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Low concentrations of intracellular K+are associated with the\n specific oligomerization and activation of the NLRP3 inflammasome, a type\n of inflammasome involved in sterile inflammation. After NLRP3\n oligomerization, ASC protein binds and forms oligomeric filaments that\n culminate in large protein complexes named ASC specks. ASC specks are also\n initiated from different inflammasome scaffolds, such as AIM2, NLRC4 or\n Pyrin. ASC oligomers recruit caspase-1 and then induce its activation\n through interactions between their respective caspase activation and\n recruitment domains (CARD). So far ASC oligomerization and caspase-1\n activation are K+-independent processes. Here we found that, when there is\n low intracellular K+, ASC oligomers change their structure independently\n of NLRP3 and make the ASCCARD domain more accessible for the recruitment\n of the pro-caspase-1CARD domain. Therefore, conditions that decrease\n intracellular K+ not only drive NLRP3 responses but also enhance the\n recruitment of pro-caspase-1 CARD domain into the ASC specks.","descriptionType":"Abstract"},{"description":"Please see the README document and the accompanying published\n article: Fátima Martín-Sánchez, Vincent Compan, Alejandro Peñín-Franch,\n Ana Tapia-Abellán, Ana I. Gómez, María C. Baños-Gregori, Florian I.\n Schmidt, Pablo Pelegrín. ASC oligomer favors caspase-1CARD domain\n recruitment after intracellular potassium efflux. 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    <title>
      Data for: ASC oligomer favors caspase-1 CARD domain recruitment after
      intracellular potassium efflux
    </title>
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    <subject>Inflammasome</subject>
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    <subject>macrophage</subject>
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  <descriptions>
    <description descriptionType="Abstract">
      Signaling through the inflammasome is important for the inflammatory
      response. Low concentrations of intracellular K+are associated with the
      specific oligomerization and activation of the NLRP3 inflammasome, a type
      of inflammasome involved in sterile inflammation. After NLRP3
      oligomerization, ASC protein binds and forms oligomeric filaments that
      culminate in large protein complexes named ASC specks. ASC specks are also
      initiated from different inflammasome scaffolds, such as AIM2, NLRC4 or
      Pyrin. ASC oligomers recruit caspase-1 and then induce its activation
      through interactions between their respective caspase activation and
      recruitment domains (CARD). So far ASC oligomerization and caspase-1
      activation are K+-independent processes. Here we found that, when there is
      low intracellular K+, ASC oligomers change their structure independently
      of NLRP3 and make the ASCCARD domain more accessible for the recruitment
      of the pro-caspase-1CARD domain. Therefore, conditions that decrease
      intracellular K+ not only drive NLRP3 responses but also enhance the
      recruitment of pro-caspase-1 CARD domain into the ASC specks.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;Please see the README document and the accompanying published
      article: Fátima Martín-Sánchez, Vincent Compan, Alejandro Peñín-Franch,
      Ana Tapia-Abellán, Ana I. Gómez, María C. Baños-Gregori, Florian I.
      Schmidt, Pablo Pelegrín. ASC oligomer favors caspase-1CARD domain
      recruitment after intracellular potassium efflux. Journal of Cell Biology.
      2023. https://doi.org/10.1083/jcb.202003053&lt;/p&gt;
    </description>
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