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(FOS)"}],"contributors":[],"dates":[{"date":"2023-05-22T02:41:13Z","dateType":"Submitted"},{"date":"2023-06-07T00:00:00Z","dateType":"Issued"},{"date":"2023-06-07T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1126/sciadv.adh0183","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["57932619 bytes"],"formats":[],"version":"6","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Spinal cord injury (SCI) often leads to physical limitations, chronic\n pain, significant life changes, and social isolation, increasing the risk\n of chronic psychological stress such as anxiety and depression. Despite\n the recognition of the negative effects of chronic stress on SCI recovery,\n the mechanisms linking stress and regeneration are not fully understood.\n In this study, we examined the impact of chronic stress on primary sensory\n axon regeneration in a mouse model of preconditioning lesions. Our\n findings showed that chronic stress caused mitochondrial damage and energy\n crisis within primary sensory neurons, hindering the regrowth of their\n central axons. The stress hormone corticosterone was identified as a\n critical factor in this process, impacting satellite glial cells instead\n of neurons by suppressing Kir4.1 expression and leading to increased\n neuronal hyperactivity and elevated ROS levels. These high levels of ROS\n altered the shape of the mitochondrial cristae and disrupted ATP\n production, which is essential for powering axonal regeneration. Our\n results highlight the importance of addressing psychological stress in SCI\n patients to promote sensory-motor rehabilitation.","descriptionType":"Abstract"},{"description":"To\n investigate how psychological stress influences axon regeneration, we\n employed a combination of the preconditioning spinal cord injury model and\n the unpredictable chronic mild stress model. Our experimental design\n comprised two mouse models: Pre-SCI and\n Pre-SCI+stress.  In these models, we conducted transcriptomic\n analyses on the lumbar 4-6 ganglions (L4-L6) dorsal root ganglia (DRGs) at\n two distinct post-injury time points, specifically 1-week post-injury (1\n wpi) and 3 weeks post-injury (3 wpi), utilizing\n RNA-sequencing. For the\n Pre-SCI_1w and Pre-SCI+stress_1w groups, DRGs were collected immediately\n after spinal cord injury, which occurred one week after peripheral nerve\n lesions. The only distinction between these two groups was the additional\n 1-week stress exposure given to the Pre-SCI+stress_1w group.Similarly, for\n the Pre-SCI_3w and Pre-SCI+stress_3w groups, DRGs were collected two weeks\n post-spinal cord injury, which equates to three weeks after peripheral\n nerve lesions. The Pre-SCI+stress_3w group, however, also underwent a\n 3-week stress exposure. ","descriptionType":"Methods"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"82171391","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"81671212","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Ministry of Science and Technology of the People's Republic of China","awardNumber":"2021ZD0201700","funderIdentifier":"https://ror.org/027s68j25","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Ministry of Science and Technology of the People's Republic of China","awardNumber":"2022ZD0207200","funderIdentifier":"https://ror.org/027s68j25","funderIdentifierType":"ROR"},{"schemeUri":"https://www.crossref.org/services/funder-registry/","funderName":"Innovative Research Team of High-level Local University in Shanghai","awardNumber":"SHSMU-ZDCX20212000","funderIdentifier":"https://doi.org/10.13039/100020732","funderIdentifierType":"Crossref Funder ID"},{"schemeUri":"https://www.crossref.org/services/funder-registry/","funderName":"Innovative Research Team of High-level Local University in Shanghai","awardNumber":"SHSMU-ZDCX20211900","funderIdentifier":"https://doi.org/10.13039/100020732","funderIdentifierType":"Crossref Funder ID"},{"schemeUri":"https://ror.org","funderName":"Science and Technology Commission of Shanghai Municipality","awardNumber":"20JC1419500","funderIdentifier":"https://ror.org/03kt66j61","funderIdentifierType":"ROR"},{"funderName":"Guangzhou Key Projects of Brain Science and Brain Like Intelligence Technology*","awardNumber":"20200730009"},{"funderName":"Guangzhou Key Projects of Brain Science and Brain Like Intelligence Technology*","awardNumber":"20220600003"},{"funderName":"Guangdong grant 'Key technologies for treatment of brain disorders'","awardNumber":"2018B030332001"},{"funderName":"\n        Program for Young Scholars of Special Appointment at Shanghai\n        Institutions of Higher Learning\n      ","awardNumber":"QD2020026"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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    <title>
      Data for: Chronic stress hinders sensory axon regeneration via impairing
      mitochondrial cristae and OXPHOS
    </title>
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    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Spinal cord injury</subject>
    <subject>axon regeneration</subject>
    <subject>corticosterone</subject>
    <subject>glucocorticoid receptor</subject>
    <subject>satellite glial cell</subject>
    <subject>Kir4.1</subject>
    <subject>primary sensory neurons</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Mitochondria</subject>
    <subject>cristae</subject>
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      Spinal cord injury (SCI) often leads to physical limitations, chronic
      pain, significant life changes, and social isolation, increasing the risk
      of chronic psychological stress such as anxiety and depression. Despite
      the recognition of the negative effects of chronic stress on SCI recovery,
      the mechanisms linking stress and regeneration are not fully understood.
      In this study, we examined the impact of chronic stress on primary sensory
      axon regeneration in a mouse model of preconditioning lesions. Our
      findings showed that chronic stress caused mitochondrial damage and energy
      crisis within primary sensory neurons, hindering the regrowth of their
      central axons. The stress hormone corticosterone was identified as a
      critical factor in this process, impacting satellite glial cells instead
      of neurons by suppressing Kir4.1 expression and leading to increased
      neuronal hyperactivity and elevated ROS levels. These high levels of ROS
      altered the shape of the mitochondrial cristae and disrupted ATP
      production, which is essential for powering axonal regeneration. Our
      results highlight the importance of addressing psychological stress in SCI
      patients to promote sensory-motor rehabilitation.
    </description>
    <description descriptionType="Methods">
      &lt;p class="MsoNormal"&gt;&lt;span lang="EN-GB"&gt;To
      investigate how psychological stress influences axon regeneration, we
      employed a combination of the preconditioning spinal cord injury model and
      the unpredictable chronic mild stress model. Our experimental design
      comprised two mouse models: Pre-SCI and
      Pre-SCI+stress.&lt;/span&gt;&lt;/p&gt; &lt;p
      class="MsoNormal"&gt;&lt;span
      lang="EN-GB"&gt; &lt;/span&gt;&lt;span
      lang="EN-GB"&gt;In these models, we conducted transcriptomic
      analyses on the lumbar 4-6 ganglions (L4-L6) dorsal root ganglia (DRGs) at
      two distinct post-injury time points, specifically 1-week post-injury (1
      wpi) and 3 weeks post-injury (3 wpi), utilizing
      RNA-sequencing.&lt;/span&gt;&lt;/p&gt; &lt;p
      class="MsoNormal"&gt;&lt;span lang="EN-GB"&gt;For the
      Pre-SCI_1w and Pre-SCI+stress_1w groups, DRGs were collected immediately
      after spinal cord injury, which occurred one week after peripheral nerve
      lesions. The only distinction between these two groups was the additional
      1-week stress exposure given to the Pre-SCI+stress_1w group.Similarly, for
      the Pre-SCI_3w and Pre-SCI+stress_3w groups, DRGs were collected two weeks
      post-spinal cord injury, which equates to three weeks after peripheral
      nerve lesions. The Pre-SCI+stress_3w group, however, also underwent a
      3-week stress exposure.&lt;/span&gt;&lt;span
      lang="EN-US"&gt; &lt;/span&gt;&lt;/p&gt;
    </description>
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