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Hiroami","nameType":"Personal","givenName":"Hiroami","familyName":"Hemmi","affiliation":["Okayama University of Science"],"nameIdentifiers":[]},{"name":"Akira, Shizuo","nameType":"Personal","givenName":"Shizuo","familyName":"Akira","affiliation":["The University of Osaka"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-7602-9617","nameIdentifierScheme":"ORCID"}]},{"name":"Miyake, Kensuke","nameType":"Personal","givenName":"Kensuke","familyName":"Miyake","affiliation":["The University of Tokyo"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6629-226X","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"TLR7/8 stress response drives histiocytosis in SLC29A3 disorders"}],"publisher":"Dryad","container":{},"publicationYear":2023,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"RNA-seq analysis"},{"subject":"AmpliSeq"}],"contributors":[],"dates":[{"date":"2023-07-07T16:44:02Z","dateType":"Created"},{"date":"2023-06-09T18:52:13Z","dateType":"Submitted"},{"date":"2023-06-13T00:00:00Z","dateType":"Issued"},{"date":"2023-06-13T00:00:00Z","dateType":"Available"},{"date":"2023-07-07T00:00:00Z","dateType":"Updated"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1101/2022.10.27.513971","relatedIdentifierType":"DOI"},{"relationType":"IsCitedBy","relatedIdentifier":"10.1084/jem.20230054","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["53066070764 bytes"],"formats":[],"version":"4","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Loss-of-function mutations in the lysosomal nucleoside transporter SLC29A3\n cause lysosomal nucleoside storage and histiocytosis: phagocyte\n accumulation in multiple organs. However, little is known about the\n mechanism by which lysosomal nucleoside storage drives histiocytosis.\n Herein, histiocytosis in Slc29a3–/– mice was shown to depend on Toll-like\n receptor 7 (TLR7), which senses a combination of nucleosides and\n oligoribonucleotides (ORNs). TLR7 increased phagocyte numbers by driving\n the proliferation of Ly6Chi immature monocytes and their maturation into\n Ly6Clow phagocytes in Slc29a3–/– mice. Downstream of TLR7, FcRγ and DAP10\n were required for monocyte proliferation. Histiocytosis is accompanied by\n inflammation in SLC29A3 disorders. However, TLR7 in nucleoside-laden\n splenic macrophages failed to activate inflammatory responses. Enhanced\n production of pro-inflammatory cytokines was observed only after\n stimulation with ssRNAs, which would increase lysosomal ORNs.\n Patient-derived monocytes harboring the G208R SLC29A3 mutation showed\n enhanced survival and proliferation in a TLR8 antagonist-sensitive manner.\n These results demonstrated that TLR7/8 responses to lysosomal nucleoside\n stress drive SLC29A3 disorders.","descriptionType":"Abstract"},{"description":"Ly6C\u003csup\u003elow\u003c/sup\u003e and\n Ly6C\u003csup\u003ehigh\u003c/sup\u003e splenic monocytes were obtained by FACS\n sorting from WT, \u003cem\u003eSlc29a3\u003csup\u003e−/−\u003c/sup\u003e\u003c/em\u003e,\n and \u003cem\u003eSlc29a3\u003c/em\u003e\u003csup\u003e\u003cem\u003e−/−\u003c/em\u003e\n \u003c/sup\u003e\u003cem\u003eTlr7\u003csup\u003e−/−\u003c/sup\u003e\u003c/em\u003e mice.\n Total RNA was extracted using RNeasy Mini Kits (Qiagen, Germany), and the\n quality of RNA was evaluated using the Agilent Bioanalyzer device (Agilent\n Technologies, Santa Clara, CA). The samples with RIN (RNA Integrity\n Number) value of more than 7.3 were subjected to library preparation.\n RNA-seq libraries were prepared with 1 ng of total RNA using an Ion\n AmpliSeq Transcriptome Mouse Gene Expression kit (Thermo Fisher\n Scientific) according to the manufacturer's instructions. The\n libraries were sequenced on Ion Proton using an Ion PI Hi-Q Sequencing 200\n kit and Ion PI Chip v3 (Thermo Fisher Scientific). The FASTQ files were\n generated using AmpliSeqRNA plug-in v5.2.0.3 in the Torrent Suite Software\n v5.2.2 (Thermo Fisher Scientific) and analyzed by ROSALIND (https://rosalind.bio/,\n OnRamp Bioinformatics, USA), which is a cloud-based bioinformatics\n software. Raw reads were trimmed using Cutadapt, and quality scores were\n assessed using FastQC2. Reads were aligned to the Mus musculus genome\n build mm10 using the STAR aligner. Individual sample reads were quantified\n using HTseq and normalized via relative log expression (RLE) using the\n DESeq2 R library. DEseq2 was used to determine the fold changes and\n p-values. Genes showing more than a 1.5-fold change in expression (p\n \u0026lt; 0.05) were considered to be significantly altered. To interpret\n gene expression profiles, gene set enrichment analysis (GSEA) was\n performed using MSigDB hallmark gene sets to explore the pathways\n associated with SLC29A3 deficiency. Enriched pathways with FDR-adjusted\n p-values lower than 0.05 are shown in Fig. 3B.","descriptionType":"Methods"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Japan Agency for Medical Research and Development","awardNumber":"JP20ek0109385","funderIdentifier":"https://ror.org/004rtk039","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <titles>
    <title>TLR7/8 stress response drives histiocytosis in SLC29A3 disorders</title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
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  <publicationYear>2023</publicationYear>
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    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject>RNA-seq analysis</subject>
    <subject>AmpliSeq</subject>
  </subjects>
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      <funderName>Japan Agency for Medical Research and Development</funderName>
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      <awardNumber>JP20ek0109385</awardNumber>
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  <dates>
    <date dateType="Created">2023-07-07T16:44:02Z</date>
    <date dateType="Submitted">2023-06-09T18:52:13Z</date>
    <date dateType="Issued">2023-06-13T00:00:00Z</date>
    <date dateType="Available">2023-06-13T00:00:00Z</date>
    <date dateType="Updated">2023-07-07T00:00:00Z</date>
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  <descriptions>
    <description descriptionType="Abstract">
      Loss-of-function mutations in the lysosomal nucleoside transporter SLC29A3
      cause lysosomal nucleoside storage and histiocytosis: phagocyte
      accumulation in multiple organs. However, little is known about the
      mechanism by which lysosomal nucleoside storage drives histiocytosis.
      Herein, histiocytosis in Slc29a3–/– mice was shown to depend on Toll-like
      receptor 7 (TLR7), which senses a combination of nucleosides and
      oligoribonucleotides (ORNs). TLR7 increased phagocyte numbers by driving
      the proliferation of Ly6Chi immature monocytes and their maturation into
      Ly6Clow phagocytes in Slc29a3–/– mice. Downstream of TLR7, FcRγ and DAP10
      were required for monocyte proliferation. Histiocytosis is accompanied by
      inflammation in SLC29A3 disorders. However, TLR7 in nucleoside-laden
      splenic macrophages failed to activate inflammatory responses. Enhanced
      production of pro-inflammatory cytokines was observed only after
      stimulation with ssRNAs, which would increase lysosomal ORNs.
      Patient-derived monocytes harboring the G208R SLC29A3 mutation showed
      enhanced survival and proliferation in a TLR8 antagonist-sensitive manner.
      These results demonstrated that TLR7/8 responses to lysosomal nucleoside
      stress drive SLC29A3 disorders.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;Ly6C&lt;sup&gt;low&lt;/sup&gt; and
      Ly6C&lt;sup&gt;high&lt;/sup&gt; splenic monocytes were obtained by FACS
      sorting from WT, &lt;em&gt;Slc29a3&lt;sup&gt;−/−&lt;/sup&gt;&lt;/em&gt;,
      and &lt;em&gt;Slc29a3&lt;/em&gt;&lt;sup&gt;&lt;em&gt;−/−&lt;/em&gt;
      &lt;/sup&gt;&lt;em&gt;Tlr7&lt;sup&gt;−/−&lt;/sup&gt;&lt;/em&gt; mice.
      Total RNA was extracted using RNeasy Mini Kits (Qiagen, Germany), and the
      quality of RNA was evaluated using the Agilent Bioanalyzer device (Agilent
      Technologies, Santa Clara, CA). The samples with RIN (RNA Integrity
      Number) value of more than 7.3 were subjected to library preparation.
      RNA-seq libraries were prepared with 1 ng of total RNA using an Ion
      AmpliSeq Transcriptome Mouse Gene Expression kit (Thermo Fisher
      Scientific) according to the manufacturer's instructions. The
      libraries were sequenced on Ion Proton using an Ion PI Hi-Q Sequencing 200
      kit and Ion PI Chip v3 (Thermo Fisher Scientific). The FASTQ files were
      generated using AmpliSeqRNA plug-in v5.2.0.3 in the Torrent Suite Software
      v5.2.2 (Thermo Fisher Scientific) and analyzed by ROSALIND (&lt;a
      href="https://rosalind.bio/"&gt;https://rosalind.bio/&lt;/a&gt;,
      OnRamp Bioinformatics, USA), which is a cloud-based bioinformatics
      software. Raw reads were trimmed using Cutadapt, and quality scores were
      assessed using FastQC2. Reads were aligned to the Mus musculus genome
      build mm10 using the STAR aligner. Individual sample reads were quantified
      using HTseq and normalized via relative log expression (RLE) using the
      DESeq2 R library. DEseq2 was used to determine the fold changes and
      p-values. Genes showing more than a 1.5-fold change in expression (p
      &amp;lt; 0.05) were considered to be significantly altered. To interpret
      gene expression profiles, gene set enrichment analysis (GSEA) was
      performed using MSigDB hallmark gene sets to explore the pathways
      associated with SLC29A3 deficiency. Enriched pathways with FDR-adjusted
      p-values lower than 0.05 are shown in Fig. 3B.&lt;/p&gt;
    </description>
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