{"data":{"id":"10.5061/dryad.d51c5b0j3","type":"dois","attributes":{"doi":"10.5061/dryad.d51c5b0j3","prefix":"10.5061","suffix":"dryad.d51c5b0j3","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Mandal, Subhasis","nameType":"Personal","affiliation":["University of Maryland Eastern Shore"],"nameIdentifiers":[]},{"name":"Kim, Lauren","nameType":"Personal","affiliation":["University of California, Los Angeles"],"nameIdentifiers":[]},{"name":"Kang, Minjee","nameType":"Personal","affiliation":["University of California, Los Angeles"],"nameIdentifiers":[]},{"name":"Elamin, Iram","nameType":"Personal","affiliation":["University of Maryland Eastern Shore"],"nameIdentifiers":[]},{"name":"Rao, Meghna","nameType":"Personal","affiliation":["University of Maryland Eastern Shore"],"nameIdentifiers":[]},{"name":"Elsayed, Ishraga","nameType":"Personal","affiliation":["University of Maryland Eastern Shore"],"nameIdentifiers":[]},{"name":"Xu, Changlu","nameType":"Personal","affiliation":["University of California, Los Angeles"],"nameIdentifiers":[]},{"name":"Aghaloo, Tara","nameType":"Personal","affiliation":["University of California, Los Angeles"],"nameIdentifiers":[]},{"name":"Lee, Min","nameType":"Personal","affiliation":["University of California, Los Angeles"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2813-2091","nameIdentifierScheme":"ORCID"}]},{"name":"Fan, Jiabing","nameType":"Personal","affiliation":["University of Maryland Eastern Shore","University of California, Los Angeles"],"nameIdentifiers":[]}],"titles":[{"title":"Mesenchymal stem/stromal cells-derived exosomal miRNA delivery enhances bone repair in osteoporotic conditions"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Biological sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Materials engineering","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Nano-technology","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"MSC-Derived Exosomes"},{"subject":"miR-423"},{"subject":"bone repair"},{"subject":"Osteoporotic Condition"}],"contributors":[],"dates":[{"date":"2026-01-23T19:14:46Z","dateType":"Created"},{"date":"2026-07-22T17:20:41Z","dateType":"Submitted"},{"date":"2026-07-27T00:00:00Z","dateType":"Issued"},{"date":"2026-07-27T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1177/19373341261471040","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["53029 bytes"],"formats":[],"version":"6","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Osteoporosis-associated bone fractures are a leading cause of disability\n in the elderly population. Developing effective therapeutic strategies to\n enhance bone repair under osteoporotic conditions remains a major clinical\n challenge. Increasing evidence indicates that aberrant lineage commitment\n of mesenchymal stem cells (MSCs) resident in bone marrow contributes to\n osteoporosis-related bone loss. However, incomplete understanding of the\n regulatory mechanisms governing MSC differentiation has limited the\n development of efficient therapeutic approaches. In this study, we\n identified microRNA-423 (miR-423) as a negative regulator of osteogenic\n differentiation, and demonstrated that inhibition of miR-423 significantly\n enhanced osteoblast differentiation of MSCs. To enable in vivo delivery of\n the miR-423 inhibitor for bone repair, MSC-derived exosomes (MSC-Exo) were\n employed as a delivery vehicle, generating Exo–miR-423 inhibitor\n construct. These exosomes were subsequently incorporated into an\n apatite-coated poly(lactic-co-glycolic acid) (PLGA) scaffold to form an\n Exo–miR-423 inhibitor/scaffold complex. Implantation of this complex\n significantly promoted bone healing in a calvarial defect model in\n ovariectomized (OVX) mice. Collectively, these findings demonstrate a\n promising miRNA modulated, exosome-based tissue engineering strategy for\n enhancing bone defect and fracture repair under osteoporotic conditions,\n and highlight its potential for further optimization and translational\n application.","descriptionType":"Abstract"},{"description":"# Mesenchymal stem/stromal cells-derived exosomal miRNA delivery enhances\n bone repair in osteoporotic conditions Dataset DOI:\n [10.5061/dryad.d51c5b0j3](https://doi.org/10.5061/dryad.d51c5b0j3) ##\n Description of the data and file structure This dataset includes raw\n measurements of the osteogenic properties of scaffolds that integrate\n cell-derived exosomes loaded with miR-423 inhibitors in vitro and in a\n mouse calvarial defect model. ### Files and variables #### File:\n Figure_1.xlsx **Description:** miR-423 inhibition promotes osteogenesis in\n OVX-derived MSCs. **(B)** Expression of osteogenic genes in OVX-derived\n MSCs treated with miR-423 inhibitor, miR-423 mimic, or control. MSCs\n isolated from OVX mice were treated with miR-423 mimic, miR-423 inhibitor,\n or PBS control and subsequently induced toward osteogenic differentiation.\n The expression of osteogenic markers was measured by a real-time PCR\n assay. #### File: Figure_2.xlsx **Description:** miR-423 inhibition\n increases ALP expression and mineral deposition in OVX-derived MSCs.\n **(B)** ALP expression in OVX-derived MSCs treated with miR-423 inhibitor,\n miR-423 mimic, or PBS at day 7. **(D)** Mineral deposition in OVX-derived\n MSCs treated with miR-423 inhibitor, miR-423 mimic, or PBS at day 21,\n evaluated by Alizarin Red staining. MSCs isolated from OVX mice were\n treated with miR-423 mimic, miR-423 inhibitor, or PBS control and\n subsequently induced toward osteogenic differentiation. To evaluate ALP\n activity, cells were lysed, incubated with ALP substrate solution, and\n absorbance was measured at 405 nm. Mineralization was evaluated using ARS\n staining. ARS-stained cells were dispersed in acetic acid, and absorbance\n was measured at 405 nm. #### File: Figure_3.xlsx\n **Description:** Exosome-based miR-423 inhibitor delivery increases\n osteogenic induction of OVX-MSCs in 3D. The apatite-PLGA scaffold was\n fabricated to deliver exosome-laden miR-423 inhibitor, exosomes alone, or\n control. Osteogenic induction of the constructs was evaluated in a 3D *in\n vitro* culture encapsulated with OVX-MSCs. **(D)** Gene expression of\n osteogenic markers (Runx2, OCN, Osterix) and the Wnt/ β-catenin signaling\n maker (CTNNB1) measured by a real-time PCR assay. **(F)** ALP expression\n at day 7. **(H)** Mineralization assessed by Alizarin Red staining at day\n 21. Exosomes were isolated from the conditioned medium of cultured MSCs.\n Exosomes loaded with miR-423 inhibitor were generated by transfecting\n exosomes with miR-423 inhibitor using Exo-Fect™ siRNA/miRNA Transfection\n Kit. Exosomes loaded with miR-423 inhibitor were adsorbed onto the apatite\n layer of the PLGA scaffold. MSCs isolated from OVX mice were cultured on\n the scaffold and subsequently induced toward osteogenic differentiation.\n The expression of osteogenic markers was measured by a real-time PCR\n assay. ALP activity and mineral deposition were evaluated using ALP and\n ARS staining. #### File: Figure_4.xlsx **Description:** Exosome-laden\n miR-423 inhibitor enhances calvarial bone repair in OVX mice.\n Quantification of bone repair, including percent bone area **(B)**,\n percent BV/TV (C), and Tb.N **(D)**. The in vivo bone regenerative effect\n of exosome/scaffold complex was evaluated using a calvarial defect model\n in OVX mice. A critical-sized calvarial defect was created in both Sham\n and OVX mice. OVX mice were implanted with blank scaffolds or scaffolds\n loaded with low-dose (10 µg) or high-dose (50 µg) Exosome-laden miR-423\n inhibitor, while Sham mice received blank scaffolds. After eight weeks of\n surgery, all the animals were sacrificed and the calvarial samples were\n collected for μCT analysis and quantification. #### File: Figure_S1.xlsx\n **Description:** Expression of miR-423 in OVX-derived MSCs treated with\n miR-423 inhibitor, miR-423 mimic, or control, as measured by real-time\n PCR. MSCs isolated from OVX mice were treated with miR-423 mimic, miR-423\n inhibitor, or PBS control, and intracellular miR-423 levels were measured\n by a real-time PCR assay. **Abbreviations:** * 3D                  \n Three-dimensional * ALP                 Alkaline phosphatase * ARS       \n          Alizarin red S * BV/TV            Bone Volume / Tissue Volume *\n CT                   Computed Tomography * CTL                 Control *\n COL1A1        Collagen type I alpha 1 * EXO                Exosome * MSC \n              Mesenchymal stem/stromal cells * OCN             \n  Osteocalcin * OVX                Ovariectomized * PBS                \n Phosphate-buffered saline * PCR                 Polymerase chain reaction\n * PLGA              Poly(lactic-co-glycolic acid) * RUNX2          \n Runt-related transcription factor 2 * SCAF               Scaffold * Tb.N \n               Trabecular number","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"awardUri":"https://reporter.nih.gov/project-details/11398256","awardTitle":"Tribbles homolog 3 and BMP-2 induced bone formation","funderName":"National Institute of Dental and Craniofacial Research","awardNumber":"5R01DE027332-07","funderIdentifier":"https://ror.org/004a2wv92","funderIdentifierType":"ROR"},{"awardUri":"https://reporter.nih.gov/project-details/11309628","awardTitle":"Hydrogel delivery of DBM and exosome mimetics for bone repair","funderName":"National Institute of Dental and Craniofacial Research","awardNumber":"5R01DE031711-05","funderIdentifier":"https://ror.org/004a2wv92","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.D51C5B0J3</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Mandal, Subhasis</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/006cymg18" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Maryland Eastern Shore</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Kim, Lauren</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/046rm7j60" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Los Angeles</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Kang, Minjee</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/046rm7j60" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Los Angeles</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Elamin, Iram</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/006cymg18" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Maryland Eastern Shore</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Rao, Meghna</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/006cymg18" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Maryland Eastern Shore</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Elsayed, Ishraga</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/006cymg18" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Maryland Eastern Shore</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Xu, Changlu</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/046rm7j60" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Los Angeles</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Aghaloo, Tara</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/046rm7j60" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Los Angeles</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Lee, Min</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-2813-2091</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/046rm7j60" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Los Angeles</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Fan, Jiabing</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/006cymg18" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Maryland Eastern Shore</affiliation>
      <affiliation affiliationIdentifier="https://ror.org/046rm7j60" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, Los Angeles</affiliation>
    </creator>
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  <titles>
    <title>
      Mesenchymal stem/stromal cells-derived exosomal miRNA delivery enhances
      bone repair in osteoporotic conditions
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2026</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Biological sciences</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Materials engineering</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Nano-technology</subject>
    <subject>MSC-Derived Exosomes</subject>
    <subject>miR-423</subject>
    <subject>bone repair</subject>
    <subject>Osteoporotic Condition</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>National Institute of Dental and Craniofacial Research</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/004a2wv92</funderIdentifier>
      <awardNumber awardURI="https://reporter.nih.gov/project-details/11398256">5R01DE027332-07</awardNumber>
      <awardTitle>Tribbles homolog 3 and BMP-2 induced bone formation</awardTitle>
    </fundingReference>
    <fundingReference>
      <funderName>National Institute of Dental and Craniofacial Research</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/004a2wv92</funderIdentifier>
      <awardNumber awardURI="https://reporter.nih.gov/project-details/11309628">5R01DE031711-05</awardNumber>
      <awardTitle>Hydrogel delivery of DBM and exosome mimetics for bone repair</awardTitle>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Created">2026-01-23T19:14:46Z</date>
    <date dateType="Submitted">2026-07-22T17:20:41Z</date>
    <date dateType="Issued">2026-07-27T00:00:00Z</date>
    <date dateType="Available">2026-07-27T00:00:00Z</date>
  </dates>
  <language>en</language>
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  <descriptions>
    <description descriptionType="Abstract">
      Osteoporosis-associated bone fractures are a leading cause of disability
      in the elderly population. Developing effective therapeutic strategies to
      enhance bone repair under osteoporotic conditions remains a major clinical
      challenge. Increasing evidence indicates that aberrant lineage commitment
      of mesenchymal stem cells (MSCs) resident in bone marrow contributes to
      osteoporosis-related bone loss. However, incomplete understanding of the
      regulatory mechanisms governing MSC differentiation has limited the
      development of efficient therapeutic approaches. In this study, we
      identified microRNA-423 (miR-423) as a negative regulator of osteogenic
      differentiation, and demonstrated that inhibition of miR-423 significantly
      enhanced osteoblast differentiation of MSCs. To enable in vivo delivery of
      the miR-423 inhibitor for bone repair, MSC-derived exosomes (MSC-Exo) were
      employed as a delivery vehicle, generating Exo–miR-423 inhibitor
      construct. These exosomes were subsequently incorporated into an
      apatite-coated poly(lactic-co-glycolic acid) (PLGA) scaffold to form an
      Exo–miR-423 inhibitor/scaffold complex. Implantation of this complex
      significantly promoted bone healing in a calvarial defect model in
      ovariectomized (OVX) mice. Collectively, these findings demonstrate a
      promising miRNA modulated, exosome-based tissue engineering strategy for
      enhancing bone defect and fracture repair under osteoporotic conditions,
      and highlight its potential for further optimization and translational
      application.
    </description>
    <description descriptionType="TechnicalInfo">
      # Mesenchymal stem/stromal cells-derived exosomal miRNA delivery enhances
      bone repair in osteoporotic conditions Dataset DOI:
      [10.5061/dryad.d51c5b0j3](https://doi.org/10.5061/dryad.d51c5b0j3) ##
      Description of the data and file structure This dataset includes raw
      measurements of the osteogenic properties of scaffolds that integrate
      cell-derived exosomes loaded with miR-423 inhibitors in vitro and in a
      mouse calvarial defect model. ### Files and variables #### File:
      Figure_1.xlsx **Description:** miR-423 inhibition promotes osteogenesis in
      OVX-derived MSCs. **(B)** Expression of osteogenic genes in OVX-derived
      MSCs treated with miR-423 inhibitor, miR-423 mimic, or control. MSCs
      isolated from OVX mice were treated with miR-423 mimic, miR-423 inhibitor,
      or PBS control and subsequently induced toward osteogenic differentiation.
      The expression of osteogenic markers was measured by a real-time PCR
      assay. #### File: Figure_2.xlsx **Description:** miR-423 inhibition
      increases ALP expression and mineral deposition in OVX-derived MSCs.
      **(B)** ALP expression in OVX-derived MSCs treated with miR-423 inhibitor,
      miR-423 mimic, or PBS at day 7. **(D)** Mineral deposition in OVX-derived
      MSCs treated with miR-423 inhibitor, miR-423 mimic, or PBS at day 21,
      evaluated by Alizarin Red staining. MSCs isolated from OVX mice were
      treated with miR-423 mimic, miR-423 inhibitor, or PBS control and
      subsequently induced toward osteogenic differentiation. To evaluate ALP
      activity, cells were lysed, incubated with ALP substrate solution, and
      absorbance was measured at 405 nm. Mineralization was evaluated using ARS
      staining. ARS-stained cells were dispersed in acetic acid, and absorbance
      was measured at 405 nm. #### File: Figure_3.xlsx
      **Description:** Exosome-based miR-423 inhibitor delivery increases
      osteogenic induction of OVX-MSCs in 3D. The apatite-PLGA scaffold was
      fabricated to deliver exosome-laden miR-423 inhibitor, exosomes alone, or
      control. Osteogenic induction of the constructs was evaluated in a 3D *in
      vitro* culture encapsulated with OVX-MSCs. **(D)** Gene expression of
      osteogenic markers (Runx2, OCN, Osterix) and the Wnt/ β-catenin signaling
      maker (CTNNB1) measured by a real-time PCR assay. **(F)** ALP expression
      at day 7. **(H)** Mineralization assessed by Alizarin Red staining at day
      21. Exosomes were isolated from the conditioned medium of cultured MSCs.
      Exosomes loaded with miR-423 inhibitor were generated by transfecting
      exosomes with miR-423 inhibitor using Exo-Fect™ siRNA/miRNA Transfection
      Kit. Exosomes loaded with miR-423 inhibitor were adsorbed onto the apatite
      layer of the PLGA scaffold. MSCs isolated from OVX mice were cultured on
      the scaffold and subsequently induced toward osteogenic differentiation.
      The expression of osteogenic markers was measured by a real-time PCR
      assay. ALP activity and mineral deposition were evaluated using ALP and
      ARS staining. #### File: Figure_4.xlsx **Description:** Exosome-laden
      miR-423 inhibitor enhances calvarial bone repair in OVX mice.
      Quantification of bone repair, including percent bone area **(B)**,
      percent BV/TV (C), and Tb.N **(D)**. The in vivo bone regenerative effect
      of exosome/scaffold complex was evaluated using a calvarial defect model
      in OVX mice. A critical-sized calvarial defect was created in both Sham
      and OVX mice. OVX mice were implanted with blank scaffolds or scaffolds
      loaded with low-dose (10 µg) or high-dose (50 µg) Exosome-laden miR-423
      inhibitor, while Sham mice received blank scaffolds. After eight weeks of
      surgery, all the animals were sacrificed and the calvarial samples were
      collected for μCT analysis and quantification. #### File: Figure_S1.xlsx
      **Description:** Expression of miR-423 in OVX-derived MSCs treated with
      miR-423 inhibitor, miR-423 mimic, or control, as measured by real-time
      PCR. MSCs isolated from OVX mice were treated with miR-423 mimic, miR-423
      inhibitor, or PBS control, and intracellular miR-423 levels were measured
      by a real-time PCR assay. **Abbreviations:** * 3D                  
      Three-dimensional * ALP                 Alkaline phosphatase * ARS       
               Alizarin red S * BV/TV            Bone Volume / Tissue Volume *
      CT                   Computed Tomography * CTL                 Control *
      COL1A1        Collagen type I alpha 1 * EXO                Exosome * MSC 
                   Mesenchymal stem/stromal cells * OCN             
       Osteocalcin * OVX                Ovariectomized * PBS                
      Phosphate-buffered saline * PCR                 Polymerase chain reaction
      * PLGA              Poly(lactic-co-glycolic acid) * RUNX2          
      Runt-related transcription factor 2 * SCAF               Scaffold * Tb.N 
                    Trabecular number
    </description>
  </descriptions>
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