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Herein, we first identified that plasma IGF1 was an independent\n risk factor in patients with abdominal aortic aneurysm. The IGF1 receptor\n was also activated in aneurysmal aortas from humans and mice, and SMC- or\n fibroblast-specific knockout of IGF1R attenuated AAA formation in mouse\n models, indicating the potential of IGF1R as a therapeutic target.\n Systemic administration of IGF1C peptide exerted an evident inhibitory\n effect on AAA formation and progression via competitive inhibition of IGF1\n binding to its receptor and modulation of downstream AKT/mTOR signaling.\n However, global inhibition of IGF1R signaling induces side effects,\n including abnormal glucose metabolism, muscular disorder, and pain\n hypersensitivity observed after systemic administration of IGF1C or the\n commercialized IGF1R antagonists. Accordingly, local administration of\n IGF1C was realized via ultrasound-guided percutaneous injection of an\n IGF1C-loaded hydrogel, and the therapeutic efficacy was confirmed in a pig\n AAA model, demonstrating its translational potential for AAA therapy.","descriptionType":"Abstract"},{"description":"Aneurysmal aortas were harvested from different groups (Control,\n GelMa, and IGF1C/GelMa) and mRNA was isolated from four aortas per sample\n using Trizol. Then, samples were sequenced by BGI using the DNBSEQ\n platform. The average mapping ratio with reference genome is 93.56%, and\n the average mapping ratio with gene is 74.53%; 18819 genes were\n identified. The complete dataset has not been processed.","descriptionType":"Methods"},{"description":"# Extravascular administration of IGF1R antagonists protects against\n aortic aneurysm in rodent and porcine models\n [https://doi.org/10.5061/dryad.g79cnp5wq](https://doi.org/10.5061/dryad.g79cnp5wq) ## Description of the data and file structure In total, 3 groups (control, GelMa, IGF1C/GelMa) of datasets have been sequenced. In each group, aortic samples were taken from four different individuals. 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    <title>
      Extravascular administration of IGF1R antagonists protects against aortic
      aneurysm in rodent and porcine models
    </title>
  </titles>
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    <subject>Abdominal aortic aneurysm</subject>
    <subject>IGF1</subject>
    <subject>Rat xenograft model</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
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    <date dateType="Created">2023-11-13T08:22:07Z</date>
    <date dateType="Submitted">2024-04-03T01:04:34Z</date>
    <date dateType="Issued">2024-04-05T00:00:00Z</date>
    <date dateType="Available">2024-04-05T00:00:00Z</date>
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    <description descriptionType="Abstract">
      Aortic aneurysm is a life-threatening cardiovascular disease with high
      mortality. Herein, we first identified that plasma IGF1 was an independent
      risk factor in patients with abdominal aortic aneurysm. The IGF1 receptor
      was also activated in aneurysmal aortas from humans and mice, and SMC- or
      fibroblast-specific knockout of IGF1R attenuated AAA formation in mouse
      models, indicating the potential of IGF1R as a therapeutic target.
      Systemic administration of IGF1C peptide exerted an evident inhibitory
      effect on AAA formation and progression via competitive inhibition of IGF1
      binding to its receptor and modulation of downstream AKT/mTOR signaling.
      However, global inhibition of IGF1R signaling induces side effects,
      including abnormal glucose metabolism, muscular disorder, and pain
      hypersensitivity observed after systemic administration of IGF1C or the
      commercialized IGF1R antagonists. Accordingly, local administration of
      IGF1C was realized via ultrasound-guided percutaneous injection of an
      IGF1C-loaded hydrogel, and the therapeutic efficacy was confirmed in a pig
      AAA model, demonstrating its translational potential for AAA therapy.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;Aneurysmal aortas were harvested from different groups (Control,
      GelMa, and IGF1C/GelMa) and mRNA was isolated from four aortas per sample
      using Trizol. Then, samples were sequenced by BGI using the DNBSEQ
      platform. The average mapping ratio with reference genome is 93.56%, and
      the average mapping ratio with gene is 74.53%; 18819 genes were
      identified. The complete dataset has not been processed.&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      # Extravascular administration of IGF1R antagonists protects against
      aortic aneurysm in rodent and porcine models
      [https://doi.org/10.5061/dryad.g79cnp5wq](https://doi.org/10.5061/dryad.g79cnp5wq) ## Description of the data and file structure In total, 3 groups (control, GelMa, IGF1C/GelMa) of datasets have been sequenced. In each group, aortic samples were taken from four different individuals. Each group corresponds to one .fq sequence file.
    </description>
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