{"data":{"id":"10.5061/dryad.jdfn2z3pr","type":"dois","attributes":{"doi":"10.5061/dryad.jdfn2z3pr","prefix":"10.5061","suffix":"dryad.jdfn2z3pr","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Martin, Richard John","nameType":"Personal","givenName":"Richard John","familyName":"Martin","affiliation":["Iowa State University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2422-1847","nameIdentifierScheme":"ORCID"}]},{"name":"Njeshi, Charity","nameType":"Personal","givenName":"Charity","familyName":"Njeshi","affiliation":["Iowa State University"],"nameIdentifiers":[]}],"titles":[{"title":"Data from: Effects of emodepside on single-channel properties of \u003cem\u003eOnchocerca volvulus\u003c/em\u003e SLO-1A (BK) potassium channels"}],"publisher":"Dryad","container":{},"publicationYear":2025,"subjects":[{"subject":"Onchocerciasis","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"SLO-1"},{"subject":"Electrophysiology","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Single-channel currents"},{"subject":"Patch clamp techniques","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Emodepside"},{"subject":"Verruculogen"},{"subject":"FOS: Medical and health sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Medical and health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[{"name":"Iowa State University","affiliation":[],"contributorType":"Sponsor","nameIdentifiers":[]}],"dates":[{"date":"2025-07-23T21:45:28Z","dateType":"Created"},{"date":"2025-08-26T15:03:12Z","dateType":"Submitted"},{"date":"2025-09-20T00:00:00Z","dateType":"Issued"},{"date":"2025-09-20T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.21203/rs.3.rs-7206784","relatedIdentifierType":"DOI"},{"relationType":"IsCitedBy","relatedIdentifier":"10.1186/s13071-025-07171-6","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["57823 bytes"],"formats":[],"version":"5","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Control of onchocerciasis (river blindness of humans due to infection with\n the filarial nematode, Onchocerca volvulus) remains a challenge because of\n the lack of effective adulticides and vaccines. Emodepside is a\n broad-spectrum veterinary anthelmintic that has been found to inhibit\n nematode muscle activity by activating their tetrameric SLO-1K\n channels. Emodepside has adulticidal activity and is being\n trialed for onchocerciasis treatment, but the molecular mode of action of\n emodepside is still being elucidated. Here we examine the single-channel\n currents of Ovo-SLO-1A, a SLO-1K splice variant from O. volvulus, and\n explore how emodepside modulates the dynamics of the opening of the\n channel. Ovo-SLO-1A was expressed in HEK 293 cells, and patch clamp\n electrophysiology techniques were used to record currents. Single-channel\n currents were recorded in a symmetrical 132 mM K⁺ solution to determine\n the main open-state channel conductance. Emodepside’s effects were tested\n at 0.3 µM and 1.0 µM. Ovo-SLO-1A had a main open-state conductance of 110\n ± 3 pS and frequent flickering sub-conductance states. The presence of the\n flickering sub-conductance states suggests that there is limited\n cooperativity between the tetrameric channel subunits required for opening\n to the main open-state. Emodepside increased mean current amplitudes.\n Emodepside also increased open-burst times, and open probability.\n Verruculogen (1 µM) inhibited channel opening in the presence or absence\n of emodepside. This study successfully expressed Ovo-SLO-1A in HEK 293\n cells, measured the conductance of the main open-state and detected the\n presence of sub-conductance states, and flickering openings. The increased\n amplitudes of the single-channel currents, open-burst times and open\n probabilities provide insights into how emodepside increases Slo-1K\n currents and illustrate dynamic actions of emodepside on Ovo-SLO-1A.","descriptionType":"Abstract"},{"description":"\u003cstrong\u003eMethods\u003c/strong\u003e\n \u003cstrong\u003eCloning\u003c/strong\u003e\n \u003cem\u003eO. volvulus\u003c/em\u003e \u003cem\u003eslo-1a\u003c/em\u003e was\n synthesized by Life Technologies GeneArt (BioPark Regensburg, Germany).\n Primers for the gene were designed with sequences flanking the pcDNA\n 3.1-T2A-GFP expression vector that included the restriction site (Nhe1).\n PCR was conducted on the \u003cem\u003eO. volvulus slo-1a\u003c/em\u003e.\n Subsequently, the amplicon was separated on a 1% Agarose SYBR Safe gel,\n purified using NucleoSpin Gel and PCR Clean-up Kit (Macherey-Nagel,\n Allentown, PA, USA), and then cloned into the pcDNA 3.1-T2A-GFP vector by\n using the Infusion HD Cloning Kit (Takara Bio USA, Inc, San Jose, CA, USA)\n according to the manufacturer’s protocols. Once cloned, the plasmids were\n verified by sequencing. \u003cstrong\u003eHEK 293 Cell\n culture and transfection\u003c/strong\u003e HEK 293 cells\n were maintained in DMEM (GIBCO, ThermoFisher Scientific Waltham MA, USA)\n with 10% FBS (GIBCO ThermoFisher Scientific Waltham MA, USA) and 1%\n penicillin/streptomycin antibiotics in a cell culture flask (CORNING, AZ,\n USA) at 37°C in a humidified environment with 5%\n CO\u003csub\u003e2\u003c/sub\u003e. Media was changed every two days. Once cells\n reached 80–90% confluency, they were sub-cultured to smaller 50ml culture\n flasks. Transfections were carried out in these smaller flasks when the\n cells reached 80–90% confluency, following standard protocol. Briefly, the\n medium was removed and replaced with Opti-MEM ® reduced serum medium\n (GIBCO ThermoFisher Scientific Waltham MA, USA) 1 hour prior to\n transfection. The pcDNA 3.1-\u003cem\u003eOvo-slo1a\u003c/em\u003e-T2A-GFP\n construct was transiently transfected into HEK 293 cells using the\n Lipofectamine™ 2000 (Invitrogen, Carlsbad, CA, USA) protocol. On separate\n flasks, transfections with empty plasmid (pcDNA 3.1-T2A-GFP) for control\n recordings were done in the same ratios as the transfections with the gene\n of interest. The GFP in the plasmid construct served as a transfection\n marker. Cells were incubated with transfection mixtures for 6-12 hours,\n after which the medium was replaced with DMEM/10% FBS and incubated at\n 29°C, 5% CO\u003csub\u003e2\u003c/sub\u003e. Cells were detached from the petri\n dish using trypsin after 24 - 48 hours, seeded on coverslips coated with\n poly-D-lysine and incubated for 2 hours at 37°C, 5%\n CO\u003csub\u003e2\u003c/sub\u003e prior to imagery and patch recordings. The\n fluorescent image was captured at 20X using the BZ 800 viewer from a\n Keyence digital microscope, equipped with a blue-to-green GFP filter box\n (EX 470/40 DM 495 BA 525/50, Osaka, Japan).\n \u003cstrong\u003eElectrophysiology\u003c/strong\u003e\n \u003cem\u003e\u003cstrong\u003eRecording\n Conditions\u003c/strong\u003e\u003c/em\u003e Borosilicate glass\n electrodes (1.50-mm OD Clark Electromedical Instruments, UK) were pulled\n with a Narishige PC-100 Vertical puller (Narishige, Tokyo, Japan). The\n pipette tips were coated with Sylgard and fire polished using a Narishige\n Micro Forge MF-900 (Narishige CO., Ltd, Tokyo, Japan). Pipette resistances\n between 4 and 12 MΩ were used for recordings. Coverslips were transferred\n to a cell chamber 2 hours after plating and mounted on the stage of a\n stabilized inverted epifluorescence microscope (Nikon ECLIPSE TE 2000-U,\n Tokyo, Japan). Fluorescent cells were identified for patching by observing\n at 20X and 40X using the SOLA light engine (Lumencor light engine\n Beaverton, OR, USA) equipped with a band pass blue to green GFP filter.\n Patch-clamp recordings were done in the whole-cell, and inside-out\n configurations. All experiments were conducted at room\n temperature. For whole cell experiments, the drug\n solution was delivered to the chamber under gravity feed through solenoid\n valves controlled using a VC-8 Eight-Channel Valve Controller (Warner\n Instruments, Hamden, CT, USA). For inside-out recordings, drugs were\n manually added to the bath and the cells exposed for 5 to 30 mins\n (depending on the drug) to allow enough time for diffusion from the point\n of application to the channels in the patches. All experiments where we\n observed channel rundown or membrane breakdown were excluded. After each\n experiment where drugs were applied to the bath, the coverslip in the\n experimental chamber was replaced with another containing a new sample of\n cells. To investigate the drug effects on the\n single-channel properties of \u003cem\u003eOvo\u003c/em\u003e-SLO-1A, we recorded\n events in the absence of drug for approximately 2 mins and then added the\n first drug (either emodepside or verruculogen). For experiments where both\n drugs were added, once the effect of the first drug added was observed,\n the second drug was added and recordings continued for 20 mins. While we\n added emodepside to patches with initial low activity, we added\n verruculogen to patches with high initial channel activity so the effect\n of each drug could be easily identified.\n \u003cem\u003e\u003cstrong\u003eRecording\n Solutions\u003c/strong\u003e\u003c/em\u003e For experiments to\n determine the conductance of the channel, we used inside-out patches with\n solutions that were symmetrical on both sides of the membrane (6 mM NaCl,\n 132 mM KCl, 1.2 mM MgCl\u003csub\u003e2\u003c/sub\u003e, 1 mM\n CaCl\u003csub\u003e2\u003c/sub\u003e, 11 mM Glucose and 10 mM HEPES, pH 7.4). For\n whole-cell experiments, the pipette solution contained 140 mM KCl, 1.2 mM\n MgCl\u003csub\u003e2\u003c/sub\u003e, 5.4 mM CaCl\u003csub\u003e2\u003c/sub\u003e, 5 mM\n EGTA, 2 mM dipotassium ATP and 10 mM HEPES, pH 7.2, giving a free\n (Ca\u003csup\u003e2\u003c/sup\u003e⁺) of 100 µM; and 137 mM NaCl, 5.9 mM KCl, 1.2\n mM MgCl2, 2.2 mM CaCl\u003csub\u003e2\u003c/sub\u003e, 14 mM Glucose and 10 mM\n HEPES, pH 7.4 in the bath. For investigation drug effects on inside-out\n patches we used solutions containing: 150 mM NaCl, 4 mM KCl, 2 mM\n MgCl\u003csub\u003e2\u003c/sub\u003e, 2 mM CaCl\u003csub\u003e2\u003c/sub\u003e and 10 mM\n HEPES, pH 7.4 in the pipette; and 150 mM KCl, 9.77 mM\n CaCl\u003csub\u003e2\u003c/sub\u003e,10 mM EGTA, and 10 mM HEPES, pH 7.2. The bath\n (Ca\u003csup\u003e2\u003c/sup\u003e⁺) was adjusted to be 100 µM using the MAX\n CHELATOR program: https://somapp.ucdmc.ucdavis.edu/pharmacology/bers/maxchelator/CaMgATPEGTA-TS.htm. \u003cstrong\u003eDrugs\u003c/strong\u003e Emodepside and verruculogen were purchased from Advanced ChemBlock Inc (Hayward, CA, USA). Stock solutions of emodepside (3 mM) and verruculogen (10 mM) for inside-out recordings were prepared in dimethyl sulfoxide (DMSO) and then diluted in the recording solution (to 3 µM for emodepside and 10 µM for verruculogen) prior to experimentation. Thus, the final concentration of DMSO in the experimental solutions was kept below 0.1%. We added a small volume of the drugs to the bath and allowed approximately 15 minutes for equilibration so that the final concentration in the bath of emodepside was 0.3 µM and the final concentration of verruculogen was 1 µM. For the whole cell recording with emodepside, the stock solution was prepared at 1 mM and diluted in recording solution to 1 µM. \u003cstrong\u003eData Analysis\u003c/strong\u003e Data were collected using an Axopatch 200B amplifier (Molecular Devices, LLC. San Jose, CA, USA), filtered at 2 kHz with an 8-pole Bessel filter, and sampled at 10 kHz with a Digidata 1550B (Molecular Devices, LLC. San Jose, CA, USA); and the pCLAMP Software versions 10.7.0 and 11.1.0 (Molecular Devices, LLC. San Jose, CA, USA). Openings or closings shorter than 0.5 ms were not well resolved. To determine the main open-state channel conductance, currents were measured at four different membrane potentials (±50 mV and ±75 mV), in the symmetrical solutions with 132 mM K⁺. A current-voltage plot was generated, and the channel conductance was determined from the slope. For whole-cell recordings, peak currents responses elicited by the drug were measured, from baseline current prior to drug addition, using Clampfit. GraphPad Prism 10.3.0 software (GraphPad Software Inc., San Diego, CA, USA) was used to generate histograms. Unpaired Student’s \u003cem\u003et-test\u003c/em\u003e to test for statistical significance was used. A \u003cem\u003ep\u003c/em\u003e value \u0026lt; 0.05 was considered significant, and results were expressed as mean ± S.E.M. Single-channel analysis (amplitudes, open burst-times and probability of being open) was performed using Clampfit 11.1.0 and Clampfit 11.7.0. For Fig. 2A, absolute maximum amplitudes were calculated while for Fig. 5, the mean current amplitude values and open burst-times were calculated from values generated over a defined recording segment in Clampfit. Data were sorted using Microsoft excel and histograms generated in Clampfit 11.1.0 and GraphPad Prism 10.3.3. Gaussian functions were fitted to describe and illustrate the presence of the sub-conductance in the presence of emodepside. The open burst-times were defined as a single opening, or groups of openings separated by a close period of ≥ 0.5 ms. Probability of being open was calculated using the formula: Where \u003cem\u003eN\u003c/em\u003e is the number of channels in the patch, \u003cem\u003eL\u003c/em\u003e is the number of channels open, \u003cem\u003eTo\u003csub\u003eL\u003c/sub\u003e\u003c/em\u003e is the total time \u003cem\u003eL\u003c/em\u003e channels are open, and \u003cem\u003eT\u003c/em\u003e is the duration of the recording analyzed. Burst-times were not normally distributed (Shapiro-Wilk test), so we used the Wilcoxon signed-rank test which is a non-parametric test to compare burst-times before and after the addition of emodepside. All error bars represent Standard Error of the Mean (SEM), and paired t-tests were utilized where appropriate. The burst-time distribution histograms ≥ 0.5 ms were fitted to a single exponential with the Clampfit software.","descriptionType":"Methods"},{"description":"# Data from: Effects of emodepside on single-channel properties of\n *Onchocerca volvulus* SLO-1A (BK) potassium channels Dataset DOI:\n [10.5061/dryad.jdfn2z3pr](10.5061/dryad.jdfn2z3pr) ## Description of the\n data and file structure **Fig 1C** Data Set consists of a list from\n different cells of peak current responses to the application of 1\n micromolar emodepside to A: non-transfected HEK293 cells and B:\n transfected HEK293 cells. **Fig 2C** Data set is a list of main state\n channel open amplitudes at the -75mV, -50mV, +50mV, and +75mV to determine\n by linear regression the slope conductance of the emodepside activated\n channels. **Fig 4B** Data set for the representative channel open\n amplitude histogram in the absence of emodepside. **Fig 4C** Data set for\n the representative channel open amplitude histogram in the presence of 0.3\n micromolar emodepside that was fitted to three Gaussian functions to\n sub-conductance openings (S1: 1.26 ± 0.02 pA; S2: 1.76 ± 0.03 pA; S3: 2.45\n ± 0.06 pA). **Fig 4D** Data set for the representative burst-times\n histogram for without emodepside with the distribution ≥ 0.5 ms fitted to\n a single exponential with a time-constant, *ϯ,* of 0.12 ms. **Fig 4E**\n Data set for Representative burst-times histogram following the addition\n of 0.3 µM emodepside with the distribution fitted to a single exponential\n with time a constant of 1.96 ms.  **Fig 5A** Data sets for mean current\n before (Mean ± SEM; 2.17 ± 0.16 pA) and after adding 0.3 µM emodepside\n (Mean ± SEM; 2.48 ± 0.21 pA); *p* = 0.03 (paired *t*-test). **Fig 5B**\n Data sets for mean burst-time before (Mean ± SEM; 1.27 ± 0.27 ms) and\n after adding 0.3 µM emodepside (Mean ± SEM; 1.87 ± 0.23 ms); *p* = 0.02\n (Wilcoxon signed-rank test). **Fig 5C** Data sets for *NPopen* before\n (Mean ± SEM; 0.01 ± 0.01) and after adding 0.3 µM emodepside (Mean ± SEM;\n 0.15 ± 0.04); *p* = 0.02 (paired *t*-test). ### Files and variables ####\n File: Fig_1C_Histogram_Data_Set.xlsx **Description:** Peak current\n responses, nA to 1 micromolar emodepside at +20 mV holding potential for\n non-transcribed HEK203 cells and transcribed HEK 293 cells ##### Variables\n * peak current responses, nA #### File:\n Fig_2B_I_V_plot_single_channel__data_set.xlsx\n **Description:** Current-Voltage plot for single channel open states\n recordings from HEK 293 cells transfected with pcDNA 3.1(+) *Ovo* *slo-1a*\n T2A GFP plasmid; slope conductance was 110 ± 3 pS, r2 = 0.96 #####\n Variables * Membrane potential: mV and current amplitude, pA. #### File:\n Fig_4B_and_C_channel_amplitudes_data_sets.xlsx **Description:** **B:**\n Representative amplitude histogram without emodepside. **C:**\n Representative amplitude histogram for with emodepside ##### Variables *\n open channel amplitudes, pA #### File:\n Fig_4D_and_E_burst_times_data_sets.xlsx **Description:** **D:**\n Representative burst-times data set for the histogram for without\n emodepside with the distribution ≥ 0.5 ms fitted to a single exponential\n with a time-constant, ϯ, of 0.12 ms. **E:** Representative burst-times\n data set histogram for without emodepside with the distribution ≥ 0.5 ms\n fitted to a single exponential with a time-constant, ϯ, of 0.12 ms #####\n Variables * Burst times ms #### File:\n Fig_5A__B___C_Data_Sets_Effects_of_0.3_emodepside.xlsx\n **Description:** Effect of emodepside on *Ovo*-SLO-1A channel kinetics.\n **A**. Data set for Mean current before (Mean ± SEM; 2.17 ± 0.16 pA) and\n after adding 0.3 µM emodepside (Mean ± SEM; 2.48 ± 0.21 pA); *p* = 0.03\n (paired *t*-test). **B**. Data set for Mean burst-time before (Mean ± SEM;\n 1.27 ± 0.27 ms) and after adding 0.3 µM emodepside (Mean ± SEM; 1.87 ±\n 0.23 ms); *p* = 0.02 (Wilcoxon signed-rank test). **C**. Data set for\n *NPopen* before (Mean ± SEM; 0.01 ± 0.01) and after adding 0.3 µM\n emodepside (Mean ± SEM; 0.15 ± 0.04); *p* = 0.02 (paired *t*-test), n = 8\n for all experiments. ##### Variables * Open channel amplitudes at +20mV\n pA; burst-times in ms; and probability of a channel being open. ##\n Code/software Excel","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","awardTitle":"Slo-1K channels, TRP-2 channels, emodepside and diethylcarbamazine in Filaria","funderName":"National Institute of Allergy and Infectious Diseases","awardNumber":"R01AI155413","funderIdentifier":"https://ror.org/043z4tv69","funderIdentifierType":"ROR"},{"funderName":"E. A. Benbrook Endowed Chair in Pathology and Parasitology"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4/metadata.xsd">
  <identifier identifierType="DOI">10.5061/DRYAD.JDFN2Z3PR</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Martin, Richard John</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-2422-1847</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/04rswrd78" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Iowa State University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Njeshi, Charity</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/04rswrd78" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Iowa State University</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Data from: Effects of emodepside on single-channel properties of
      &lt;em&gt;Onchocerca volvulus&lt;/em&gt; SLO-1A (BK) potassium channels
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2025</publicationYear>
  <subjects>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Onchocerciasis</subject>
    <subject>SLO-1</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Electrophysiology</subject>
    <subject>Single-channel currents</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Patch clamp techniques</subject>
    <subject>Emodepside</subject>
    <subject>Verruculogen</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Medical and health sciences</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>National Institute of Allergy and Infectious Diseases</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/043z4tv69</funderIdentifier>
      <awardNumber>R01AI155413</awardNumber>
      <awardTitle>Slo-1K channels, TRP-2 channels, emodepside and diethylcarbamazine in Filaria</awardTitle>
    </fundingReference>
    <fundingReference>
      <funderName>E. A. Benbrook Endowed Chair in Pathology and Parasitology</funderName>
      <awardTitle/>
    </fundingReference>
  </fundingReferences>
  <contributors>
    <contributor contributorType="Sponsor">
      <contributorName>Iowa State University</contributorName>
    </contributor>
  </contributors>
  <dates>
    <date dateType="Created">2025-07-23T21:45:28Z</date>
    <date dateType="Submitted">2025-08-26T15:03:12Z</date>
    <date dateType="Issued">2025-09-20T00:00:00Z</date>
    <date dateType="Available">2025-09-20T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.21203/rs.3.rs-7206784</relatedIdentifier>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1186/s13071-025-07171-6</relatedIdentifier>
  </relatedIdentifiers>
  <sizes>
    <size>57823 bytes</size>
  </sizes>
  <version>5</version>
  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      Control of onchocerciasis (river blindness of humans due to infection with
      the filarial nematode, Onchocerca volvulus) remains a challenge because of
      the lack of effective adulticides and vaccines. Emodepside is a
      broad-spectrum veterinary anthelmintic that has been found to inhibit
      nematode muscle activity by activating their tetrameric SLO-1K
      channels.&amp;nbsp;Emodepside has adulticidal activity and is being
      trialed for onchocerciasis treatment, but the molecular mode of action of
      emodepside is still being elucidated. Here we examine the single-channel
      currents of Ovo-SLO-1A, a SLO-1K splice variant from O. volvulus, and
      explore how emodepside modulates the dynamics of the opening of the
      channel. Ovo-SLO-1A was expressed in HEK 293 cells, and patch clamp
      electrophysiology techniques were used to record currents. Single-channel
      currents were recorded in a symmetrical 132 mM K⁺ solution to determine
      the main open-state channel conductance. Emodepside’s effects were tested
      at 0.3 µM and 1.0 µM. Ovo-SLO-1A had a main open-state conductance of 110
      ± 3 pS and frequent flickering sub-conductance states. The presence of the
      flickering sub-conductance states suggests that there is limited
      cooperativity between the tetrameric channel subunits required for opening
      to the main open-state. Emodepside increased mean current amplitudes.
      Emodepside also increased open-burst times, and open probability.
      Verruculogen (1 µM) inhibited channel opening in the presence or absence
      of emodepside. This study successfully expressed Ovo-SLO-1A in HEK 293
      cells, measured the conductance of the main open-state and detected the
      presence of sub-conductance states, and flickering openings. The increased
      amplitudes of the single-channel currents, open-burst times and open
      probabilities provide insights into how emodepside increases Slo-1K
      currents and illustrate dynamic actions of emodepside on Ovo-SLO-1A.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;&lt;strong&gt;Methods&lt;/strong&gt;&lt;/p&gt;
      &lt;p&gt;&lt;strong&gt;Cloning&lt;/strong&gt;&lt;/p&gt;
      &lt;p&gt;&lt;em&gt;O. volvulus&lt;/em&gt; &lt;em&gt;slo-1a&lt;/em&gt; was
      synthesized by Life Technologies GeneArt (BioPark Regensburg, Germany).
      Primers for the gene were designed with sequences flanking the pcDNA
      3.1-T2A-GFP expression vector that included the restriction site (Nhe1).
      PCR was conducted on the &lt;em&gt;O. volvulus slo-1a&lt;/em&gt;.
      Subsequently, the amplicon was separated on a 1% Agarose SYBR Safe gel,
      purified using NucleoSpin Gel and PCR Clean-up Kit (Macherey-Nagel,
      Allentown, PA, USA), and then cloned into the pcDNA 3.1-T2A-GFP vector by
      using the Infusion HD Cloning Kit (Takara Bio USA, Inc, San Jose, CA, USA)
      according to the manufacturer’s protocols. Once cloned, the plasmids were
      verified by sequencing.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;HEK 293 Cell
      culture and transfection&lt;/strong&gt;&lt;/p&gt; &lt;p&gt;HEK 293 cells
      were maintained in DMEM (GIBCO, ThermoFisher Scientific Waltham MA, USA)
      with 10% FBS (GIBCO ThermoFisher Scientific Waltham MA, USA) and 1%
      penicillin/streptomycin antibiotics in a cell culture flask (CORNING, AZ,
      USA) at 37°C in a humidified environment with 5%
      CO&lt;sub&gt;2&lt;/sub&gt;. Media was changed every two days. Once cells
      reached 80–90% confluency, they were sub-cultured to smaller 50ml culture
      flasks. Transfections were carried out in these smaller flasks when the
      cells reached 80–90% confluency, following standard protocol. Briefly, the
      medium was removed and replaced with Opti-MEM ® reduced serum medium
      (GIBCO ThermoFisher Scientific Waltham MA, USA) 1 hour prior to
      transfection. The pcDNA 3.1-&lt;em&gt;Ovo-slo1a&lt;/em&gt;-T2A-GFP
      construct was transiently transfected into HEK 293 cells using the
      Lipofectamine™ 2000 (Invitrogen, Carlsbad, CA, USA) protocol. On separate
      flasks, transfections with empty plasmid (pcDNA 3.1-T2A-GFP) for control
      recordings were done in the same ratios as the transfections with the gene
      of interest. The GFP in the plasmid construct served as a transfection
      marker. Cells were incubated with transfection mixtures for 6-12 hours,
      after which the medium was replaced with DMEM/10% FBS and incubated at
      29°C, 5% CO&lt;sub&gt;2&lt;/sub&gt;. Cells were detached from the petri
      dish using trypsin after 24 - 48 hours, seeded on coverslips coated with
      poly-D-lysine and incubated for 2 hours at 37°C, 5%
      CO&lt;sub&gt;2&lt;/sub&gt; prior to imagery and patch recordings. The
      fluorescent image was captured at 20X using the BZ 800 viewer from a
      Keyence digital microscope, equipped with a blue-to-green GFP filter box
      (EX 470/40 DM 495 BA 525/50, Osaka, Japan).&lt;/p&gt;
      &lt;p&gt;&lt;strong&gt;Electrophysiology&lt;/strong&gt;&lt;/p&gt;
      &lt;p&gt;&lt;em&gt;&lt;strong&gt;Recording
      Conditions&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;Borosilicate glass
      electrodes (1.50-mm OD Clark Electromedical Instruments, UK) were pulled
      with a Narishige PC-100 Vertical puller (Narishige, Tokyo, Japan). The
      pipette tips were coated with Sylgard and fire polished using a Narishige
      Micro Forge MF-900 (Narishige CO., Ltd, Tokyo, Japan). Pipette resistances
      between 4 and 12 MΩ were used for recordings. Coverslips were transferred
      to a cell chamber 2 hours after plating and mounted on the stage of a
      stabilized inverted epifluorescence microscope (Nikon ECLIPSE TE 2000-U,
      Tokyo, Japan). Fluorescent cells were identified for patching by observing
      at 20X and 40X using the SOLA light engine (Lumencor light engine
      Beaverton, OR, USA) equipped with a band pass blue to green GFP filter.
      Patch-clamp recordings were done in the whole-cell, and inside-out
      configurations. All experiments were conducted at room
      temperature.&lt;/p&gt; &lt;p&gt;For whole cell experiments, the drug
      solution was delivered to the chamber under gravity feed through solenoid
      valves controlled using a VC-8 Eight-Channel Valve Controller (Warner
      Instruments, Hamden, CT, USA). For inside-out recordings, drugs were
      manually added to the bath and the cells exposed for 5 to 30 mins
      (depending on the drug) to allow enough time for diffusion from the point
      of application to the channels in the patches. All experiments where we
      observed channel rundown or membrane breakdown were excluded. After each
      experiment where drugs were applied to the bath, the coverslip in the
      experimental chamber was replaced with another containing a new sample of
      cells.&lt;/p&gt; &lt;p&gt;To investigate the drug effects on the
      single-channel properties of &lt;em&gt;Ovo&lt;/em&gt;-SLO-1A, we recorded
      events in the absence of drug for approximately 2 mins and then added the
      first drug (either emodepside or verruculogen). For experiments where both
      drugs were added, once the effect of the first drug added was observed,
      the second drug was added and recordings continued for 20 mins. While we
      added emodepside to patches with initial low activity, we added
      verruculogen to patches with high initial channel activity so the effect
      of each drug could be easily identified.&lt;/p&gt;
      &lt;p&gt;&lt;em&gt;&lt;strong&gt;Recording
      Solutions&lt;/strong&gt;&lt;/em&gt;&lt;/p&gt; &lt;p&gt;For experiments to
      determine the conductance of the channel, we used inside-out patches with
      solutions that were symmetrical on both sides of the membrane (6 mM NaCl,
      132 mM KCl, 1.2 mM MgCl&lt;sub&gt;2&lt;/sub&gt;, 1 mM
      CaCl&lt;sub&gt;2&lt;/sub&gt;, 11 mM Glucose and 10 mM HEPES, pH 7.4). For
      whole-cell experiments, the pipette solution contained 140 mM KCl, 1.2 mM
      MgCl&lt;sub&gt;2&lt;/sub&gt;, 5.4 mM CaCl&lt;sub&gt;2&lt;/sub&gt;, 5 mM
      EGTA, 2 mM dipotassium ATP and 10 mM HEPES, pH 7.2, giving a free
      (Ca&lt;sup&gt;2&lt;/sup&gt;⁺) of 100 µM; and 137 mM NaCl, 5.9 mM KCl, 1.2
      mM MgCl2, 2.2 mM CaCl&lt;sub&gt;2&lt;/sub&gt;, 14 mM Glucose and 10 mM
      HEPES, pH 7.4 in the bath. For investigation drug effects on inside-out
      patches we used solutions containing: 150 mM NaCl, 4 mM KCl, 2 mM
      MgCl&lt;sub&gt;2&lt;/sub&gt;, 2 mM CaCl&lt;sub&gt;2&lt;/sub&gt; and 10 mM
      HEPES, pH 7.4 in the pipette; and 150 mM KCl, 9.77 mM
      CaCl&lt;sub&gt;2&lt;/sub&gt;,10 mM EGTA, and 10 mM HEPES, pH 7.2. The bath
      (Ca&lt;sup&gt;2&lt;/sup&gt;⁺) was adjusted to be 100 µM using the MAX
      CHELATOR program: &lt;a
      href="https://somapp.ucdmc.ucdavis.edu/pharmacology/bers/maxchelator/CaMgATPEGTA-TS.htm"&gt;https://somapp.ucdmc.ucdavis.edu/pharmacology/bers/maxchelator/CaMgATPEGTA-TS.htm&lt;/a&gt;.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Drugs&lt;/strong&gt;&lt;/p&gt; &lt;p&gt;Emodepside and verruculogen were purchased from Advanced ChemBlock Inc (Hayward, CA, USA). Stock solutions of emodepside (3 mM) and verruculogen (10 mM) for inside-out recordings were prepared in dimethyl sulfoxide (DMSO) and then diluted in the recording solution (to 3 µM for emodepside and 10 µM for verruculogen) prior to experimentation. Thus, the final concentration of DMSO in the experimental solutions was kept below 0.1%. We added a small volume of the drugs to the bath and allowed approximately 15 minutes for equilibration so that the final concentration in the bath of emodepside was 0.3 µM and the final concentration of verruculogen was 1 µM. For the whole cell recording with emodepside, the stock solution was prepared at 1 mM and diluted in recording solution to 1 µM.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Data Analysis&lt;/strong&gt;&lt;/p&gt; &lt;p&gt;Data were collected using an Axopatch 200B amplifier (Molecular Devices, LLC. San Jose, CA, USA), filtered at 2 kHz with an 8-pole Bessel filter, and sampled at 10 kHz with a Digidata 1550B (Molecular Devices, LLC. San Jose, CA, USA); and the pCLAMP Software versions 10.7.0 and 11.1.0 (Molecular Devices, LLC. San Jose, CA, USA). Openings or closings shorter than 0.5 ms were not well resolved. To determine the main open-state channel conductance, currents were measured at four different membrane potentials (±50 mV and ±75 mV), in the symmetrical solutions with 132 mM K⁺. A current-voltage plot was generated, and the channel conductance was determined from the slope.&lt;/p&gt; &lt;p&gt;For whole-cell recordings, peak currents responses elicited by the drug were measured, from baseline current prior to drug addition, using Clampfit. GraphPad Prism 10.3.0 software (GraphPad Software Inc., San Diego, CA, USA) was used to generate histograms. Unpaired Student’s &lt;em&gt;t-test&lt;/em&gt; to test for statistical significance was used. A &lt;em&gt;p&lt;/em&gt; value &amp;lt; 0.05 was considered significant, and results were expressed as mean ± S.E.M.&lt;/p&gt; &lt;p&gt;Single-channel analysis (amplitudes, open burst-times and probability of being open) was performed using Clampfit 11.1.0 and Clampfit 11.7.0. For Fig. 2A, absolute maximum amplitudes were calculated while for Fig. 5, the mean current amplitude values and open burst-times were calculated from values generated over a defined recording segment in Clampfit. Data were sorted using Microsoft excel and histograms generated in Clampfit 11.1.0 and GraphPad Prism 10.3.3. Gaussian functions were fitted to describe and illustrate the presence of the sub-conductance in the presence of emodepside. The open burst-times were defined as a single opening, or groups of openings separated by a close period of ≥ 0.5 ms. Probability of being open was calculated using the formula:&lt;/p&gt; &lt;p&gt;&lt;img src="data:image/png;base64,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"&gt;&lt;/p&gt; &lt;p&gt;Where &lt;em&gt;N&lt;/em&gt; is the number of channels in the patch, &lt;em&gt;L&lt;/em&gt; is the number of channels open, &lt;em&gt;To&lt;sub&gt;L&lt;/sub&gt;&lt;/em&gt; is the total time &lt;em&gt;L&lt;/em&gt; channels are open, and &lt;em&gt;T&lt;/em&gt; is the duration of the recording analyzed.&lt;/p&gt; &lt;p&gt;Burst-times were not normally distributed (Shapiro-Wilk test), so we used the Wilcoxon signed-rank test which is a non-parametric test to compare burst-times before and after the addition of emodepside. All error bars represent Standard Error of the Mean (SEM), and paired t-tests were utilized where appropriate. The burst-time distribution histograms ≥ 0.5 ms were fitted to a single exponential with the Clampfit software.&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      # Data from: Effects of emodepside on single-channel properties of
      *Onchocerca volvulus* SLO-1A (BK) potassium channels Dataset DOI:
      [10.5061/dryad.jdfn2z3pr](10.5061/dryad.jdfn2z3pr) ## Description of the
      data and file structure **Fig 1C** Data Set consists of a list from
      different cells of peak current responses to the application of 1
      micromolar emodepside to A: non-transfected HEK293 cells and B:
      transfected HEK293 cells. **Fig 2C** Data set is a list of main state
      channel open amplitudes at the -75mV, -50mV, +50mV, and +75mV to determine
      by linear regression the slope conductance of the emodepside activated
      channels. **Fig 4B** Data set for the representative channel open
      amplitude histogram in the absence of emodepside. **Fig 4C** Data set for
      the representative channel open amplitude histogram in the presence of 0.3
      micromolar emodepside that was fitted to three Gaussian functions to
      sub-conductance openings (S1: 1.26 ± 0.02 pA; S2: 1.76 ± 0.03 pA; S3: 2.45
      ± 0.06 pA). **Fig 4D** Data set for the representative burst-times
      histogram for without emodepside with the distribution ≥ 0.5 ms fitted to
      a single exponential with a time-constant, *ϯ,* of 0.12 ms. **Fig 4E**
      Data set for Representative burst-times histogram following the addition
      of 0.3 µM emodepside with the distribution fitted to a single exponential
      with time a constant of 1.96 ms.  **Fig 5A** Data sets for mean current
      before (Mean ± SEM; 2.17 ± 0.16 pA) and after adding 0.3 µM emodepside
      (Mean ± SEM; 2.48 ± 0.21 pA); *p* = 0.03 (paired *t*-test). **Fig 5B**
      Data sets for mean burst-time before (Mean ± SEM; 1.27 ± 0.27 ms) and
      after adding 0.3 µM emodepside (Mean ± SEM; 1.87 ± 0.23 ms); *p* = 0.02
      (Wilcoxon signed-rank test). **Fig 5C** Data sets for *NPopen* before
      (Mean ± SEM; 0.01 ± 0.01) and after adding 0.3 µM emodepside (Mean ± SEM;
      0.15 ± 0.04); *p* = 0.02 (paired *t*-test). ### Files and variables ####
      File: Fig_1C_Histogram_Data_Set.xlsx **Description:** Peak current
      responses, nA to 1 micromolar emodepside at +20 mV holding potential for
      non-transcribed HEK203 cells and transcribed HEK 293 cells ##### Variables
      * peak current responses, nA #### File:
      Fig_2B_I_V_plot_single_channel__data_set.xlsx
      **Description:** Current-Voltage plot for single channel open states
      recordings from HEK 293 cells transfected with pcDNA 3.1(+) *Ovo* *slo-1a*
      T2A GFP plasmid; slope conductance was 110 ± 3 pS, r2 = 0.96 #####
      Variables * Membrane potential: mV and current amplitude, pA. #### File:
      Fig_4B_and_C_channel_amplitudes_data_sets.xlsx **Description:** **B:**
      Representative amplitude histogram without emodepside. **C:**
      Representative amplitude histogram for with emodepside ##### Variables *
      open channel amplitudes, pA #### File:
      Fig_4D_and_E_burst_times_data_sets.xlsx **Description:** **D:**
      Representative burst-times data set for the histogram for without
      emodepside with the distribution ≥ 0.5 ms fitted to a single exponential
      with a time-constant, ϯ, of 0.12 ms. **E:** Representative burst-times
      data set histogram for without emodepside with the distribution ≥ 0.5 ms
      fitted to a single exponential with a time-constant, ϯ, of 0.12 ms #####
      Variables * Burst times ms #### File:
      Fig_5A__B___C_Data_Sets_Effects_of_0.3_emodepside.xlsx
      **Description:** Effect of emodepside on *Ovo*-SLO-1A channel kinetics.
      **A**. Data set for Mean current before (Mean ± SEM; 2.17 ± 0.16 pA) and
      after adding 0.3 µM emodepside (Mean ± SEM; 2.48 ± 0.21 pA); *p* = 0.03
      (paired *t*-test). **B**. Data set for Mean burst-time before (Mean ± SEM;
      1.27 ± 0.27 ms) and after adding 0.3 µM emodepside (Mean ± SEM; 1.87 ±
      0.23 ms); *p* = 0.02 (Wilcoxon signed-rank test). **C**. Data set for
      *NPopen* before (Mean ± SEM; 0.01 ± 0.01) and after adding 0.3 µM
      emodepside (Mean ± SEM; 0.15 ± 0.04); *p* = 0.02 (paired *t*-test), n = 8
      for all experiments. ##### Variables * Open channel amplitudes at +20mV
      pA; burst-times in ms; and probability of a channel being open. ##
      Code/software Excel
    </description>
  </descriptions>
</resource>","url":"https://datadryad.org/dataset/doi:10.5061/dryad.jdfn2z3pr","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":29,"viewsOverTime":[{"yearMonth":"2025-09","total":6},{"yearMonth":"2025-10","total":7},{"yearMonth":"2025-12","total":7},{"yearMonth":"2026-02","total":1},{"yearMonth":"2026-03","total":2},{"yearMonth":"2026-05","total":1},{"yearMonth":"2026-09","total":5}],"downloadCount":4,"downloadsOverTime":[{"yearMonth":"2025-09","total":2},{"yearMonth":"2025-10","total":2},{"yearMonth":"2025-12","total":0},{"yearMonth":"2026-02","total":0},{"yearMonth":"2026-03","total":0},{"yearMonth":"2026-04","total":0},{"yearMonth":"2026-05","total":0},{"yearMonth":"2026-09","total":0}],"referenceCount":0,"citationCount":2,"citationsOverTime":[{"year":"2026","total":2}],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2025-09-20T02:35:16.000Z","registered":"2025-09-20T02:35:17.000Z","published":"2025","updated":"2026-01-29T00:44:16.000Z"},"relationships":{"client":{"data":{"id":"dryad.dryad","type":"clients"}},"provider":{"data":{"id":"dryad","type":"providers"}},"media":{"data":{"id":"10.5061/dryad.jdfn2z3pr","type":"media"}},"references":{"data":[]},"citations":{"data":[{"id":"10.1186/s13071-025-07171-6","type":"dois"},{"id":"10.21203/rs.3.rs-7206784","type":"dois"}]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}