{"data":{"id":"10.5061/dryad.cnp5hqc4q","type":"dois","attributes":{"doi":"10.5061/dryad.cnp5hqc4q","prefix":"10.5061","suffix":"dryad.cnp5hqc4q","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Ali, Sameh","nameType":"Personal","givenName":"Sameh","familyName":"Ali","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-0339-6106","nameIdentifierScheme":"ORCID"}]},{"name":"Badawy, Mohamed","nameType":"Personal","givenName":"Mohamed","familyName":"Badawy","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"Yasseen, Basma","nameType":"Personal","givenName":"Basma","familyName":"Yasseen","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"El-Messiery, Riem","nameType":"Personal","givenName":"Riem","familyName":"El-Messiery","affiliation":["Cairo University"],"nameIdentifiers":[]},{"name":"Abdel-Rahman, Engy","nameType":"Personal","givenName":"Engy","familyName":"Abdel-Rahman","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"Elkhodiry, Aya","nameType":"Personal","givenName":"Aya","familyName":"Elkhodiry","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"Kamel, Azza","nameType":"Personal","givenName":"Azza","familyName":"Kamel","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"El-sayed, Hajar","nameType":"Personal","givenName":"Hajar","familyName":"El-sayed","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"Shedra, Asmaa","nameType":"Personal","givenName":"Asmaa","familyName":"Shedra","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"Hamdy, Rehab","nameType":"Personal","givenName":"Rehab","familyName":"Hamdy","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"Zidan, Mona","nameType":"Personal","givenName":"Mona","familyName":"Zidan","affiliation":["Children's Cancer Hospital Egypt*"],"nameIdentifiers":[]},{"name":"Al-Raawi, Diaa","nameType":"Personal","givenName":"Diaa","familyName":"Al-Raawi","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"Hammad, Mahmoud","nameType":"Personal","givenName":"Mahmoud","familyName":"Hammad","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"Elsharkawy, Nahla","nameType":"Personal","givenName":"Nahla","familyName":"Elsharkawy","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"Ansary, Mohamed El","nameType":"Personal","givenName":"Mohamed El","familyName":"Ansary","affiliation":["Cairo University"],"nameIdentifiers":[]},{"name":"Al-Halfawy, Ahmed","nameType":"Personal","givenName":"Ahmed","familyName":"Al-Halfawy","affiliation":["Cairo University"],"nameIdentifiers":[]},{"name":"Elhadad, Alaa","nameType":"Personal","givenName":"Alaa","familyName":"Elhadad","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"Hatem, Ashraf","nameType":"Personal","givenName":"Ashraf","familyName":"Hatem","affiliation":["Cairo University"],"nameIdentifiers":[]},{"name":"Abouelnaga, Sherif","nameType":"Personal","givenName":"Sherif","familyName":"Abouelnaga","affiliation":["Children's Cancer Hospital Egypt"],"nameIdentifiers":[]},{"name":"Dugan, Laura","nameType":"Personal","givenName":"Laura","familyName":"Dugan","affiliation":["Vanderbilt University Medical Center"],"nameIdentifiers":[]}],"titles":[{"title":"Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality"}],"publisher":"Dryad","container":{},"publicationYear":2021,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2021-11-25T10:55:15Z","dateType":"Submitted"},{"date":"2021-12-16T00:00:00Z","dateType":"Issued"},{"date":"2021-12-16T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1101/2021.04.01.21254767","relatedIdentifierType":"DOI"},{"relationType":"IsCitedBy","relatedIdentifier":"10.7554/elife.69417","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["51189531 bytes"],"formats":[],"version":"5","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This work reports that COVID-19-induced oxidative stress inflicts\n structural damages to human serum albumin (HSA) and is linked with\n mortality outcome in critically ill patients. Analyzing blood samples from\n patients and healthy individuals, the paper provides evidence that\n neutrophils are major sources of oxidative stress in blood and that\n hydrogen peroxide is highly accumulated in plasmas of non-survivors. The\n electron paramagnetic resonance spectra of spin-labeled fatty acids\n (SLFAs) bound with HSA in whole blood of control, survivor, and\n non-survivor subjects (n=10–11) were analyzed to probe structural damages\n to the protein. Non-survivors’ HSA showed dramatically altered biophysical\n parameters that reflect remarkably fluid protein microenvironments.\n Following loading/unloading of 16-DSA, the results show that the transport\n function of HSA may be impaired in severe patients. Stratified at the\n means, Kaplan–Meier survival analysis indicated that lower values of S/W\n ratio and accumulated H2O2 in plasma significantly predicted in-hospital\n mortality.","descriptionType":"Abstract"},{"description":"All patients were recruited\n from Kasr Alainy Cairo University Hospital/ICU-facility at the Internal\n Medicine Quarantine Hospital. Supportive therapy, including supplemental\n oxygen and symptomatic treatment, was administered as required. Patients\n with moderate to severe hypoxia (defined as requiring fraction of inspired\n oxygen [FiO2]≥40%) were transferred to intensive care for further\n management including invasive mechanical ventilation when necessary.\n Patients recruited in the current study were divided into two arms based\n on future mortality outcome: those who survived the past 15 days following\n blood samples collection (Sev-R) and those who died within 15 days of\n samples collection (Sev-D). Details of samples collection and handlings\n are described in details in the published manuscript.","descriptionType":"Methods"},{"description":"The dataset includes source data for all experimental results. A\n few missing values are to be found in the excel sheets. Missing data due\n to insufficient sample size (blood volume received) or processing\n errors. The\n readme file contains an explanation of each of the variables in the\n dataset, its measurement units, and the way it was calculated from the\n primary data. N/A = values not available. Information on how the\n measurements were done can be found in the associated manuscript\n referenced above.","descriptionType":"Other"}],"geoLocations":[],"fundingReferences":[{"funderName":"Children's Cancer Hospital*","awardNumber":"SA-COVID19-2020"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4/metadata.xsd">
  <identifier identifierType="DOI">10.5061/DRYAD.CNP5HQC4Q</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Ali, Sameh</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-0339-6106</nameIdentifier>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Badawy, Mohamed</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Yasseen, Basma</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">El-Messiery, Riem</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03q21mh05" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Cairo University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Abdel-Rahman, Engy</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Elkhodiry, Aya</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Kamel, Azza</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">El-sayed, Hajar</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Shedra, Asmaa</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Hamdy, Rehab</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zidan, Mona</creatorName>
      <affiliation>Children's Cancer Hospital Egypt*</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Al-Raawi, Diaa</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Hammad, Mahmoud</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Elsharkawy, Nahla</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ansary, Mohamed El</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03q21mh05" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Cairo University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Al-Halfawy, Ahmed</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03q21mh05" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Cairo University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Elhadad, Alaa</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Hatem, Ashraf</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03q21mh05" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Cairo University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Abouelnaga, Sherif</creatorName>
      <affiliation>Children's Cancer Hospital Egypt</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Dugan, Laura</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05dq2gs74" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Vanderbilt University Medical Center</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Neutrophil-mediated oxidative stress and albumin structural damage predict
      COVID-19-associated mortality
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2021</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>Children's Cancer Hospital*</funderName>
      <awardNumber>SA-COVID19-2020</awardNumber>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Submitted">2021-11-25T10:55:15Z</date>
    <date dateType="Issued">2021-12-16T00:00:00Z</date>
    <date dateType="Available">2021-12-16T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1101/2021.04.01.21254767</relatedIdentifier>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.7554/eLife.69417</relatedIdentifier>
  </relatedIdentifiers>
  <sizes>
    <size>51189531 bytes</size>
  </sizes>
  <version>5</version>
  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      This work reports that COVID-19-induced oxidative stress inflicts
      structural damages to human serum albumin (HSA) and is linked with
      mortality outcome in critically ill patients. Analyzing blood samples from
      patients and healthy individuals, the paper provides evidence that
      neutrophils are major sources of oxidative stress in blood and that
      hydrogen peroxide is highly accumulated in plasmas of non-survivors. The
      electron paramagnetic resonance spectra of spin-labeled fatty acids
      (SLFAs) bound with HSA in whole blood of control, survivor, and
      non-survivor subjects (n=10–11) were analyzed to probe structural damages
      to the protein. Non-survivors’ HSA showed dramatically altered biophysical
      parameters that reflect remarkably fluid protein microenvironments.
      Following loading/unloading of 16-DSA, the results show that the transport
      function of HSA may be impaired in severe patients. Stratified at the
      means, Kaplan–Meier survival analysis indicated that lower values of S/W
      ratio and accumulated H2O2 in plasma significantly predicted in-hospital
      mortality.
    </description>
    <description descriptionType="Methods">
      &lt;p style="margin-bottom:12px;"&gt;All patients were recruited
      from Kasr Alainy Cairo University Hospital/ICU-facility at the Internal
      Medicine Quarantine Hospital. Supportive therapy, including supplemental
      oxygen and symptomatic treatment, was administered as required. Patients
      with moderate to severe hypoxia (defined as requiring fraction of inspired
      oxygen [FiO2]≥40%) were transferred to intensive care for further
      management including invasive mechanical ventilation when necessary.
      Patients recruited in the current study were divided into two arms based
      on future mortality outcome: those who survived the past 15 days following
      blood samples collection (Sev-R) and those who died within 15 days of
      samples collection (Sev-D). Details of samples collection and handlings
      are described in details in the published manuscript.&lt;/p&gt;
    </description>
    <description descriptionType="Other">
      &lt;p&gt;The dataset includes source data for all experimental results. A
      few missing values are to be found in the excel sheets. Missing data due
      to insufficient sample size (blood volume received) or processing
      errors.&lt;/p&gt; &lt;p style="margin-bottom:12px;"&gt;The
      readme file contains an explanation of each of the variables in the
      dataset, its measurement units, and the way it was calculated from the
      primary data. N/A = values not available. Information on how the
      measurements were done can be found in the associated manuscript
      referenced above.&lt;/p&gt;
    </description>
  </descriptions>
</resource>","url":"https://datadryad.org/dataset/doi:10.5061/dryad.cnp5hqc4q","contentUrl":null,"metadataVersion":8,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":279,"viewsOverTime":[{"yearMonth":"2022-01","total":6},{"yearMonth":"2022-02","total":10},{"yearMonth":"2022-03","total":33},{"yearMonth":"2022-04","total":2},{"yearMonth":"2022-05","total":4},{"yearMonth":"2022-06","total":4},{"yearMonth":"2022-07","total":4},{"yearMonth":"2022-08","total":2},{"yearMonth":"2022-09","total":3},{"yearMonth":"2022-10","total":5},{"yearMonth":"2022-11","total":4},{"yearMonth":"2022-12","total":7},{"yearMonth":"2023-01","total":7},{"yearMonth":"2023-02","total":6},{"yearMonth":"2023-03","total":7},{"yearMonth":"2023-04","total":10},{"yearMonth":"2023-05","total":4},{"yearMonth":"2023-06","total":3},{"yearMonth":"2023-07","total":4},{"yearMonth":"2023-08","total":30},{"yearMonth":"2023-09","total":29},{"yearMonth":"2023-10","total":11},{"yearMonth":"2023-11","total":6},{"yearMonth":"2024-01","total":1},{"yearMonth":"2024-02","total":2},{"yearMonth":"2024-03","total":2},{"yearMonth":"2024-04","total":4},{"yearMonth":"2024-05","total":3},{"yearMonth":"2024-06","total":3},{"yearMonth":"2024-07","total":3},{"yearMonth":"2024-08","total":2},{"yearMonth":"2024-09","total":1},{"yearMonth":"2024-10","total":4},{"yearMonth":"2024-11","total":1},{"yearMonth":"2024-12","total":1},{"yearMonth":"2025-01","total":4},{"yearMonth":"2025-02","total":3},{"yearMonth":"2025-04","total":8},{"yearMonth":"2025-06","total":1},{"yearMonth":"2025-07","total":2},{"yearMonth":"2025-08","total":2},{"yearMonth":"2025-09","total":2},{"yearMonth":"2025-10","total":2},{"yearMonth":"2025-11","total":3},{"yearMonth":"2025-12","total":3},{"yearMonth":"2026-01","total":2},{"yearMonth":"2026-02","total":5},{"yearMonth":"2026-03","total":1},{"yearMonth":"2026-05","total":2},{"yearMonth":"2026-08","total":6},{"yearMonth":"2026-09","total":5}],"downloadCount":50,"downloadsOverTime":[{"yearMonth":"2022-01","total":3},{"yearMonth":"2022-02","total":1},{"yearMonth":"2022-03","total":1},{"yearMonth":"2022-05","total":1},{"yearMonth":"2022-08","total":1},{"yearMonth":"2022-11","total":1},{"yearMonth":"2022-12","total":2},{"yearMonth":"2023-01","total":4},{"yearMonth":"2023-02","total":1},{"yearMonth":"2023-03","total":3},{"yearMonth":"2023-04","total":5},{"yearMonth":"2023-10","total":2},{"yearMonth":"2023-11","total":1},{"yearMonth":"2024-01","total":0},{"yearMonth":"2024-02","total":1},{"yearMonth":"2024-03","total":2},{"yearMonth":"2024-04","total":0},{"yearMonth":"2024-05","total":0},{"yearMonth":"2024-06","total":2},{"yearMonth":"2024-07","total":2},{"yearMonth":"2024-08","total":2},{"yearMonth":"2024-09","total":1},{"yearMonth":"2024-10","total":1},{"yearMonth":"2024-11","total":1},{"yearMonth":"2024-12","total":1},{"yearMonth":"2025-01","total":1},{"yearMonth":"2025-02","total":1},{"yearMonth":"2025-04","total":2},{"yearMonth":"2025-06","total":0},{"yearMonth":"2025-07","total":0},{"yearMonth":"2025-08","total":1},{"yearMonth":"2025-09","total":0},{"yearMonth":"2025-10","total":1},{"yearMonth":"2025-11","total":0},{"yearMonth":"2025-12","total":2},{"yearMonth":"2026-01","total":1},{"yearMonth":"2026-02","total":1},{"yearMonth":"2026-03","total":0},{"yearMonth":"2026-05","total":0},{"yearMonth":"2026-08","total":0},{"yearMonth":"2026-09","total":1}],"referenceCount":0,"citationCount":2,"citationsOverTime":[{"year":"2025","total":2}],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2021-12-16T19:51:14.000Z","registered":"2021-12-16T19:51:15.000Z","published":"2021","updated":"2026-03-13T20:58:44.000Z"},"relationships":{"client":{"data":{"id":"dryad.dryad","type":"clients"}},"provider":{"data":{"id":"dryad","type":"providers"}},"media":{"data":{"id":"10.5061/dryad.cnp5hqc4q","type":"media"}},"references":{"data":[]},"citations":{"data":[{"id":"10.1101/2021.04.01.21254767","type":"dois"},{"id":"10.7554/elife.69417","type":"dois"}]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}