{"data":{"id":"10.5061/dryad.crjdfn377","type":"dois","attributes":{"doi":"10.5061/dryad.crjdfn377","prefix":"10.5061","suffix":"dryad.crjdfn377","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Xiang-yuan, Yu","nameType":"Personal","givenName":"Yu","familyName":"Xiang-yuan","affiliation":["Guilin Medical University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7675-4103","nameIdentifierScheme":"ORCID"}]},{"name":"Gong-chen, Huang","nameType":"Personal","givenName":"Huang","familyName":"Gong-chen","affiliation":["Guilin Medical University"],"nameIdentifiers":[]},{"name":"Yu-kun, Wang","nameType":"Personal","givenName":"Wang","familyName":"Yu-kun","affiliation":["Guilin Medical University"],"nameIdentifiers":[]},{"name":"Lin-yuan, Qin","nameType":"Personal","givenName":"Qin","familyName":"Lin-yuan","affiliation":["Guilin Medical University"],"nameIdentifiers":[]},{"name":"Bo, Huang","nameType":"Personal","givenName":"Huang","familyName":"Bo","affiliation":["Guilin Medical University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-1135-6937","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Raw data: Association and functional analysis of angiotensin-converting enzyme 2 gene genetic variants with the pathogenesis of pre-eclampsia"}],"publisher":"Dryad","container":{},"publicationYear":2022,"subjects":[{"subject":"Angiotensin-converting enzyme 2"},{"subject":"variants"},{"subject":"Preeclampsia","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2022-08-31T04:27:05Z","dateType":"Submitted"},{"date":"2022-09-01T00:00:00Z","dateType":"Issued"},{"date":"2022-09-01T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.3389/fendo.2022.926512","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["247751 bytes"],"formats":[],"version":"4","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"These data were generated to investigate the association and functional\n analysis of angiotensin-converting enzyme 2 genetic variants with the\n pathogenesis of pre-eclampsia(PE). This study conducted a case-control\n study involving 327 PE patients and 591 healthy pregnant women to explore\n the associations between candidate variants in the ACE2 gene \n variants and the pathogenesis of PE.This study collected clinical samples\n and data, and used logistic regression, false positive report rate, multi\n factor dimension reduction, functional analysis and other analysis methods\n to process the research data. Potential functional ACE2 gene\n variants (rs2106809 A\u0026gt;G, rs6632677 G\u0026gt;C, and rs2074192\n C\u0026gt;T) were selected and genotyped using kompetitive allele-specific\n PCR. The strength of the associations between the studied genetic variants\n and the risk of PE were evaluated using odds ratios (ORs) and\n corresponding 95% confidence intervals (CIs). Finally,it showed\n that the rs2106809 A\u0026gt;Gis significantly associated with the risk of\n PE via individual locus effects and/or complex gene-gene and\n gene-environment interactions. ","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[{"funderName":"Department of Education, Guangxi, 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