 * DRR493583_2.fastq.bz2 DRR493584 *\n DRR493584_1.fastq.bz2 * DRR493584_2.fastq.bz2 DRR493585 *\n DRR493585_1.fastq.bz2 * DRR493585_2.fastq.bz2 2\\) Analysis of gut\n microbiota by 16S rRNA gene sequencing following with nicotine\n administration by drinking water 1\\) Vehicle control group (n = 8)\n DRR493586 * DRR493586_1.fastq.bz2 * DRR493586_2.fastq.bz2 DRR493587 *\n DRR493587_1.fastq.bz2 * DRR493587_2.fastq.bz2 DRR493588 *\n DRR493588_1.fastq.bz2 * DRR493588_2.fastq.bz2 DRR493589 *\n DRR493589_1.fastq.bz2 * DRR493589_2.fastq.bz2 DRR493590 *\n DRR493590_1.fastq.bz2 * DRR493590_2.fastq.bz2 DRR493591 *\n DRR493591_1.fastq.bz2 * DRR493591_2.fastq.bz2 DRR493592 *\n DRR493592_1.fastq.bz2 * DRR493592_2.fastq.bz2 DRR493593 *\n DRR493593_1.fastq.bz2 * DRR493593_2.fastq.bz2 2\\) 2% Saccharin group (n =\n 8) DRR493594 * DRR493594_1.fastq.bz2 * DRR493594_2.fastq.bz2 DRR493595 *\n DRR493595_1.fastq.bz2 * DRR493595_2.fastq.bz2 DRR493596 *\n DRR493596_1.fastq.bz2 * DRR493596_2.fastq.bz2 DRR493597 *\n DRR493597_1.fastq.bz2 * DRR493597_2.fastq.bz2 DRR493598 *\n DRR493598_1.fastq.bz2 * DRR493598_2.fastq.bz2 DRR493599 *\n DRR493599_1.fastq.bz2 * DRR493599_2.fastq.bz2 DRR493600 *\n DRR493600_1.fastq.bz2 * DRR493600_2.fastq.bz2 DRR493601 *\n DRR493601_1.fastq.bz2 * DRR493601_2.fastq.bz2 3\\) 2% Saccharin with 200\n μg/mL nicotine group (n = 8) DRR493602 * DRR493602_1.fastq.bz2 *\n DRR493602_2.fastq.bz2 DRR493603 * DRR493603_1.fastq.bz2 *\n DRR493603_2.fastq.bz2 DRR493604 * DRR493604_1.fastq.bz2 *\n DRR493604_2.fastq.bz2 DRR493605 * DRR493605_1.fastq.bz2 *\n DRR493605_2.fastq.bz2 DRR493606 * DRR493606_1.fastq.bz2 *\n DRR493606_2.fastq.bz2 DRR493607 * DRR493607_1.fastq.bz2 *\n DRR493607_2.fastq.bz2 DRR493608 * DRR493608_1.fastq.bz2 *\n DRR493608_2.fastq.bz2 DRR493609 * DRR493609_1.fastq.bz2 *\n DRR493609_2.fastq.bz2","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Smoking Research Foundation","funderIdentifier":"https://ror.org/04q4hbm31","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4/metadata.xsd">
  <identifier identifierType="DOI">10.5061/DRYAD.RXWDBRVFH</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Ohue-Kitano, Ryuji</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-4609-0980</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/02kpeqv85" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Kyoto University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Banno, Yukika</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02kpeqv85" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Kyoto University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Masujima, Yuki</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02kpeqv85" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Kyoto University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Kimura, Ikuo</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02kpeqv85" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Kyoto University</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Gut microbial metabolites reveal diet-dependent metabolic changes induced
      by nicotine administration
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2024</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject>16S rRNA gene sequence data</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Gut bacteria</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Nicotine</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>Smoking Research Foundation</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/04q4hbm31</funderIdentifier>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Created">2023-07-24T05:38:05Z</date>
    <date dateType="Submitted">2024-01-09T15:50:54Z</date>
    <date dateType="Issued">2024-01-12T00:00:00Z</date>
    <date dateType="Available">2024-01-12T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1038/s41598-024-51528-3</relatedIdentifier>
  </relatedIdentifiers>
  <sizes>
    <size>2417806886 bytes</size>
  </sizes>
  <version>5</version>
  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      The gut microbiota has emerged as an important factor that potentially
      influences various physiological functions and pathophysiological
      processes such as obesity and type 2 diabetes mellitus. Accumulating
      evidence from human and animal studies suggests that gut microbial
      metabolites play a critical role as integral molecules in host–microbe
      interactions. Notably, several dietary environment-dependent fatty acid
      metabolites have been recognized as potent modulators of host metabolic
      homeostasis. More recently, nicotine, the primary active molecule in
      tobacco, has been shown to potentially affect host metabolism through
      alterations in the gut microbiota and its metabolites. However, the
      mechanisms underlying the interplay between host nutritional status,
      diet-derived microbial metabolites, and metabolic homeostasis during
      nicotine exposure remain unclear. Our findings revealed that nicotine
      administration had potential effects on weight regulation and metabolic
      phenotype, independent of reduced caloric intake. Moreover,
      nicotine-induced body weight suppression is associated with specific
      changes in gut microbial composition, including Lactobacillus spp., and
      KetoB, a nicotine-sensitive gut microbiota metabolite, which could be
      linked to changes in host body weight, suggesting its potential role in
      modulating host metabolism. Our findings highlight the remarkable impact
      of the interplay between nutritional control and the gut environment on
      host metabolism during smoking and smoking cessation.
    </description>
    <description descriptionType="Methods">
      &lt;p class="MsoNormal"
      style="line-height:150%;"&gt;&lt;span lang="EN-US"
      style="line-height:150%;"&gt;Fecal samples were collected from
      mice treated with nicotine under normal diet or high-fat diet feeding
      condition. Fecal DNA was extracted using the FastDNA® SPIN Kit for Feces.
      Sequencing of the amplicons was carried out on an Illumina MiSeq
      instrument with a MiSeq Reagent Kit V3, following established protocols.
      Read processing and quality filtering were performed using Quantitative
      Insights into Microbial Ecology (QIIME) version 1.9.1. and aligned with
      the SILVA database (&lt;a
      href="http://www.arb-silva.de"&gt;http://www.arb-silva.de&lt;/a&gt;) at the Unclassified level. &lt;/span&gt;&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      # Gut microbial metabolites reveal diet-dependent metabolic changes
      induced by nicotine administration
      &lt;https://doi.org/10.5061/dryad.rxwdbrvfh&gt; 1. Analysis of gut
      microbiota by 16S rRNA gene sequencing following with nicotine
      administration by intraperitoneal injection. At 7 weeks of age, the male
      mice with comparable average body weight were divided into two groups: the
      normal diet (ND) group and the high-fat diet (HFD) group (D12492, 60% kcal
      fat; Research Diets, Inc., NJ, USA) and received twice daily injections of
      nicotine (0.75 mg/kg body weight, intraperitoneal administration) or
      saline for 4 weeks. 2. Analysis of gut microbiota by 16S rRNA gene
      sequencing following with nicotine administration by drinking water. At 7
      weeks of age, the male mice received a nicotine solution (200 mg/mL in 2%
      saccharin vehicle) in drinking water during the 4-week period of HFD
      exposure. The V4 region of the 16S rRNA gene was amplified using
      dual-indexed primers. Sequencing of the amplicons was carried out on an
      Illumina MiSeq instrument with a MiSeq Reagent Kit V3 (Illumina, San
      Diego, CA, USA). Description of the data and file structure 1\) Analysis
      of gut microbiota by 16S rRNA gene sequencing followed with nicotine
      administration by intraperitoneal injection 1\) Fecal DNA from mice fed
      normal diet (ND) Vehicle control group (n = 8) DRR493554 *
      DRR493554_1.fastq.bz2 * DRR493554_2.fastq.bz2 DRR493555 *
      DRR493555_1.fastq.bz2 * DRR493555_2.fastq.bz2 DRR493556 *
      DRR493556_1.fastq.bz2 * DRR493556_2.fastq.bz2 DRR493557 *
      DRR493557_1.fastq.bz2 * DRR493557_2.fastq.bz2 DRR493558 *
      DRR493558_1.fastq.bz2 * DRR493558_2.fastq.bz2 DRR493559 *
      DRR493559_1.fastq.bz2 * DRR493559_2.fastq.bz2 DRR493560 *
      DRR493560_1.fastq.bz2 * DRR493560_2.fastq.bz2 DRR493561 *
      DRR493561_1.fastq.bz2 * DRR493561_2.fastq.bz2 Nicotine administered group
      (n = 8) DRR493562 * DRR493562_1.fastq.bz2 * DRR493562_2.fastq.bz2
      DRR493563 * DRR493563_1.fastq.bz2 * DRR493563_2.fastq.bz2 DRR493564 *
      DRR493564_1.fastq.bz2 * DRR493564_2.fastq.bz2 DRR493565 *
      DRR493565_1.fastq.bz2 * DRR493565_2.fastq.bz2 DRR493566 *
      DRR493566_1.fastq.bz2 * DRR493566_2.fastq.bz2 DRR493567 *
      DRR493567_1.fastq.bz2 * DRR493567_2.fastq.bz2 DRR493568 *
      DRR493568_1.fastq.bz2 * DRR493568_2.fastq.bz2 DRR493569 *
      DRR493569_1.fastq.bz2 * DRR493569_2.fastq.bz2 2\)  Fecal DNA from mice fed
      high-fat diet (HFD) Vehicle control group (n = 8) DRR493570 *
      DRR493570_1.fastq.bz2 * DRR493570_2.fastq.bz2 DRR493571 *
      DRR493571_1.fastq.bz2 * DRR493571_2.fastq.bz2 DRR493572 *
      DRR493572_1.fastq.bz2 * DRR493572_2.fastq.bz2 DRR493573 *
      DRR493573_1.fastq.bz2 * DRR493573_2.fastq.bz2 DRR493574 *
      DRR493574_1.fastq.bz2 * DRR493574_2.fastq.bz2 DRR493575 *
      DRR493575_1.fastq.bz2 * DRR493575_2.fastq.bz2 DRR493576 *
      DRR493576_1.fastq.bz2 * DRR493576_2.fastq.bz2 DRR493577 *
      DRR493577_1.fastq.bz2 * DRR493577_2.fastq.bz2 Nicotine administered group
      (n = 8) DRR493578 * DRR493578_1.fastq.bz2 * DRR493578_2.fastq.bz2
      DRR493579 * DRR493579_1.fastq.bz2 * DRR493579_2.fastq.bz2 DRR493580 *
      DRR493580_1.fastq.bz2 * DRR493580_2.fastq.bz2 DRR493581 *
      DRR493581_1.fastq.bz2 * DRR493581_2.fastq.bz2 DRR493582 *
      DRR493582_1.fastq.bz2 * DRR493582_2.fastq.bz2 DRR493583 *
      DRR493583_1.fastq.bz2 * DRR493583_2.fastq.bz2 DRR493584 *
      DRR493584_1.fastq.bz2 * DRR493584_2.fastq.bz2 DRR493585 *
      DRR493585_1.fastq.bz2 * DRR493585_2.fastq.bz2 2\) Analysis of gut
      microbiota by 16S rRNA gene sequencing following with nicotine
      administration by drinking water 1\) Vehicle control group (n = 8)
      DRR493586 * DRR493586_1.fastq.bz2 * DRR493586_2.fastq.bz2 DRR493587 *
      DRR493587_1.fastq.bz2 * DRR493587_2.fastq.bz2 DRR493588 *
      DRR493588_1.fastq.bz2 * DRR493588_2.fastq.bz2 DRR493589 *
      DRR493589_1.fastq.bz2 * DRR493589_2.fastq.bz2 DRR493590 *
      DRR493590_1.fastq.bz2 * DRR493590_2.fastq.bz2 DRR493591 *
      DRR493591_1.fastq.bz2 * DRR493591_2.fastq.bz2 DRR493592 *
      DRR493592_1.fastq.bz2 * DRR493592_2.fastq.bz2 DRR493593 *
      DRR493593_1.fastq.bz2 * DRR493593_2.fastq.bz2 2\) 2% Saccharin group (n =
      8) DRR493594 * DRR493594_1.fastq.bz2 * DRR493594_2.fastq.bz2 DRR493595 *
      DRR493595_1.fastq.bz2 * DRR493595_2.fastq.bz2 DRR493596 *
      DRR493596_1.fastq.bz2 * DRR493596_2.fastq.bz2 DRR493597 *
      DRR493597_1.fastq.bz2 * DRR493597_2.fastq.bz2 DRR493598 *
      DRR493598_1.fastq.bz2 * DRR493598_2.fastq.bz2 DRR493599 *
      DRR493599_1.fastq.bz2 * DRR493599_2.fastq.bz2 DRR493600 *
      DRR493600_1.fastq.bz2 * DRR493600_2.fastq.bz2 DRR493601 *
      DRR493601_1.fastq.bz2 * DRR493601_2.fastq.bz2 3\) 2% Saccharin with 200
      μg/mL nicotine group (n = 8) DRR493602 * DRR493602_1.fastq.bz2 *
      DRR493602_2.fastq.bz2 DRR493603 * DRR493603_1.fastq.bz2 *
      DRR493603_2.fastq.bz2 DRR493604 * DRR493604_1.fastq.bz2 *
      DRR493604_2.fastq.bz2 DRR493605 * DRR493605_1.fastq.bz2 *
      DRR493605_2.fastq.bz2 DRR493606 * DRR493606_1.fastq.bz2 *
      DRR493606_2.fastq.bz2 DRR493607 * DRR493607_1.fastq.bz2 *
      DRR493607_2.fastq.bz2 DRR493608 * DRR493608_1.fastq.bz2 *
      DRR493608_2.fastq.bz2 DRR493609 * DRR493609_1.fastq.bz2 *
      DRR493609_2.fastq.bz2
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