{"data":{"id":"10.5061/dryad.9cnp5hr0x","type":"dois","attributes":{"doi":"10.5061/dryad.9cnp5hr0x","prefix":"10.5061","suffix":"dryad.9cnp5hr0x","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Zhang, Xiaohua","nameType":"Personal","givenName":"Xiaohua","familyName":"Zhang","affiliation":["Renji Hospital"],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0009-0007-7805-733X","nameIdentifierScheme":"ORCID"}]}],"titles":[{"title":"Supplementary data for: IRG1/itaconate inhibits microglial senescence-like transition by modulating mitochondrial dynamics through RhoA alkylation in subarachnoid hemorrhage"}],"publisher":"Dryad","container":{},"publicationYear":2026,"subjects":[{"subject":"FOS: Basic medicine","schemeUri":"https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf","subjectScheme":"fos"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"neuroinflammation"},{"subject":"Stroke","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Subarachnoid hemorrhage"},{"subject":"microglia"}],"contributors":[],"dates":[{"date":"2026-03-31T16:18:26Z","dateType":"Created"},{"date":"2026-03-31T16:18:27Z","dateType":"Submitted"},{"date":"2026-04-27T00:00:00Z","dateType":"Issued"},{"date":"2026-04-27T00:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":["1301913 bytes"],"formats":[],"version":"4","rightsList":[{"rights":"Creative Commons Zero v1.0 Universal","rightsUri":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc0-1.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Aging is a potent risk factor for poor prognosis in subarachnoid\n hemorrhage (SAH), yet the molecular mechanisms underlying the age-related\n exacerbation of early brain injury remain incompletely understood. This\n study investigates the immunometabolic regulation of the microglial\n senescence-like transition following SAH, focusing on the\n immune-responsive gene 1 (IRG1)/itaconate axis. We observed that the\n endogenous upregulation of IRG1 and itaconate is a protective response to\n hemorrhagic stress that is significantly blunted in aged mice.\n Microglia-specific IRG1 deficiency exacerbated SAH-induced brain injury,\n characterized by an accelerated senescence-like transition and the\n secretion of senescence-associated secretory phenotype (SASP) factors.\n Mechanistically, we demonstrate that IRG1 deficiency leads to excessive\n mitochondrial fission and dysfunction via the hyperactivity of\n Dynamin-related protein 1 (Drp1). Using click chemistry-based proteomics\n and site-directed mutagenesis, we identified that itaconate exerts its\n neuroprotective effects by directly alkylating the small GTPase RhoA at\n the cysteine 107 (C107) residue. This specific post-translational\n modification inhibits RhoA-GTP binding and downstream ROCK1 activation,\n thereby suppressing Drp1-mediated mitochondrial fragmentation.\n Importantly, treatment with the cell-permeable itaconate derivative\n 4-octyl itaconate (4-OI) rescued mitochondrial dynamics and attenuated\n microglial senescence and neurological deficits, whereas the RhoA-C107S\n mutation abolished these protective effects. Collectively, our findings\n unveil a novel metabolic-mitochondrial checkpoint involving the\n IRG1/itaconate-RhoA-Drp1 axis. Restoring this pathway represents a\n promising therapeutic strategy to combat the age-related exacerbation of\n neuroinflammation and improve outcomes in SAH patients.","descriptionType":"Abstract"},{"description":"# Supplementary data for: IRG1/itaconate inhibits microglial\n senescence-like transition by modulating mitochondrial dynamics through\n RhoA alkylation in subarachnoid hemorrhage Dataset DOI:\n [10.5061/dryad.9cnp5hr0x](https://doi.org/10.5061/dryad.9cnp5hr0x) ##\n Description of the data and file structure The data is in three files:\n Supplementary Table 3: Summary of statistical tests and exact p-values for\n all comparisons Supplementary Table 4: Drp1-related signaling molecules in\n PPI network Supplementary Table 5: Potential targets of cysteine\n alkylation modification by itaconate ### Files and variables #### File:\n Supplementary_Table_3.pdf **Description:** Summary of statistical tests\n and exact p-values for all comparisons #### File:\n Supplementary_Table_4.pdf **Description:** Drp1-related signaling\n molecules in PPI network #### File: Supplementary_Table_5.pdf\n **Description:** Potential targets of cysteine alkylation modification by\n itaconate ## Code/software Sumatra PDF Microsoft Edge Google Chrome Adobe\n Acrobat Reader Foxit PDF Reader","descriptionType":"TechnicalInfo"}],"geoLocations":[],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"82371309","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"},{"schemeUri":"https://ror.org","funderName":"National Natural Science Foundation of China","awardNumber":"82271310","funderIdentifier":"https://ror.org/01h0zpd94","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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      <creatorName nameType="Personal">Zhang, Xiaohua</creatorName>
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      <affiliation affiliationIdentifier="https://ror.org/03ypbx660" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Renji Hospital</affiliation>
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  <titles>
    <title>
      Supplementary data for: IRG1/itaconate inhibits microglial senescence-like
      transition by modulating mitochondrial dynamics through RhoA alkylation in
      subarachnoid hemorrhage
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
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    <subject subjectScheme="fos" schemeURI="https://web-archive.oecd.org/2012-06-15/138575-38235147.pdf">FOS: Basic medicine</subject>
    <subject>neuroinflammation</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Stroke</subject>
    <subject>Subarachnoid hemorrhage</subject>
    <subject>microglia</subject>
  </subjects>
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    <fundingReference>
      <funderName>National Natural Science Foundation of China</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01h0zpd94</funderIdentifier>
      <awardNumber>82371309</awardNumber>
      <awardTitle/>
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      <funderName>National Natural Science Foundation of China</funderName>
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      <awardNumber>82271310</awardNumber>
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    <date dateType="Created">2026-03-31T16:18:26Z</date>
    <date dateType="Submitted">2026-03-31T16:18:27Z</date>
    <date dateType="Issued">2026-04-27T00:00:00Z</date>
    <date dateType="Available">2026-04-27T00:00:00Z</date>
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    <description descriptionType="Abstract">
      Aging is a potent risk factor for poor prognosis in subarachnoid
      hemorrhage (SAH), yet the molecular mechanisms underlying the age-related
      exacerbation of early brain injury remain incompletely understood. This
      study investigates the immunometabolic regulation of the microglial
      senescence-like transition following SAH, focusing on the
      immune-responsive gene 1 (IRG1)/itaconate axis. We observed that the
      endogenous upregulation of IRG1 and itaconate is a protective response to
      hemorrhagic stress that is significantly blunted in aged mice.
      Microglia-specific IRG1 deficiency exacerbated SAH-induced brain injury,
      characterized by an accelerated senescence-like transition and the
      secretion of senescence-associated secretory phenotype (SASP) factors.
      Mechanistically, we demonstrate that IRG1 deficiency leads to excessive
      mitochondrial fission and dysfunction via the hyperactivity of
      Dynamin-related protein 1 (Drp1). Using click chemistry-based proteomics
      and site-directed mutagenesis, we identified that itaconate exerts its
      neuroprotective effects by directly alkylating the small GTPase RhoA at
      the cysteine 107 (C107) residue. This specific post-translational
      modification inhibits RhoA-GTP binding and downstream ROCK1 activation,
      thereby suppressing Drp1-mediated mitochondrial fragmentation.
      Importantly, treatment with the cell-permeable itaconate derivative
      4-octyl itaconate (4-OI) rescued mitochondrial dynamics and attenuated
      microglial senescence and neurological deficits, whereas the RhoA-C107S
      mutation abolished these protective effects. Collectively, our findings
      unveil a novel metabolic-mitochondrial checkpoint involving the
      IRG1/itaconate-RhoA-Drp1 axis. Restoring this pathway represents a
      promising therapeutic strategy to combat the age-related exacerbation of
      neuroinflammation and improve outcomes in SAH patients.
    </description>
    <description descriptionType="TechnicalInfo">
      # Supplementary data for: IRG1/itaconate inhibits microglial
      senescence-like transition by modulating mitochondrial dynamics through
      RhoA alkylation in subarachnoid hemorrhage Dataset DOI:
      [10.5061/dryad.9cnp5hr0x](https://doi.org/10.5061/dryad.9cnp5hr0x) ##
      Description of the data and file structure The data is in three files:
      Supplementary Table 3: Summary of statistical tests and exact p-values for
      all comparisons Supplementary Table 4: Drp1-related signaling molecules in
      PPI network Supplementary Table 5: Potential targets of cysteine
      alkylation modification by itaconate ### Files and variables #### File:
      Supplementary_Table_3.pdf **Description:** Summary of statistical tests
      and exact p-values for all comparisons #### File:
      Supplementary_Table_4.pdf **Description:** Drp1-related signaling
      molecules in PPI network #### File: Supplementary_Table_5.pdf
      **Description:** Potential targets of cysteine alkylation modification by
      itaconate ## Code/software Sumatra PDF Microsoft Edge Google Chrome Adobe
      Acrobat Reader Foxit PDF Reader
    </description>
  </descriptions>
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