{"data":{"id":"10.5061/dryad.d51c5b0hd","type":"dois","attributes":{"doi":"10.5061/dryad.d51c5b0hd","prefix":"10.5061","suffix":"dryad.d51c5b0hd","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Zhang, Jianye","nameType":"Personal","givenName":"Jianye","familyName":"Zhang","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Holubowicz, Rafal","nameType":"Personal","givenName":"Rafal","familyName":"Holubowicz","affiliation":["University of California, Irvine"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-2555-2069","nameIdentifierScheme":"ORCID"}]},{"name":"Smidak, Roman","nameType":"Personal","givenName":"Roman","familyName":"Smidak","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Hu, Yulun","nameType":"Personal","givenName":"Yulun","familyName":"Hu","affiliation":["Case Western Reserve University"],"nameIdentifiers":[]},{"name":"Du, Samuel","nameType":"Personal","givenName":"Samuel","familyName":"Du","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Felgner, Jiin","nameType":"Personal","givenName":"Jiin","familyName":"Felgner","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Palczewska, Grazyna","nameType":"Personal","givenName":"Grazyna","familyName":"Palczewska","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Rodrigues Menezes, Carolline","nameType":"Personal","givenName":"Carolline","familyName":"Rodrigues Menezes","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Risaliti, Eleonora","nameType":"Personal","givenName":"Eleonora","familyName":"Risaliti","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Dong, Zhiqian","nameType":"Personal","givenName":"Zhiqian","familyName":"Dong","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Ma, Xiuli","nameType":"Personal","givenName":"Xiuli","familyName":"Ma","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Shayegan, Mojtaba","nameType":"Personal","givenName":"Mojtaba","familyName":"Shayegan","affiliation":["Case Western Reserve University"],"nameIdentifiers":[]},{"name":"Chen, Paul","nameType":"Personal","givenName":"Paul","familyName":"Chen","affiliation":["Broad Institute","Harvard University","Massachusetts Institute of Technology","Howard Hughes Medical Institute"],"nameIdentifiers":[]},{"name":"Xing, Li","nameType":"Personal","givenName":"Li","familyName":"Xing","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Holubowicz, Maria","nameType":"Personal","givenName":"Maria","familyName":"Holubowicz","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Li, Bowen","nameType":"Personal","givenName":"Bowen","familyName":"Li","affiliation":["Case Western Reserve University"],"nameIdentifiers":[]},{"name":"Liu, David","nameType":"Personal","givenName":"David","familyName":"Liu","affiliation":["Broad Institute","Harvard University","Howard Hughes Medical Institute"],"nameIdentifiers":[]},{"name":"Felgner, Philip","nameType":"Personal","givenName":"Philip","familyName":"Felgner","affiliation":["University of California, Irvine"],"nameIdentifiers":[]},{"name":"Tochtrop, Gregory","nameType":"Personal","givenName":"Gregory","familyName":"Tochtrop","affiliation":["Case Western Reserve University"],"nameIdentifiers":[]},{"name":"Palczewski, Krzysztof","nameType":"Personal","givenName":"Krzysztof","familyName":"Palczewski","affiliation":["University of California, Irvine"],"nameIdentifiers":[]}],"titles":[{"title":"Data from: A combinatorial synthetic strategy for developing genome-editing protein-delivery agents targeting mouse retina"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Biological sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Engineering and technology","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Engineering and technology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Materials engineering","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Materials engineering","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Medical and health sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Medical and health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Medical engineering","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Medical engineering","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Nano-technology","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"CRISPR","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Retina","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Nanomedicine","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[],"dates":[{"date":"2025-11-16T01:25:22Z","dateType":"Created"},{"date":"2025-12-20T06:54:25Z","dateType":"Submitted"},{"date":"2026-02-03T00:00:00Z","dateType":"Issued"},{"date":"2026-02-03T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1038/s41467-026-69077-w","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["322805104 bytes"],"formats":[],"version":"12","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"CRISPR/Cas9-based gene-editing technologies offer promise for treating\n inherited retinal diseases (IRDs); however, safe and efficient ocular\n delivery of precision editors remains challenging. To address this\n challenge, we report a new class of Coomassie brilliant blue (CBB)-derived\n lipidoids that bind and deliver proteins. Subretinal injection of Cre\n complexed with these lipidoids into mT/mG mice leads to robust\n recombination in the retinal pigment epithelium and photoreceptors. We\n employ the CBB-lipidoid platform to deliver adenine base editor (ABE)\n ribonucleoproteins (RNP). Incorporating CBB lipidoids into liposomes\n improves delivery efficiency. CBB11 stands out for facilitating precise in\n vivo ABE-mediated gene editing. Delivery of liposome-CBB11-RNP complexes\n results in a 120-fold increase in base editing compared to RNP alone and\n restores the scotopic ERG b-wave response in the rd12 mouse model. These\n results demonstrate the potential of CBB-augmented, liposome-RNP systems\n for therapeutic gene editing in the eye, paving the way for single-dose\n precision medicines to treat IRDs.","descriptionType":"Abstract"},{"description":"# Data from: A combinatorial synthetic strategy for developing\n genome-editing protein-delivery agents targeting mouse retina ####\n Description of the data and file structure CRISPR/Cas9-based gene-editing\n technologies offer promise for treating inherited retinal diseases (IRDs);\n however, safe and efficient ocular delivery of precision editors remains\n challenging. To address this challenge, we report a new class of Coomassie\n brilliant blue (CBB)-derived lipidoids that bind and deliver proteins.\n Subretinal injection of Cre complexed with these lipidoids into mT/mG mice\n leads to robust recombination in the retinal pigment epithelium and\n photoreceptors. We employ the CBB-lipidoid platform to deliver adenine\n base editor (ABE) ribonucleoproteins (RNP). Incorporating CBB lipidoids\n into liposomes improves delivery efficiency. CBB11 stands out for\n facilitating precise *in vivo* ABE-mediated gene editing. Delivery of\n liposome-CBB11-RNP complexes results in a 120-fold increase in base\n editing compared to RNP alone and restores the scotopic ERG b-wave\n response in the rd12 mouse model. These results demonstrate the potential\n of CBB-augmented, liposome-RNP systems for therapeutic gene editing in the\n eye, paving the way for single-dose precision medicines to treat IRDs. The\n data is organized in compressed subdirectories whose name correspond to\n figures in the main directory (Figure_2b, Figure_3, Figure_S1, etc.).\n Abbreviations: * ABE - adenine base editor - CBB - Coomassie Brilliant\n Blue * CBBZ - Coomassie Brilliant Blue with alkyne moiety - DAPI -\n 4',6-diamidino-2-phenylindole * DMSO - dimethylsulfoxide - EndoV -\n endonuclease V * ERG - electroretinography - GFP - green fluorescent\n protein * HEK - human embryonic kidney cells - IRDs - inherited retinal\n diseases * kDa - kilodaltons - m/z - mass to charge ratio * MW - molecular\n weight - OCT - optical coherence tomography * PAGE - polyacrylamide gel\n electrophoresis - PdI - polydispersity index * RFP - red fluorescent\n protein - RPE - retinal pigment epithelium * RNP - ribonucleoprotein - TAS\n - tris-acetate-sucrose buffer * TEM - transmission electron microscopy\n Source_data.xlsx: contains data used to draw graphs and the statistical\n analyses as reported by GraphPad. The contents are described below.\n Figure_2b.zip. CBB-mediated delivery of Cre recombinase *in vitro* into\n color-switching Cre reporter cells (CS cells). Fluorescence microscopic\n images of HEK color-switch (CS) cells treated with Cre complexed with CBB\n lipidoids. C, Cre without CBB. (c, d) Quantification of GFP-to-RFP\n conversion in CS cells treated with the complexes of Cre recombinase with\n CBB compounds (c) by flow cytometry or with CBBZ compounds (d) by\n fluorescence microscopy. [Cre]/[CBB(Z)] = 1:8; Cre delivery mediated by\n Lipofectamine 3000 (LF) as a positive control is also shown. C, Cre\n recombinase only. NE, no enzyme. Figure_3b.zip Cell-specific delivery of\n Cre recombinase mediated by CBB lipidoids in the mT/mG mouse retina.\n Representative two-photon microscopy images indicating the switch in\n expression from tdTomato to eGFP, one week after subretinal injection of\n Cre recombinase complexed with CBB lipidoids. The RPE layer is orientated\n toward the top. C, Cre recombinase only. The scale is provided in\n micrometers. Images are representative of at least 3 eyes. Figure_4.zip.\n Delivery of ABE-RNPs to *rd12*-reporter cells mediated by CBB lipidoids.\n Fluorescence microscopy images of rd12 reporter cells treated with ABE8e\n NG RNP-CBB complexes. A = ABE RNP only; LF = ABE RNP with Lipofectamine\n 3000, CBB = ABE with specified CBB compound). (c,d) Quantitative\n assessment of ABE-RNP delivery into *rd12*-reporter cells, mediated by\n lipidoid complexes of ABE8e with CBB compounds (c) by flow cytometry; or\n CBBZ compounds (d) by fluorescence-microscopic imaging only.\n [ABE8e]/[CBB(Z)] = 1:8. A, ABE8e-RNP only. NE, no enzyme. (f - Figure_4f)\n Representative urea-PAGE-gel image of products of ABE deamination cleaved\n by EndoV. The gel was imaged with a fluorescein filter. N, no enzyme; P,\n positive control: 60 bp DNA with inosine in the middle; A, ABE-RNP in TAS;\n D, ABE-RNP in TAS with 10% DMSO. Numbers indicate molar excess of the CBB\n compound *versus* ABE. Left to right: N; P; A; D; CBB22: 4, 8, 16; CBB11:\n 4, 8, 16; CBB14: 4, 8, 16. (g) Fluorescence quantification of substrate\n and products of deamination and EndoV cleavage. Two independent samples\n per data point were assayed in parallel. Deaminated (%) is the ratio of\n intensity of the 30 nt band to total intensity of 30 and 60 nt bands.\n Figure_5.zip. Liposome delivery of Cre- and ABE-RNPs to reporter cells.\n (b) The size distribution of the CBB11-alone and CBB11-doped liposomes\n (Lipo1), in TAS buffer. Average of 3 replicates. (c) Fluorescence\n microscopic quantification of the recombination activity triggered by\n Cre-recombinase delivery, mediated by Lipo1 or Lipo2. CBB14 and\n Lipofectamine 3000 served as positive controls. C, Cre recombinase only;\n NE, no enzyme. Data are presented as a mean of 2 replicates. (d) The zeta\n potentials of Lipo1 and Lipo2 in the absence or the presence of ABE-RNP.\n The ratio of ABE-RNP to CBB11 is 1:8. Means of two biological replicates.\n (e - Figure_5e) Representative images of cryo-TEM of Lipo1, ABE-RNP only\n and Lipo1 with ABE-RNP (f) Titration of *in vitro* delivery of ABE8e-RNPs\n mediated by CBB11, CBB14, and Lipo1 ~5 h after the RNP was complexed with\n the CBB compounds and liposomes. The ratio [CBB]/[RNP] = 8:1. The total\n lipid amounts of Lipo 2 and Lipofectamine 3000 were comparable to those\n for Lipo1. (g, h) Titration of *in vitro* delivery of ABE8e-RNPs mediated\n by Lipo3/Lipo4 (g); and Lipo5/Lipo6 (h), respectively, after allowing 15\n min for complex formation in each case. The ionizable lipid concentration\n was always 80-fold greater than the concentration of ABE-RNP. ABE-RNP in\n TAS buffer served as negative control. (i - Figure_5i)\n Fluorescence-microscopic images of *rd12*-reporter cells treated with\n liposome-RNP complex. The RNP concentration was 100 nM. Representative of\n 2 biological replicates. Fluorescence microscopy images of rd12 reporter\n cells treated with ABE8e NG RNP-CBB liposome complexes. e = enhanced. CH1\n = green channel, GFP. CH2 = red channel, TxRed. Overlay = overlay of CH1\n and CH2.\\ CBB11 = 10x_XY08\\ CBB14 = 10x_XY14\\ Lipo1 = 10x_XY20\\ Lipo2 =\n 10x_XY26\\ LF = 10x_XY02\\ NE = 10x_XY38. Figure 6. ABE-RNP delivery\n mediated by CBB-containing liposomes *in rd12* mice. Four-week-old *rd12*\n mice were treated *via* subretinal injection with 20 µM ABE8e-RNPs with\n indicated reagents, with 8-fold molar excess of CBB and 80-fold molar\n excess of SM-102, where applicable. (a) B-wave amplitudes of ERG responses\n of *rd12* mice recorded two weeks after treatments. (b) Quantification of\n the visual chromophore 11-*cis* retinal in the eyes from ABE-treated\n *rd12* mice obtained after a 24-h dark adaptation. *n* = 6 eyes. (c-f)\n Quantification of (c) total DNA editing, (d) total cDNA editing, (e)\n precise DNA editing and (f) precise cDNA editing in the retinal pigment\n epithelium isolated from the treated *rd12* mice. (g) Off-target adenine\n genome-editing in *rd12* mouse RPE after delivery of ABE-RNPs by Lipo1.\n *N* = 4 isolates picked randomly from samples analyzed in c-d.\n Supplementary Figure 2. Identification of oxidation sites on oxCBB11 with\n mass spectrometry. (a,d) Two isomers of oxCBB11 that eluted from the\n silica gel column were injected into the LC-MS and analyzed by\n selected-ion monitoring at m/z 543.5. (b, e) The MS1 spectrum of the peak\n that eluted at 4.65 min (b) and the MS1 spectrum of the peak at 4.93 min\n (e) were similar. (c, f) The MS2 spectrum (c) of the ion at m/z 543.02 in\n panel b suggested hydroxylation events on one of the polyunsaturated fatty\n acid moieties. The MS2 spectrum (f) of the ion at m/z 543.02 in panel e is\n consistent with hydroxylation events on the tertiary amine of CBB11.\n Supplementary Figure 4. Concentration dependence of the in vitro delivery\n of gene editors mediated by representative CBB compounds. (a)\n Quantification by fluorescence microscopic imaging of GFP-to-RFP\n conversion in CS cells. Cells were treated with Cre recombinase (0.5 μM)\n complexed with CBB compounds at increasing concentrations (1-8 μM). The\n cells emit green fluorescence at baseline and red fluorescence after\n editing. (b) Quantification by fluorescence microscopic imaging of the\n area ratio of eGFP to mCherry in rd12-reporter cells treated with ABE-RNPs\n (100 nM) complexed with CBB compounds at increasing concentrations\n (0.2-1.6 μM). Supplementary Figure 5. Relative viability of reporter cells\n treated with Cre or ABE-RNPs, along with CBB compounds. Color-switching\n cells treated with Cre recombinase and CBB compounds 1-22 (a), or\n rd12-reporter cells treated with ABE-RNPs and CBB compounds 1-22 (b), were\n assessed for viability by DAPI exclusion, measured with flow cytometry.\n LF, lipofectamine 3000; C, Cre recombinase only; A, ABE-RNP only; NE, no\n enzyme. Supplementary Figure 6: Cre is complexed by CBB compounds into\n large macromolecular complexes. The particle size distributions of Cre\n complexed with CBB11 and CBB14. CBB11-Cre formed homogenous particles (d =\n 1443 nm, PdI = 0.182), whereas CBB14-Cre formed heterogenous particles\n (average d = 1514 nm, PdI = 0.33) with two species whose d were 167 and\n 2129 nm. d = diameter; PdI = polydispersity index. Supplementary Figure 7\n - Figure_S7.pptx: In vivo two‐photon excitation microscopy demonstrating\n Cre recombinase delivery via CBB lipidoids or lipid-nanoparticle\n formulations in the intact mT/mG mouse eye. One week after subretinal\n injection of the Cre‐containing vector, tdTomato‐to‐eGFP expression\n switching was assessed in the mT/mG model. The left panels show the eGFP\n channel (green), and the right panels display the overlay of the tdTomato\n (red) and eGFP (green) channels. The RPE layer, oriented toward the top,\n is marked by open yellow triangles, and the photoreceptor layer is denoted\n by open blue triangles. Scale numbers correspond to micrometers. Images\n are representative of n = at least 3 eyes. Supplementary Figure 8 -\n Figure_S8.zip: Size-exclusion chromatography of CBB liposomes. (a)\n Coomassie fluorescence scan of a 96-well plate containing samples\n collected from PD10 desalting columns. Ve = elution volume. (b,c) A\n photograph (b) and a Coomassie fluorescence scan (c) of the PD10 desalting\n columns after the size-exclusion chromatography. Column Ve (ml) 1 2.00 2\n 2.25 3 2.50 4 2.75 5 3.00 6 3.25 7 3.50 8 3.75 9 4.00 10 4.25 11 4.50 12\n 4.75 Figure_S9.zip: Addition of CBB11 boosts the liposomal delivery of\n ABE8e-RNPs in rd12-reporter cells. Lipo3-6 correspond to formulations as\n in Fig 5. (a) The particle size distribution of Lipo3 (dark blue) was\n average diameter = 155 nm, with PDI = 0.19; and Lipo4 (orange) was average\n diameter = 155 nm, with PDI = 0.20. (b) The particle size distribution of\n Lipo5 (pale blue) was average diameter = 154 nm, with PDI = 0.17; and\n Lipo6 (yellow) was average diameter = 161 nm, with PDI = 0.15. (c) The\n zeta potential of Lipo3 (dark blue) was -2.64 mV, slightly higher than\n that of Lipo4 (orange), -4.11 mV. (d) The zeta potential of Lipo5 (pale\n blue) was -3.25 mV, slightly lower than that of Lipo6 (yellow), -2.25 mV.\n The measurements for a-d were done 3 replicates. (e) Representative\n fluorescence-microscopic images of rd12-reporter cells treated with\n liposome-RNP complex. The RNP concentration was 50 nM. Lipofectamine 3000\n (LF) served as positive control, and ABE8e-RNPs delivered without vehicles\n (A) served as negative control. The images are representative of 4\n biological replicates. CH1 = green channel, GFP. CH2 = red channel,\n TxRed.\\ XY16 = Lipo3\\ XY22 = Lipo4\\ XY28 = Lipo5\\ XY34 = Lipo6\\ XY40 =\n Lipofectamine 3000\\ XY45 = ABE RNP only. Figure_S10.zip: Representative\n cryo-TEM images of Lipo1. The round vesicles in the images represent lipid\n bilayers of Lipo1 surrounding aqueous cores. Scale bar = 100 nm.\n Figure_S11_RIMG3165.JPG: : Digestion of ABE8e-RNPs (without, or with\n Lipo1) with proteinase K. ABE8e-RNPs were incubated with proteinase K\n (protein:enzyme weight ratio = 100:1) at room temperature for 5, 10, 15,\n or 60 min. ABE8e-RNPs with Lipo1 in the absence of protease K served as a\n negative control.  Left to right: Protein molecular weight marker Bio-Rad\n Precision Plus Prestained; Lipo1 + Proteinase K - 5 min, 10 min, 60 min;\n Lipo1 - Proteinase K + 5 min, 15 min, 60 min; Lipo1 + Proteinase K + 5\n min, 10 min, 60 min; Protein molecular weight marker. From top to bottom,\n protein molecular weight marker bands represent molecular weight (MW) in\n kDa: 250, 150, 100, 75, 50, 37, 25, 20, 15. Molecular weight of ABE: 187.1\n kDa. Figure_S12.zip. (a) Fluorescence microscopic quantification of\n delivery of ABE8e RNP into rd12 reporter cells mediated by liposomes with\n CBB11 (Lipo1, Lipo7) and SM102 (Lipo1, Lipo2). Lipofectamine 3000 (LF) was\n used as a positive control, buffer (TAS) as a negative control. (b)\n Representative fluorescence microscopic images of rd12 reporter cells\n treated with ABE8e RNP complexed with liposomes. The images are\n representative of 4 replicates. Figure_S13.zip.. Treatment of TIGER-HEK\n cells with ABE-RNPs. (b, c) The conversion of non-fluorescent TIGER HEK\n cells to fluorescent after the treatment with ABE8e-NG-RNPs (b) or\n ABE8e-N108Q-NG-RNPs (c), complexed with CBB11, CBB14, Lipo1, or Lipo2.\n [CBB]/[RNP] ratio = 8:1. Results for Lipofectamine 3000 (as a positive\n control) were comparable to Lipo1. Cells treated with ABE-RNP without any\n vehicles (TAS) served as a negative control. Figure_S14.zip: Evaluation of\n the safety and efficacy of Lipo1. (a) Particle size distributions of fresh\n Lipo1, diameter 148 nm and PDI = 0.23; and stored Lipo1, size = 140 nm,\n PDI = 0.16. (b) Fluorescence microscopic quantification of the ratio of\n eGFP to mCherry for rd12 reporter cells, treated with the fresh Lipo1-RNPs\n (100 nM). RNPs with Lipofectamine 3000 (LF) served as positive control,\n and RNPs alone (A) as negative control; [CBB]/[RNP] ratio = 8:1. (c)\n Representative optical coherence tomography (OCT) images of female WT mice\n treated with 20 μM ABE-RNPs alone (R20), 160 μM CBB11 as Lipo1 (L160),\n with 10 μM RNPs and 80 μM CBB11 as Lipo1 (L80R10), or with 20 μM RNPs with\n 160 μM CBB11 as Lipo1 (L160R20); control WT mice (WT N) were non-treated.\n The injection volume was 1 μl. N = 4 eyes per treatment. (d) ERG b-wave\n amplitudes of WT mice whose OCT scans are in panel c. (e) 11-cis-retinal\n levels in WT mice whose ERG responses are presented in d. (f) ERG b-wave\n amplitudes of rd12 mice treated with 0.5 μl of L80R10; 1 μl of L80R10; or\n 1 μl of L160R20. Untreated WT mice (WT N) and rd12 mice (rd12 N) served as\n positive and negative controls, respectively. (g) Quantification of\n 11-cis-retinal levels in rd12 mice whose ERG responses are presented in\n panel f. Figure_S15.zip. Flow cytometry gating strategies. Gating\n strategies used in flow cytometry quantification of (a) CS cells and (b)\n rd12 reporter cells. SSC-A: side scatter area; FSC-A: forward scatter\n area; SSC-H: side scatter, height; FSC-H: forward scatter height; FITC-A:\n green fluorescence intensity; PE-A: red fluorescence intensity; Pacific\n Blue-A: blue fluorescence intensity; P1, P2, P4: gates. Synthesis of CBB:\n Mass spectrometry traces of the CBB compounds. m/z = mass to charge ratio;\n Intensity = signal intensity. ## Sharing/Access information. Amplicon\n sequencing data are available in NCBI Sequencing Read Archive:\n PRJNA1240374 and PRJNA1358750. ## Code/Software. 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  <titles>
    <title>
      Data from: A combinatorial synthetic strategy for developing
      genome-editing protein-delivery agents targeting mouse retina
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
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    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Chemical sciences</subject>
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    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">CRISPR</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Retina</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Nanomedicine</subject>
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  <dates>
    <date dateType="Created">2025-11-16T01:25:22Z</date>
    <date dateType="Submitted">2025-12-20T06:54:25Z</date>
    <date dateType="Issued">2026-02-03T00:00:00Z</date>
    <date dateType="Available">2026-02-03T00:00:00Z</date>
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  <descriptions>
    <description descriptionType="Abstract">
      CRISPR/Cas9-based gene-editing technologies offer promise for treating
      inherited retinal diseases (IRDs); however, safe and efficient ocular
      delivery of precision editors remains challenging. To address this
      challenge, we report a new class of Coomassie brilliant blue (CBB)-derived
      lipidoids that bind and deliver proteins. Subretinal injection of Cre
      complexed with these lipidoids into mT/mG mice leads to robust
      recombination in the retinal pigment epithelium and photoreceptors. We
      employ the CBB-lipidoid platform to deliver adenine base editor (ABE)
      ribonucleoproteins (RNP). Incorporating CBB lipidoids into liposomes
      improves delivery efficiency. CBB11 stands out for facilitating precise in
      vivo ABE-mediated gene editing. Delivery of liposome-CBB11-RNP complexes
      results in a 120-fold increase in base editing compared to RNP alone and
      restores the scotopic ERG b-wave response in the rd12 mouse model. These
      results demonstrate the potential of CBB-augmented, liposome-RNP systems
      for therapeutic gene editing in the eye, paving the way for single-dose
      precision medicines to treat IRDs.
    </description>
    <description descriptionType="TechnicalInfo">
      # Data from: A combinatorial synthetic strategy for developing
      genome-editing protein-delivery agents targeting mouse retina ####
      Description of the data and file structure CRISPR/Cas9-based gene-editing
      technologies offer promise for treating inherited retinal diseases (IRDs);
      however, safe and efficient ocular delivery of precision editors remains
      challenging. To address this challenge, we report a new class of Coomassie
      brilliant blue (CBB)-derived lipidoids that bind and deliver proteins.
      Subretinal injection of Cre complexed with these lipidoids into mT/mG mice
      leads to robust recombination in the retinal pigment epithelium and
      photoreceptors. We employ the CBB-lipidoid platform to deliver adenine
      base editor (ABE) ribonucleoproteins (RNP). Incorporating CBB lipidoids
      into liposomes improves delivery efficiency. CBB11 stands out for
      facilitating precise *in vivo* ABE-mediated gene editing. Delivery of
      liposome-CBB11-RNP complexes results in a 120-fold increase in base
      editing compared to RNP alone and restores the scotopic ERG b-wave
      response in the rd12 mouse model. These results demonstrate the potential
      of CBB-augmented, liposome-RNP systems for therapeutic gene editing in the
      eye, paving the way for single-dose precision medicines to treat IRDs. The
      data is organized in compressed subdirectories whose name correspond to
      figures in the main directory (Figure_2b, Figure_3, Figure_S1, etc.).
      Abbreviations: * ABE - adenine base editor - CBB - Coomassie Brilliant
      Blue * CBBZ - Coomassie Brilliant Blue with alkyne moiety - DAPI -
      4',6-diamidino-2-phenylindole * DMSO - dimethylsulfoxide - EndoV -
      endonuclease V * ERG - electroretinography - GFP - green fluorescent
      protein * HEK - human embryonic kidney cells - IRDs - inherited retinal
      diseases * kDa - kilodaltons - m/z - mass to charge ratio * MW - molecular
      weight - OCT - optical coherence tomography * PAGE - polyacrylamide gel
      electrophoresis - PdI - polydispersity index * RFP - red fluorescent
      protein - RPE - retinal pigment epithelium * RNP - ribonucleoprotein - TAS
      - tris-acetate-sucrose buffer * TEM - transmission electron microscopy
      Source_data.xlsx: contains data used to draw graphs and the statistical
      analyses as reported by GraphPad. The contents are described below.
      Figure_2b.zip. CBB-mediated delivery of Cre recombinase *in vitro* into
      color-switching Cre reporter cells (CS cells). Fluorescence microscopic
      images of HEK color-switch (CS) cells treated with Cre complexed with CBB
      lipidoids. C, Cre without CBB. (c, d) Quantification of GFP-to-RFP
      conversion in CS cells treated with the complexes of Cre recombinase with
      CBB compounds (c) by flow cytometry or with CBBZ compounds (d) by
      fluorescence microscopy. [Cre]/[CBB(Z)] = 1:8; Cre delivery mediated by
      Lipofectamine 3000 (LF) as a positive control is also shown. C, Cre
      recombinase only. NE, no enzyme. Figure_3b.zip Cell-specific delivery of
      Cre recombinase mediated by CBB lipidoids in the mT/mG mouse retina.
      Representative two-photon microscopy images indicating the switch in
      expression from tdTomato to eGFP, one week after subretinal injection of
      Cre recombinase complexed with CBB lipidoids. The RPE layer is orientated
      toward the top. C, Cre recombinase only. The scale is provided in
      micrometers. Images are representative of at least 3 eyes. Figure_4.zip.
      Delivery of ABE-RNPs to *rd12*-reporter cells mediated by CBB lipidoids.
      Fluorescence microscopy images of rd12 reporter cells treated with ABE8e
      NG RNP-CBB complexes. A = ABE RNP only; LF = ABE RNP with Lipofectamine
      3000, CBB = ABE with specified CBB compound). (c,d) Quantitative
      assessment of ABE-RNP delivery into *rd12*-reporter cells, mediated by
      lipidoid complexes of ABE8e with CBB compounds (c) by flow cytometry; or
      CBBZ compounds (d) by fluorescence-microscopic imaging only.
      [ABE8e]/[CBB(Z)] = 1:8. A, ABE8e-RNP only. NE, no enzyme. (f - Figure_4f)
      Representative urea-PAGE-gel image of products of ABE deamination cleaved
      by EndoV. The gel was imaged with a fluorescein filter. N, no enzyme; P,
      positive control: 60 bp DNA with inosine in the middle; A, ABE-RNP in TAS;
      D, ABE-RNP in TAS with 10% DMSO. Numbers indicate molar excess of the CBB
      compound *versus* ABE. Left to right: N; P; A; D; CBB22: 4, 8, 16; CBB11:
      4, 8, 16; CBB14: 4, 8, 16. (g) Fluorescence quantification of substrate
      and products of deamination and EndoV cleavage. Two independent samples
      per data point were assayed in parallel. Deaminated (%) is the ratio of
      intensity of the 30 nt band to total intensity of 30 and 60 nt bands.
      Figure_5.zip. Liposome delivery of Cre- and ABE-RNPs to reporter cells.
      (b) The size distribution of the CBB11-alone and CBB11-doped liposomes
      (Lipo1), in TAS buffer. Average of 3 replicates. (c) Fluorescence
      microscopic quantification of the recombination activity triggered by
      Cre-recombinase delivery, mediated by Lipo1 or Lipo2. CBB14 and
      Lipofectamine 3000 served as positive controls. C, Cre recombinase only;
      NE, no enzyme. Data are presented as a mean of 2 replicates. (d) The zeta
      potentials of Lipo1 and Lipo2 in the absence or the presence of ABE-RNP.
      The ratio of ABE-RNP to CBB11 is 1:8. Means of two biological replicates.
      (e - Figure_5e) Representative images of cryo-TEM of Lipo1, ABE-RNP only
      and Lipo1 with ABE-RNP (f) Titration of *in vitro* delivery of ABE8e-RNPs
      mediated by CBB11, CBB14, and Lipo1 ~5 h after the RNP was complexed with
      the CBB compounds and liposomes. The ratio [CBB]/[RNP] = 8:1. The total
      lipid amounts of Lipo 2 and Lipofectamine 3000 were comparable to those
      for Lipo1. (g, h) Titration of *in vitro* delivery of ABE8e-RNPs mediated
      by Lipo3/Lipo4 (g); and Lipo5/Lipo6 (h), respectively, after allowing 15
      min for complex formation in each case. The ionizable lipid concentration
      was always 80-fold greater than the concentration of ABE-RNP. ABE-RNP in
      TAS buffer served as negative control. (i - Figure_5i)
      Fluorescence-microscopic images of *rd12*-reporter cells treated with
      liposome-RNP complex. The RNP concentration was 100 nM. Representative of
      2 biological replicates. Fluorescence microscopy images of rd12 reporter
      cells treated with ABE8e NG RNP-CBB liposome complexes. e = enhanced. CH1
      = green channel, GFP. CH2 = red channel, TxRed. Overlay = overlay of CH1
      and CH2.\ CBB11 = 10x_XY08\ CBB14 = 10x_XY14\ Lipo1 = 10x_XY20\ Lipo2 =
      10x_XY26\ LF = 10x_XY02\ NE = 10x_XY38. Figure 6. ABE-RNP delivery
      mediated by CBB-containing liposomes *in rd12* mice. Four-week-old *rd12*
      mice were treated *via* subretinal injection with 20 µM ABE8e-RNPs with
      indicated reagents, with 8-fold molar excess of CBB and 80-fold molar
      excess of SM-102, where applicable. (a) B-wave amplitudes of ERG responses
      of *rd12* mice recorded two weeks after treatments. (b) Quantification of
      the visual chromophore 11-*cis* retinal in the eyes from ABE-treated
      *rd12* mice obtained after a 24-h dark adaptation. *n* = 6 eyes. (c-f)
      Quantification of (c) total DNA editing, (d) total cDNA editing, (e)
      precise DNA editing and (f) precise cDNA editing in the retinal pigment
      epithelium isolated from the treated *rd12* mice. (g) Off-target adenine
      genome-editing in *rd12* mouse RPE after delivery of ABE-RNPs by Lipo1.
      *N* = 4 isolates picked randomly from samples analyzed in c-d.
      Supplementary Figure 2. Identification of oxidation sites on oxCBB11 with
      mass spectrometry. (a,d) Two isomers of oxCBB11 that eluted from the
      silica gel column were injected into the LC-MS and analyzed by
      selected-ion monitoring at m/z 543.5. (b, e) The MS1 spectrum of the peak
      that eluted at 4.65 min (b) and the MS1 spectrum of the peak at 4.93 min
      (e) were similar. (c, f) The MS2 spectrum (c) of the ion at m/z 543.02 in
      panel b suggested hydroxylation events on one of the polyunsaturated fatty
      acid moieties. The MS2 spectrum (f) of the ion at m/z 543.02 in panel e is
      consistent with hydroxylation events on the tertiary amine of CBB11.
      Supplementary Figure 4. Concentration dependence of the in vitro delivery
      of gene editors mediated by representative CBB compounds. (a)
      Quantification by fluorescence microscopic imaging of GFP-to-RFP
      conversion in CS cells. Cells were treated with Cre recombinase (0.5 μM)
      complexed with CBB compounds at increasing concentrations (1-8 μM). The
      cells emit green fluorescence at baseline and red fluorescence after
      editing. (b) Quantification by fluorescence microscopic imaging of the
      area ratio of eGFP to mCherry in rd12-reporter cells treated with ABE-RNPs
      (100 nM) complexed with CBB compounds at increasing concentrations
      (0.2-1.6 μM). Supplementary Figure 5. Relative viability of reporter cells
      treated with Cre or ABE-RNPs, along with CBB compounds. Color-switching
      cells treated with Cre recombinase and CBB compounds 1-22 (a), or
      rd12-reporter cells treated with ABE-RNPs and CBB compounds 1-22 (b), were
      assessed for viability by DAPI exclusion, measured with flow cytometry.
      LF, lipofectamine 3000; C, Cre recombinase only; A, ABE-RNP only; NE, no
      enzyme. Supplementary Figure 6: Cre is complexed by CBB compounds into
      large macromolecular complexes. The particle size distributions of Cre
      complexed with CBB11 and CBB14. CBB11-Cre formed homogenous particles (d =
      1443 nm, PdI = 0.182), whereas CBB14-Cre formed heterogenous particles
      (average d = 1514 nm, PdI = 0.33) with two species whose d were 167 and
      2129 nm. d = diameter; PdI = polydispersity index. Supplementary Figure 7
      - Figure_S7.pptx: In vivo two‐photon excitation microscopy demonstrating
      Cre recombinase delivery via CBB lipidoids or lipid-nanoparticle
      formulations in the intact mT/mG mouse eye. One week after subretinal
      injection of the Cre‐containing vector, tdTomato‐to‐eGFP expression
      switching was assessed in the mT/mG model. The left panels show the eGFP
      channel (green), and the right panels display the overlay of the tdTomato
      (red) and eGFP (green) channels. The RPE layer, oriented toward the top,
      is marked by open yellow triangles, and the photoreceptor layer is denoted
      by open blue triangles. Scale numbers correspond to micrometers. Images
      are representative of n = at least 3 eyes. Supplementary Figure 8 -
      Figure_S8.zip: Size-exclusion chromatography of CBB liposomes. (a)
      Coomassie fluorescence scan of a 96-well plate containing samples
      collected from PD10 desalting columns. Ve = elution volume. (b,c) A
      photograph (b) and a Coomassie fluorescence scan (c) of the PD10 desalting
      columns after the size-exclusion chromatography. Column Ve (ml) 1 2.00 2
      2.25 3 2.50 4 2.75 5 3.00 6 3.25 7 3.50 8 3.75 9 4.00 10 4.25 11 4.50 12
      4.75 Figure_S9.zip: Addition of CBB11 boosts the liposomal delivery of
      ABE8e-RNPs in rd12-reporter cells. Lipo3-6 correspond to formulations as
      in Fig 5. (a) The particle size distribution of Lipo3 (dark blue) was
      average diameter = 155 nm, with PDI = 0.19; and Lipo4 (orange) was average
      diameter = 155 nm, with PDI = 0.20. (b) The particle size distribution of
      Lipo5 (pale blue) was average diameter = 154 nm, with PDI = 0.17; and
      Lipo6 (yellow) was average diameter = 161 nm, with PDI = 0.15. (c) The
      zeta potential of Lipo3 (dark blue) was -2.64 mV, slightly higher than
      that of Lipo4 (orange), -4.11 mV. (d) The zeta potential of Lipo5 (pale
      blue) was -3.25 mV, slightly lower than that of Lipo6 (yellow), -2.25 mV.
      The measurements for a-d were done 3 replicates. (e) Representative
      fluorescence-microscopic images of rd12-reporter cells treated with
      liposome-RNP complex. The RNP concentration was 50 nM. Lipofectamine 3000
      (LF) served as positive control, and ABE8e-RNPs delivered without vehicles
      (A) served as negative control. The images are representative of 4
      biological replicates. CH1 = green channel, GFP. CH2 = red channel,
      TxRed.\ XY16 = Lipo3\ XY22 = Lipo4\ XY28 = Lipo5\ XY34 = Lipo6\ XY40 =
      Lipofectamine 3000\ XY45 = ABE RNP only. Figure_S10.zip: Representative
      cryo-TEM images of Lipo1. The round vesicles in the images represent lipid
      bilayers of Lipo1 surrounding aqueous cores. Scale bar = 100 nm.
      Figure_S11_RIMG3165.JPG: : Digestion of ABE8e-RNPs (without, or with
      Lipo1) with proteinase K. ABE8e-RNPs were incubated with proteinase K
      (protein:enzyme weight ratio = 100:1) at room temperature for 5, 10, 15,
      or 60 min. ABE8e-RNPs with Lipo1 in the absence of protease K served as a
      negative control.  Left to right: Protein molecular weight marker Bio-Rad
      Precision Plus Prestained; Lipo1 + Proteinase K - 5 min, 10 min, 60 min;
      Lipo1 - Proteinase K + 5 min, 15 min, 60 min; Lipo1 + Proteinase K + 5
      min, 10 min, 60 min; Protein molecular weight marker. From top to bottom,
      protein molecular weight marker bands represent molecular weight (MW) in
      kDa: 250, 150, 100, 75, 50, 37, 25, 20, 15. Molecular weight of ABE: 187.1
      kDa. Figure_S12.zip. (a) Fluorescence microscopic quantification of
      delivery of ABE8e RNP into rd12 reporter cells mediated by liposomes with
      CBB11 (Lipo1, Lipo7) and SM102 (Lipo1, Lipo2). Lipofectamine 3000 (LF) was
      used as a positive control, buffer (TAS) as a negative control. (b)
      Representative fluorescence microscopic images of rd12 reporter cells
      treated with ABE8e RNP complexed with liposomes. The images are
      representative of 4 replicates. Figure_S13.zip.. Treatment of TIGER-HEK
      cells with ABE-RNPs. (b, c) The conversion of non-fluorescent TIGER HEK
      cells to fluorescent after the treatment with ABE8e-NG-RNPs (b) or
      ABE8e-N108Q-NG-RNPs (c), complexed with CBB11, CBB14, Lipo1, or Lipo2.
      [CBB]/[RNP] ratio = 8:1. Results for Lipofectamine 3000 (as a positive
      control) were comparable to Lipo1. Cells treated with ABE-RNP without any
      vehicles (TAS) served as a negative control. Figure_S14.zip: Evaluation of
      the safety and efficacy of Lipo1. (a) Particle size distributions of fresh
      Lipo1, diameter 148 nm and PDI = 0.23; and stored Lipo1, size = 140 nm,
      PDI = 0.16. (b) Fluorescence microscopic quantification of the ratio of
      eGFP to mCherry for rd12 reporter cells, treated with the fresh Lipo1-RNPs
      (100 nM). RNPs with Lipofectamine 3000 (LF) served as positive control,
      and RNPs alone (A) as negative control; [CBB]/[RNP] ratio = 8:1. (c)
      Representative optical coherence tomography (OCT) images of female WT mice
      treated with 20 μM ABE-RNPs alone (R20), 160 μM CBB11 as Lipo1 (L160),
      with 10 μM RNPs and 80 μM CBB11 as Lipo1 (L80R10), or with 20 μM RNPs with
      160 μM CBB11 as Lipo1 (L160R20); control WT mice (WT N) were non-treated.
      The injection volume was 1 μl. N = 4 eyes per treatment. (d) ERG b-wave
      amplitudes of WT mice whose OCT scans are in panel c. (e) 11-cis-retinal
      levels in WT mice whose ERG responses are presented in d. (f) ERG b-wave
      amplitudes of rd12 mice treated with 0.5 μl of L80R10; 1 μl of L80R10; or
      1 μl of L160R20. Untreated WT mice (WT N) and rd12 mice (rd12 N) served as
      positive and negative controls, respectively. (g) Quantification of
      11-cis-retinal levels in rd12 mice whose ERG responses are presented in
      panel f. Figure_S15.zip. Flow cytometry gating strategies. Gating
      strategies used in flow cytometry quantification of (a) CS cells and (b)
      rd12 reporter cells. SSC-A: side scatter area; FSC-A: forward scatter
      area; SSC-H: side scatter, height; FSC-H: forward scatter height; FITC-A:
      green fluorescence intensity; PE-A: red fluorescence intensity; Pacific
      Blue-A: blue fluorescence intensity; P1, P2, P4: gates. Synthesis of CBB:
      Mass spectrometry traces of the CBB compounds. m/z = mass to charge ratio;
      Intensity = signal intensity. ## Sharing/Access information. Amplicon
      sequencing data are available in NCBI Sequencing Read Archive:
      PRJNA1240374 and PRJNA1358750. ## Code/Software. ImageJ was used for
      image-based estimation of conversion of fluorescent reporter cells.
    </description>
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