{"data":{"id":"10.5061/dryad.ck2cm","type":"dois","attributes":{"doi":"10.5061/dryad.ck2cm","prefix":"10.5061","suffix":"dryad.ck2cm","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Comeault, Aaron Arthur","nameType":"Personal","givenName":"Aaron Arthur","familyName":"Comeault","affiliation":[],"nameIdentifiers":[]},{"name":"Soria-Carrasco, Víctor","nameType":"Personal","givenName":"Víctor","familyName":"Soria-Carrasco","affiliation":[],"nameIdentifiers":[]},{"name":"Gompert, Zach","nameType":"Personal","givenName":"Zach","familyName":"Gompert","affiliation":[],"nameIdentifiers":[]},{"name":"Farkas, Timothy E.","nameType":"Personal","givenName":"Timothy E.","familyName":"Farkas","affiliation":[],"nameIdentifiers":[]},{"name":"Buerkle, C. Alex","nameType":"Personal","givenName":"C. 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Here we\n quantitatively describe the genetic architecture of traits that are\n subject to known intensities of differential selection between host plant\n species in Timema cristinae stick insects. Specifically, we used\n phenotypic measurements of 10 traits and 211,004 single-nucleotide\n polymorphisms (SNPs) to conduct multilocus genome-wide association\n mapping. We identified a modest number of SNPs that were associated with\n traits and sometimes explained a large proportion of trait variation.\n These SNPs varied in their strength of association with traits, and both\n major and minor effect loci were discovered. However, we found no\n relationship between variation in levels of divergence among traits in\n nature and variation in parameters describing the genetic architecture of\n those same traits. Our results provide a first step toward identifying\n loci underlying adaptation in T. cristinae. Future studies will examine\n the genomic location, population differentiation, and response to\n selection of the trait-associated SNPs described here.","descriptionType":"Abstract"},{"description":"Phenotypic measurements\n of Timema cristinaeFile contains all the\n raw phenotypic measurements for all individuals included in the\n genome-wide association mapping analyses (\"individual\" begins\n with \"FHA\") and the same measurements for individuals collected\n from two additional populations (\"individual\" begins with\n \"VPC\" or \"HVA\").Tcris_FHA_phenotypes.txtTcris_fin_mod_snpcntII.txtFile contains variant counts (snp calling) for each individual. This file was used to estimate genotype probabilities that were ultimately used to generate the composite genotypes (see \"Tcris_pimass_composite_genotypes.txt\" file for these) use in GWAS analyses carried out in piMASS.Tcris_pimass_composite_genotypes.txtInput genotype file for piMASS. Contains composite genotypic values for each individual.Tcris_pimass_FHA_hiPIP_snpFile contains all snps (snp_id) with Rao-Blackwell posterior inclusion probabilities (PIP_rb) greater than 0.01 and includes the trait a given snp was associated with (trait) and the estimate of beta given by piMASS (B_rb).","descriptionType":"Other"}],"geoLocations":[{"geoLocationPlace":"Far Hill Adenostoma"},{"geoLocationPlace":"Los Padres National Forest"},{"geoLocationPlace":"California"}],"fundingReferences":[],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.CK2CM</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Comeault, Aaron Arthur</creatorName>
    </creator>
    <creator>
      <creatorName nameType="Personal">Soria-Carrasco, Víctor</creatorName>
    </creator>
    <creator>
      <creatorName nameType="Personal">Gompert, Zach</creatorName>
    </creator>
    <creator>
      <creatorName nameType="Personal">Farkas, Timothy E.</creatorName>
    </creator>
    <creator>
      <creatorName nameType="Personal">Buerkle, C. Alex</creatorName>
    </creator>
    <creator>
      <creatorName nameType="Personal">Parchman, Thomas L.</creatorName>
    </creator>
    <creator>
      <creatorName nameType="Personal">Nosil, Patrik</creatorName>
    </creator>
  </creators>
  <titles>
    <title>
      Data from: Genome-wide association mapping of phenotypic traits subject to
      a range of intensities of natural selection in Timema cristinae
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2013</publicationYear>
  <subjects>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Genetics</subject>
    <subject>Timema cristinae</subject>
    <subject>stick-insect</subject>
  </subjects>
  <dates>
    <date dateType="Submitted">2013-09-26T10:16:23Z</date>
    <date dateType="Issued">2013-09-26T14:16:41Z</date>
    <date dateType="Available">2013-09-26T14:16:41Z</date>
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    <description descriptionType="Abstract">
      The genetic architecture of adaptive traits can reflect the evolutionary
      history of populations and also shape divergence among populations.
      Despite this central role in evolution, relatively little is known
      regarding the genetic architecture of adaptive traits in nature,
      particularly for traits subject to known selection intensities. Here we
      quantitatively describe the genetic architecture of traits that are
      subject to known intensities of differential selection between host plant
      species in Timema cristinae stick insects. Specifically, we used
      phenotypic measurements of 10 traits and 211,004 single-nucleotide
      polymorphisms (SNPs) to conduct multilocus genome-wide association
      mapping. We identified a modest number of SNPs that were associated with
      traits and sometimes explained a large proportion of trait variation.
      These SNPs varied in their strength of association with traits, and both
      major and minor effect loci were discovered. However, we found no
      relationship between variation in levels of divergence among traits in
      nature and variation in parameters describing the genetic architecture of
      those same traits. Our results provide a first step toward identifying
      loci underlying adaptation in T. cristinae. Future studies will examine
      the genomic location, population differentiation, and response to
      selection of the trait-associated SNPs described here.
    </description>
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      class="o-heading__level3-file-title"&gt;Phenotypic measurements
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      class="o-metadata__file-description"&gt;File contains all the
      raw phenotypic measurements for all individuals included in the
      genome-wide association mapping analyses ("individual" begins
      with "FHA") and the same measurements for individuals collected
      from two additional populations ("individual" begins with
      "VPC" or "HVA").&lt;/div&gt;&lt;div
      class="o-metadata__file-name"&gt;Tcris_FHA_phenotypes.txt&lt;/br&gt;&lt;/div&gt;&lt;div class="o-metadata__file-name"&gt;&lt;/div&gt;&lt;/div&gt;&lt;div class="o-metadata__file-usage-entry"&gt;&lt;h4 class="o-heading__level3-file-title"&gt;Tcris_fin_mod_snpcntII.txt&lt;/h4&gt;&lt;div class="o-metadata__file-description"&gt;File contains variant counts (snp calling) for each individual. This file was used to estimate genotype probabilities that were ultimately used to generate the composite genotypes (see "Tcris_pimass_composite_genotypes.txt" file for these) use in GWAS analyses carried out in piMASS.&lt;/div&gt;&lt;div class="o-metadata__file-name"&gt;&lt;/div&gt;&lt;/div&gt;&lt;div class="o-metadata__file-usage-entry"&gt;&lt;h4 class="o-heading__level3-file-title"&gt;Tcris_pimass_composite_genotypes.txt&lt;/h4&gt;&lt;div class="o-metadata__file-description"&gt;Input genotype file for piMASS. Contains composite genotypic values for each individual.&lt;/div&gt;&lt;div class="o-metadata__file-name"&gt;&lt;/div&gt;&lt;/div&gt;&lt;div class="o-metadata__file-usage-entry"&gt;&lt;h4 class="o-heading__level3-file-title"&gt;Tcris_pimass_FHA_hiPIP_snp&lt;/h4&gt;&lt;div class="o-metadata__file-description"&gt;File contains all snps (snp_id) with Rao-Blackwell posterior inclusion probabilities (PIP_rb) greater than 0.01 and includes the trait a given snp was associated with (trait) and the estimate of beta given by piMASS (B_rb).&lt;/div&gt;&lt;div class="o-metadata__file-name"&gt;&lt;/div&gt;&lt;/div&gt;
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