{"data":{"id":"10.5061/dryad.9p8cz8wwr","type":"dois","attributes":{"doi":"10.5061/dryad.9p8cz8wwr","prefix":"10.5061","suffix":"dryad.9p8cz8wwr","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Frydenholm, Jonathan","nameType":"Personal","givenName":"Jonathan","familyName":"Frydenholm","affiliation":["Copenhagen University Hospital"],"nameIdentifiers":[]},{"name":"Bechshøft, Cecilie","nameType":"Personal","givenName":"Cecilie","familyName":"Bechshøft","affiliation":["Copenhagen University Hospital"],"nameIdentifiers":[]},{"name":"Kjaer, Michael","nameType":"Personal","givenName":"Michael","familyName":"Kjaer","affiliation":["Copenhagen University Hospital"],"nameIdentifiers":[]},{"name":"Mackey, Abigail L.","nameType":"Personal","givenName":"Abigail L.","familyName":"Mackey","affiliation":["Copenhagen University Hospital"],"nameIdentifiers":[]},{"name":"Gliemann, Lasse","nameType":"Personal","givenName":"Lasse","familyName":"Gliemann","affiliation":["University of Copenhagen"],"nameIdentifiers":[]},{"name":"Soendenbroe, Casper","nameType":"Personal","givenName":"Casper","familyName":"Soendenbroe","affiliation":["Copenhagen University Hospital"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-6579-5700","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Capillary differences with age and fiber type are attenuated by accounting for fiber shape"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Health sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Skeletal muscles","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"capil"},{"subject":"Capillaries","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Aging","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"fiber morphology"},{"subject":"Capillary supply"}],"contributors":[],"dates":[{"date":"2025-09-09T06:21:11Z","dateType":"Created"},{"date":"2025-12-07T10:27:29Z","dateType":"Submitted"},{"date":"2026-01-06T00:00:00Z","dateType":"Issued"},{"date":"2026-01-06T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1111/febs.70401","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["37741 bytes"],"formats":[],"version":"4","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This dataset contains quantitative measurements of skeletal muscle fiber\n morphology and capillarization in young and older women. Muscle biopsies\n were obtained from both a rested leg and a leg that had performed a single\n bout of heavy resistance exercise five days prior to sampling. Variables\n include muscle fiber cross-sectional area, perimeter, and Shape Factor\n Index (SFI), as well as multiple indices of capillarization, including\n capillary density, capillary-to-fiber ratio, individual capillary-to-fiber\n ratio, and morphology-adjusted capillarization metrics. The dataset\n enables analysis of age-, fiber type-, and condition-related differences\n in muscle fiber geometry and capillary supply.","descriptionType":"Abstract"},{"description":"# Capillary differences with age and fiber type are attenuated by\n accounting for fiber shape Dataset DOI:\n [10.5061/dryad.9p8cz8wwr](10.5061/dryad.9p8cz8wwr) ## Description of the\n data and file structure This dataset derives from a study of skeletal\n muscle capillarization in young and older women. Muscle biopsies were\n collected from both legs of each participant. One leg performed a single\n bout of heavy resistance exercise five days prior to sampling (Exercised\n leg), while the contralateral leg served as the rested control (Rested\n leg). Each sample is identified by a unique alphanumeric sample ID\n corresponding to participant and leg. Muscle biopsies were embedded,\n frozen, cryosectioned, and immunohistochemically stained for type I myosin\n heavy chain (fiber type identification), laminin (fiber borders), and CD31\n (capillaries). From these sections, muscle fiber cross-sectional area,\n perimeter, and the derived Shape Factor Index (SFI) were quantified.\n Capillarization was evaluated using several established and\n morphology-adjusted indices. All data are provided in a single spreadsheet\n file (Dryad-Data-Deposition.xlsx) with two sheets, described below:\n **Sheet: “CD+CF”** This sheet contains whole-section capillarization\n metrics quantified at the sample level (i.e., not fiber type–specific).\n **Variables:** ·       **A: Sample ID**\\ Unique identifier for each biopsy\n sample (participant × leg). ·       **B: Age group**\\ Categorical variable\n indicating participant age group (Young or Old). ·       **C: Leg**\\\n Experimental condition of the leg (Rested or Exercised). ·       **D:\n Total tissue area quantified**\\ Total analyzed tissue area per sample.\\\n *Unit: mm^2^* ·       **E: Total number of myofibers**\\ Total number of\n muscle fibers counted within the analyzed area. ·       **F: Total number\n of capillaries**\\ Total number of capillaries identified within the\n analyzed area. ·       **G: Capillary density (CD)**\\ Number of\n capillaries per unit tissue area.\\ *Unit: capillaries/mm²* ·       **H:\n Capillary-to-fiber ratio (C:F)**\\ Average number of capillaries per muscle\n fiber. \n \n **Sheet: “CSA+Per+SFI+CAF+CFi”** This sheet contains fiber type–specific\n and mixed-fiber capillarization and morphology metrics. Values represent\n averages derived from approximately 25 fibers per fiber type per sample.\n **Variables:** ·       **A: Sample ID**\\ Unique identifier for each biopsy\n sample. ·       **B: Age group**\\ Categorical variable indicating\n participant age group (Young or Old). ·       **C: Leg**\\ Experimental\n condition of the leg (Rested or Exercised). ·       **D: Fiber type**\\\n Categorical variable indicating fiber type: o   Type I (MyHC I positive)\n o   Type II (MyHC I negative) o   Mixed (average of Type I and Type II\n fibers) ·       **E: Cross-sectional area (CSA)**\\ Average muscle fiber\n cross-sectional area.\\ *Unit: µm²* ·       **F: Fiber perimeter**\\ Average\n muscle fiber perimeter.\\ *Unit: µm* ·       **G: Shape Factor Index\n (SFI)**\\ Dimensionless geometric index describing fiber shape\n irregularity, calculated as:\\ perimeter^2^ / (4π × CSA) ·       **H:\n Capillaries around fiber (CAF)**\\ Average number of capillaries in direct\n contact with each muscle fiber. ·       **I: Individual capillary-to-fiber\n ratio (C:Fi)**\\ Average number of capillaries per muscle fiber, adjusted\n for capillary sharing between adjacent fibers. ·       **J:\n Capillary-to-fiber perimeter exchange index (CFPE)**\\ C:Fi normalized to\n muscle fiber perimeter. ·       **K: Capillary-to-fiber cross-sectional\n area exchange index (CFCE)**\\ C:Fi normalized to muscle fiber\n cross-sectional area. ·       **L: Shape-adjusted CFPE\n (CFPE_SFI-adjusted)**\\ CFPE multiplied by SFI to account for differences\n in muscle fiber geometry. ## Human subjects data All participants provided\n explicit written consent for their data to be made publicly available in\n de-identified form. Prior to sharing, all direct identifiers were removed.\n The resulting dataset contains no information that could be used to\n re-identify individuals.","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Lundbeck Foundation","awardNumber":"R402-2022-1387","funderIdentifier":"https://ror.org/03hz8wd80","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"Nordea-fonden","funderIdentifier":"https://ror.org/03qadc961","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.5061/DRYAD.9P8CZ8WWR</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Frydenholm, Jonathan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05bpbnx46" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Copenhagen University Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Bechshøft, Cecilie</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05bpbnx46" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Copenhagen University Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Kjaer, Michael</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05bpbnx46" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Copenhagen University Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Mackey, Abigail L.</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05bpbnx46" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Copenhagen University Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Gliemann, Lasse</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/035b05819" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of Copenhagen</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Soendenbroe, Casper</creatorName>
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      <affiliation affiliationIdentifier="https://ror.org/05bpbnx46" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Copenhagen University Hospital</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Capillary differences with age and fiber type are attenuated by accounting
      for fiber shape
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2026</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Health sciences</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Biological sciences</subject>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Skeletal muscles</subject>
    <subject>capil</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Capillaries</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Aging</subject>
    <subject>fiber morphology</subject>
    <subject>Capillary supply</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>Lundbeck Foundation</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/03hz8wd80</funderIdentifier>
      <awardNumber>R402-2022-1387</awardNumber>
      <awardTitle/>
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    <date dateType="Created">2025-09-09T06:21:11Z</date>
    <date dateType="Submitted">2025-12-07T10:27:29Z</date>
    <date dateType="Issued">2026-01-06T00:00:00Z</date>
    <date dateType="Available">2026-01-06T00:00:00Z</date>
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  <descriptions>
    <description descriptionType="Abstract">
      This dataset contains quantitative measurements of skeletal muscle fiber
      morphology and capillarization in young and older women. Muscle biopsies
      were obtained from both a rested leg and a leg that had performed a single
      bout of heavy resistance exercise five days prior to sampling. Variables
      include muscle fiber cross-sectional area, perimeter, and Shape Factor
      Index (SFI), as well as multiple indices of capillarization, including
      capillary density, capillary-to-fiber ratio, individual capillary-to-fiber
      ratio, and morphology-adjusted capillarization metrics. The dataset
      enables analysis of age-, fiber type-, and condition-related differences
      in muscle fiber geometry and capillary supply.
    </description>
    <description descriptionType="TechnicalInfo">
      # Capillary differences with age and fiber type are attenuated by
      accounting for fiber shape Dataset DOI:
      [10.5061/dryad.9p8cz8wwr](10.5061/dryad.9p8cz8wwr) ## Description of the
      data and file structure This dataset derives from a study of skeletal
      muscle capillarization in young and older women. Muscle biopsies were
      collected from both legs of each participant. One leg performed a single
      bout of heavy resistance exercise five days prior to sampling (Exercised
      leg), while the contralateral leg served as the rested control (Rested
      leg). Each sample is identified by a unique alphanumeric sample ID
      corresponding to participant and leg. Muscle biopsies were embedded,
      frozen, cryosectioned, and immunohistochemically stained for type I myosin
      heavy chain (fiber type identification), laminin (fiber borders), and CD31
      (capillaries). From these sections, muscle fiber cross-sectional area,
      perimeter, and the derived Shape Factor Index (SFI) were quantified.
      Capillarization was evaluated using several established and
      morphology-adjusted indices. All data are provided in a single spreadsheet
      file (Dryad-Data-Deposition.xlsx) with two sheets, described below:
      **Sheet: “CD+CF”** This sheet contains whole-section capillarization
      metrics quantified at the sample level (i.e., not fiber type–specific).
      **Variables:** ·       **A: Sample ID**\ Unique identifier for each biopsy
      sample (participant × leg). ·       **B: Age group**\ Categorical variable
      indicating participant age group (Young or Old). ·       **C: Leg**\
      Experimental condition of the leg (Rested or Exercised). ·       **D:
      Total tissue area quantified**\ Total analyzed tissue area per sample.\
      *Unit: mm^2^* ·       **E: Total number of myofibers**\ Total number of
      muscle fibers counted within the analyzed area. ·       **F: Total number
      of capillaries**\ Total number of capillaries identified within the
      analyzed area. ·       **G: Capillary density (CD)**\ Number of
      capillaries per unit tissue area.\ *Unit: capillaries/mm²* ·       **H:
      Capillary-to-fiber ratio (C:F)**\ Average number of capillaries per muscle
      fiber. 
      <br/>
       **Sheet: “CSA+Per+SFI+CAF+CFi”** This sheet contains fiber type–specific
      and mixed-fiber capillarization and morphology metrics. Values represent
      averages derived from approximately 25 fibers per fiber type per sample.
      **Variables:** ·       **A: Sample ID**\ Unique identifier for each biopsy
      sample. ·       **B: Age group**\ Categorical variable indicating
      participant age group (Young or Old). ·       **C: Leg**\ Experimental
      condition of the leg (Rested or Exercised). ·       **D: Fiber type**\
      Categorical variable indicating fiber type: o   Type I (MyHC I positive)
      o   Type II (MyHC I negative) o   Mixed (average of Type I and Type II
      fibers) ·       **E: Cross-sectional area (CSA)**\ Average muscle fiber
      cross-sectional area.\ *Unit: µm²* ·       **F: Fiber perimeter**\ Average
      muscle fiber perimeter.\ *Unit: µm* ·       **G: Shape Factor Index
      (SFI)**\ Dimensionless geometric index describing fiber shape
      irregularity, calculated as:\ perimeter^2^ / (4π × CSA) ·       **H:
      Capillaries around fiber (CAF)**\ Average number of capillaries in direct
      contact with each muscle fiber. ·       **I: Individual capillary-to-fiber
      ratio (C:Fi)**\ Average number of capillaries per muscle fiber, adjusted
      for capillary sharing between adjacent fibers. ·       **J:
      Capillary-to-fiber perimeter exchange index (CFPE)**\ C:Fi normalized to
      muscle fiber perimeter. ·       **K: Capillary-to-fiber cross-sectional
      area exchange index (CFCE)**\ C:Fi normalized to muscle fiber
      cross-sectional area. ·       **L: Shape-adjusted CFPE
      (CFPE_SFI-adjusted)**\ CFPE multiplied by SFI to account for differences
      in muscle fiber geometry. ## Human subjects data All participants provided
      explicit written consent for their data to be made publicly available in
      de-identified form. Prior to sharing, all direct identifiers were removed.
      The resulting dataset contains no information that could be used to
      re-identify individuals.
    </description>
  </descriptions>
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