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MRI data is stored as NIFTI files, with one file per\n hemisphere. Gradient echo times were chosen to be approximately 20 ms to\n maximize sensitivity to GGT pathology.","descriptionType":"Abstract"},{"description":"Samples were placed in Fomblin (California Vacuum Technology;\n Freemont, CA), a proton-free fluid with volume magnetic susceptibility\n close to that of tissue. Samples were enclosed in either custom-build\n cylindrical holders or plastic bags, and then left to rest for at least\n two days to allow air bubbles to escape from the tissue. Depending on\n their size, samples were scanned using either a custom-built birdcage coil\n or a custom-modified quadrature birdcage (Varian, Palo Alto, CA, USA)\n coil. These transmit/receive coils were attached to a two-channel\n transmit-receive adapter (Stark Contrast, Erlangen, Germany). The smallest\n coil was chosen that could hold each sample, tuned/matched by hand, and\n then placed into our whole-body 7 T scanner (MAGNETOM Terra, Siemens\n Healthineers, Erlangen, Germany) using plastic shims under the coils to\n position the sample near isocenter. MRI data were\n acquired with a 3D-encoded, multi-echo gradient-recalled echo (GRE)\n sequence with non-selective RF pulses. The final echo was followed by an\n additional completely rephrased readout to measure frequency drifts. Scans\n for individual patients were acquired with somewhat different scanning\n protocols, reflecting the evolution of standard practices at our imaging\n center. Specific details of the scanning parameters for each patient are\n listed in the associated journal article:\n Clinicoanatomic localization of iron-rich gliosis in aphasic\n presentations of globular glial tauopathy, Brain Communications, in\n press Images were reconstructed using the vendor’s\n on-scanner reconstruction software which automatically corrected the\n global frequency drift, combined the signal averages in k-space, and\n produced magnitude images for each echo.","descriptionType":"Methods"},{"description":"# Ex vivo MRI of human brain hemispheres from patients with globular glial\n tauopathy and one typical control Dataset DOI:\n [10.5061/dryad.dbrv15fgk](https://doi.org/10.5061/dryad.dbrv15fgk) ##\n Description of the data and file structure ``` For questions related to\n this dataset, please contact Dylan Tisdall\n (mtisdall@pennmedicine.upenn.edu). Image data is in NIFTI format,\n organized with one file per patient. Imaging data dimensions are described\n in the NIFTI data headers. Details of the specific imaging parameters, as\n well as the patients' clinical and demographic information are\n included in the associated manuscript. ``` ### Files and variables ####\n File: sub-patient1_acq-280um_echo-3_FLASH.nii.gz **Description:** NIFTI\n file of ex vivo MRI for patient 1, 280 um isotropic resolution #### File:\n sub-patient2_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of\n ex vivo MRI for patient 2, 160 um isotropic resolution #### File:\n sub-patient3_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of\n ex vivo MRI for patient 3, 160 um isotropic resolution #### File:\n sub-patient4_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of\n ex vivo MRI for patient 4, 160 um isotropic resolution #### File:\n sub-patient5_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of\n ex vivo MRI for patient 5, 160 um isotropic resolution #### File:\n sub-patient6_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of\n ex vivo MRI for patient 6, 160 um isotropic resolution #### ## Human\n subjects data Consent to publish de-identified data was received as part\n of the research protocol approved by the University of Pennsylvania's\n IRB. All PII has been removed from image headers, and no identifying\n information is included in the associated manuscript.","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"awardUri":"https://reporter.nih.gov/project-details/11265588","schemeUri":"https://ror.org","awardTitle":"Neuropathology \u0026 Genetics Core","funderName":"National Institute on Aging","awardNumber":"2P01AG066597-06A1","funderIdentifier":"https://ror.org/049v75w11","funderIdentifierType":"ROR"},{"awardUri":"https://reporter.nih.gov/project-details/10685403","schemeUri":"https://ror.org","awardTitle":"\n        Microscopic and Large-Scale Networks of Molecular Pathology in\n        Frontotemporal Lobar Degeneration\n      ","funderName":"National Institute of Neurological Disorders and Stroke","awardNumber":"5R01NS109260-05","funderIdentifier":"https://ror.org/01s5ya894","funderIdentifierType":"ROR"},{"awardUri":"https://reporter.nih.gov/project-details/11240344","schemeUri":"https://ror.org","awardTitle":"Glial-mediated Inflammation and Iron Accumulation in Frontotemporal Dementia","funderName":"National Institute on Aging","awardNumber":"5R01AG090414-02","funderIdentifier":"https://ror.org/049v75w11","funderIdentifierType":"ROR"},{"awardUri":"https://reporter.nih.gov/project-details/11126828","schemeUri":"https://ror.org","awardTitle":"Data Management and Statistical Core","funderName":"National Institute on Aging","awardNumber":"5P30AG072979-05","funderIdentifier":"https://ror.org/049v75w11","funderIdentifierType":"ROR"},{"awardUri":"https://reporter.nih.gov/project-details/11184458","schemeUri":"https://ror.org","awardTitle":"\n        Project II: Deciphering the Signatures of Pathological Changes on\n        Alpha-Synuclein\n      ","funderName":"National Institute on Aging","awardNumber":"5P01AG084497-02","funderIdentifier":"https://ror.org/049v75w11","funderIdentifierType":"ROR"},{"awardUri":"https://reporter.nih.gov/project-details/11139447","schemeUri":"https://ror.org","awardTitle":"Spreading Tau Pathology in Non-Amnestic Alzheimer's Disease","funderName":"National Institute on Aging","awardNumber":"5R01AG054519-08","funderIdentifier":"https://ror.org/049v75w11","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Institute of Neurological Disorders and Stroke","awardNumber":"R01NS115068","funderIdentifier":"https://ror.org/01s5ya894","funderIdentifierType":"ROR"},{"awardUri":"https://reporter.nih.gov/project-details/11299009","schemeUri":"https://ror.org","awardTitle":"Imaging Iron-Rich Pathology to Monitor and Diagnose FLTD Subtypes","funderName":"National Institute on Aging","awardNumber":"5R01AG080734-04","funderIdentifier":"https://ror.org/049v75w11","funderIdentifierType":"ROR"},{"funderName":"Penn Institute on Aging"},{"funderName":"DeCrane Family Foundation"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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    <title>
      Ex-vivo MRI of human brain hemispheres from patients with globular glial
      tauopathy and one typical control
    </title>
  </titles>
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    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Frontotemporal dementia</subject>
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    <date dateType="Created">2026-01-26T15:42:12Z</date>
    <date dateType="Submitted">2026-01-26T15:42:46Z</date>
    <date dateType="Issued">2026-02-28T00:00:00Z</date>
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    <description descriptionType="Abstract">
      Ex vivo whole-hemisphere T2*-weighted MRI of 6 human brain hemispheres, 5
      from patients with globular glial tauopathy (GGT) and 1 from a typically
      aging patient. MRI data is stored as NIFTI files, with one file per
      hemisphere. Gradient echo times were chosen to be approximately 20 ms to
      maximize sensitivity to GGT pathology.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;Samples were placed in Fomblin (California Vacuum Technology;
      Freemont, CA), a proton-free fluid with volume magnetic susceptibility
      close to that of tissue. Samples were enclosed in either custom-build
      cylindrical holders or plastic bags, and then left to rest for at least
      two days to allow air bubbles to escape from the tissue. Depending on
      their size, samples were scanned using either a custom-built birdcage coil
      or a custom-modified quadrature birdcage (Varian, Palo Alto, CA, USA)
      coil. These transmit/receive coils were attached to a two-channel
      transmit-receive adapter (Stark Contrast, Erlangen, Germany). The smallest
      coil was chosen that could hold each sample, tuned/matched by hand, and
      then placed into our whole-body 7 T scanner (MAGNETOM Terra, Siemens
      Healthineers, Erlangen, Germany) using plastic shims under the coils to
      position the sample near isocenter.&lt;/p&gt; &lt;p&gt;MRI data were
      acquired with a 3D-encoded, multi-echo gradient-recalled echo (GRE)
      sequence with non-selective RF pulses. The final echo was followed by an
      additional completely rephrased readout to measure frequency drifts. Scans
      for individual patients were acquired with somewhat different scanning
      protocols, reflecting the evolution of standard practices at our imaging
      center. Specific details of the scanning parameters for each patient are
      listed in the associated journal article:&lt;/p&gt;
      &lt;p&gt;Clinicoanatomic localization of iron-rich gliosis in aphasic
      presentations of globular glial tauopathy, Brain Communications, in
      press&lt;/p&gt; &lt;p&gt;Images were reconstructed using the vendor’s
      on-scanner reconstruction software which automatically corrected the
      global frequency drift, combined the signal averages in k-space, and
      produced magnitude images for each echo.&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      # Ex vivo MRI of human brain hemispheres from patients with globular glial
      tauopathy and one typical control Dataset DOI:
      [10.5061/dryad.dbrv15fgk](https://doi.org/10.5061/dryad.dbrv15fgk) ##
      Description of the data and file structure ``` For questions related to
      this dataset, please contact Dylan Tisdall
      (mtisdall@pennmedicine.upenn.edu). Image data is in NIFTI format,
      organized with one file per patient. Imaging data dimensions are described
      in the NIFTI data headers. Details of the specific imaging parameters, as
      well as the patients' clinical and demographic information are
      included in the associated manuscript. ``` ### Files and variables ####
      File: sub-patient1_acq-280um_echo-3_FLASH.nii.gz **Description:** NIFTI
      file of ex vivo MRI for patient 1, 280 um isotropic resolution #### File:
      sub-patient2_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of
      ex vivo MRI for patient 2, 160 um isotropic resolution #### File:
      sub-patient3_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of
      ex vivo MRI for patient 3, 160 um isotropic resolution #### File:
      sub-patient4_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of
      ex vivo MRI for patient 4, 160 um isotropic resolution #### File:
      sub-patient5_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of
      ex vivo MRI for patient 5, 160 um isotropic resolution #### File:
      sub-patient6_acq-160um_echo-2_FLASH.nii.gz **Description:** NIFTI file of
      ex vivo MRI for patient 6, 160 um isotropic resolution #### ## Human
      subjects data Consent to publish de-identified data was received as part
      of the research protocol approved by the University of Pennsylvania's
      IRB. All PII has been removed from image headers, and no identifying
      information is included in the associated manuscript.
    </description>
  </descriptions>
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