{"data":{"id":"10.5061/dryad.9zw3r22qj","type":"dois","attributes":{"doi":"10.5061/dryad.9zw3r22qj","prefix":"10.5061","suffix":"dryad.9zw3r22qj","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Beaucoté, Victor","nameType":"Personal","givenName":"Victor","familyName":"Beaucoté","affiliation":["Hôpital Lariboisière"],"nameIdentifiers":[]},{"name":"Cartailler, Jérôme","nameType":"Personal","givenName":"Jérôme","familyName":"Cartailler","affiliation":["Inserm"],"nameIdentifiers":[]},{"name":"Trillat, Bernard","nameType":"Personal","givenName":"Bernard","familyName":"Trillat","affiliation":["Hôpital Foch"],"nameIdentifiers":[]},{"name":"Gayat, Etienne","nameType":"Personal","givenName":"Etienne","familyName":"Gayat","affiliation":["Hôpital Lariboisière"],"nameIdentifiers":[]},{"name":"Fischler, Marc","nameType":"Personal","givenName":"Marc","familyName":"Fischler","affiliation":["Hôpital Foch"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0729-5430","nameIdentifierScheme":"ORCID"}]},{"name":"Le Guen, Morgan","nameType":"Personal","givenName":"Morgan","familyName":"Le Guen","affiliation":["Hôpital Foch"],"nameIdentifiers":[]},{"name":"Vallée, Alexandre","nameType":"Personal","givenName":"Alexandre","familyName":"Vallée","affiliation":["Hôpital Foch"],"nameIdentifiers":[]}],"titles":[{"title":"Relationship between intraoperative drop in pulse pressure and minimum mean arterial pressure with postoperative length of stay according to main patients’ characteristics: A retrospective monocentric study"}],"publisher":"Dryad","container":{},"publicationYear":2024,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Age groups","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Anesthesia","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Hypotension","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Sex"},{"subject":"Length of Stay"}],"contributors":[],"dates":[{"date":"2024-09-18T18:48:48Z","dateType":"Created"},{"date":"2024-09-18T18:48:58Z","dateType":"Submitted"},{"date":"2024-10-09T00:00:00Z","dateType":"Issued"},{"date":"2024-10-09T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":["22069433 bytes"],"formats":[],"version":"2","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Intraoperative hypotension (IOH) is associated with organ failure. There\n is no consensus on the IOH definition, but the recommendations agree on a\n threshold of mean arterial pressure (MAP) between 60-70 mmHg. Prolonged\n postoperative length of stay (pLOS) is a surrogate for organ injuries. Our\n study focuses on the relationship between IOH and pLOS risk considering\n the main patient characteristics (sex and age) using\n a retrospective single-centre cohort study of adult patients\n having received general anesthesia for a scheduled non-cardiac surgical\n procedure. pLOS was defined as a LOS higher than the median value (main\n outcome). Relationships between the IOH variables selected from a previous\n study (difference between the larger and smaller pulse pressure values\n (DropPP), minimal MAP (MinMAP), and cumulative time pulse pressure spent\n above 61mmHg (CumTimePP\u0026gt;61mmHg) and the risk of pLOS are\n represented by knotted linear splines. Our study examined 9,516\n patients. The relationship between DropPP and pLOS risk was pseudolinear\n with no activation threshold (slope 0.29-0.52%/mmHg). For MinMAP, this\n relationship describes an activation threshold at 73 mmHg below which the\n association is linear (slope -0.64%/mmHg). For CumTimePP\u0026gt;61, the\n risk of pLOS rapidly rises (initial slope 8.39%/min) up to a saturation\n threshold at two minutes. Women had a lower pLOS risk and IOH threshold.\n Older patients had a higher pLOS risk and did not exhibit an IOH\n threshold. The IOH threshold (MAP\u0026lt;73 mmHg) is consistent\n with the existing literature. The variability of PP as well as age and sex\n are key parameters in pLOS risk.","descriptionType":"Abstract"},{"description":"This retrospective single-centre study was managed in a tertiary\n academic private non-profit hospital. Patients were collectively informed\n (by means of posters) that their data could be used for research purposes,\n on condition that the data were anonymized. This information included the\n necessary information to enable them to refuse their participation. As a\n result of this procedure, the need for consent was waived by the local\n Ethics Committee which approved this retrospective study. Authors had no\n access to information that could identify individual participants during\n or after data collection. Patient characteristics and\n preoperative medications were collected from Cesare™, a computerized\n software for preoperative anesthetic evaluation (Bow Médical, 80440 Boves,\n France). Centricity Anesthesia software was used to collect intraoperative\n variables (GE Healthcare, 78 530 Buc, France). The length of stay and\n in-hospital mortality were obtained by questioning the health data\n warehouse.","descriptionType":"Methods"},{"description":"# Relationship between intraoperative drop in pulse pressure and minimum\n mean arterial pressure with postoperative length of stay according to main\n patients’ characteristics in a retrospective monocentric study\n [https://doi.org/10.5061/dryad.9zw3r22qj](https://doi.org/10.5061/dryad.9zw3r22qj) ## Description of the data and file structure #### The demography table contains the main patients' characteristics. (Demography.csv)  id_data | Patient number  surgery | 1: general; 2: lung; 3:neurosurgery; 4: urology; 5: vascular; 6: gynecology; 7: ENT  age | 1: below 65 years; 2: 65 years and more  sex | 1:M; 2: F  los | Length of postoperative stay (days)  time_quartile | Quartile of surgery duration (absolute number)  median_Stay | Median length of stay (days)  Q3_Stay | Third quartile of the length of stay (days)  Q90_Stay | 90th percentile of the length of stay (days)  Short_IQR | Interquartile range of length of stay \u0026lt;=1 (Q3-Q1) (days) #### The measurements table contains intraoperative blood pressure measurements. (Demography.csv)  id_data | Patient number Min_MAP | minimal value of mean arterial pressure (mmHg) Max_MAP | maximal value of mean arterial pressure (mmHg) Delta_MAP | Largest Drop in MAP during surgery (mmHg) Mean_MAP | Mean MAP (mmHg) Median_MAP | Median MAP (mmHg) std_MAP | standard deviation of MAP (mmHg) Var_MAP | MAP variability (absolute number) Cum_time*MAP*[XX] | cumulative time of mean arterial pressure below [XX] mmHg (minutes) Area_time*MAP*[XX] | cumulative area of mean arterial pressure below [XX] mmHg (absolute number) Min_PP | minimal value of pulse pressure (mmHg) Max_PP | maximal value of pulse pressure (mmHg) Delta_PP | Largest Drop in PP during surgery (mmHg) Mean_PP | Mean PP (mmHg) Median_PP | Median PP (mmHg) std_PP | standard deviation of PP (mmHg) Var_PP | PP variability (absolute number) Cum_time*PP*[XX] | cumulative time of pulse pressure below [XX] mmHg (minutes) Cum_area*PP*[XX] | cumulative area of pulse pressure below [XX] mmHg (absolute number) Min_S | minimal value of systolic arterial pressure (mmHg) Max_S | maximal value of systolic arterial pressure (mmHg) Delta_S | Largest Drop in S during surgery (mmHg) Mean_S | Mean S (mmHg) Median_S | Median S (mmHg) std_S | standard deviation of S (mmHg) Var_S | S variability (absolute number) Cum_time*S*[XX] | cumulative time of systolic arterial pressure below [XX] mmHg (minutes) Area_time*S*[XX] cumulative area of systolic arterial pressure below [XX] mmHg (absolute number) Min_D | minimal value of diastolic arterial pressure (mmHg) Max_D | maximal value of diastolic arterial pressure (mmHg) Delta_D | Largest Drop in diastolic arterial during surgery (mmHg) Mean_D | Mean diastolic arterial (mmHg) Median_D | Median diastolic arterial (mmHg) std_D | standard deviation of diastolic arterial (mmHg) Var_D | diastolic arterial variability (absolute number) Cum_time*D*[XX] | cumulative time of diastolic pressure below [XX] mmHg (minutes) Area_time*D*[XX] | cumulative area of diastolic pressure below [XX] mmHg (absolute number) ## Code/software NA ## Access information NA","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.9ZW3R22QJ</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Beaucoté, Victor</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02mqtne57" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Hôpital Lariboisière</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Cartailler, Jérôme</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02vjkv261" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Inserm</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Trillat, Bernard</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/058td2q88" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Hôpital Foch</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Gayat, Etienne</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02mqtne57" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Hôpital Lariboisière</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Fischler, Marc</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0729-5430</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/058td2q88" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Hôpital Foch</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Le Guen, Morgan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/058td2q88" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Hôpital Foch</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Vallée, Alexandre</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/058td2q88" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Hôpital Foch</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Relationship between intraoperative drop in pulse pressure and minimum
      mean arterial pressure with postoperative length of stay according to main
      patients’ characteristics: A retrospective monocentric study
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2024</publicationYear>
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    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Age groups</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Anesthesia</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Hypotension</subject>
    <subject>Sex</subject>
    <subject>Length of Stay</subject>
  </subjects>
  <dates>
    <date dateType="Created">2024-09-18T18:48:48Z</date>
    <date dateType="Submitted">2024-09-18T18:48:58Z</date>
    <date dateType="Issued">2024-10-09T00:00:00Z</date>
    <date dateType="Available">2024-10-09T00:00:00Z</date>
  </dates>
  <language>en</language>
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    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      Intraoperative hypotension (IOH) is associated with organ failure. There
      is no consensus on the IOH definition, but the recommendations agree on a
      threshold of mean arterial pressure (MAP) between 60-70 mmHg. Prolonged
      postoperative length of stay (pLOS) is a surrogate for organ injuries. Our
      study focuses on the relationship between IOH and pLOS risk considering
      the main patient characteristics (sex and age) using
      a&amp;nbsp;retrospective single-centre cohort study of adult patients
      having received general anesthesia for a scheduled non-cardiac surgical
      procedure. pLOS was defined as a LOS higher than the median value (main
      outcome). Relationships between the IOH variables selected from a previous
      study (difference between the larger and smaller pulse pressure values
      (DropPP), minimal MAP (MinMAP), and cumulative time pulse pressure spent
      above 61mmHg (CumTimePP&amp;gt;61mmHg) and the risk of pLOS are
      represented by knotted linear splines.&amp;nbsp;Our study examined 9,516
      patients. The relationship between DropPP and pLOS risk was pseudolinear
      with no activation threshold (slope 0.29-0.52%/mmHg). For MinMAP, this
      relationship describes an activation threshold at 73 mmHg below which the
      association is linear (slope -0.64%/mmHg). For CumTimePP&amp;gt;61, the
      risk of pLOS rapidly rises (initial slope 8.39%/min) up to a saturation
      threshold at two minutes. Women had a lower pLOS risk and IOH threshold.
      Older patients had a higher pLOS risk and did not exhibit an IOH
      threshold.&amp;nbsp;The IOH threshold (MAP&amp;lt;73 mmHg) is consistent
      with the existing literature. The variability of PP as well as age and sex
      are key parameters in pLOS risk.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;This retrospective single-centre study was managed in a tertiary
      academic private non-profit hospital. Patients were collectively informed
      (by means of posters) that their data could be used for research purposes,
      on condition that the data were anonymized. This information included the
      necessary information to enable them to refuse their participation. As a
      result of this procedure, the need for consent was waived by the local
      Ethics Committee which approved this retrospective study. Authors had no
      access to information that could identify individual participants during
      or after data collection.&lt;/p&gt; &lt;p&gt;Patient characteristics and
      preoperative medications were collected from Cesare™, a computerized
      software for preoperative anesthetic evaluation (Bow Médical, 80440 Boves,
      France). Centricity Anesthesia software was used to collect intraoperative
      variables (GE Healthcare, 78 530 Buc, France). The length of stay and
      in-hospital mortality were obtained by questioning the health data
      warehouse.&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      # Relationship between intraoperative drop in pulse pressure and minimum
      mean arterial pressure with postoperative length of stay according to main
      patients’ characteristics in a retrospective monocentric study
      [https://doi.org/10.5061/dryad.9zw3r22qj](https://doi.org/10.5061/dryad.9zw3r22qj) ## Description of the data and file structure #### The demography table contains the main patients' characteristics. (Demography.csv)  id_data | Patient number  surgery | 1: general; 2: lung; 3:neurosurgery; 4: urology; 5: vascular; 6: gynecology; 7: ENT  age | 1: below 65 years; 2: 65 years and more  sex | 1:M; 2: F  los | Length of postoperative stay (days)  time_quartile | Quartile of surgery duration (absolute number)  median_Stay | Median length of stay (days)  Q3_Stay | Third quartile of the length of stay (days)  Q90_Stay | 90th percentile of the length of stay (days)  Short_IQR | Interquartile range of length of stay &lt;=1 (Q3-Q1) (days) #### The measurements table contains intraoperative blood pressure measurements. (Demography.csv)  id_data | Patient number Min_MAP | minimal value of mean arterial pressure (mmHg) Max_MAP | maximal value of mean arterial pressure (mmHg) Delta_MAP | Largest Drop in MAP during surgery (mmHg) Mean_MAP | Mean MAP (mmHg) Median_MAP | Median MAP (mmHg) std_MAP | standard deviation of MAP (mmHg) Var_MAP | MAP variability (absolute number) Cum_time*MAP*[XX] | cumulative time of mean arterial pressure below [XX] mmHg (minutes) Area_time*MAP*[XX] | cumulative area of mean arterial pressure below [XX] mmHg (absolute number) Min_PP | minimal value of pulse pressure (mmHg) Max_PP | maximal value of pulse pressure (mmHg) Delta_PP | Largest Drop in PP during surgery (mmHg) Mean_PP | Mean PP (mmHg) Median_PP | Median PP (mmHg) std_PP | standard deviation of PP (mmHg) Var_PP | PP variability (absolute number) Cum_time*PP*[XX] | cumulative time of pulse pressure below [XX] mmHg (minutes) Cum_area*PP*[XX] | cumulative area of pulse pressure below [XX] mmHg (absolute number) Min_S | minimal value of systolic arterial pressure (mmHg) Max_S | maximal value of systolic arterial pressure (mmHg) Delta_S | Largest Drop in S during surgery (mmHg) Mean_S | Mean S (mmHg) Median_S | Median S (mmHg) std_S | standard deviation of S (mmHg) Var_S | S variability (absolute number) Cum_time*S*[XX] | cumulative time of systolic arterial pressure below [XX] mmHg (minutes) Area_time*S*[XX] cumulative area of systolic arterial pressure below [XX] mmHg (absolute number) Min_D | minimal value of diastolic arterial pressure (mmHg) Max_D | maximal value of diastolic arterial pressure (mmHg) Delta_D | Largest Drop in diastolic arterial during surgery (mmHg) Mean_D | Mean diastolic arterial (mmHg) Median_D | Median diastolic arterial (mmHg) std_D | standard deviation of diastolic arterial (mmHg) Var_D | diastolic arterial variability (absolute number) Cum_time*D*[XX] | cumulative time of diastolic pressure below [XX] mmHg (minutes) Area_time*D*[XX] | cumulative area of diastolic pressure below [XX] mmHg (absolute number) ## Code/software NA ## Access information NA
    </description>
  </descriptions>
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