{"data":{"id":"10.5061/dryad.f4qrfj78s","type":"dois","attributes":{"doi":"10.5061/dryad.f4qrfj78s","prefix":"10.5061","suffix":"dryad.f4qrfj78s","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Kura, Branislav","nameType":"Personal","givenName":"Branislav","familyName":"Kura","affiliation":["Centre of Experimental Medicine of the Slovak Academy of Sciences"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6743-491X","nameIdentifierScheme":"ORCID"}]},{"name":"Pavelkova, Patricia","nameType":"Personal","givenName":"Patricia","familyName":"Pavelkova","affiliation":["Centre of Experimental Medicine of the Slovak Academy of Sciences"],"nameIdentifiers":[]},{"name":"Kalocayova, Barbora","nameType":"Personal","givenName":"Barbora","familyName":"Kalocayova","affiliation":["Centre of Experimental Medicine of the Slovak Academy of Sciences","Comenius University Bratislava"],"nameIdentifiers":[]},{"name":"Sykora, Matus","nameType":"Personal","givenName":"Matus","familyName":"Sykora","affiliation":["Centre of Experimental Medicine of the Slovak Academy of Sciences"],"nameIdentifiers":[]},{"name":"Vlkovicova, Jana","nameType":"Personal","givenName":"Jana","familyName":"Vlkovicova","affiliation":["Centre of Experimental Medicine of the Slovak Academy of Sciences"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-1366-3826","nameIdentifierScheme":"ORCID"}]},{"name":"Kluknavsky, Michal","nameType":"Personal","givenName":"Michal","familyName":"Kluknavsky","affiliation":["Centre of Experimental Medicine of the Slovak Academy of Sciences"],"nameIdentifiers":[]},{"name":"LeBaron, Tyler","nameType":"Personal","givenName":"Tyler","familyName":"LeBaron","affiliation":["Southern Utah University","Molecular Hydrogen Institute"],"nameIdentifiers":[]},{"name":"Pobijakova, Margita","nameType":"Personal","givenName":"Margita","familyName":"Pobijakova","affiliation":["Nemocnica Bory, a.s","Slovak Medical University"],"nameIdentifiers":[]},{"name":"Sagatova, Andrea","nameType":"Personal","givenName":"Andrea","familyName":"Sagatova","affiliation":["Slovak University of Technology in Bratislava"],"nameIdentifiers":[]},{"name":"Slezak, Jan","nameType":"Personal","givenName":"Jan","familyName":"Slezak","affiliation":["Centre of Experimental Medicine of the Slovak Academy of Sciences"],"nameIdentifiers":[]}],"titles":[{"title":"Comparison of hydrogen administration methods in the treatment of radiation-induced heart disease in rats"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"Cardiovascular diseases","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Inflammation","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area 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(FOS)"}],"contributors":[],"dates":[{"date":"2025-11-19T08:13:04Z","dateType":"Created"},{"date":"2025-12-11T21:10:16Z","dateType":"Submitted"},{"date":"2026-03-03T00:00:00Z","dateType":"Issued"},{"date":"2026-03-03T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1139/cjpp-2025-0085","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["71351 bytes"],"formats":[],"version":"9","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Ionizing radiation is a known risk factor for the occurrence and\n development of cardiovascular diseases, particularly in patients receiving\n thoracic radiotherapy. This exposure leads to oxidative stress and\n inflammation, which can damage cardiac tissue and vascular endothelium.\n Molecular hydrogen (H2) has been recognized for its therapeutic potential,\n including antioxidant effects. In this study, male Wistar rats were\n irradiated with a dose of 10 Gy (X-rays) in the chest area. Two and nine\n days post-irradiation, significant increases in lactate dehydrogenase\n (LDH), catalase, glutathione peroxidase activity, malondialdehyde,\n superoxide, and tumor necrosis factor alpha levels were observed in the\n rat blood plasma or heart tissue. Administration of H2 either via drinking\n H2-rich water (min. 4 mg/L) or inhaling H2 in air (4%), effectively\n decreased oxidative stress, LDH, and inflammatory proteins to normal\n levels. H2 also normalized the nuclear factor erythroid 2-related factor\n 2/Kelch-like ECH-associating protein 1 (Nrf2/Keap1) pathway, an important\n antioxidative response regulator activated by irradiation. Based on these\n results, we can conclude that H2 administration through both routes\n mitigated heart damage caused by irradiation after two and nine days. The\n mitigating effect was more pronounced with H2 gas inhalation, but further\n research is needed for statistically relevant data and mechanistic\n insights.","descriptionType":"Abstract"},{"description":"# Comparison of hydrogen administration methods in the treatment of\n radiation-induced heart disease in rats Dataset DOI:\n [10.5061/dryad.f4qrfj78s](https://doi.org/10.5061/dryad.f4qrfj78s) ##\n Description of the data and file structure **README – Dataset\n description** **Dataset title** Comparison of hydrogen administration\n methods in the treatment of radiation-induced heart disease in rats\n Dataset DOI: 10.5061/dryad.f4qrfj78s **1. Study overview** This dataset\n contains individual-level experimental data from a controlled animal study\n investigating the effects of different hydrogen administration methods on\n radiation-induced heart injury in rats. All measurements are provided at\n the level of individual animals. The dataset allows independent reanalysis\n and full reconstruction of statistical results reported in the manuscript.\n   **2. Experimental design** Animals were randomly assigned to four\n experimental groups: * Control (non-irradiated) * IR (irradiated) * HRW\n (irradiated + hydrogen-rich water) * HRA (irradiated + hydrogen-rich air)\n Measurements were performed at two timepoints: * 2 days post-irradiation\n (2d) * 9 days post-irradiation (9d) **3. File description** File:\n for_Dryad_raw_final_010326.xlsx The file contains one worksheet named: Raw\n data – original laboratory worksheet name (no experimental significance).\n Each row represents one measurement of a single parameter obtained from\n one animal at a specific timepoint. The dataset is organized in\n long-format (tidy data structure). **4. Variables** | **Variable** |\n **Description** | **Possible values / Units** | | :---------------- |\n :-------------------------------- |\n :------------------------------------------------ | | animal\\_id | Unique\n identifier for each animal | e.g., C1, IR3, HRW5 | | group | Experimental\n group | Control, IR, HRW, HRA | | timepoint | Time of measurement | 2d, 9d\n | | measurement\\_type | Type of measurement | biochemistry,\n oxidative\\_stress, gene\\_expression | | parameter | Measured biological\n parameter | see Section 5 | | value | Measured numeric value | Units\n depend on parameter | Missing values: Empty cells indicate missing\n measurements. No artificial numeric placeholders were used. **5. Parameter\n definitions and units** **5.1 Biochemical parameters** | **Parameter** |\n **Description** | **Units** | | :------------ | :----------------------- |\n :-------- | | ALB | Albumin | g/L | | CRE | Creatinine | µmol/L | | GLU |\n Glucose | mmol/L | | ALT | Alanine aminotransferase | µkat/L | | TCHO |\n Total cholesterol | mmol/L | | UA | Uric acid | µmol/L | **5.2 Enzymatic\n and oxidative stress assays** For the following parameters, the dataset\n contains raw spectrophotometric absorbance values measured for individual\n samples. Final enzyme activities reported in the manuscript were\n calculated from these absorbance values according to the\n manufacturer's assay protocols. | **Parameter** | **Description** |\n **Units in dataset** | | :------------------------------ |\n :-------------------------------------- | :-------------------------------\n | | lactate dehydrogenase-1st read | LDH assay, first technical\n measurement | absorbance (optical density, OD) | | lactate\n dehydrogenase-2nd read | LDH assay, second technical measurement |\n absorbance (optical density, OD) | | catalase | Catalase assay (CAT) |\n absorbance (OD) | | glutathione peroxidase-1st read | GPx assay, first\n technical measurement | absorbance (OD) | | glutathione peroxidase-2nd\n read | GPx assay, second technical measurement | absorbance (OD) | |\n malondialdehyde | MDA assay (lipid peroxidation marker) | absorbance (OD)\n | | superoxide | Superoxide chemiluminescence assay | cpm/mg | Note:\n Conversion of absorbance values to enzyme activity units (e.g., U/mL,\n nmol/min/mL) was performed during statistical analysis using\n manufacturer-provided formulas and calibration factors.   **5.3 Western\n blot protein expression** Western blot data represent raw densitometric\n band intensity values obtained from image analysis software (ImageJ). The\n dataset includes: * raw intensity values for target proteins * raw\n intensity values for the housekeeping protein (GAPDH) No normalization was\n applied within the dataset. Normalized protein expression values (target\n protein relative to GAPDH) reported in the manuscript were calculated\n during statistical analysis. Units in dataset: arbitrary densitometric\n units (raw intensity values). | Parameter | Description | | :-------- |\n :------------------------------------------------------------- | | IL-6 |\n Interleukin-6 protein expression | | TNF-a | Tumor necrosis factor alpha\n protein expression | | Nrf2 | Nuclear factor erythroid 2–related factor 2\n protein expression | | Keap1 | Kelch-like ECH-associated protein 1 protein\n expression | | GAPDH | Housekeeping protein used for normalization | **6.\n Software** The dataset is provided as a Microsoft Excel (.xlsx) file and\n can be opened using: * Microsoft Excel (2019 or later) * LibreOffice Calc\n (7.0 or later) * Google Sheets Statistical analyses were performed using:\n GraphPad Prism version 9 (GraphPad Software, USA) No custom scripts were\n used.","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Slovak Research and Development Agency","awardNumber":"APVV-19-0317","funderIdentifier":"https://ror.org/037nx0e70","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Slovak Research and Development Agency","awardNumber":"APVV 21-0410","funderIdentifier":"https://ror.org/037nx0e70","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Slovak Academy of Sciences","awardNumber":"VEGA 2/0092/22","funderIdentifier":"https://ror.org/03h7qq074","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Slovak Academy of Sciences","awardNumber":"VEGA 2/0051/25","funderIdentifier":"https://ror.org/03h7qq074","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Slovak Academy of Sciences","awardNumber":"VEGA 2/0148/22","funderIdentifier":"https://ror.org/03h7qq074","funderIdentifierType":"ROR"},{"funderName":"European Union Structural funds","awardNumber":"ITMS 26230120009"},{"funderName":"Ministry of Education, Research, Development and Youth of the Slovak Republic","awardNumber":"2018/7838:1-26C0"},{"funderName":"Miinistry of Health of The Slovak Republic","awardNumber":"2019/4-CEMSAV-1"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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    <title>
      Comparison of hydrogen administration methods in the treatment of
      radiation-induced heart disease in rats
    </title>
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    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Inflammation</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Oxidative stress</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Radiation</subject>
    <subject>molecular hydrogen</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Health sciences</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Medical and health sciences</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Natural sciences</subject>
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    <date dateType="Created">2025-11-19T08:13:04Z</date>
    <date dateType="Submitted">2025-12-11T21:10:16Z</date>
    <date dateType="Issued">2026-03-03T00:00:00Z</date>
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  <descriptions>
    <description descriptionType="Abstract">
      Ionizing radiation is a known risk factor for the occurrence and
      development of cardiovascular diseases, particularly in patients receiving
      thoracic radiotherapy. This exposure leads to oxidative stress and
      inflammation, which can damage cardiac tissue and vascular endothelium.
      Molecular hydrogen (H2) has been recognized for its therapeutic potential,
      including antioxidant effects. In this study, male Wistar rats were
      irradiated with a dose of 10 Gy (X-rays) in the chest area. Two and nine
      days post-irradiation, significant increases in lactate dehydrogenase
      (LDH), catalase, glutathione peroxidase activity, malondialdehyde,
      superoxide, and tumor necrosis factor alpha levels were observed in the
      rat blood plasma or heart tissue. Administration of H2 either via drinking
      H2-rich water (min. 4 mg/L) or inhaling H2 in air (4%), effectively
      decreased oxidative stress, LDH, and inflammatory proteins to normal
      levels. H2 also normalized the nuclear factor erythroid 2-related factor
      2/Kelch-like ECH-associating protein 1 (Nrf2/Keap1) pathway, an important
      antioxidative response regulator activated by irradiation. Based on these
      results, we can conclude that H2 administration through both routes
      mitigated heart damage caused by irradiation after two and nine days. The
      mitigating effect was more pronounced with H2 gas inhalation, but further
      research is needed for statistically relevant data and mechanistic
      insights.
    </description>
    <description descriptionType="TechnicalInfo">
      # Comparison of hydrogen administration methods in the treatment of
      radiation-induced heart disease in rats Dataset DOI:
      [10.5061/dryad.f4qrfj78s](https://doi.org/10.5061/dryad.f4qrfj78s) ##
      Description of the data and file structure **README – Dataset
      description** **Dataset title** Comparison of hydrogen administration
      methods in the treatment of radiation-induced heart disease in rats
      Dataset DOI: 10.5061/dryad.f4qrfj78s **1. Study overview** This dataset
      contains individual-level experimental data from a controlled animal study
      investigating the effects of different hydrogen administration methods on
      radiation-induced heart injury in rats. All measurements are provided at
      the level of individual animals. The dataset allows independent reanalysis
      and full reconstruction of statistical results reported in the manuscript.
        **2. Experimental design** Animals were randomly assigned to four
      experimental groups: * Control (non-irradiated) * IR (irradiated) * HRW
      (irradiated + hydrogen-rich water) * HRA (irradiated + hydrogen-rich air)
      Measurements were performed at two timepoints: * 2 days post-irradiation
      (2d) * 9 days post-irradiation (9d) **3. File description** File:
      for_Dryad_raw_final_010326.xlsx The file contains one worksheet named: Raw
      data – original laboratory worksheet name (no experimental significance).
      Each row represents one measurement of a single parameter obtained from
      one animal at a specific timepoint. The dataset is organized in
      long-format (tidy data structure). **4. Variables** | **Variable** |
      **Description** | **Possible values / Units** | | :---------------- |
      :-------------------------------- |
      :------------------------------------------------ | | animal\_id | Unique
      identifier for each animal | e.g., C1, IR3, HRW5 | | group | Experimental
      group | Control, IR, HRW, HRA | | timepoint | Time of measurement | 2d, 9d
      | | measurement\_type | Type of measurement | biochemistry,
      oxidative\_stress, gene\_expression | | parameter | Measured biological
      parameter | see Section 5 | | value | Measured numeric value | Units
      depend on parameter | Missing values: Empty cells indicate missing
      measurements. No artificial numeric placeholders were used. **5. Parameter
      definitions and units** **5.1 Biochemical parameters** | **Parameter** |
      **Description** | **Units** | | :------------ | :----------------------- |
      :-------- | | ALB | Albumin | g/L | | CRE | Creatinine | µmol/L | | GLU |
      Glucose | mmol/L | | ALT | Alanine aminotransferase | µkat/L | | TCHO |
      Total cholesterol | mmol/L | | UA | Uric acid | µmol/L | **5.2 Enzymatic
      and oxidative stress assays** For the following parameters, the dataset
      contains raw spectrophotometric absorbance values measured for individual
      samples. Final enzyme activities reported in the manuscript were
      calculated from these absorbance values according to the
      manufacturer's assay protocols. | **Parameter** | **Description** |
      **Units in dataset** | | :------------------------------ |
      :-------------------------------------- | :-------------------------------
      | | lactate dehydrogenase-1st read | LDH assay, first technical
      measurement | absorbance (optical density, OD) | | lactate
      dehydrogenase-2nd read | LDH assay, second technical measurement |
      absorbance (optical density, OD) | | catalase | Catalase assay (CAT) |
      absorbance (OD) | | glutathione peroxidase-1st read | GPx assay, first
      technical measurement | absorbance (OD) | | glutathione peroxidase-2nd
      read | GPx assay, second technical measurement | absorbance (OD) | |
      malondialdehyde | MDA assay (lipid peroxidation marker) | absorbance (OD)
      | | superoxide | Superoxide chemiluminescence assay | cpm/mg | Note:
      Conversion of absorbance values to enzyme activity units (e.g., U/mL,
      nmol/min/mL) was performed during statistical analysis using
      manufacturer-provided formulas and calibration factors.   **5.3 Western
      blot protein expression** Western blot data represent raw densitometric
      band intensity values obtained from image analysis software (ImageJ). The
      dataset includes: * raw intensity values for target proteins * raw
      intensity values for the housekeeping protein (GAPDH) No normalization was
      applied within the dataset. Normalized protein expression values (target
      protein relative to GAPDH) reported in the manuscript were calculated
      during statistical analysis. Units in dataset: arbitrary densitometric
      units (raw intensity values). | Parameter | Description | | :-------- |
      :------------------------------------------------------------- | | IL-6 |
      Interleukin-6 protein expression | | TNF-a | Tumor necrosis factor alpha
      protein expression | | Nrf2 | Nuclear factor erythroid 2–related factor 2
      protein expression | | Keap1 | Kelch-like ECH-associated protein 1 protein
      expression | | GAPDH | Housekeeping protein used for normalization | **6.
      Software** The dataset is provided as a Microsoft Excel (.xlsx) file and
      can be opened using: * Microsoft Excel (2019 or later) * LibreOffice Calc
      (7.0 or later) * Google Sheets Statistical analyses were performed using:
      GraphPad Prism version 9 (GraphPad Software, USA) No custom scripts were
      used.
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