{"data":{"id":"10.5061/dryad.9ghx3ffpr","type":"dois","attributes":{"doi":"10.5061/dryad.9ghx3ffpr","prefix":"10.5061","suffix":"dryad.9ghx3ffpr","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Ma, Shuaiya","nameType":"Personal","givenName":"Shuaiya","familyName":"Ma","affiliation":["Shandong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6089-5246","nameIdentifierScheme":"ORCID"}]},{"name":"Tian, Ye","nameType":"Personal","givenName":"Ye","familyName":"Tian","affiliation":["Shandong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0007-6084-8993","nameIdentifierScheme":"ORCID"}]},{"name":"Peng, Jiali","nameType":"Personal","givenName":"Jiali","familyName":"Peng","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Chen, Chaojia","nameType":"Personal","givenName":"Chaojia","familyName":"Chen","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Peng, Xueqi","nameType":"Personal","givenName":"Xueqi","familyName":"Peng","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Zhao, Fabao","nameType":"Personal","givenName":"Fabao","familyName":"Zhao","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Li, Zhenyu","nameType":"Personal","givenName":"Zhenyu","familyName":"Li","affiliation":["Shandong Provincial Hospital"],"nameIdentifiers":[]},{"name":"Li, Mengzhen","nameType":"Personal","givenName":"Mengzhen","familyName":"Li","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Zhao, Fangcheng","nameType":"Personal","givenName":"Fangcheng","familyName":"Zhao","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Sheng, Xue","nameType":"Personal","givenName":"Xue","familyName":"Sheng","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Zong, Runzhe","nameType":"Personal","givenName":"Runzhe","familyName":"Zong","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Li, Yiquan","nameType":"Personal","givenName":"Yiquan","familyName":"Li","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Zhang, Jiwei","nameType":"Personal","givenName":"Jiwei","familyName":"Zhang","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Yu, Mingyan","nameType":"Personal","givenName":"Mingyan","familyName":"Yu","affiliation":["Shandong Institute for Food and Drug Control"],"nameIdentifiers":[]},{"name":"Zhu, Qingfen","nameType":"Personal","givenName":"Qingfen","familyName":"Zhu","affiliation":["Shandong Institute for Food and Drug Control"],"nameIdentifiers":[]},{"name":"Tian, Xiaoyu","nameType":"Personal","givenName":"Xiaoyu","familyName":"Tian","affiliation":["Shandong Normal University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-1384-8687","nameIdentifierScheme":"ORCID"}]},{"name":"Li, Yuyang","nameType":"Personal","givenName":"Yuyang","familyName":"Li","affiliation":["Shandong Normal University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-8489-3296","nameIdentifierScheme":"ORCID"}]},{"name":"Neckenig, Markus","nameType":"Personal","givenName":"Markus","familyName":"Neckenig","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Liu, Huiqing","nameType":"Personal","givenName":"Huiqing","familyName":"Liu","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Zhan, Peng","nameType":"Personal","givenName":"Peng","familyName":"Zhan","affiliation":["Shandong University"],"nameIdentifiers":[]},{"name":"Yue, Xuetian","nameType":"Personal","givenName":"Xuetian","familyName":"Yue","affiliation":["Shandong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5561-4964","nameIdentifierScheme":"ORCID"}]},{"name":"Wu, Zhuanchang","nameType":"Personal","givenName":"Zhuanchang","familyName":"Wu","affiliation":["Shandong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-8121-4718","nameIdentifierScheme":"ORCID"}]},{"name":"Gao, Lifen","nameType":"Personal","givenName":"Lifen","familyName":"Gao","affiliation":["Shandong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-2404-7439","nameIdentifierScheme":"ORCID"}]},{"name":"Liang, Xiaohong","nameType":"Personal","givenName":"Xiaohong","familyName":"Liang","affiliation":["Shandong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7626-3478","nameIdentifierScheme":"ORCID"}]},{"name":"Liu, Xinyong","nameType":"Personal","givenName":"Xinyong","familyName":"Liu","affiliation":["Shandong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7302-2214","nameIdentifierScheme":"ORCID"}]},{"name":"Li, Chunyang","nameType":"Personal","givenName":"Chunyang","familyName":"Li","affiliation":["Shandong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-5798-2274","nameIdentifierScheme":"ORCID"}]},{"name":"Ma, Chunhong","nameType":"Personal","givenName":"Chunhong","familyName":"Ma","affiliation":["Shandong University"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-7430-8484","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Identification of a small molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical models"}],"publisher":"Dryad","container":{},"publicationYear":2023,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"RNA-seq"},{"subject":"CD8+ Tcells"},{"subject":"small-molecule Tim-3 inhibitor"}],"contributors":[],"dates":[{"date":"2023-09-16T09:33:36Z","dateType":"Created"},{"date":"2023-10-30T11:44:00Z","dateType":"Submitted"},{"date":"2023-11-07T00:00:00Z","dateType":"Issued"},{"date":"2023-11-07T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1126/scitranslmed.adg6752","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["199026284 bytes"],"formats":[],"version":"7","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), expressed\n in dysfunctional and exhausted T cells, has been widely acknowledged as a\n promising immune checkpoint target for tumor immunotherapy. Here, using a\n strategy combining virtual and functional screening, we identified a\n compound named ML-T7 that targets the FG-CC’ cleft of Tim-3, a highly\n conserved binding site of phosphatidylserine (PtdSer) and carcinoembryonic\n antigen-related cell adhesion molecule 1 (CEACAM1). ML-T7 enhanced the\n survival and antitumor activity of primary CD8+ cytotoxic T lymphocytes\n (CTLs) and human chimeric antigen receptor (CAR) T cells and reduced their\n exhaustion in vitro and in vivo. In addition, ML-T7 promoted NK cells’\n killing activity and DC antigen-presenting capacity, consistent with the\n reported activity of Tim-3. Notably, ML-T7 strengthened DCs’ functions\n through both Tim-3 and Tim-4, consistent with the hypothesis that Tim-4\n contains a similar FG-CC’ loop. Intraperitoneal dosing of ML-T7 showed\n comparable tumor inhibitory effects to Tim-3 blocking antibody. ML-T7\n reduced syngeneic tumor progression in both wildtype and Tim-3 humanized\n mice and alleviated the immunosuppressive microenvironment. Furthermore,\n combined ML-T7 and anti-PD-1 therapy had greater therapeutic efficacy than\n monotherapy in mice, supporting further development of ML-T7 for tumor\n immunotherapy. Our study demonstrates a potential small molecule for\n selectively blocking Tim-3 and warrants further study.","descriptionType":"Abstract"},{"description":"Splenocytes from OT-Ι mice were\n stimulated with 10 nM OVA\u003csub\u003e257-264\u003c/sub\u003e peptide in RPMI\n 1640 medium containing 10% FBS, 50 U/mL penicillin-streptomycin, 50 μM\n 2-Mercaptoethanol, 20 U/mL human recombinant IL-2 and 10 μM ML-T7/DMSO for\n 3 days, followed by 3 days culture in the presence of ML-T7/DMSO to get\n mature CTLs unless otherwise indicated.Total RNA was isolated from DMSO or\n ML-T7 treated CD8\u003csup\u003e+\u003c/sup\u003e CTLs using TRIzol reagent\n (Invitrogen). RNA-Seq analysis was performed with an Illumina HiSeq 2500\n or BGISEQ-500 by BGI (Shenzhen, Guangdong, China). Data quality was\n assessed with fastqc software and aligned to the mouse genome (mm10 build)\n using TopHat (with Bowtie2), and data was curated and visualized using the\n BGI Interactive analysis platform.RNAseq detected 1271 differentially\n expressed transcripts (1.5-fold or more) in ML-T7-treated\n CD8\u003csup\u003e+\u003c/sup\u003e CTLs. Specifically, ML-T7 treatment\n upregulated several effector T cell-associated genes, including\n \u003cem\u003eLck\u003c/em\u003e, \u003cem\u003eZap70\u003c/em\u003e,\n \u003cem\u003eErk1\u003c/em\u003e, \u003cem\u003eIl-2\u003c/em\u003e and\n \u003cem\u003eCd69\u003c/em\u003e, while downregulated several exhausted T\n cell-associated genes, including \u003cem\u003eHavcr2, Tigit\u003c/em\u003e and\n \u003cem\u003eCtla4\u003c/em\u003e. Gene set enrichment analysis (GSEA) showed\n that TCR signaling pathway and IL2-STAT5 pathway were significantly\n enriched in ML-T7-treated CTLs.","descriptionType":"Methods"},{"description":"# Identification of a small molecule Tim-3 inhibitor to potentiate T\n cell-mediated antitumor immunotherapy in preclinical models\n [https://doi.org/10.5061/dryad.9ghx3ffpr](https://doi.org/10.5061/dryad.9ghx3ffpr) Methods and results: As mentioned in the paper, splenocytes from OT-Ι mice were stimulated with 10 nM OVA\u003csub\u003e257-264\u003c/sub\u003e peptide in RPMI 1640 medium containing 10% FBS, 50 U/mL penicillin-streptomycin, 50 μM 2-Mercaptoethanol, 20 U/mL human recombinant IL-2 and 10 μM ML-T7/DMSO for 3 days, followed by 3 days culture in the presence of ML-T7/DMSO to get mature CTLs unless otherwise indicated.Total RNA was isolated from DMSO or ML-T7 treated CD8\u003csup\u003e+\u003c/sup\u003e CTLs using TRIzol reagent (Invitrogen). RNA-Seq analysis was performed with an Illumina HiSeq 2500 or BGISEQ-500 by BGI (Shenzhen, Guangdong, China). Data quality was assessed with fastqc software and aligned to the mouse genome (mm10 build) using TopHat (with Bowtie2), and data was curated and visualized using the BGI Interactive analysis platform.RNAseq detected 1271 differentially expressed transcripts (1.5-fold or more) in ML-T7-treated CD8\u003csup\u003e+\u003c/sup\u003e CTLs. Specifically, ML-T7 treatment upregulated several effector T cell-associated genes, including *Lck*, *Zap70*, *Erk1*, *Il-2* and *Cd69*, while downregulated several exhausted T cell-associated genes, including *Havcr2, Tigit* and *Ctla4*. Gene set enrichment analysis (GSEA) showed that TCR signaling pathway and IL2-STAT5 pathway were significantly enriched in ML-T7-treated CTLs. ## Description of the data and file structure File list: ML-T720201210fpkm.anno File description: The following text describes files named \"ML-T720201210fpkm.anno\".This csv data file contains differential gene expression patterns and gene signatures. \\| File name \\| File category \\| File type \\| Experiment or Analysis \\| Related to Figure\\(s\\) \\| Description \\| ML\\-T720201210fpkm\\.anno \\| inh7\\-vs\\-MOCK\\.csv \\| fpkm list \\| RNA sequencing of DMSO\\(MOCK\\)\\-treated cells and ML\\-T7\\(inh7\\)\\-treated cells \\| Fig2 and FigS3 \\| Differential expression results table for ML\\-T7\\(inh7\\)\\-treated cells vs DMSO\\(MOCK\\)\\-treated cells \\*\\*Plain text (.csv) files can be interpreted as follows:\\*\\* Stand-alone plain csv files, containing a csv file of differential expression results, for all genes. These tables can be used to search for results of genes not discussed in the text. Tables contain the following information (in columns) for each gene (in rows): ML-T720201210fpkm.anno.csv result file description: * name = ID of the gene * MOCK\\_1,2,3 = DMSO1,2,3-Control group in the article * inh7\\_1,2,3 = ML-T71,2,3-Experimental group in the article * GeneName = Name of the gene * Biotype = gene type * Positon = coordinates of genes * NR:Seq-id = optimal comparison results between genes and NR database * NR:Score = the score of gene comparison with NR database * NR:Evalue = The Evalue value of genes compared with the NR database * NR: Description = Function description of the gene in the NR database * NT:Seq-id = optimal comparison results between genes and NT database * NT:Score = comparison score between gene and NT database * NT:Evalue = The Evalue value of genes compared with NT database * NT: Description = Description: Function description of the gene in the NT database * Uniprot:UniprotKB-AC = optimal comparison results between genes and Uniprot database * Uniprot:Score = the score of genes compared with Uniprot database * Uniprot: Evalue = The Evalue value of genes compared with Uniprot database * Uniprot: Description = Function description of the gene in niprot database * COG:gene =gene name in the COG database compare * COG:Score = the score compared with the COG database * COG:Eval = comparison with the COG database Evalue value * COG:num = gene ID in the COG database compared * Pfam:pfam\\_ID = gene ID of the protein family Pfam compared * Pfam:pfam\\_Name = the gene name of the protein family Pfam compared * Pfam:pfam\\_Description = Functional description of the protein family Pfam compared * GO:biological\\_process = Annotated GO Term describing the biological process * GO:cellular\\_component = Annotated GO Term describing cell components * GO:molecular\\_function = the commented GO Term describing the molecular function * KEGG:KO = the ID in KEGG commented to * KEGG:Description = Function description in KEGG ## Sharing and access information  No licenses or restrictions are placed on the data.","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"81830017","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"31600714","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"81903454","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"funderName":"National Postdoctoral Program for Innovative Talents","awardNumber":"BX201700147"},{"funderName":"Young Elite Scientist Sponsorship Program by CAST","awardNumber":"YESS20160077"},{"funderName":"Taishan Scholarship","awardNumber":"20181201"},{"schemeUri":"https://www.crossref.org/services/funder-registry/","funderName":"Shandong Natural Science Foundation","awardNumber":"ZR2020ZD12","funderIdentifier":"https://doi.org/10.13039/501100007129","funderIdentifierType":"Crossref Funder ID"},{"schemeUri":"https://www.crossref.org/services/funder-registry/","funderName":"National Key Research and Development Program","awardNumber":"2021YFC2300603","funderIdentifier":"https://doi.org/10.13039/501100012166","funderIdentifierType":"Crossref Funder ID"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4/metadata.xsd">
  <identifier identifierType="DOI">10.5061/DRYAD.9GHX3FFPR</identifier>
  <creators>
    <creator>
      <creatorName nameType="Personal">Ma, Shuaiya</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-6089-5246</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Tian, Ye</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0009-0007-6084-8993</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Peng, Jiali</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Chen, Chaojia</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Peng, Xueqi</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhao, Fabao</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Li, Zhenyu</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/02ar2nf05" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong Provincial Hospital</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Li, Mengzhen</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhao, Fangcheng</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Sheng, Xue</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zong, Runzhe</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Li, Yiquan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhang, Jiwei</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Yu, Mingyan</creatorName>
      <affiliation>Shandong Institute for Food and Drug Control</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhu, Qingfen</creatorName>
      <affiliation>Shandong Institute for Food and Drug Control</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Tian, Xiaoyu</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-1384-8687</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/01wy3h363" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong Normal University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Li, Yuyang</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-8489-3296</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/01wy3h363" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong Normal University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Neckenig, Markus</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Liu, Huiqing</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Zhan, Peng</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Yue, Xuetian</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-5561-4964</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Wu, Zhuanchang</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-8121-4718</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Gao, Lifen</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-2404-7439</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Liang, Xiaohong</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-7626-3478</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Liu, Xinyong</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-7302-2214</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Li, Chunyang</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-5798-2274</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Ma, Chunhong</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-7430-8484</nameIdentifier>
      <affiliation affiliationIdentifier="https://ror.org/0207yh398" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Shandong University</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Identification of a small molecule Tim-3 inhibitor to potentiate T
      cell-mediated antitumor immunotherapy in preclinical models
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2023</publicationYear>
  <subjects>
    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject>RNA-seq</subject>
    <subject>CD8+ Tcells</subject>
    <subject>small-molecule Tim-3 inhibitor</subject>
  </subjects>
  <fundingReferences>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>81830017</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>31600714</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>81903454</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Postdoctoral Program for Innovative Talents</funderName>
      <awardNumber>BX201700147</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Young Elite Scientist Sponsorship Program by CAST</funderName>
      <awardNumber>YESS20160077</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Taishan Scholarship</funderName>
      <awardNumber>20181201</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>Shandong Natural Science Foundation</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID" schemeURI="https://www.crossref.org/services/funder-registry/">http://dx.doi.org/10.13039/501100007129</funderIdentifier>
      <awardNumber>ZR2020ZD12</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>National Key Research and Development Program</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID" schemeURI="https://www.crossref.org/services/funder-registry/">http://dx.doi.org/10.13039/501100012166</funderIdentifier>
      <awardNumber>2021YFC2300603</awardNumber>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Created">2023-09-16T09:33:36Z</date>
    <date dateType="Submitted">2023-10-30T11:44:00Z</date>
    <date dateType="Issued">2023-11-07T00:00:00Z</date>
    <date dateType="Available">2023-11-07T00:00:00Z</date>
  </dates>
  <language>en</language>
  <relatedIdentifiers>
    <relatedIdentifier relationType="IsCitedBy" relatedIdentifierType="DOI">https://doi.org/10.1126/scitranslmed.adg6752</relatedIdentifier>
  </relatedIdentifiers>
  <sizes>
    <size>199026284 bytes</size>
  </sizes>
  <version>7</version>
  <rightsList>
    <rights rightsURI="https://spdx.org/licenses/CC0-1.0.html">Creative Commons Zero v1.0 Universal</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">
      T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), expressed
      in dysfunctional and exhausted T cells, has been widely acknowledged as a
      promising immune checkpoint target for tumor immunotherapy. Here, using a
      strategy combining virtual and functional screening, we identified a
      compound named ML-T7 that targets the FG-CC’ cleft of Tim-3, a highly
      conserved binding site of phosphatidylserine (PtdSer) and carcinoembryonic
      antigen-related cell adhesion molecule 1 (CEACAM1). ML-T7 enhanced the
      survival and antitumor activity of primary CD8+ cytotoxic T lymphocytes
      (CTLs) and human chimeric antigen receptor (CAR) T cells and reduced their
      exhaustion in vitro and in vivo. In addition, ML-T7 promoted NK cells’
      killing activity and DC antigen-presenting capacity, consistent with the
      reported activity of Tim-3. Notably, ML-T7 strengthened DCs’ functions
      through both Tim-3 and Tim-4, consistent with the hypothesis that Tim-4
      contains a similar FG-CC’ loop. Intraperitoneal dosing of ML-T7 showed
      comparable tumor inhibitory effects to Tim-3 blocking antibody. ML-T7
      reduced syngeneic tumor progression in both wildtype and Tim-3 humanized
      mice and alleviated the immunosuppressive microenvironment. Furthermore,
      combined ML-T7 and anti-PD-1 therapy had greater therapeutic efficacy than
      monotherapy in mice, supporting further development of ML-T7 for tumor
      immunotherapy. Our study demonstrates a potential small molecule for
      selectively blocking Tim-3 and warrants further study.
    </description>
    <description descriptionType="Methods">
      &lt;p data-pm-slice="1 1 []"&gt;Splenocytes from OT-Ι mice were
      stimulated with 10 nM OVA&lt;sub&gt;257-264&lt;/sub&gt; peptide in RPMI
      1640 medium containing 10% FBS, 50 U/mL penicillin-streptomycin, 50 μM
      2-Mercaptoethanol, 20 U/mL human recombinant IL-2 and 10 μM ML-T7/DMSO for
      3 days, followed by 3 days culture in the presence of ML-T7/DMSO to get
      mature CTLs unless otherwise indicated.Total RNA was isolated from DMSO or
      ML-T7 treated CD8&lt;sup&gt;+&lt;/sup&gt; CTLs using TRIzol reagent
      (Invitrogen). RNA-Seq analysis was performed with an Illumina HiSeq 2500
      or BGISEQ-500 by BGI (Shenzhen, Guangdong, China). Data quality was
      assessed with fastqc software and aligned to the mouse genome (mm10 build)
      using TopHat (with Bowtie2), and data was curated and visualized using the
      BGI Interactive analysis platform.RNAseq detected 1271 differentially
      expressed transcripts (1.5-fold or more) in ML-T7-treated
      CD8&lt;sup&gt;+&lt;/sup&gt; CTLs. Specifically, ML-T7 treatment
      upregulated several effector T cell-associated genes, including
      &lt;em&gt;Lck&lt;/em&gt;, &lt;em&gt;Zap70&lt;/em&gt;,
      &lt;em&gt;Erk1&lt;/em&gt;, &lt;em&gt;Il-2&lt;/em&gt; and
      &lt;em&gt;Cd69&lt;/em&gt;, while downregulated several exhausted T
      cell-associated genes, including &lt;em&gt;Havcr2, Tigit&lt;/em&gt; and
      &lt;em&gt;Ctla4&lt;/em&gt;. Gene set enrichment analysis (GSEA) showed
      that TCR signaling pathway and IL2-STAT5 pathway were significantly
      enriched in ML-T7-treated CTLs.&lt;/p&gt;
    </description>
    <description descriptionType="TechnicalInfo">
      # Identification of a small molecule Tim-3 inhibitor to potentiate T
      cell-mediated antitumor immunotherapy in preclinical models
      [https://doi.org/10.5061/dryad.9ghx3ffpr](https://doi.org/10.5061/dryad.9ghx3ffpr) Methods and results: As mentioned in the paper, splenocytes from OT-Ι mice were stimulated with 10 nM OVA&lt;sub&gt;257-264&lt;/sub&gt; peptide in RPMI 1640 medium containing 10% FBS, 50 U/mL penicillin-streptomycin, 50 μM 2-Mercaptoethanol, 20 U/mL human recombinant IL-2 and 10 μM ML-T7/DMSO for 3 days, followed by 3 days culture in the presence of ML-T7/DMSO to get mature CTLs unless otherwise indicated.Total RNA was isolated from DMSO or ML-T7 treated CD8&lt;sup&gt;+&lt;/sup&gt; CTLs using TRIzol reagent (Invitrogen). RNA-Seq analysis was performed with an Illumina HiSeq 2500 or BGISEQ-500 by BGI (Shenzhen, Guangdong, China). Data quality was assessed with fastqc software and aligned to the mouse genome (mm10 build) using TopHat (with Bowtie2), and data was curated and visualized using the BGI Interactive analysis platform.RNAseq detected 1271 differentially expressed transcripts (1.5-fold or more) in ML-T7-treated CD8&lt;sup&gt;+&lt;/sup&gt; CTLs. Specifically, ML-T7 treatment upregulated several effector T cell-associated genes, including *Lck*, *Zap70*, *Erk1*, *Il-2* and *Cd69*, while downregulated several exhausted T cell-associated genes, including *Havcr2, Tigit* and *Ctla4*. Gene set enrichment analysis (GSEA) showed that TCR signaling pathway and IL2-STAT5 pathway were significantly enriched in ML-T7-treated CTLs. ## Description of the data and file structure File list: ML-T720201210fpkm.anno File description: The following text describes files named "ML-T720201210fpkm.anno".This csv data file contains differential gene expression patterns and gene signatures. \| File name \| File category \| File type \| Experiment or Analysis \| Related to Figure\(s\) \| Description \| ML\-T720201210fpkm\.anno \| inh7\-vs\-MOCK\.csv \| fpkm list \| RNA sequencing of DMSO\(MOCK\)\-treated cells and ML\-T7\(inh7\)\-treated cells \| Fig2 and FigS3 \| Differential expression results table for ML\-T7\(inh7\)\-treated cells vs DMSO\(MOCK\)\-treated cells \*\*Plain text (.csv) files can be interpreted as follows:\*\* Stand-alone plain csv files, containing a csv file of differential expression results, for all genes. These tables can be used to search for results of genes not discussed in the text. Tables contain the following information (in columns) for each gene (in rows): ML-T720201210fpkm.anno.csv result file description: * name = ID of the gene * MOCK\_1,2,3 = DMSO1,2,3-Control group in the article * inh7\_1,2,3 = ML-T71,2,3-Experimental group in the article * GeneName = Name of the gene * Biotype = gene type * Positon = coordinates of genes * NR:Seq-id = optimal comparison results between genes and NR database * NR:Score = the score of gene comparison with NR database * NR:Evalue = The Evalue value of genes compared with the NR database * NR: Description = Function description of the gene in the NR database * NT:Seq-id = optimal comparison results between genes and NT database * NT:Score = comparison score between gene and NT database * NT:Evalue = The Evalue value of genes compared with NT database * NT: Description = Description: Function description of the gene in the NT database * Uniprot:UniprotKB-AC = optimal comparison results between genes and Uniprot database * Uniprot:Score = the score of genes compared with Uniprot database * Uniprot: Evalue = The Evalue value of genes compared with Uniprot database * Uniprot: Description = Function description of the gene in niprot database * COG:gene =gene name in the COG database compare * COG:Score = the score compared with the COG database * COG:Eval = comparison with the COG database Evalue value * COG:num = gene ID in the COG database compared * Pfam:pfam\_ID = gene ID of the protein family Pfam compared * Pfam:pfam\_Name = the gene name of the protein family Pfam compared * Pfam:pfam\_Description = Functional description of the protein family Pfam compared * GO:biological\_process = Annotated GO Term describing the biological process * GO:cellular\_component = Annotated GO Term describing cell components * GO:molecular\_function = the commented GO Term describing the molecular function * KEGG:KO = the ID in KEGG commented to * KEGG:Description = Function description in KEGG ## Sharing and access information  No licenses or restrictions are placed on the data.
    </description>
  </descriptions>
</resource>","url":"https://datadryad.org/dataset/doi:10.5061/dryad.9ghx3ffpr","contentUrl":null,"metadataVersion":6,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":154,"viewsOverTime":[{"yearMonth":"2023-11","total":64},{"yearMonth":"2023-12","total":13},{"yearMonth":"2024-01","total":1},{"yearMonth":"2024-02","total":5},{"yearMonth":"2024-03","total":1},{"yearMonth":"2024-04","total":1},{"yearMonth":"2024-05","total":1},{"yearMonth":"2024-07","total":8},{"yearMonth":"2024-08","total":1},{"yearMonth":"2024-10","total":13},{"yearMonth":"2024-11","total":1},{"yearMonth":"2025-01","total":3},{"yearMonth":"2025-03","total":1},{"yearMonth":"2025-04","total":2},{"yearMonth":"2025-05","total":1},{"yearMonth":"2025-08","total":1},{"yearMonth":"2025-09","total":2},{"yearMonth":"2025-11","total":2},{"yearMonth":"2026-01","total":3},{"yearMonth":"2026-03","total":1},{"yearMonth":"2026-04","total":1},{"yearMonth":"2026-05","total":2},{"yearMonth":"2026-07","total":7},{"yearMonth":"2026-08","total":12},{"yearMonth":"2026-09","total":7}],"downloadCount":16,"downloadsOverTime":[{"yearMonth":"2023-11","total":3},{"yearMonth":"2023-12","total":1},{"yearMonth":"2024-01","total":1},{"yearMonth":"2024-02","total":0},{"yearMonth":"2024-03","total":1},{"yearMonth":"2024-04","total":0},{"yearMonth":"2024-05","total":0},{"yearMonth":"2024-07","total":1},{"yearMonth":"2024-08","total":1},{"yearMonth":"2024-10","total":5},{"yearMonth":"2024-11","total":0},{"yearMonth":"2025-01","total":0},{"yearMonth":"2025-03","total":0},{"yearMonth":"2025-04","total":1},{"yearMonth":"2025-05","total":0},{"yearMonth":"2025-08","total":0},{"yearMonth":"2025-09","total":1},{"yearMonth":"2025-11","total":0},{"yearMonth":"2026-01","total":1},{"yearMonth":"2026-03","total":0},{"yearMonth":"2026-04","total":0},{"yearMonth":"2026-05","total":0},{"yearMonth":"2026-07","total":0},{"yearMonth":"2026-08","total":0},{"yearMonth":"2026-09","total":0}],"referenceCount":0,"citationCount":1,"citationsOverTime":[{"year":"2026","total":1}],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2023-11-07T17:02:46.000Z","registered":"2023-11-07T17:02:47.000Z","published":"2023","updated":"2026-01-28T16:22:01.000Z"},"relationships":{"client":{"data":{"id":"dryad.dryad","type":"clients"}},"provider":{"data":{"id":"dryad","type":"providers"}},"media":{"data":{"id":"10.5061/dryad.9ghx3ffpr","type":"media"}},"references":{"data":[]},"citations":{"data":[{"id":"10.1126/scitranslmed.adg6752","type":"dois"}]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}