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Health problems significantly impacted\n his career as a composer and pianist, including progressive hearing loss,\n recurring gastrointestinal complaints and liver disease. In 1802,\n Beethoven requested that following his death, his disease be described and\n made public. Medical biographers have since proposed numerous hypotheses,\n including many substantially heritable conditions. Here we attempt a\n genomic analysis of Beethoven in order to elucidate potential underlying\n genetic and infectious causes of his illnesses. We incorporated\n improvements in ancient DNA methods into existing protocols for ancient\n hair samples, enabling the sequencing of high-coverage genomes from small\n quantities of historical hair. We analyzed eight independently sourced\n locks of hair attributed to Beethoven, five of which originated from a\n single European male. We deemed these matching samples to be almost\n certainly authentic and sequenced Beethoven’s genome to 24-fold genomic\n coverage. 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    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Hepatitis B virus</subject>
    <subject>medical genetics</subject>
    <subject>genetic genealogy</subject>
    <subject>extra-pair paternity</subject>
    <subject>genobiography</subject>
    <subject>The Beethoven Genome Project</subject>
    <subject>geo-genetic triangulation</subject>
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      Ludwig van Beethoven (1770–1827) remains among the most influential and
      popular classical music composers. Health problems significantly impacted
      his career as a composer and pianist, including progressive hearing loss,
      recurring gastrointestinal complaints and liver disease. In 1802,
      Beethoven requested that following his death, his disease be described and
      made public. Medical biographers have since proposed numerous hypotheses,
      including many substantially heritable conditions. Here we attempt a
      genomic analysis of Beethoven in order to elucidate potential underlying
      genetic and infectious causes of his illnesses. We incorporated
      improvements in ancient DNA methods into existing protocols for ancient
      hair samples, enabling the sequencing of high-coverage genomes from small
      quantities of historical hair. We analyzed eight independently sourced
      locks of hair attributed to Beethoven, five of which originated from a
      single European male. We deemed these matching samples to be almost
      certainly authentic and sequenced Beethoven’s genome to 24-fold genomic
      coverage. Although we could not identify a genetic explanation for
      Beethoven's hearing disorder or gastrointestinal problems, we found
      that Beethoven had a genetic predisposition for liver disease. Metagenomic
      analyses revealed furthermore that Beethoven had a hepatitis B infection
      during at least the months prior to his death. Together with the genetic
      predisposition and his broadly accepted alcohol consumption, these present
      plausible explanations for Beethoven’s severe liver disease, which
      culminated in his death. Unexpectedly, an analysis of Y-chromosomes
      sequenced from five living members of the Van Beethoven patrilineage
      revealed the occurrence of an extra-pair paternity event in Ludwig van
      Beethoven’s patrilineal ancestry.
    </description>
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      &lt;p&gt;For all methodology, see the article, Supplementary Information,
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    </description>
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