{"data":{"id":"10.5061/dryad.j0zpc86wh","type":"dois","attributes":{"doi":"10.5061/dryad.j0zpc86wh","prefix":"10.5061","suffix":"dryad.j0zpc86wh","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Lari, Eros","nameType":"Personal","givenName":"Eros","familyName":"Lari","affiliation":["Weill Cornell Medicine"],"nameIdentifiers":[]},{"name":"Ng, Lily","nameType":"Personal","givenName":"Lily","familyName":"Ng","affiliation":["Weill Cornell Medicine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0000-2742-5250","nameIdentifierScheme":"ORCID"}]},{"name":"Xie, Philip","nameType":"Personal","givenName":"Philip","familyName":"Xie","affiliation":["Weill Cornell Medicine"],"nameIdentifiers":[]},{"name":"Cheung, Stephanie","nameType":"Personal","givenName":"Stephanie","familyName":"Cheung","affiliation":["Weill Cornell Medicine"],"nameIdentifiers":[]},{"name":"Bains, Sabrina","nameType":"Personal","givenName":"Sabrina","familyName":"Bains","affiliation":["Weill Cornell Medicine"],"nameIdentifiers":[]},{"name":"Rosenwaks, Zev","nameType":"Personal","givenName":"Zev","familyName":"Rosenwaks","affiliation":["Weill Cornell Medicine"],"nameIdentifiers":[]},{"name":"Palermo, Gianpiero","nameType":"Personal","givenName":"Gianpiero","familyName":"Palermo","affiliation":["Weill Cornell Medicine"],"nameIdentifiers":[]}],"titles":[{"title":"Induction of male neogametogenesis in a three-dimensional microenvironment supporting successful fertilization and proper embryo development"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Spermatogenesis","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Male infertility","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Fertilization","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[],"dates":[{"date":"2026-04-01T14:26:50Z","dateType":"Created"},{"date":"2026-05-05T22:14:25Z","dateType":"Submitted"},{"date":"2026-05-13T00:00:00Z","dateType":"Issued"},{"date":"2026-05-13T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1093/molehr/gaag036","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1442013803 bytes"],"formats":[],"version":"3","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"In regenerative medicine, several attempts have been made to produce\n functional de novo gametes from mouse embryonic stem cells by utilizing 3D\n culture systems. We attempted to perform neogametogensis in a novel 3D\n niche to generate neo-gametes ready to be used for insemination. Mouse\n ESCs were initially cultured on a gelatin-coated 6-well plate with a\n monolayer of fibroblasts before being encapsulated in sodium alginate\n spheres. These spheres were then immersed in specially formulated EpiLC\n followed by PGCLC medium to promote differentiation into germ-like cells.\n Over the course of differentiation, immunofluorescence analysis revealed\n consistent expression patterns of spermatogenic markers. Cells were\n assessed for DAZL (early germ cell marker) VASA (spermatocyte), BOULE\n (post-meiotic) and acrosin (spermatid). The differentiated cells were then\n injected into oocytes and activated by calcium ionophore. Embryo\n development was monitored via time-lapse microscopy. Spherified neogametes\n on D22, 29, and 36 achieved fertilization rates of 61.1%, 82.7%, and\n 80.0%, respectively, and blastulation rates of 20.5%, 36.0%, 26.3%,\n respectively. Controls exhibited fertilization rates of 89.1% and\n blastulation rates of 76.3%. When embryo morphokinetics were taken in\n consideration, D29 embryos reached compaction at 64h and blastulation at\n 77h, mirroring closely the control’s timing of 63h and 77h, respectively.\n D22 embryos displayed the most delayed embryo development, of which\n compaction occurred at 68h and blastulation at 106h. Despite normal\n fertilization and successful blastulation, the efficiency rate remained\n below optimal levels. Nevertheless, our system could produce viable\n offspring, demonstrating that replicating the three-dimensional\n seminiferous tubule environment is crucial for generating artificial\n gametes. This eliminates the need for allo-/xeno-genic transplantation in\n experimental animals.","descriptionType":"Abstract"},{"description":"A blastomere biopsy was performed on some embryos at the 8-cell\n stage for aneuploidy assessment. Whole genome amplification was performed\n on the samples using the SurePlex DNA Amplification kit (Illumina, San\n Diego, CA, USA), and next generation sequencing was used to identify\n chromosomal gain(s) and/or loss(es), as well as to detect\n mosaicism.","descriptionType":"Methods"},{"description":"# Induction of male neogametogenesis in a three-dimensional\n microenvironment supporting successful fertilization and proper embryo\n development Dataset DOI:\n [10.5061/dryad.j0zpc86wh](https://doi.org/10.5061/dryad.j0zpc86wh) ##\n Description of the data and file structure ***Ploidy study on the\n conceptuses*** ### Files and variables #### File: Control_Sample1.fastq.gz\n **Description:** Euploid embryo generated from injection of natural\n spermatozoon #### File: Control_Sample2.fastq.gz **Description:** Euploid\n embryo generated from injection of natural spermatozoon #### File:\n Control_Sample3.fastq.gz **Description:** Aneuploid embryo generated from\n injection of natural spermatozoon #### File: Control_Sample4.fastq.gz\n **Description:** Euploid embryo generated from injection of natural\n spermatozoon #### File: Control_Sample5.fastq.gz **Description:** Euploid\n embryo generated from injection of natural spermatozoon #### File:\n Control_Sample6.fastq.gz **Description:** Euploid embryo generated from\n injection of natural spermatozoon #### File: Control_Sample7.fastq.gz\n **Description:** Euploid embryo generated from injection of natural\n spermatozoon #### File: Control_Sample8.fastq.gz **Description:** Euploid\n embryo generated from injection of natural spermatozoon #### File:\n Control_Sample9.fastq.gz **Description:** Euploid embryo generated from\n injection of natural spermatozoon #### File: Control_Sample10.fastq.gz\n **Description:** Euploid embryo generated from injection of natural\n spermatozoon #### File: D22_Sample1.fastq.gz **Description:** Aneuploid\n embryo generated from injection of neogamete extracted from D22 sphere\n #### File: D22_Sample2.fastq.gz **Description:** Aneuploid embryo\n generated from injection of neogamete extracted from D22 sphere #### File:\n D22_Sample3.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D22 sphere #### File:\n D22_Sample4.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D22 sphere #### File:\n D22_Sample5.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D22 sphere #### File:\n D22_Sample6.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D22 sphere #### File:\n D22_Sample7.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D22 sphere #### File:\n D22_Sample8.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D22 sphere #### File:\n D22_Sample9.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D22 sphere #### File:\n D22_Sample10.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D22 sphere #### File:\n D29_Sample1.fastq.gz **Description:** Euploid embryo generated from\n injection of neogamete extracted from D29 sphere #### File:\n D29_Sample2.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D29 sphere #### File:\n D29_Sample3.fastq.gz **Description:** Euploid embryo generated from\n injection of neogamete extracted from D29 sphere #### File:\n D29_Sample4.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D29 sphere #### File:\n D29_Sample5.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D29 sphere #### File:\n D29_Sample6.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D29 sphere #### File:\n D29_Sample7.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D29 sphere #### File:\n D29_Sample8.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D29 sphere #### File:\n D29_Sample9.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D29 sphere #### File:\n D29_Sample10.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D29 sphere #### File:\n D36_Sample1.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D36 sphere #### File:\n D36_Sample2.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D36 sphere #### File:\n D36_Sample3.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D36 sphere #### File:\n D36_Sample4.fastq.gz **Description:** Euploid embryo generated from\n injection of neogamete extracted from D36 sphere #### File:\n D36_Sample5.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D36 sphere #### File:\n D36_Sample6.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D36 sphere #### File:\n D36_Sample7.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D36 sphere #### File:\n D36_Sample8.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D36 sphere #### File:\n D36_Sample9.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D36 sphere #### File:\n D36_Sample10.fastq.gz **Description:** Aneuploid embryo generated from\n injection of neogamete extracted from D36 sphere ## Code/software Command\n Line Tool downloaded and installed through XCode, available from Apple\n (Mac) Alternatively, a programming library such as BioPython 1.87 from\n Python can be used ## Access information Other publicly accessible\n locations of the data: * N/A Data was derived from the following sources:\n * N/A","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Weill Cornell Medicine","funderIdentifier":"https://ror.org/02r109517","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.J0ZPC86WH</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Lari, Eros</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02r109517" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Weill Cornell Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ng, Lily</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0009-0000-2742-5250</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/02r109517" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Weill Cornell Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Xie, Philip</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02r109517" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Weill Cornell Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Cheung, Stephanie</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02r109517" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Weill Cornell Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Bains, Sabrina</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02r109517" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Weill Cornell Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Rosenwaks, Zev</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02r109517" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Weill Cornell Medicine</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Palermo, Gianpiero</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02r109517" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Weill Cornell Medicine</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Induction of male neogametogenesis in a three-dimensional microenvironment
      supporting successful fertilization and proper embryo development
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2026</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Spermatogenesis</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Male infertility</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Fertilization</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>Weill Cornell Medicine</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/02r109517</funderIdentifier>
      <awardTitle/>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Created">2026-04-01T14:26:50Z</date>
    <date dateType="Submitted">2026-05-05T22:14:25Z</date>
    <date dateType="Issued">2026-05-13T00:00:00Z</date>
    <date dateType="Available">2026-05-13T00:00:00Z</date>
  </dates>
  <language>en</language>
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  <descriptions>
    <description descriptionType="Abstract">
      In regenerative medicine, several attempts have been made to produce
      functional de novo gametes from mouse embryonic stem cells by utilizing 3D
      culture systems. We attempted to perform neogametogensis in a novel 3D
      niche to generate neo-gametes ready to be used for insemination. Mouse
      ESCs were initially cultured on a gelatin-coated 6-well plate with a
      monolayer of fibroblasts before being encapsulated in sodium alginate
      spheres. These spheres were then immersed in specially formulated EpiLC
      followed by PGCLC medium to promote differentiation into germ-like cells.
      Over the course of differentiation, immunofluorescence analysis revealed
      consistent expression patterns of spermatogenic markers. Cells were
      assessed for DAZL (early germ cell marker) VASA (spermatocyte), BOULE
      (post-meiotic) and acrosin (spermatid). The differentiated cells were then
      injected into oocytes and activated by calcium ionophore. Embryo
      development was monitored via time-lapse microscopy. Spherified neogametes
      on D22, 29, and 36 achieved fertilization rates of 61.1%, 82.7%, and
      80.0%, respectively, and blastulation rates of 20.5%, 36.0%, 26.3%,
      respectively. Controls exhibited fertilization rates of 89.1% and
      blastulation rates of 76.3%. When embryo morphokinetics were taken in
      consideration, D29 embryos reached compaction at 64h and blastulation at
      77h, mirroring closely the control’s timing of 63h and 77h, respectively.
      D22 embryos displayed the most delayed embryo development, of which
      compaction occurred at 68h and blastulation at 106h. Despite normal
      fertilization and successful blastulation, the efficiency rate remained
      below optimal levels. Nevertheless, our system could produce viable
      offspring, demonstrating that replicating the three-dimensional
      seminiferous tubule environment is crucial for generating artificial
      gametes. This eliminates the need for allo-/xeno-genic transplantation in
      experimental animals.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;A blastomere biopsy was performed on some embryos at the 8-cell
      stage for aneuploidy assessment. Whole genome amplification was performed
      on the samples using the SurePlex DNA Amplification kit (Illumina, San
      Diego, CA, USA), and next generation sequencing was used to identify
      chromosomal gain(s) and/or loss(es), as well as to detect
      mosaicism.&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      # Induction of male neogametogenesis in a three-dimensional
      microenvironment supporting successful fertilization and proper embryo
      development Dataset DOI:
      [10.5061/dryad.j0zpc86wh](https://doi.org/10.5061/dryad.j0zpc86wh) ##
      Description of the data and file structure ***Ploidy study on the
      conceptuses*** ### Files and variables #### File: Control_Sample1.fastq.gz
      **Description:** Euploid embryo generated from injection of natural
      spermatozoon #### File: Control_Sample2.fastq.gz **Description:** Euploid
      embryo generated from injection of natural spermatozoon #### File:
      Control_Sample3.fastq.gz **Description:** Aneuploid embryo generated from
      injection of natural spermatozoon #### File: Control_Sample4.fastq.gz
      **Description:** Euploid embryo generated from injection of natural
      spermatozoon #### File: Control_Sample5.fastq.gz **Description:** Euploid
      embryo generated from injection of natural spermatozoon #### File:
      Control_Sample6.fastq.gz **Description:** Euploid embryo generated from
      injection of natural spermatozoon #### File: Control_Sample7.fastq.gz
      **Description:** Euploid embryo generated from injection of natural
      spermatozoon #### File: Control_Sample8.fastq.gz **Description:** Euploid
      embryo generated from injection of natural spermatozoon #### File:
      Control_Sample9.fastq.gz **Description:** Euploid embryo generated from
      injection of natural spermatozoon #### File: Control_Sample10.fastq.gz
      **Description:** Euploid embryo generated from injection of natural
      spermatozoon #### File: D22_Sample1.fastq.gz **Description:** Aneuploid
      embryo generated from injection of neogamete extracted from D22 sphere
      #### File: D22_Sample2.fastq.gz **Description:** Aneuploid embryo
      generated from injection of neogamete extracted from D22 sphere #### File:
      D22_Sample3.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D22 sphere #### File:
      D22_Sample4.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D22 sphere #### File:
      D22_Sample5.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D22 sphere #### File:
      D22_Sample6.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D22 sphere #### File:
      D22_Sample7.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D22 sphere #### File:
      D22_Sample8.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D22 sphere #### File:
      D22_Sample9.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D22 sphere #### File:
      D22_Sample10.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D22 sphere #### File:
      D29_Sample1.fastq.gz **Description:** Euploid embryo generated from
      injection of neogamete extracted from D29 sphere #### File:
      D29_Sample2.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D29 sphere #### File:
      D29_Sample3.fastq.gz **Description:** Euploid embryo generated from
      injection of neogamete extracted from D29 sphere #### File:
      D29_Sample4.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D29 sphere #### File:
      D29_Sample5.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D29 sphere #### File:
      D29_Sample6.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D29 sphere #### File:
      D29_Sample7.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D29 sphere #### File:
      D29_Sample8.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D29 sphere #### File:
      D29_Sample9.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D29 sphere #### File:
      D29_Sample10.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D29 sphere #### File:
      D36_Sample1.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D36 sphere #### File:
      D36_Sample2.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D36 sphere #### File:
      D36_Sample3.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D36 sphere #### File:
      D36_Sample4.fastq.gz **Description:** Euploid embryo generated from
      injection of neogamete extracted from D36 sphere #### File:
      D36_Sample5.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D36 sphere #### File:
      D36_Sample6.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D36 sphere #### File:
      D36_Sample7.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D36 sphere #### File:
      D36_Sample8.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D36 sphere #### File:
      D36_Sample9.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D36 sphere #### File:
      D36_Sample10.fastq.gz **Description:** Aneuploid embryo generated from
      injection of neogamete extracted from D36 sphere ## Code/software Command
      Line Tool downloaded and installed through XCode, available from Apple
      (Mac) Alternatively, a programming library such as BioPython 1.87 from
      Python can be used ## Access information Other publicly accessible
      locations of the data: * N/A Data was derived from the following sources:
      * N/A
    </description>
  </descriptions>
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