{"data":{"id":"10.5061/dryad.k6djh9wks","type":"dois","attributes":{"doi":"10.5061/dryad.k6djh9wks","prefix":"10.5061","suffix":"dryad.k6djh9wks","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Prakash, Arun","nameType":"Personal","givenName":"Arun","familyName":"Prakash","affiliation":["University of California, San Francisco"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-1424-0932","nameIdentifierScheme":"ORCID"}]},{"name":"Maruyama, Daisuke","nameType":"Personal","givenName":"Daisuke","familyName":"Maruyama","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Tian, Xiaoli","nameType":"Personal","givenName":"Xiaoli","familyName":"Tian","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Doan, Thien N. M.","nameType":"Personal","givenName":"Thien N. M.","familyName":"Doan","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Liao, Wen-I","nameType":"Personal","givenName":"Wen-I","familyName":"Liao","affiliation":["National Defense University"],"nameIdentifiers":[]},{"name":"Chaki, Tomohiro","nameType":"Personal","givenName":"Tomohiro","familyName":"Chaki","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Taenaka, Hiroki","nameType":"Personal","givenName":"Hiroki","familyName":"Taenaka","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Maishan, Mazharul","nameType":"Personal","givenName":"Mazharul","familyName":"Maishan","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Matthay, Michael A.","nameType":"Personal","givenName":"Michael A.","familyName":"Matthay","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]}],"titles":[{"title":"Data from: Gut microbiome-derived propionate reprograms alveolar macrophages metabolically and regulates lung injury responses in mice"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Microbiome","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Metabolites","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Lungs","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[{"name":"University of California, San Francisco","nameType":"Personal","givenName":"San Francisco","familyName":"University of California","affiliation":[],"contributorType":"Sponsor","nameIdentifiers":[]}],"dates":[{"date":"2025-07-22T20:52:25Z","dateType":"Created"},{"date":"2026-01-22T18:53:42Z","dateType":"Submitted"},{"date":"2026-06-24T00:00:00Z","dateType":"Issued"},{"date":"2026-06-24T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1101/2025.04.14.648797","relatedIdentifierType":"DOI"},{"relationType":"IsCitedBy","relatedIdentifier":"10.1080/19490976.2025.2606486","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["97494866943 bytes"],"formats":[],"version":"5","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Responses to lung injury can vary between individuals with the diet and\n gut microbiome representing two underappreciated sources for this\n variability. The gut microbiome can influence lung injury outcomes through\n the gut‒lung axis, but exactly how diet and its effects on the microbiota\n are involved remains unclear. We hypothesized that dietary fiber\n interventions would favor the presence of short-chain fatty acid\n (SCFA)-producing fermentative bacteria presence in the gut microbiome,\n thereby influencing the resting lung immunometabolic tone as well as\n influencing downstream responses to lung injury and infection. To test\n this hypothesis, we fed mice fiber-rich (FR) and fiber-free (FF) diets,\n and observed changes in the steady-state transcriptional programming of\n alveolar macrophages (AM). Next, we examined the effects of the FR and FF\n diets on murine responses to sterile and infectious lung injury in vivo\n while simultaneously profiling the gut microbiota and SCFA levels\n transmitted along the gut‒lung axis. Finally, we validated our in vivo\n observations with mechanistic studies of the metabolic, signaling, and\n chromatin-modifying effects of specific SCFAs on lung AM ex vivo and in\n vitro. Overall, our fiber-rich diet reprogrammed AMs and attenuated lung\n inflammation after sterile injury while exacerbating lung infection. This\n effect of FR diets could be transferred to germ-free (GF) mice by fecal\n microbiome transplantation (FMT) and depended on the ability of the\n microbiota to produce propionate. Mechanistically, SCFAs altered the\n metabolic programming of AMs and lung tissue ex vivo without a clear role\n for free fatty acid receptors (FFAR) or chromatin remodeling. These\n findings demonstrate that the gut‒lung axis can regulate resting lung\n metabolic tone through dietary fiber intake and the enrichment of\n SCFA-producing gut bacteria, as well as influence sterile and non-sterile\n lung injury responses. These results provide evidence to support the\n development of therapeutic dietary interventions to preserve or enhance\n specific aspects of host pulmonary immunity.","descriptionType":"Abstract"},{"description":"# Data from: Gut microbiome-derived propionate reprograms alveolar\n macrophages metabolically and regulates lung injury responses in mice\n Dataset DOI: 10.5061/dryad.k6djh9wks ## Associated Publication Maruyama,\n D., Tian, X., Doan, T. N. M., Liao, W. I., Chaki, T., Taenaka, H., …\n Prakash, A. (2026). Gut microbiome-derived propionate reprograms alveolar\n macrophages metabolically and regulates lung injury responses in mice.\n *Gut Microbes*, *18*(1).\n [https://doi.org/10.1080/19490976.2025.2606486](https://doi.org/10.1080/19490976.2025.2606486) --- # Study Overview This repository contains the primary sequencing data and processed datasets supporting the manuscript investigating how dietary fiber alters the gut microbiome, short-chain fatty acid (SCFA) production, alveolar macrophage immunometabolic programming, and pulmonary injury responses. The study includes four related experimental cohorts: | Dataset | Experimental Cohort | Primary Data Type | Manuscript Figures | | :------ | :------------------------------------------------------------ | :----------------------------------------------------------------------------------- | :----------------- | | AP210 | Dietary fiber intervention + lung ischemia-reperfusion injury | 16S microbiome sequencing, metabolomics, cytokines, qPCR, integrated multi-omic data | Figures 2–3 | | AP240 | Dietary fiber intervention (no lung injury) | Bulk RNA sequencing of BAL cells + microbiome sequencing | Figure 1 | | AP276 | Dietary fiber intervention (no lung injury) | Single-nucleus ATAC sequencing + microbiome sequencing | Figure 6C–D | | AP282 | Germ-free fecal microbiota transplantation (FMT) | 16S microbiome sequencing and FMT validation | Figure 4 | --- # Deposited Files ## 1. AP210_16S_Fastq_files.zip Raw paired-end 16S rRNA sequencing FASTQ files from the dietary fiber intervention and lung ischemia-reperfusion injury experiments. Associated manuscript figures: * Figure 2B–D * Figure 2E * Figure 3A–D * Supplementary Figures S3–S4 ### Experimental Groups | Biological Sample Numbers | Group | | :------------------------ | :-------------------------- | | 1–5, 16–20 | Fiber-Free (FF) | | 6–15, 21–30 | Fiber-Rich 1 Week (FR 1wk) | | 31–40 | Fiber-Rich 2 Weeks (FR 2wk) | Samples 12–14 were excluded from downstream analyses due to evidence of gastrointestinal infection (Escherichia coli/Shigella contamination). ### FASTQ Naming Convention Examples: HFD_31_S70_R1_001.fastq.gz HFD_31_S70_R2_001.fastq.gz LD_1_S1_R1_001.fastq.gz LFD_6_S27_R1_001.fastq.gz | Prefix | Meaning | | :----- | :------------------------- | | HFD | Fiber-Rich Diet (FR 2wk) | | LFD | Fiber-Rich Diet (FR 1wk) | | LD | Fiber-Free Diet (FF) | | S## | Illumina sample identifier | | R1 | Forward read | | R2 | Reverse read | ### Sequencing Controls Included control samples: * MC_HFD = Mock microbial community controls * NEC_HFD = Negative extraction controls * PCR_HFD_NTC = PCR no-template controls These controls were used for sequencing quality control and contamination monitoring and were excluded from biological analyses. --- ## 2. AP277_16S_AP_Fastq_raw_includes_AP240_and_AP276.zip Raw paired-end 16S rRNA sequencing FASTQ files from microbiome sequencing performed on samples originating from the AP240 and AP276 experimental cohorts. The AP277 designation refers to the sequencing experiment itself. ### AP240 Microbiome Samples Associated manuscript figure: * Figure 1B | Sample Numbers | Group | | :------------- | :-------------- | | AP277\\_1–10 | Fiber-Rich (FR) | | AP277\\_11–20 | Fiber-Free (FF) | These microbiome samples correspond to the mice used for bulk RNA sequencing of bronchoalveolar lavage (BAL) cells. ### AP276 Microbiome Samples Associated manuscript figure: * Supplementary Figure S5 | Sample Numbers | Group | | :------------- | :-------------- | | AP277\\_21–24 | Fiber-Rich (FR) | | AP277\\_25–28 | Fiber-Free (FF) | These microbiome samples correspond to the mice used for single-nucleus ATAC sequencing. ### FASTQ Naming Convention Example: AP277_21_S280_R1_001.fastq.gz AP277_21_S280_R2_001.fastq.gz where: * AP277_21 = biological sample 21 * S280 = Illumina sample identifier * R1 = forward read * R2 = reverse read ### Sequencing Controls Included controls: * Mock_P5 * NEC_stool * PCR_P5 These samples were used for contamination monitoring and sequencing quality control. --- ## 3. AP282_GF_FMT_Hi_vs_LoFib_diet.zip Raw paired-end 16S rRNA sequencing FASTQ files from the germ-free fecal microbiota transplantation (FMT) experiments. Associated manuscript figures: * Figure 4A–D ### Recipient Mice #### FR FMT Recipients Samples: 1–5, 11–15 #### FF FMT Recipients Samples: 6–10, 16–20 ### FMT Donor Inoculum Samples | Sample Number | Description | | :------------ | :------------------------ | | 21 | Fiber-Rich donor inoculum | | 22 | Fiber-Free donor inoculum | ### Germ-Free Controls | Sample Number | Description | | :------------ | :---------------- | | 23 | Germ-free control | | 24 | Germ-free control | ### FASTQ Naming Convention Example: AP282-12_S36_R1_001.fastq.gz AP282-12_S36_R2_001.fastq.gz where: * AP282-12 = biological sample number * S36 = Illumina sample identifier * R1 = forward read * R2 = reverse read ### Sequencing Controls Included controls: * Mock_X01 * NEC_X01 * PCR_X01 * PCR_X02 * PCR_X03 These samples were used for sequencing quality control and contamination monitoring. --- ## 4. Data_used_for_bioinformatics_analyses.zip This archive contains processed datasets used for downstream statistical and bioinformatic analyses. ### AP210 Compiled data in csv format 7 corrected.csv This file contains the integrated multi-omic dataset used to generate: * Figure 3A * Figure 3B * Figure 3C * Figure 3D * Supplementary Figure S4 The file combines measurements from the AP210 cohort including: * Cytokine ELISA measurements * qPCR measurements * Stool SCFA measurements * Portal blood SCFA measurements * Plasma SCFA measurements * Lung tissue SCFA measurements These data were used for: * Correlation analyses * Principal component analysis (PCA) * Procrustes analyses * Multi-omic integration analyses --- ## 5. RNAseq_bulk_dataset.zip Bulk RNA sequencing data generated from bronchoalveolar lavage (BAL) cells. Associated manuscript figures: * Figure 1C * Figure 1D * Figure 1E * Table S1 ### Experimental Groups #### Fiber-Rich Group Files beginning with: 1117-Hi-JAX Correspond to: Hi 1–10 (Manuscript mice 1–10) #### Fiber-Free Group Files beginning with: 1117-Lo-JAX Correspond to: Lo 1–10 (Manuscript mice 11–20) ### FASTQ Naming Convention Example: 1117-Hi-JAX-1_S47_L008_R1_001.fastq.gz 1117-Hi-JAX-1_S47_L008_R2_001.fastq.gz Additional files: 1117-Hi-JAX-1_S47_L008_I1_001.fastq.gz 1117-Hi-JAX-1_S47_L008_I2_001.fastq.gz where: | Component | Meaning | | :-------- | :------------------------- | | Hi | Fiber-Rich diet | | Lo | Fiber-Free diet | | JAX | Mouse cohort identifier | | 1–10 | Mouse number within group | | S## | Illumina sample identifier | | L008 | Sequencing lane | | I1/I2 | Index reads | | R1/R2 | Sequencing reads | The BAL populations consisted predominantly of alveolar macrophages. --- ## 6. snATACseq_dataset.zip Single-nucleus ATAC sequencing data generated from whole lung tissue. Associated manuscript figures: * Figure 6C * Figure 6D * Supplementary Figure S6 * Table S4 ### Experimental Groups #### Fiber-Rich Group | Mouse Number | | :----------- | | 21 | | 22 | | 23 | | 24 | #### Fiber-Free Group | Mouse Number | | :----------- | | 25 | | 26 | | 27 | | 28 | ### File Naming Convention Example: AP276 Mouse 21 (HiFib) filtered_peak_bc_matrix.h5 where: | Component | Meaning | | :---------------------------- | :------------------------------------ | | AP276 | Experimental cohort | | Mouse 21 | Biological mouse number | | HiFib | Fiber-Rich diet | | LoFib | Fiber-Free diet | | filtered\\_peak\\_bc\\_matrix.h5 | Cell Ranger ATAC filtered peak matrix | These files contain filtered peak-by-cell barcode matrices generated by the 10x Genomics Cell Ranger ATAC pipeline and can be analyzed using Signac, Seurat, ArchR, or Cell Ranger ATAC-compatible workflows. --- # Abbreviations | Abbreviation | Meaning | | :----------- | :------------------------------------------------ | | FF | Fiber-Free Diet | | FR | Fiber-Rich Diet | | FR 1wk | Fiber-Rich Diet for 1 Week | | FR 2wk | Fiber-Rich Diet for 2 Weeks | | GF | Germ-Free | | FMT | Fecal Microbiota Transplant | | BAL | Bronchoalveolar Lavage | | SCFA | Short-Chain Fatty Acid | | HiFib | High Fiber | | LoFib | Low Fiber | | HFD | High Fiber Diet | | LFD | Low Fiber Diet (Fiber-Rich 1wk cohort identifier) | | LD | Low Diet/Fiber-Free cohort identifier | --- # Contact For questions regarding the datasets, analyses, or sample assignments, please contact: **Arun Prakash, MD, PhD**\\ Department of Anesthesia and Perioperative Care\\ University of California San Francisco\\ [arun.prakash@ucsf.edu](mailto:arun.prakash@ucsf.edu)","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"awardUri":"https://reporter.nih.gov/project-details/9886123","schemeUri":"https://ror.org","funderName":"National Heart Lung and Blood Institute","awardNumber":"1R01HL146753-01A1","funderIdentifier":"https://ror.org/012pb6c26","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4/metadata.xsd">
  <identifier identifierType="DOI">10.5061/DRYAD.K6DJH9WKS</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Prakash, Arun</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-1424-0932</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/043mz5j54" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, San Francisco</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Maruyama, Daisuke</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/043mz5j54" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, San Francisco</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Tian, Xiaoli</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/043mz5j54" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, San Francisco</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Doan, Thien N. M.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/043mz5j54" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, San Francisco</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Liao, Wen-I</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/00hkj1v53" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">National Defense University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Chaki, Tomohiro</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/043mz5j54" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, San Francisco</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Taenaka, Hiroki</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/043mz5j54" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, San Francisco</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Maishan, Mazharul</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/043mz5j54" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, San Francisco</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Matthay, Michael A.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/043mz5j54" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, San Francisco</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Data from: Gut microbiome-derived propionate reprograms alveolar
      macrophages metabolically and regulates lung injury responses in mice
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2026</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Microbiome</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Metabolites</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Lungs</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>National Heart Lung and Blood Institute</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/012pb6c26</funderIdentifier>
      <awardNumber awardURI="https://reporter.nih.gov/project-details/9886123">1R01HL146753-01A1</awardNumber>
      <awardTitle/>
    </fundingReference>
  </fundingReferences>
  <contributors>
    <contributor contributorType="Sponsor">
      <contributorName>University of California, San Francisco</contributorName>
    </contributor>
  </contributors>
  <dates>
    <date dateType="Created">2025-07-22T20:52:25Z</date>
    <date dateType="Submitted">2026-01-22T18:53:42Z</date>
    <date dateType="Issued">2026-06-24T00:00:00Z</date>
    <date dateType="Available">2026-06-24T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1101/2025.04.14.648797</relatedIdentifier>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1080/19490976.2025.2606486</relatedIdentifier>
  </relatedIdentifiers>
  <sizes>
    <size>97494866943 bytes</size>
  </sizes>
  <version>5</version>
  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      Responses to lung injury can vary between individuals with the diet and
      gut microbiome representing two underappreciated sources for this
      variability. The gut microbiome can influence lung injury outcomes through
      the gut‒lung axis, but exactly how diet and its effects on the microbiota
      are involved remains unclear. We hypothesized that dietary fiber
      interventions would favor the presence of short-chain fatty acid
      (SCFA)-producing fermentative bacteria presence in the gut microbiome,
      thereby influencing the resting lung immunometabolic tone as well as
      influencing downstream responses to lung injury and infection. To test
      this hypothesis, we fed mice fiber-rich (FR) and fiber-free (FF) diets,
      and observed changes in the steady-state transcriptional programming of
      alveolar macrophages (AM). Next, we examined the effects of the FR and FF
      diets on murine responses to sterile and infectious lung injury in vivo
      while simultaneously profiling the gut microbiota and SCFA levels
      transmitted along the gut‒lung axis. Finally, we validated our in vivo
      observations with mechanistic studies of the metabolic, signaling, and
      chromatin-modifying effects of specific SCFAs on lung AM ex vivo and in
      vitro. Overall, our fiber-rich diet reprogrammed AMs and attenuated lung
      inflammation after sterile injury while exacerbating lung infection. This
      effect of FR diets could be transferred to germ-free (GF) mice by fecal
      microbiome transplantation (FMT) and depended on the ability of the
      microbiota to produce propionate. Mechanistically, SCFAs altered the
      metabolic programming of AMs and lung tissue ex vivo without a clear role
      for free fatty acid receptors (FFAR) or chromatin remodeling. These
      findings demonstrate that the gut‒lung axis can regulate resting lung
      metabolic tone through dietary fiber intake and the enrichment of
      SCFA-producing gut bacteria, as well as influence sterile and non-sterile
      lung injury responses. These results provide evidence to support the
      development of therapeutic dietary interventions to preserve or enhance
      specific aspects of host pulmonary immunity.
    </description>
    <description descriptionType="TechnicalInfo">
      # Data from: Gut microbiome-derived propionate reprograms alveolar
      macrophages metabolically and regulates lung injury responses in mice
      Dataset DOI: 10.5061/dryad.k6djh9wks ## Associated Publication Maruyama,
      D., Tian, X., Doan, T. N. M., Liao, W. I., Chaki, T., Taenaka, H., …
      Prakash, A. (2026). Gut microbiome-derived propionate reprograms alveolar
      macrophages metabolically and regulates lung injury responses in mice.
      *Gut Microbes*, *18*(1).
      [https://doi.org/10.1080/19490976.2025.2606486](https://doi.org/10.1080/19490976.2025.2606486) --- # Study Overview This repository contains the primary sequencing data and processed datasets supporting the manuscript investigating how dietary fiber alters the gut microbiome, short-chain fatty acid (SCFA) production, alveolar macrophage immunometabolic programming, and pulmonary injury responses. The study includes four related experimental cohorts: | Dataset | Experimental Cohort | Primary Data Type | Manuscript Figures | | :------ | :------------------------------------------------------------ | :----------------------------------------------------------------------------------- | :----------------- | | AP210 | Dietary fiber intervention + lung ischemia-reperfusion injury | 16S microbiome sequencing, metabolomics, cytokines, qPCR, integrated multi-omic data | Figures 2–3 | | AP240 | Dietary fiber intervention (no lung injury) | Bulk RNA sequencing of BAL cells + microbiome sequencing | Figure 1 | | AP276 | Dietary fiber intervention (no lung injury) | Single-nucleus ATAC sequencing + microbiome sequencing | Figure 6C–D | | AP282 | Germ-free fecal microbiota transplantation (FMT) | 16S microbiome sequencing and FMT validation | Figure 4 | --- # Deposited Files ## 1. AP210_16S_Fastq_files.zip Raw paired-end 16S rRNA sequencing FASTQ files from the dietary fiber intervention and lung ischemia-reperfusion injury experiments. Associated manuscript figures: * Figure 2B–D * Figure 2E * Figure 3A–D * Supplementary Figures S3–S4 ### Experimental Groups | Biological Sample Numbers | Group | | :------------------------ | :-------------------------- | | 1–5, 16–20 | Fiber-Free (FF) | | 6–15, 21–30 | Fiber-Rich 1 Week (FR 1wk) | | 31–40 | Fiber-Rich 2 Weeks (FR 2wk) | Samples 12–14 were excluded from downstream analyses due to evidence of gastrointestinal infection (Escherichia coli/Shigella contamination). ### FASTQ Naming Convention Examples: HFD_31_S70_R1_001.fastq.gz HFD_31_S70_R2_001.fastq.gz LD_1_S1_R1_001.fastq.gz LFD_6_S27_R1_001.fastq.gz | Prefix | Meaning | | :----- | :------------------------- | | HFD | Fiber-Rich Diet (FR 2wk) | | LFD | Fiber-Rich Diet (FR 1wk) | | LD | Fiber-Free Diet (FF) | | S## | Illumina sample identifier | | R1 | Forward read | | R2 | Reverse read | ### Sequencing Controls Included control samples: * MC_HFD = Mock microbial community controls * NEC_HFD = Negative extraction controls * PCR_HFD_NTC = PCR no-template controls These controls were used for sequencing quality control and contamination monitoring and were excluded from biological analyses. --- ## 2. AP277_16S_AP_Fastq_raw_includes_AP240_and_AP276.zip Raw paired-end 16S rRNA sequencing FASTQ files from microbiome sequencing performed on samples originating from the AP240 and AP276 experimental cohorts. The AP277 designation refers to the sequencing experiment itself. ### AP240 Microbiome Samples Associated manuscript figure: * Figure 1B | Sample Numbers | Group | | :------------- | :-------------- | | AP277\_1–10 | Fiber-Rich (FR) | | AP277\_11–20 | Fiber-Free (FF) | These microbiome samples correspond to the mice used for bulk RNA sequencing of bronchoalveolar lavage (BAL) cells. ### AP276 Microbiome Samples Associated manuscript figure: * Supplementary Figure S5 | Sample Numbers | Group | | :------------- | :-------------- | | AP277\_21–24 | Fiber-Rich (FR) | | AP277\_25–28 | Fiber-Free (FF) | These microbiome samples correspond to the mice used for single-nucleus ATAC sequencing. ### FASTQ Naming Convention Example: AP277_21_S280_R1_001.fastq.gz AP277_21_S280_R2_001.fastq.gz where: * AP277_21 = biological sample 21 * S280 = Illumina sample identifier * R1 = forward read * R2 = reverse read ### Sequencing Controls Included controls: * Mock_P5 * NEC_stool * PCR_P5 These samples were used for contamination monitoring and sequencing quality control. --- ## 3. AP282_GF_FMT_Hi_vs_LoFib_diet.zip Raw paired-end 16S rRNA sequencing FASTQ files from the germ-free fecal microbiota transplantation (FMT) experiments. Associated manuscript figures: * Figure 4A–D ### Recipient Mice #### FR FMT Recipients Samples: 1–5, 11–15 #### FF FMT Recipients Samples: 6–10, 16–20 ### FMT Donor Inoculum Samples | Sample Number | Description | | :------------ | :------------------------ | | 21 | Fiber-Rich donor inoculum | | 22 | Fiber-Free donor inoculum | ### Germ-Free Controls | Sample Number | Description | | :------------ | :---------------- | | 23 | Germ-free control | | 24 | Germ-free control | ### FASTQ Naming Convention Example: AP282-12_S36_R1_001.fastq.gz AP282-12_S36_R2_001.fastq.gz where: * AP282-12 = biological sample number * S36 = Illumina sample identifier * R1 = forward read * R2 = reverse read ### Sequencing Controls Included controls: * Mock_X01 * NEC_X01 * PCR_X01 * PCR_X02 * PCR_X03 These samples were used for sequencing quality control and contamination monitoring. --- ## 4. Data_used_for_bioinformatics_analyses.zip This archive contains processed datasets used for downstream statistical and bioinformatic analyses. ### AP210 Compiled data in csv format 7 corrected.csv This file contains the integrated multi-omic dataset used to generate: * Figure 3A * Figure 3B * Figure 3C * Figure 3D * Supplementary Figure S4 The file combines measurements from the AP210 cohort including: * Cytokine ELISA measurements * qPCR measurements * Stool SCFA measurements * Portal blood SCFA measurements * Plasma SCFA measurements * Lung tissue SCFA measurements These data were used for: * Correlation analyses * Principal component analysis (PCA) * Procrustes analyses * Multi-omic integration analyses --- ## 5. RNAseq_bulk_dataset.zip Bulk RNA sequencing data generated from bronchoalveolar lavage (BAL) cells. Associated manuscript figures: * Figure 1C * Figure 1D * Figure 1E * Table S1 ### Experimental Groups #### Fiber-Rich Group Files beginning with: 1117-Hi-JAX Correspond to: Hi 1–10 (Manuscript mice 1–10) #### Fiber-Free Group Files beginning with: 1117-Lo-JAX Correspond to: Lo 1–10 (Manuscript mice 11–20) ### FASTQ Naming Convention Example: 1117-Hi-JAX-1_S47_L008_R1_001.fastq.gz 1117-Hi-JAX-1_S47_L008_R2_001.fastq.gz Additional files: 1117-Hi-JAX-1_S47_L008_I1_001.fastq.gz 1117-Hi-JAX-1_S47_L008_I2_001.fastq.gz where: | Component | Meaning | | :-------- | :------------------------- | | Hi | Fiber-Rich diet | | Lo | Fiber-Free diet | | JAX | Mouse cohort identifier | | 1–10 | Mouse number within group | | S## | Illumina sample identifier | | L008 | Sequencing lane | | I1/I2 | Index reads | | R1/R2 | Sequencing reads | The BAL populations consisted predominantly of alveolar macrophages. --- ## 6. snATACseq_dataset.zip Single-nucleus ATAC sequencing data generated from whole lung tissue. Associated manuscript figures: * Figure 6C * Figure 6D * Supplementary Figure S6 * Table S4 ### Experimental Groups #### Fiber-Rich Group | Mouse Number | | :----------- | | 21 | | 22 | | 23 | | 24 | #### Fiber-Free Group | Mouse Number | | :----------- | | 25 | | 26 | | 27 | | 28 | ### File Naming Convention Example: AP276 Mouse 21 (HiFib) filtered_peak_bc_matrix.h5 where: | Component | Meaning | | :---------------------------- | :------------------------------------ | | AP276 | Experimental cohort | | Mouse 21 | Biological mouse number | | HiFib | Fiber-Rich diet | | LoFib | Fiber-Free diet | | filtered\_peak\_bc\_matrix.h5 | Cell Ranger ATAC filtered peak matrix | These files contain filtered peak-by-cell barcode matrices generated by the 10x Genomics Cell Ranger ATAC pipeline and can be analyzed using Signac, Seurat, ArchR, or Cell Ranger ATAC-compatible workflows. --- # Abbreviations | Abbreviation | Meaning | | :----------- | :------------------------------------------------ | | FF | Fiber-Free Diet | | FR | Fiber-Rich Diet | | FR 1wk | Fiber-Rich Diet for 1 Week | | FR 2wk | Fiber-Rich Diet for 2 Weeks | | GF | Germ-Free | | FMT | Fecal Microbiota Transplant | | BAL | Bronchoalveolar Lavage | | SCFA | Short-Chain Fatty Acid | | HiFib | High Fiber | | LoFib | Low Fiber | | HFD | High Fiber Diet | | LFD | Low Fiber Diet (Fiber-Rich 1wk cohort identifier) | | LD | Low Diet/Fiber-Free cohort identifier | --- # Contact For questions regarding the datasets, analyses, or sample assignments, please contact: **Arun Prakash, MD, PhD**\ Department of Anesthesia and Perioperative Care\ University of California San Francisco\ [arun.prakash@ucsf.edu](mailto:arun.prakash@ucsf.edu)
    </description>
  </descriptions>
</resource>","url":"https://datadryad.org/dataset/doi:10.5061/dryad.k6djh9wks","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":4,"viewsOverTime":[{"yearMonth":"2026-03","total":0},{"yearMonth":"2026-05","total":0},{"yearMonth":"2026-09","total":4}],"downloadCount":5,"downloadsOverTime":[{"yearMonth":"2026-03","total":4},{"yearMonth":"2026-05","total":1},{"yearMonth":"2026-09","total":0}],"referenceCount":0,"citationCount":2,"citationsOverTime":[{"year":"2026","total":2}],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2026-06-24T15:22:26.000Z","registered":"2026-06-24T15:22:27.000Z","published":"2026","updated":"2026-06-24T15:22:27.000Z"},"relationships":{"client":{"data":{"id":"dryad.dryad","type":"clients"}},"provider":{"data":{"id":"dryad","type":"providers"}},"media":{"data":{"id":"10.5061/dryad.k6djh9wks","type":"media"}},"references":{"data":[]},"citations":{"data":[{"id":"10.1101/2025.04.14.648797","type":"dois"},{"id":"10.1080/19490976.2025.2606486","type":"dois"}]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}