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Impaired\n intestinal regeneration and survival in STING-deficient mice are fully\n rescued by a single IFN beta  treatment given 48 hours after\n irradiation but not by wild-type (WT) bone marrow. IFN treatment\n remarkably improves the survival of WT mice and Lgr5+ stem cell\n regeneration through elevated compensatory proliferation and more rapid\n DNA damage removal. Our findings support that inducible IFN production in\n the niche couples ISC injury and regeneration and its potential use to\n treat acute radiation injury.","descriptionType":"Abstract"},{"description":"Please refer to referenced publication.\n Leibowitz et.al  Science Advances (2021), Ms# abi5253","descriptionType":"Methods"},{"description":"Please refer to ReadMe file.","descriptionType":"Other"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"National Institute of Allergy and Infectious 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