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In order to\n derive accurate concentration-response relationships, it is important to\n determine the local concentration of nanoparticles to which the cells are\n actually exposed rather than the nominal concentration of nanoparticles in\n the cell-culture medium. In this study, the sedimentation–diffusion\n process of different sized and charged gold nanoparticles has been\n investigated in vitro by evaluating their settling dynamics and by\n developing a theoretical model to predict the concentration depth-profile\n of nanoparticles in solution over time. Experiments were carried out in\n water and in cell-culture media at a range of controlled temperatures. The\n optical phenomenon of caustics was exploited to track nanoparticles in\n real-time in a conventional optical microscope without any requirement for\n fluorescent labelling that potentially affects the dynamics of the\n nanoparticles. The results obtained demonstrate that size, temperature and\n the stability of the nanoparticles play a pivotal role in regulating\n settling dynamics of nanoparticles. For gold nanoparticles larger than 60\n nm in diameter, the initial nominal concentration did not accurately\n represent the concentration of nanoparticles local to the cells.","descriptionType":"Abstract"},{"description":"The dataset consist of TIF files related to the raw z-stacks\n aquired of the gold nanoparticles suspension tested. Each TIF file\n contains images acquired progressively from the bottom (1st image at 0 μm)\n to the top (last image at 250 μm ± 10 μm) of each nanoparticles suspension\n at a given acquisition time. For more info related to the technique used\n to acquire the images please refer to the original manuscript.\n The file name of each TIF file contains all the information\n related to the nanoparticles and solution properties and of the time step\n of acquisition: File_name=\n size_charge_solution_temperature_acquisition time","descriptionType":"Other"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Engineering and Physical Sciences Research Council","funderIdentifier":"https://ror.org/0439y7842","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Directorate-General Joint Research Centre","funderIdentifier":"https://ror.org/04j5wtv36","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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      <creatorName nameType="Personal">Macko, Peter</creatorName>
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      <creatorName nameType="Personal">Worth, Andrew</creatorName>
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      <creatorName nameType="Personal">Whelan, Maurice</creatorName>
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  <titles>
    <title>Data from: Settling dynamics of nanoparticles in simple and biological media</title>
  </titles>
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    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Nano-technology</subject>
    <subject>gold nanoparticles</subject>
    <subject>sedimentation–diffusion equilibrium</subject>
    <subject>settling dynamics</subject>
    <subject>gravitational sedimentation</subject>
    <subject>target dose</subject>
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    <date dateType="Issued">2020-09-10T00:00:00Z</date>
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    <description descriptionType="Abstract">
      The biological response of organisms exposed to nanoparticles is often
      studied in vitro using adherent monolayers of cultured cells. In order to
      derive accurate concentration-response relationships, it is important to
      determine the local concentration of nanoparticles to which the cells are
      actually exposed rather than the nominal concentration of nanoparticles in
      the cell-culture medium. In this study, the sedimentation–diffusion
      process of different sized and charged gold nanoparticles has been
      investigated in vitro by evaluating their settling dynamics and by
      developing a theoretical model to predict the concentration depth-profile
      of nanoparticles in solution over time. Experiments were carried out in
      water and in cell-culture media at a range of controlled temperatures. The
      optical phenomenon of caustics was exploited to track nanoparticles in
      real-time in a conventional optical microscope without any requirement for
      fluorescent labelling that potentially affects the dynamics of the
      nanoparticles. The results obtained demonstrate that size, temperature and
      the stability of the nanoparticles play a pivotal role in regulating
      settling dynamics of nanoparticles. For gold nanoparticles larger than 60
      nm in diameter, the initial nominal concentration did not accurately
      represent the concentration of nanoparticles local to the cells.
    </description>
    <description descriptionType="Other">
      &lt;p&gt;The dataset consist of TIF files related to the raw z-stacks
      aquired of the gold nanoparticles suspension tested. Each TIF file
      contains images acquired progressively from the bottom (1st image at 0 μm)
      to the top (last image at 250 μm ± 10 μm) of each nanoparticles suspension
      at a given acquisition time. For more info related to the technique used
      to acquire the images please refer to the original manuscript.&lt;/p&gt;
      &lt;p&gt;The file name of each TIF file contains all the information
      related to the nanoparticles and solution properties and of the time step
      of acquisition:&lt;/p&gt; &lt;p&gt;File_name=
      size_charge_solution_temperature_acquisition time&lt;/p&gt;
    </description>
  </descriptions>
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